ESTUDOS EM CONTRATILIDADE MIOCARDICA. III. COMPORTAMENTO DO INOTROPISMO CARDIACO DURANTE A ELEVACAO DA PRESSAO ARTERIAL, PELA INFUSAO DE ANGIOTENSINA II
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1975 |
| Outros Autores: | , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://hdl.handle.net/11449/230772 |
Resumo: | The inotropic effects consequent to the elevation of arterial pressure by infusion of angiotensin II were studied in dogs with intact autonomic nervous systems and in dogs previously submitted to ganglionic blockade. Maximal velocity of contraction (VmaxTP) was used to evaluate the inotropic state. When the heart rate was allowed to vary or when it was maintained constant by atrial stimulation the rise in blood pressure was accompanied by impaired contractility in the animals with intact nervous sytem. This negative inotropic influence seems to be due to changes of the neurovegetative tone due to baroreceptor reflexes. In the dogs submitted to ganglionic blockade, during the administration of the drug, there was elevation of VmaxTP. The improved inotropic state in these animals was explained by adrenergic hyperactivity produced by the polypeptide. |
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ESTUDOS EM CONTRATILIDADE MIOCARDICA. III. COMPORTAMENTO DO INOTROPISMO CARDIACO DURANTE A ELEVACAO DA PRESSAO ARTERIAL, PELA INFUSAO DE ANGIOTENSINA IIMyocardial contractility. III. The effect on cardiac inotropism during elevation of arterial blood pressure during infusion of angiotensin IIThe inotropic effects consequent to the elevation of arterial pressure by infusion of angiotensin II were studied in dogs with intact autonomic nervous systems and in dogs previously submitted to ganglionic blockade. Maximal velocity of contraction (VmaxTP) was used to evaluate the inotropic state. When the heart rate was allowed to vary or when it was maintained constant by atrial stimulation the rise in blood pressure was accompanied by impaired contractility in the animals with intact nervous sytem. This negative inotropic influence seems to be due to changes of the neurovegetative tone due to baroreceptor reflexes. In the dogs submitted to ganglionic blockade, during the administration of the drug, there was elevation of VmaxTP. The improved inotropic state in these animals was explained by adrenergic hyperactivity produced by the polypeptide.Unidade Hemodinamica, Dept. Clin. Med., Fac. Ci. Med. Biol., Botucatu2022-04-29T08:41:57Z2022-04-29T08:41:57Z1975-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article403-408Arquivos Brasileiros de Cardiologia, v. 28, n. 4, p. 403-408, 1975.0066-782Xhttp://hdl.handle.net/11449/2307722-s2.0-0016711453Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporArquivos Brasileiros de CardiologiaTucci, P. J.F.Spadaro, J.Cicogna, A. C.info:eu-repo/semantics/openAccess2024-08-14T17:22:36Zoai:repositorio.unesp.br:11449/230772Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:36Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
ESTUDOS EM CONTRATILIDADE MIOCARDICA. III. COMPORTAMENTO DO INOTROPISMO CARDIACO DURANTE A ELEVACAO DA PRESSAO ARTERIAL, PELA INFUSAO DE ANGIOTENSINA II Myocardial contractility. III. The effect on cardiac inotropism during elevation of arterial blood pressure during infusion of angiotensin II |
| title |
ESTUDOS EM CONTRATILIDADE MIOCARDICA. III. COMPORTAMENTO DO INOTROPISMO CARDIACO DURANTE A ELEVACAO DA PRESSAO ARTERIAL, PELA INFUSAO DE ANGIOTENSINA II |
| spellingShingle |
ESTUDOS EM CONTRATILIDADE MIOCARDICA. III. COMPORTAMENTO DO INOTROPISMO CARDIACO DURANTE A ELEVACAO DA PRESSAO ARTERIAL, PELA INFUSAO DE ANGIOTENSINA II Tucci, P. J.F. |
| title_short |
ESTUDOS EM CONTRATILIDADE MIOCARDICA. III. COMPORTAMENTO DO INOTROPISMO CARDIACO DURANTE A ELEVACAO DA PRESSAO ARTERIAL, PELA INFUSAO DE ANGIOTENSINA II |
| title_full |
ESTUDOS EM CONTRATILIDADE MIOCARDICA. III. COMPORTAMENTO DO INOTROPISMO CARDIACO DURANTE A ELEVACAO DA PRESSAO ARTERIAL, PELA INFUSAO DE ANGIOTENSINA II |
| title_fullStr |
ESTUDOS EM CONTRATILIDADE MIOCARDICA. III. COMPORTAMENTO DO INOTROPISMO CARDIACO DURANTE A ELEVACAO DA PRESSAO ARTERIAL, PELA INFUSAO DE ANGIOTENSINA II |
| title_full_unstemmed |
ESTUDOS EM CONTRATILIDADE MIOCARDICA. III. COMPORTAMENTO DO INOTROPISMO CARDIACO DURANTE A ELEVACAO DA PRESSAO ARTERIAL, PELA INFUSAO DE ANGIOTENSINA II |
| title_sort |
ESTUDOS EM CONTRATILIDADE MIOCARDICA. III. COMPORTAMENTO DO INOTROPISMO CARDIACO DURANTE A ELEVACAO DA PRESSAO ARTERIAL, PELA INFUSAO DE ANGIOTENSINA II |
| author |
Tucci, P. J.F. |
| author_facet |
Tucci, P. J.F. Spadaro, J. Cicogna, A. C. |
| author_role |
author |
| author2 |
Spadaro, J. Cicogna, A. C. |
| author2_role |
author author |
| dc.contributor.author.fl_str_mv |
Tucci, P. J.F. Spadaro, J. Cicogna, A. C. |
| description |
The inotropic effects consequent to the elevation of arterial pressure by infusion of angiotensin II were studied in dogs with intact autonomic nervous systems and in dogs previously submitted to ganglionic blockade. Maximal velocity of contraction (VmaxTP) was used to evaluate the inotropic state. When the heart rate was allowed to vary or when it was maintained constant by atrial stimulation the rise in blood pressure was accompanied by impaired contractility in the animals with intact nervous sytem. This negative inotropic influence seems to be due to changes of the neurovegetative tone due to baroreceptor reflexes. In the dogs submitted to ganglionic blockade, during the administration of the drug, there was elevation of VmaxTP. The improved inotropic state in these animals was explained by adrenergic hyperactivity produced by the polypeptide. |
| publishDate |
1975 |
| dc.date.none.fl_str_mv |
1975-01-01 2022-04-29T08:41:57Z 2022-04-29T08:41:57Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
Arquivos Brasileiros de Cardiologia, v. 28, n. 4, p. 403-408, 1975. 0066-782X http://hdl.handle.net/11449/230772 2-s2.0-0016711453 |
| identifier_str_mv |
Arquivos Brasileiros de Cardiologia, v. 28, n. 4, p. 403-408, 1975. 0066-782X 2-s2.0-0016711453 |
| url |
http://hdl.handle.net/11449/230772 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
403-408 |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
| repository.mail.fl_str_mv |
|
| _version_ |
1808128127955632128 |