Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.vprsr.2023.100864 http://hdl.handle.net/11449/249856 |
Resumo: | The indiscriminate use of drugs to control gastrointestinal helminths in horses can lead to serious consequences for the animals, which represents a growing problem for health, animal welfare and productivity. Therefore, the present study aimed to evaluate the anthelmintic efficacy of ivermectin in naturally infected horses in the western region of the state of São Paulo. From May 2021 to April 2022, 123 naturally infected adult horses in 12 equine breeding farms (7 to 14 animals per farm) were evaluated with the fecal egg count reduction test. The horses had not been treated with anthelmintic drugs for at least 60 days before the start of the study. The animals were treated with ivermectin (0.2 mg/kg; Eqvalan®, Merial) administered orally according to recommended dosage by the manufacturer. Individual fecal samples were collected directly from the rectal ampulla and used to determine the eggs per gram of feces (EPG) and perform coproculture for identification of larvae on the day of anthelmintic treatment (D0) and 14 days later (D14). The fecal egg count reduction (FECR) on each property was calculated using the program Shiny-egg Counts R version 3.6.1, and the presence of anthelmintic resistance was confirmed when the FECR percentage was less than 95%, and when the lower confidence limit [LCI] was less than 90%. The pre-treatment average EPG count in the 12 properties was 991. In five properties the FECR was lower than 90%; in three properties between 90% and 95%; and in four properties equal to or greater than 95% after treatment with ivermectin. The occurrence of cyathostomins with resistance to ivermectin was recorded in the majority of the farms. |
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Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, BrazilCyathostominsEquinesHelminthsStrongylusThe indiscriminate use of drugs to control gastrointestinal helminths in horses can lead to serious consequences for the animals, which represents a growing problem for health, animal welfare and productivity. Therefore, the present study aimed to evaluate the anthelmintic efficacy of ivermectin in naturally infected horses in the western region of the state of São Paulo. From May 2021 to April 2022, 123 naturally infected adult horses in 12 equine breeding farms (7 to 14 animals per farm) were evaluated with the fecal egg count reduction test. The horses had not been treated with anthelmintic drugs for at least 60 days before the start of the study. The animals were treated with ivermectin (0.2 mg/kg; Eqvalan®, Merial) administered orally according to recommended dosage by the manufacturer. Individual fecal samples were collected directly from the rectal ampulla and used to determine the eggs per gram of feces (EPG) and perform coproculture for identification of larvae on the day of anthelmintic treatment (D0) and 14 days later (D14). The fecal egg count reduction (FECR) on each property was calculated using the program Shiny-egg Counts R version 3.6.1, and the presence of anthelmintic resistance was confirmed when the FECR percentage was less than 95%, and when the lower confidence limit [LCI] was less than 90%. The pre-treatment average EPG count in the 12 properties was 991. In five properties the FECR was lower than 90%; in three properties between 90% and 95%; and in four properties equal to or greater than 95% after treatment with ivermectin. The occurrence of cyathostomins with resistance to ivermectin was recorded in the majority of the farms.Universidade Estadual Paulista (UNESP) School of Agrarian and Technological Sciences (FCAT), Dracena, SPFaculty of Veterinary Medicine and Animal Science – Unesp/FMVZ, SPUniversidade Estadual Paulista (UNESP) School of Agrarian and Technological Sciences (FCAT), Dracena, SPFaculty of Veterinary Medicine and Animal Science – Unesp/FMVZ, SPUniversidade Estadual Paulista (UNESP)de Favare, Giordani Mascoli [UNESP]de Almeida Cipriano, Isabela [UNESP]do Carmo, Tábata Alves [UNESP]Mena, Mateus Oliveira [UNESP]Guelpa, Gabriel Jabismar [UNESP]do Amarante, Alessandro Francisco Talamini [UNESP]de Soutello, Ricardo Velludo Gomes [UNESP]2023-07-29T16:11:04Z2023-07-29T16:11:04Z2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.vprsr.2023.100864Veterinary Parasitology: Regional Studies and Reports, v. 41.2405-9390http://hdl.handle.net/11449/24985610.1016/j.vprsr.2023.1008642-s2.0-85152446120Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVeterinary Parasitology: Regional Studies and Reportsinfo:eu-repo/semantics/openAccess2024-05-07T13:47:35Zoai:repositorio.unesp.br:11449/249856Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:13:32.248008Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil |
title |
Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil |
spellingShingle |
Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil de Favare, Giordani Mascoli [UNESP] Cyathostomins Equines Helminths Strongylus |
title_short |
Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil |
title_full |
Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil |
title_fullStr |
Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil |
title_full_unstemmed |
Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil |
title_sort |
Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil |
author |
de Favare, Giordani Mascoli [UNESP] |
author_facet |
de Favare, Giordani Mascoli [UNESP] de Almeida Cipriano, Isabela [UNESP] do Carmo, Tábata Alves [UNESP] Mena, Mateus Oliveira [UNESP] Guelpa, Gabriel Jabismar [UNESP] do Amarante, Alessandro Francisco Talamini [UNESP] de Soutello, Ricardo Velludo Gomes [UNESP] |
author_role |
author |
author2 |
de Almeida Cipriano, Isabela [UNESP] do Carmo, Tábata Alves [UNESP] Mena, Mateus Oliveira [UNESP] Guelpa, Gabriel Jabismar [UNESP] do Amarante, Alessandro Francisco Talamini [UNESP] de Soutello, Ricardo Velludo Gomes [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
de Favare, Giordani Mascoli [UNESP] de Almeida Cipriano, Isabela [UNESP] do Carmo, Tábata Alves [UNESP] Mena, Mateus Oliveira [UNESP] Guelpa, Gabriel Jabismar [UNESP] do Amarante, Alessandro Francisco Talamini [UNESP] de Soutello, Ricardo Velludo Gomes [UNESP] |
dc.subject.por.fl_str_mv |
Cyathostomins Equines Helminths Strongylus |
topic |
Cyathostomins Equines Helminths Strongylus |
description |
The indiscriminate use of drugs to control gastrointestinal helminths in horses can lead to serious consequences for the animals, which represents a growing problem for health, animal welfare and productivity. Therefore, the present study aimed to evaluate the anthelmintic efficacy of ivermectin in naturally infected horses in the western region of the state of São Paulo. From May 2021 to April 2022, 123 naturally infected adult horses in 12 equine breeding farms (7 to 14 animals per farm) were evaluated with the fecal egg count reduction test. The horses had not been treated with anthelmintic drugs for at least 60 days before the start of the study. The animals were treated with ivermectin (0.2 mg/kg; Eqvalan®, Merial) administered orally according to recommended dosage by the manufacturer. Individual fecal samples were collected directly from the rectal ampulla and used to determine the eggs per gram of feces (EPG) and perform coproculture for identification of larvae on the day of anthelmintic treatment (D0) and 14 days later (D14). The fecal egg count reduction (FECR) on each property was calculated using the program Shiny-egg Counts R version 3.6.1, and the presence of anthelmintic resistance was confirmed when the FECR percentage was less than 95%, and when the lower confidence limit [LCI] was less than 90%. The pre-treatment average EPG count in the 12 properties was 991. In five properties the FECR was lower than 90%; in three properties between 90% and 95%; and in four properties equal to or greater than 95% after treatment with ivermectin. The occurrence of cyathostomins with resistance to ivermectin was recorded in the majority of the farms. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T16:11:04Z 2023-07-29T16:11:04Z 2023-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.vprsr.2023.100864 Veterinary Parasitology: Regional Studies and Reports, v. 41. 2405-9390 http://hdl.handle.net/11449/249856 10.1016/j.vprsr.2023.100864 2-s2.0-85152446120 |
url |
http://dx.doi.org/10.1016/j.vprsr.2023.100864 http://hdl.handle.net/11449/249856 |
identifier_str_mv |
Veterinary Parasitology: Regional Studies and Reports, v. 41. 2405-9390 10.1016/j.vprsr.2023.100864 2-s2.0-85152446120 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Veterinary Parasitology: Regional Studies and Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129036538347520 |