Effects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bjane.2021.08.015 http://hdl.handle.net/11449/230041 |
Resumo: | Background: The influence of different crystalloid solutions infused during deceased-donor kidney transplant on the incidence of delayed graft function remains unclear. We investigated the influence of Plasma-Lyte® vs. 0.9% saline on the incidence of delayed graft function in deceased-donor kidney transplant recipients. Methods: We conducted a single-blind randomized controlled trial of 104 patients aged 18 to 65 years who underwent deceased-donor kidney transplant under general anesthesia. Patients were randomly assigned to receive either Plasma-Lyte® (n = 52) or 0.9% saline (n = 52), at the same infusion volume, for intraoperative fluid replacement. The primary outcome was the occurrence of delayed graft function. Secondary outcomes included metabolic and electrolytic changes at the end of surgery. Results: Two patients in the Plasma-Lyte® group and one in the 0.9% saline group died postoperatively and were not included for analysis. The incidence of delayed graft function in Plasma-Lyte® and 0.9% saline groups were 60.0% (95% Confidence Interval [95% CI 46.2–72.4]) and 74.5% (95% CI 61.1–84.4), respectively (p = 0.140). Mean (standard deviation) values of immediate postoperative pH and serum chloride levels in Plasma-Lyte® and 0.9% saline groups were 7.306 (0.071) and 7.273 (0.061) (p = 0.013), and 99.6 (4.2) mEq.L-1 and 103.3 (5.6) mEq.L-1, respectively (p < 0.001). All other postoperative metabolic and electrolyte variables were not statistically different at the immediate postoperative period (p > 0.05). Conclusion: In deceased-donor kidney transplant recipients, the incidence of delayed graft function is not influenced by Plasma-Lyte® or 0.9% saline used for intraoperative fluid replacement. |
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Effects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trialAcid-base equilibriumAnesthesiaCrystalloid solutionsDelayed graft functionElectrolytesKidney transplantationBackground: The influence of different crystalloid solutions infused during deceased-donor kidney transplant on the incidence of delayed graft function remains unclear. We investigated the influence of Plasma-Lyte® vs. 0.9% saline on the incidence of delayed graft function in deceased-donor kidney transplant recipients. Methods: We conducted a single-blind randomized controlled trial of 104 patients aged 18 to 65 years who underwent deceased-donor kidney transplant under general anesthesia. Patients were randomly assigned to receive either Plasma-Lyte® (n = 52) or 0.9% saline (n = 52), at the same infusion volume, for intraoperative fluid replacement. The primary outcome was the occurrence of delayed graft function. Secondary outcomes included metabolic and electrolytic changes at the end of surgery. Results: Two patients in the Plasma-Lyte® group and one in the 0.9% saline group died postoperatively and were not included for analysis. The incidence of delayed graft function in Plasma-Lyte® and 0.9% saline groups were 60.0% (95% Confidence Interval [95% CI 46.2–72.4]) and 74.5% (95% CI 61.1–84.4), respectively (p = 0.140). Mean (standard deviation) values of immediate postoperative pH and serum chloride levels in Plasma-Lyte® and 0.9% saline groups were 7.306 (0.071) and 7.273 (0.061) (p = 0.013), and 99.6 (4.2) mEq.L-1 and 103.3 (5.6) mEq.L-1, respectively (p < 0.001). All other postoperative metabolic and electrolyte variables were not statistically different at the immediate postoperative period (p > 0.05). Conclusion: In deceased-donor kidney transplant recipients, the incidence of delayed graft function is not influenced by Plasma-Lyte® or 0.9% saline used for intraoperative fluid replacement.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de Especialidades Cirúrgicas e AnestesiologiaUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Hospital das Clínicas Programa de Transplante RenalUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de Especialidades Cirúrgicas e AnestesiologiaUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Hospital das Clínicas Programa de Transplante RenalCNPq: #305109/2017-0.Universidade Estadual Paulista (UNESP)do Nascimento Junior, Paulo [UNESP]Dohler, Lucas Esteves [UNESP]Ogawa, Cindy Midori Uchida [UNESP]de Andrade, Luís Gustavo Modelli [UNESP]Braz, Leandro Gobbo [UNESP]Módolo, Norma Sueli Pinheiro [UNESP]2022-04-29T08:37:19Z2022-04-29T08:37:19Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.bjane.2021.08.015Brazilian Journal of Anesthesiology (English Edition).2352-22910104-0014http://hdl.handle.net/11449/23004110.1016/j.bjane.2021.08.0152-s2.0-85120999892Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Anesthesiology (English Edition)info:eu-repo/semantics/openAccess2022-04-29T08:37:19Zoai:repositorio.unesp.br:11449/230041Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:37:19Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial |
title |
Effects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial |
spellingShingle |
Effects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial do Nascimento Junior, Paulo [UNESP] Acid-base equilibrium Anesthesia Crystalloid solutions Delayed graft function Electrolytes Kidney transplantation |
title_short |
Effects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial |
title_full |
Effects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial |
title_fullStr |
Effects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial |
title_full_unstemmed |
Effects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial |
title_sort |
Effects of Plasma-Lyte® and 0.9% saline in renal function after deceased-donor kidney transplant: a randomized controlled trial |
author |
do Nascimento Junior, Paulo [UNESP] |
author_facet |
do Nascimento Junior, Paulo [UNESP] Dohler, Lucas Esteves [UNESP] Ogawa, Cindy Midori Uchida [UNESP] de Andrade, Luís Gustavo Modelli [UNESP] Braz, Leandro Gobbo [UNESP] Módolo, Norma Sueli Pinheiro [UNESP] |
author_role |
author |
author2 |
Dohler, Lucas Esteves [UNESP] Ogawa, Cindy Midori Uchida [UNESP] de Andrade, Luís Gustavo Modelli [UNESP] Braz, Leandro Gobbo [UNESP] Módolo, Norma Sueli Pinheiro [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
do Nascimento Junior, Paulo [UNESP] Dohler, Lucas Esteves [UNESP] Ogawa, Cindy Midori Uchida [UNESP] de Andrade, Luís Gustavo Modelli [UNESP] Braz, Leandro Gobbo [UNESP] Módolo, Norma Sueli Pinheiro [UNESP] |
dc.subject.por.fl_str_mv |
Acid-base equilibrium Anesthesia Crystalloid solutions Delayed graft function Electrolytes Kidney transplantation |
topic |
Acid-base equilibrium Anesthesia Crystalloid solutions Delayed graft function Electrolytes Kidney transplantation |
description |
Background: The influence of different crystalloid solutions infused during deceased-donor kidney transplant on the incidence of delayed graft function remains unclear. We investigated the influence of Plasma-Lyte® vs. 0.9% saline on the incidence of delayed graft function in deceased-donor kidney transplant recipients. Methods: We conducted a single-blind randomized controlled trial of 104 patients aged 18 to 65 years who underwent deceased-donor kidney transplant under general anesthesia. Patients were randomly assigned to receive either Plasma-Lyte® (n = 52) or 0.9% saline (n = 52), at the same infusion volume, for intraoperative fluid replacement. The primary outcome was the occurrence of delayed graft function. Secondary outcomes included metabolic and electrolytic changes at the end of surgery. Results: Two patients in the Plasma-Lyte® group and one in the 0.9% saline group died postoperatively and were not included for analysis. The incidence of delayed graft function in Plasma-Lyte® and 0.9% saline groups were 60.0% (95% Confidence Interval [95% CI 46.2–72.4]) and 74.5% (95% CI 61.1–84.4), respectively (p = 0.140). Mean (standard deviation) values of immediate postoperative pH and serum chloride levels in Plasma-Lyte® and 0.9% saline groups were 7.306 (0.071) and 7.273 (0.061) (p = 0.013), and 99.6 (4.2) mEq.L-1 and 103.3 (5.6) mEq.L-1, respectively (p < 0.001). All other postoperative metabolic and electrolyte variables were not statistically different at the immediate postoperative period (p > 0.05). Conclusion: In deceased-donor kidney transplant recipients, the incidence of delayed graft function is not influenced by Plasma-Lyte® or 0.9% saline used for intraoperative fluid replacement. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-29T08:37:19Z 2022-04-29T08:37:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bjane.2021.08.015 Brazilian Journal of Anesthesiology (English Edition). 2352-2291 0104-0014 http://hdl.handle.net/11449/230041 10.1016/j.bjane.2021.08.015 2-s2.0-85120999892 |
url |
http://dx.doi.org/10.1016/j.bjane.2021.08.015 http://hdl.handle.net/11449/230041 |
identifier_str_mv |
Brazilian Journal of Anesthesiology (English Edition). 2352-2291 0104-0014 10.1016/j.bjane.2021.08.015 2-s2.0-85120999892 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Anesthesiology (English Edition) |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964724723449856 |