Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based beta-Amino Alcohol Derivatives
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.21577/0103-5053.20170178 http://hdl.handle.net/11449/165973 |
Resumo: | The synthesis of novel amino alcohol derivatives based on cardanol and glycerol were achieved in good yields and characterized by H-1 and C-13 NMR (nuclear magnetic resonance) and MS (mass spectrometry). In addition, we evaluated the in vitro antimicrobial activity against Gram-positive (Staphylococcus aureus, standard and clinical strains), Gram-negative (Escherichia coli) and M. tuberculosis bacterial strains. The bioassay results indicated that four compounds showed activity against S. aureus, including the clinical resistant strain, with MIC (minimum inhibitory concentration) ranging from 3.90 to 15.60 mu g mL(-1) and M. tuberculosis, with MIC90 (minimum inhibitory concentration required to inhibit the growth of 90% of organisms) ranging from 3.18 to 7.36 mu g mL(-1). |
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Repositório Institucional da UNESP |
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Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based beta-Amino Alcohol DerivativesCNSLcardanolamino alcoholsepoxide ring openingantimicrobial activityThe synthesis of novel amino alcohol derivatives based on cardanol and glycerol were achieved in good yields and characterized by H-1 and C-13 NMR (nuclear magnetic resonance) and MS (mass spectrometry). In addition, we evaluated the in vitro antimicrobial activity against Gram-positive (Staphylococcus aureus, standard and clinical strains), Gram-negative (Escherichia coli) and M. tuberculosis bacterial strains. The bioassay results indicated that four compounds showed activity against S. aureus, including the clinical resistant strain, with MIC (minimum inhibitory concentration) ranging from 3.90 to 15.60 mu g mL(-1) and M. tuberculosis, with MIC90 (minimum inhibitory concentration required to inhibit the growth of 90% of organisms) ranging from 3.18 to 7.36 mu g mL(-1).FUNDECT (PRONEM)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Kardol Ind. Quimica Ltda.Univ Fed Mato Grosso Do Sul, Inst Quim INQUI, Av Senador Felinto Muller 1555, BR-79074460 Campo Grande, MS, BrazilUniv Fed Espirito Santo, Dept Quim, BR-29075910 Vitoria, ES, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, BrazilUniv Fed Mato Grosso Do Sul, Inst Biociencias INBIO, Cidade Univ S-N,CP 549, BR-79070900 Campo Grande, MS, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, BrazilFUNDECT (PRONEM): 054/12Soc Brasileira QuimicaUniversidade Federal de Mato Grosso do Sul (UFMS)Universidade Federal do Espírito Santo (UFES)Universidade Estadual Paulista (Unesp)Manda, Bhaskar R.Prasad, Avvari N.Thatikonda, Narendar R.Lacerda, ValdemarBarbosa, Layla R.Santos, HeloaRomao, WandersonPavan, Fernando R. [UNESP]Ribeiro, Camila M. [UNESP]Santos, Edson A. dosMarques, Maria R.Lima, Denis P. deMicheletti, Ana C.Beatriz, Adilson2018-11-29T06:20:41Z2018-11-29T06:20:41Z2018-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article639-648application/pdfhttp://dx.doi.org/10.21577/0103-5053.20170178Journal Of The Brazilian Chemical Society. Sao Paulo: Soc Brasileira Quimica, v. 29, n. 3, p. 639-648, 2018.0103-5053http://hdl.handle.net/11449/16597310.21577/0103-5053.20170178S0103-50532018000300639WOS:000423214300023S0103-50532018000300639.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of The Brazilian Chemical Societyinfo:eu-repo/semantics/openAccess2023-11-15T06:11:28Zoai:repositorio.unesp.br:11449/165973Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-15T06:11:28Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based beta-Amino Alcohol Derivatives |
title |
Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based beta-Amino Alcohol Derivatives |
spellingShingle |
Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based beta-Amino Alcohol Derivatives Manda, Bhaskar R. CNSL cardanol amino alcohols epoxide ring opening antimicrobial activity |
title_short |
Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based beta-Amino Alcohol Derivatives |
title_full |
Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based beta-Amino Alcohol Derivatives |
title_fullStr |
Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based beta-Amino Alcohol Derivatives |
title_full_unstemmed |
Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based beta-Amino Alcohol Derivatives |
title_sort |
Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol-Based beta-Amino Alcohol Derivatives |
author |
Manda, Bhaskar R. |
author_facet |
Manda, Bhaskar R. Prasad, Avvari N. Thatikonda, Narendar R. Lacerda, Valdemar Barbosa, Layla R. Santos, Heloa Romao, Wanderson Pavan, Fernando R. [UNESP] Ribeiro, Camila M. [UNESP] Santos, Edson A. dos Marques, Maria R. Lima, Denis P. de Micheletti, Ana C. Beatriz, Adilson |
author_role |
author |
author2 |
Prasad, Avvari N. Thatikonda, Narendar R. Lacerda, Valdemar Barbosa, Layla R. Santos, Heloa Romao, Wanderson Pavan, Fernando R. [UNESP] Ribeiro, Camila M. [UNESP] Santos, Edson A. dos Marques, Maria R. Lima, Denis P. de Micheletti, Ana C. Beatriz, Adilson |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Mato Grosso do Sul (UFMS) Universidade Federal do Espírito Santo (UFES) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Manda, Bhaskar R. Prasad, Avvari N. Thatikonda, Narendar R. Lacerda, Valdemar Barbosa, Layla R. Santos, Heloa Romao, Wanderson Pavan, Fernando R. [UNESP] Ribeiro, Camila M. [UNESP] Santos, Edson A. dos Marques, Maria R. Lima, Denis P. de Micheletti, Ana C. Beatriz, Adilson |
dc.subject.por.fl_str_mv |
CNSL cardanol amino alcohols epoxide ring opening antimicrobial activity |
topic |
CNSL cardanol amino alcohols epoxide ring opening antimicrobial activity |
description |
The synthesis of novel amino alcohol derivatives based on cardanol and glycerol were achieved in good yields and characterized by H-1 and C-13 NMR (nuclear magnetic resonance) and MS (mass spectrometry). In addition, we evaluated the in vitro antimicrobial activity against Gram-positive (Staphylococcus aureus, standard and clinical strains), Gram-negative (Escherichia coli) and M. tuberculosis bacterial strains. The bioassay results indicated that four compounds showed activity against S. aureus, including the clinical resistant strain, with MIC (minimum inhibitory concentration) ranging from 3.90 to 15.60 mu g mL(-1) and M. tuberculosis, with MIC90 (minimum inhibitory concentration required to inhibit the growth of 90% of organisms) ranging from 3.18 to 7.36 mu g mL(-1). |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-29T06:20:41Z 2018-11-29T06:20:41Z 2018-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.21577/0103-5053.20170178 Journal Of The Brazilian Chemical Society. Sao Paulo: Soc Brasileira Quimica, v. 29, n. 3, p. 639-648, 2018. 0103-5053 http://hdl.handle.net/11449/165973 10.21577/0103-5053.20170178 S0103-50532018000300639 WOS:000423214300023 S0103-50532018000300639.pdf |
url |
http://dx.doi.org/10.21577/0103-5053.20170178 http://hdl.handle.net/11449/165973 |
identifier_str_mv |
Journal Of The Brazilian Chemical Society. Sao Paulo: Soc Brasileira Quimica, v. 29, n. 3, p. 639-648, 2018. 0103-5053 10.21577/0103-5053.20170178 S0103-50532018000300639 WOS:000423214300023 S0103-50532018000300639.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of The Brazilian Chemical Society |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
639-648 application/pdf |
dc.publisher.none.fl_str_mv |
Soc Brasileira Quimica |
publisher.none.fl_str_mv |
Soc Brasileira Quimica |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964940268732416 |