uPAR expression in canine normal prostate and with proliferative disorders

Detalhes bibliográficos
Autor(a) principal: Faleiro, Mariana Rodrigues
Data de Publicação: 2013
Outros Autores: Toledo, Denise Caroline, Rodrigues, Marcela Marcondes Pinto [UNESP], Amorim, Renée Laufer [UNESP], Brito, Luiz Augusto Batista, Damasceno, Adilson Donizeti, Moura, Veridiana Maria Brianezi Dignani de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.5216/cab.v14i2.18930
http://hdl.handle.net/11449/109875
Resumo: Prostatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human and canine species due to their malignance potential. The plasminogen activator (PA) system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR) is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC) was evaluated by immunohistochemistry in a tissue microarray (TMA) slide to establish the role of this enzyme in extracellular matrix (ECM) remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1%) normal prostates, 46 (13.0%) with BPH, 128 (36.1%) with PIA, 74 (20.8%) with PIN and 71 (20.0%) with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.
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spelling uPAR expression in canine normal prostate and with proliferative disordersExpressão de uPAR na próstata canina normal e com lesões proliferativascarcinoma prostáticoCD87PIAPINTMACD87PIAPINprostatic carcinomaTMAProstatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human and canine species due to their malignance potential. The plasminogen activator (PA) system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR) is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC) was evaluated by immunohistochemistry in a tissue microarray (TMA) slide to establish the role of this enzyme in extracellular matrix (ECM) remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1%) normal prostates, 46 (13.0%) with BPH, 128 (36.1%) with PIA, 74 (20.8%) with PIN and 71 (20.0%) with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.Lesões prostáticas como a neoplasia intraepitelial prostática (PIN) e a atrofia inflamatória proliferativa (PIA) são estudadas na espécie humana e canina devido ao seu potencial de malignidade. O sistema de ativador de plasminogênio (PA) tem sido sugerido como um importante mecanismo na adesão celular, angiogênese, inflamação e invasão tumoral. O receptor ativador de plasminogênio do tipo uroquinase (uPAR) é um componente do PA, expresso em células tumorais e estromais. Avaliou-se, por imunoistoquímica em lâmina de microarranjo tecidual (TMA), a expressão de uPAR no tecido prostático canino normal e com desordens proliferativas (hiperplasia prostática benigna-HPB, atrofia inflamatória proliferativa-PIA, neoplasia epitelial prostática-PIN e carcinoma-CP), com o objetivo de verificar o papel desta enzima na remodelação de matriz extracelular (ECM) e no processo de invasão tecidual. Foram obtidos 298 cores e 355 diagnósticos, sendo 36 (10,1%) próstatas normais, 46 (13,0%) com HPB, 128 (36,1%) com PIA, 74 (20,8%) com PIN e 71 (20,0%) com CP. Há variação na expressão de uPAR na próstata canina de acordo com a lesão, com menor expressão nas glândulas normais e com HPB, e maior naquelas com lesões displásicas e (PIA e PIN) e neoplásicas (CP). A superexpressão de uPAR nos microambientes inflamatório e neoplásico indica aumento da atividade proteolítica em próstatas caninas com PIA, PIN e CP.Universidade Federal de Goiás Escola de Veterinária e ZootecniaUniversidade Estadual PaulistaUniversidade Estadual Paulista Escola de Veterinária e ZootecniaUniversidade Estadual PaulistaUniversidade Estadual Paulista Escola de Veterinária e ZootecniaUniversidade Federal de GoiásUniversidade Federal de Goiás (UFG)Universidade Estadual Paulista (Unesp)Faleiro, Mariana RodriguesToledo, Denise CarolineRodrigues, Marcela Marcondes Pinto [UNESP]Amorim, Renée Laufer [UNESP]Brito, Luiz Augusto BatistaDamasceno, Adilson DonizetiMoura, Veridiana Maria Brianezi Dignani de2014-10-01T13:08:38Z2014-10-01T13:08:38Z2013-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article237-244application/pdfhttp://dx.doi.org/10.5216/cab.v14i2.18930Ciência Animal Brasileira. Universidade Federal de Goiás, v. 14, n. 2, p. 237-244, 2013.1809-6891http://hdl.handle.net/11449/10987510.5216/cab.v14i2.18930S1809-689120130002000122-s2.0-84885365664S1809-68912013000200012.pdf9795829022108105SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCiência Animal Brasileira0,216info:eu-repo/semantics/openAccess2023-10-04T06:07:28Zoai:repositorio.unesp.br:11449/109875Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:00:37.619200Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv uPAR expression in canine normal prostate and with proliferative disorders
Expressão de uPAR na próstata canina normal e com lesões proliferativas
title uPAR expression in canine normal prostate and with proliferative disorders
spellingShingle uPAR expression in canine normal prostate and with proliferative disorders
Faleiro, Mariana Rodrigues
carcinoma prostático
CD87
PIA
PIN
TMA
CD87
PIA
PIN
prostatic carcinoma
TMA
title_short uPAR expression in canine normal prostate and with proliferative disorders
title_full uPAR expression in canine normal prostate and with proliferative disorders
title_fullStr uPAR expression in canine normal prostate and with proliferative disorders
title_full_unstemmed uPAR expression in canine normal prostate and with proliferative disorders
title_sort uPAR expression in canine normal prostate and with proliferative disorders
author Faleiro, Mariana Rodrigues
author_facet Faleiro, Mariana Rodrigues
Toledo, Denise Caroline
Rodrigues, Marcela Marcondes Pinto [UNESP]
Amorim, Renée Laufer [UNESP]
Brito, Luiz Augusto Batista
Damasceno, Adilson Donizeti
Moura, Veridiana Maria Brianezi Dignani de
author_role author
author2 Toledo, Denise Caroline
Rodrigues, Marcela Marcondes Pinto [UNESP]
Amorim, Renée Laufer [UNESP]
Brito, Luiz Augusto Batista
Damasceno, Adilson Donizeti
Moura, Veridiana Maria Brianezi Dignani de
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Goiás (UFG)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Faleiro, Mariana Rodrigues
Toledo, Denise Caroline
Rodrigues, Marcela Marcondes Pinto [UNESP]
Amorim, Renée Laufer [UNESP]
Brito, Luiz Augusto Batista
Damasceno, Adilson Donizeti
Moura, Veridiana Maria Brianezi Dignani de
dc.subject.por.fl_str_mv carcinoma prostático
CD87
PIA
PIN
TMA
CD87
PIA
PIN
prostatic carcinoma
TMA
topic carcinoma prostático
CD87
PIA
PIN
TMA
CD87
PIA
PIN
prostatic carcinoma
TMA
description Prostatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human and canine species due to their malignance potential. The plasminogen activator (PA) system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR) is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC) was evaluated by immunohistochemistry in a tissue microarray (TMA) slide to establish the role of this enzyme in extracellular matrix (ECM) remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1%) normal prostates, 46 (13.0%) with BPH, 128 (36.1%) with PIA, 74 (20.8%) with PIN and 71 (20.0%) with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.
publishDate 2013
dc.date.none.fl_str_mv 2013-06-01
2014-10-01T13:08:38Z
2014-10-01T13:08:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5216/cab.v14i2.18930
Ciência Animal Brasileira. Universidade Federal de Goiás, v. 14, n. 2, p. 237-244, 2013.
1809-6891
http://hdl.handle.net/11449/109875
10.5216/cab.v14i2.18930
S1809-68912013000200012
2-s2.0-84885365664
S1809-68912013000200012.pdf
9795829022108105
url http://dx.doi.org/10.5216/cab.v14i2.18930
http://hdl.handle.net/11449/109875
identifier_str_mv Ciência Animal Brasileira. Universidade Federal de Goiás, v. 14, n. 2, p. 237-244, 2013.
1809-6891
10.5216/cab.v14i2.18930
S1809-68912013000200012
2-s2.0-84885365664
S1809-68912013000200012.pdf
9795829022108105
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ciência Animal Brasileira
0,216
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 237-244
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Goiás
publisher.none.fl_str_mv Universidade Federal de Goiás
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128303846916096

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