Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil

Detalhes bibliográficos
Autor(a) principal: de Favare, Giordani Mascoli [UNESP]
Data de Publicação: 2023
Outros Autores: de Almeida Cipriano, Isabela [UNESP], do Carmo, Tábata Alves [UNESP], Mena, Mateus Oliveira [UNESP], Guelpa, Gabriel Jabismar [UNESP], do Amarante, Alessandro Francisco Talamini [UNESP], de Soutello, Ricardo Velludo Gomes [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.vprsr.2023.100864
http://hdl.handle.net/11449/249856
Resumo: The indiscriminate use of drugs to control gastrointestinal helminths in horses can lead to serious consequences for the animals, which represents a growing problem for health, animal welfare and productivity. Therefore, the present study aimed to evaluate the anthelmintic efficacy of ivermectin in naturally infected horses in the western region of the state of São Paulo. From May 2021 to April 2022, 123 naturally infected adult horses in 12 equine breeding farms (7 to 14 animals per farm) were evaluated with the fecal egg count reduction test. The horses had not been treated with anthelmintic drugs for at least 60 days before the start of the study. The animals were treated with ivermectin (0.2 mg/kg; Eqvalan®, Merial) administered orally according to recommended dosage by the manufacturer. Individual fecal samples were collected directly from the rectal ampulla and used to determine the eggs per gram of feces (EPG) and perform coproculture for identification of larvae on the day of anthelmintic treatment (D0) and 14 days later (D14). The fecal egg count reduction (FECR) on each property was calculated using the program Shiny-egg Counts R version 3.6.1, and the presence of anthelmintic resistance was confirmed when the FECR percentage was less than 95%, and when the lower confidence limit [LCI] was less than 90%. The pre-treatment average EPG count in the 12 properties was 991. In five properties the FECR was lower than 90%; in three properties between 90% and 95%; and in four properties equal to or greater than 95% after treatment with ivermectin. The occurrence of cyathostomins with resistance to ivermectin was recorded in the majority of the farms.
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spelling Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, BrazilCyathostominsEquinesHelminthsStrongylusThe indiscriminate use of drugs to control gastrointestinal helminths in horses can lead to serious consequences for the animals, which represents a growing problem for health, animal welfare and productivity. Therefore, the present study aimed to evaluate the anthelmintic efficacy of ivermectin in naturally infected horses in the western region of the state of São Paulo. From May 2021 to April 2022, 123 naturally infected adult horses in 12 equine breeding farms (7 to 14 animals per farm) were evaluated with the fecal egg count reduction test. The horses had not been treated with anthelmintic drugs for at least 60 days before the start of the study. The animals were treated with ivermectin (0.2 mg/kg; Eqvalan®, Merial) administered orally according to recommended dosage by the manufacturer. Individual fecal samples were collected directly from the rectal ampulla and used to determine the eggs per gram of feces (EPG) and perform coproculture for identification of larvae on the day of anthelmintic treatment (D0) and 14 days later (D14). The fecal egg count reduction (FECR) on each property was calculated using the program Shiny-egg Counts R version 3.6.1, and the presence of anthelmintic resistance was confirmed when the FECR percentage was less than 95%, and when the lower confidence limit [LCI] was less than 90%. The pre-treatment average EPG count in the 12 properties was 991. In five properties the FECR was lower than 90%; in three properties between 90% and 95%; and in four properties equal to or greater than 95% after treatment with ivermectin. The occurrence of cyathostomins with resistance to ivermectin was recorded in the majority of the farms.Universidade Estadual Paulista (UNESP) School of Agrarian and Technological Sciences (FCAT), Dracena, SPFaculty of Veterinary Medicine and Animal Science – Unesp/FMVZ, SPUniversidade Estadual Paulista (UNESP) School of Agrarian and Technological Sciences (FCAT), Dracena, SPFaculty of Veterinary Medicine and Animal Science – Unesp/FMVZ, SPUniversidade Estadual Paulista (UNESP)de Favare, Giordani Mascoli [UNESP]de Almeida Cipriano, Isabela [UNESP]do Carmo, Tábata Alves [UNESP]Mena, Mateus Oliveira [UNESP]Guelpa, Gabriel Jabismar [UNESP]do Amarante, Alessandro Francisco Talamini [UNESP]de Soutello, Ricardo Velludo Gomes [UNESP]2023-07-29T16:11:04Z2023-07-29T16:11:04Z2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.vprsr.2023.100864Veterinary Parasitology: Regional Studies and Reports, v. 41.2405-9390http://hdl.handle.net/11449/24985610.1016/j.vprsr.2023.1008642-s2.0-85152446120Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVeterinary Parasitology: Regional Studies and Reportsinfo:eu-repo/semantics/openAccess2024-05-07T13:47:35Zoai:repositorio.unesp.br:11449/249856Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:13:32.248008Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil
title Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil
spellingShingle Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil
de Favare, Giordani Mascoli [UNESP]
Cyathostomins
Equines
Helminths
Strongylus
title_short Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil
title_full Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil
title_fullStr Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil
title_full_unstemmed Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil
title_sort Anthelmintic resistance of horse strongyle nematodes to ivermectin in São Paulo state, Brazil
author de Favare, Giordani Mascoli [UNESP]
author_facet de Favare, Giordani Mascoli [UNESP]
de Almeida Cipriano, Isabela [UNESP]
do Carmo, Tábata Alves [UNESP]
Mena, Mateus Oliveira [UNESP]
Guelpa, Gabriel Jabismar [UNESP]
do Amarante, Alessandro Francisco Talamini [UNESP]
de Soutello, Ricardo Velludo Gomes [UNESP]
author_role author
author2 de Almeida Cipriano, Isabela [UNESP]
do Carmo, Tábata Alves [UNESP]
Mena, Mateus Oliveira [UNESP]
Guelpa, Gabriel Jabismar [UNESP]
do Amarante, Alessandro Francisco Talamini [UNESP]
de Soutello, Ricardo Velludo Gomes [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv de Favare, Giordani Mascoli [UNESP]
de Almeida Cipriano, Isabela [UNESP]
do Carmo, Tábata Alves [UNESP]
Mena, Mateus Oliveira [UNESP]
Guelpa, Gabriel Jabismar [UNESP]
do Amarante, Alessandro Francisco Talamini [UNESP]
de Soutello, Ricardo Velludo Gomes [UNESP]
dc.subject.por.fl_str_mv Cyathostomins
Equines
Helminths
Strongylus
topic Cyathostomins
Equines
Helminths
Strongylus
description The indiscriminate use of drugs to control gastrointestinal helminths in horses can lead to serious consequences for the animals, which represents a growing problem for health, animal welfare and productivity. Therefore, the present study aimed to evaluate the anthelmintic efficacy of ivermectin in naturally infected horses in the western region of the state of São Paulo. From May 2021 to April 2022, 123 naturally infected adult horses in 12 equine breeding farms (7 to 14 animals per farm) were evaluated with the fecal egg count reduction test. The horses had not been treated with anthelmintic drugs for at least 60 days before the start of the study. The animals were treated with ivermectin (0.2 mg/kg; Eqvalan®, Merial) administered orally according to recommended dosage by the manufacturer. Individual fecal samples were collected directly from the rectal ampulla and used to determine the eggs per gram of feces (EPG) and perform coproculture for identification of larvae on the day of anthelmintic treatment (D0) and 14 days later (D14). The fecal egg count reduction (FECR) on each property was calculated using the program Shiny-egg Counts R version 3.6.1, and the presence of anthelmintic resistance was confirmed when the FECR percentage was less than 95%, and when the lower confidence limit [LCI] was less than 90%. The pre-treatment average EPG count in the 12 properties was 991. In five properties the FECR was lower than 90%; in three properties between 90% and 95%; and in four properties equal to or greater than 95% after treatment with ivermectin. The occurrence of cyathostomins with resistance to ivermectin was recorded in the majority of the farms.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-29T16:11:04Z
2023-07-29T16:11:04Z
2023-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.vprsr.2023.100864
Veterinary Parasitology: Regional Studies and Reports, v. 41.
2405-9390
http://hdl.handle.net/11449/249856
10.1016/j.vprsr.2023.100864
2-s2.0-85152446120
url http://dx.doi.org/10.1016/j.vprsr.2023.100864
http://hdl.handle.net/11449/249856
identifier_str_mv Veterinary Parasitology: Regional Studies and Reports, v. 41.
2405-9390
10.1016/j.vprsr.2023.100864
2-s2.0-85152446120
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Veterinary Parasitology: Regional Studies and Reports
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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