Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.aquatox.2019.03.011 http://hdl.handle.net/11449/187520 |
Resumo: | The excessive proliferation of toxin producing cyanobacteria constitutes a significant health risk to the environment and humans. This is due to the contamination of potable water and accumulation of cyanotoxins in plant and animal tissues. As a means of controlling bloom forming cyanobacteria, secondary metabolites with pro-oxidative activities from plants are used to treat water bodies contaminated with cyanobacterial blooms and their associated toxins. The objective of the present study was to evaluate the mechanism of action of extract, fractions and isolated flavonoids of Tridax procumbens L. on Microcystis aeruginosa (Kützing) Kützing. by monitoring changes in growth, oxidative stress, antioxidant response, and cyanatoxin microcystins (MCs) production. The extract, fraction 3 and the isolated flavonoids significantly reduced the cell density of the cyanobacterium. Furthermore, the extract and fraction 3 increased the production of reactive oxygen species, induced lipid peroxidation, and altered antioxidant enzyme activities of M. aeruginosa. The total MCs content of the cyanobacterium was negatively affected by the presence of the extract, fractions and isolated flavonoids. The present study show that T. procumbens has secondary metabolites that are capable of interfering with the physiology and microcystins production of M. aeruginosa. These characteristics are promising for the control of this noxious cyanobacterium in aquatic ecosystems. |
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Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginosCyanobactericidal activityFlavonoidsLipid peroxidationLuteolinMicrocystinsQuercetagetinThe excessive proliferation of toxin producing cyanobacteria constitutes a significant health risk to the environment and humans. This is due to the contamination of potable water and accumulation of cyanotoxins in plant and animal tissues. As a means of controlling bloom forming cyanobacteria, secondary metabolites with pro-oxidative activities from plants are used to treat water bodies contaminated with cyanobacterial blooms and their associated toxins. The objective of the present study was to evaluate the mechanism of action of extract, fractions and isolated flavonoids of Tridax procumbens L. on Microcystis aeruginosa (Kützing) Kützing. by monitoring changes in growth, oxidative stress, antioxidant response, and cyanatoxin microcystins (MCs) production. The extract, fraction 3 and the isolated flavonoids significantly reduced the cell density of the cyanobacterium. Furthermore, the extract and fraction 3 increased the production of reactive oxygen species, induced lipid peroxidation, and altered antioxidant enzyme activities of M. aeruginosa. The total MCs content of the cyanobacterium was negatively affected by the presence of the extract, fractions and isolated flavonoids. The present study show that T. procumbens has secondary metabolites that are capable of interfering with the physiology and microcystins production of M. aeruginosa. These characteristics are promising for the control of this noxious cyanobacterium in aquatic ecosystems.São Paulo State University (UNESP) School of Sciences Humanities and Languages Assis Department of Biotechnology Laboratory of Herbal Medicine and Natural Products, Avenida Dom Antônio 2100São Paulo State University (UNESP) Institute of Chemistry, Rua Prof. Francisco Degni 55Departamento de Ciências Biológicas Escola Superior de Agricultura Luiz de Queiroz Universidade de São PauloAllelopathy Group Department of Organic Chemistry Institute of Biomolecules (INBIO) School of Science University of Cadiz, Campus de Excelencia Internacional 6 (ceiA3), C/República Saharaui 7Department of Botany Ahmadu Bello UniversitySão Paulo State University (UNESP) School of Sciences Humanities and Languages Assis Department of Biotechnology Laboratory of Herbal Medicine and Natural Products, Avenida Dom Antônio 2100São Paulo State University (UNESP) Institute of Chemistry, Rua Prof. Francisco Degni 55Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)University of CadizAhmadu Bello UniversityMecina, Gustavo Franciscatti [UNESP]Chia, Mathias AhiiCordeiro-Araújo, Micheline KéziaBittencourt-Oliveira, Maria do CarmoRosa, Maria VarelaTorres, AscensiónGonzales Molinillo, José MariaMacías, Francisco Antônioda Silva, Regildo Márcio Gonçalves [UNESP]2019-10-06T15:38:38Z2019-10-06T15:38:38Z2019-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article81-91http://dx.doi.org/10.1016/j.aquatox.2019.03.011Aquatic Toxicology, v. 211, p. 81-91.1879-15140166-445Xhttp://hdl.handle.net/11449/18752010.1016/j.aquatox.2019.03.0112-s2.0-85063760196Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAquatic Toxicologyinfo:eu-repo/semantics/openAccess2021-10-23T20:19:26Zoai:repositorio.unesp.br:11449/187520Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:40:23.686153Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos |
title |
Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos |
spellingShingle |
Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos Mecina, Gustavo Franciscatti [UNESP] Cyanobactericidal activity Flavonoids Lipid peroxidation Luteolin Microcystins Quercetagetin |
title_short |
Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos |
title_full |
Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos |
title_fullStr |
Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos |
title_full_unstemmed |
Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos |
title_sort |
Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos |
author |
Mecina, Gustavo Franciscatti [UNESP] |
author_facet |
Mecina, Gustavo Franciscatti [UNESP] Chia, Mathias Ahii Cordeiro-Araújo, Micheline Kézia Bittencourt-Oliveira, Maria do Carmo Rosa, Maria Varela Torres, Ascensión Gonzales Molinillo, José Maria Macías, Francisco Antônio da Silva, Regildo Márcio Gonçalves [UNESP] |
author_role |
author |
author2 |
Chia, Mathias Ahii Cordeiro-Araújo, Micheline Kézia Bittencourt-Oliveira, Maria do Carmo Rosa, Maria Varela Torres, Ascensión Gonzales Molinillo, José Maria Macías, Francisco Antônio da Silva, Regildo Márcio Gonçalves [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) University of Cadiz Ahmadu Bello University |
dc.contributor.author.fl_str_mv |
Mecina, Gustavo Franciscatti [UNESP] Chia, Mathias Ahii Cordeiro-Araújo, Micheline Kézia Bittencourt-Oliveira, Maria do Carmo Rosa, Maria Varela Torres, Ascensión Gonzales Molinillo, José Maria Macías, Francisco Antônio da Silva, Regildo Márcio Gonçalves [UNESP] |
dc.subject.por.fl_str_mv |
Cyanobactericidal activity Flavonoids Lipid peroxidation Luteolin Microcystins Quercetagetin |
topic |
Cyanobactericidal activity Flavonoids Lipid peroxidation Luteolin Microcystins Quercetagetin |
description |
The excessive proliferation of toxin producing cyanobacteria constitutes a significant health risk to the environment and humans. This is due to the contamination of potable water and accumulation of cyanotoxins in plant and animal tissues. As a means of controlling bloom forming cyanobacteria, secondary metabolites with pro-oxidative activities from plants are used to treat water bodies contaminated with cyanobacterial blooms and their associated toxins. The objective of the present study was to evaluate the mechanism of action of extract, fractions and isolated flavonoids of Tridax procumbens L. on Microcystis aeruginosa (Kützing) Kützing. by monitoring changes in growth, oxidative stress, antioxidant response, and cyanatoxin microcystins (MCs) production. The extract, fraction 3 and the isolated flavonoids significantly reduced the cell density of the cyanobacterium. Furthermore, the extract and fraction 3 increased the production of reactive oxygen species, induced lipid peroxidation, and altered antioxidant enzyme activities of M. aeruginosa. The total MCs content of the cyanobacterium was negatively affected by the presence of the extract, fractions and isolated flavonoids. The present study show that T. procumbens has secondary metabolites that are capable of interfering with the physiology and microcystins production of M. aeruginosa. These characteristics are promising for the control of this noxious cyanobacterium in aquatic ecosystems. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T15:38:38Z 2019-10-06T15:38:38Z 2019-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.aquatox.2019.03.011 Aquatic Toxicology, v. 211, p. 81-91. 1879-1514 0166-445X http://hdl.handle.net/11449/187520 10.1016/j.aquatox.2019.03.011 2-s2.0-85063760196 |
url |
http://dx.doi.org/10.1016/j.aquatox.2019.03.011 http://hdl.handle.net/11449/187520 |
identifier_str_mv |
Aquatic Toxicology, v. 211, p. 81-91. 1879-1514 0166-445X 10.1016/j.aquatox.2019.03.011 2-s2.0-85063760196 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Aquatic Toxicology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
81-91 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128397392478208 |