Neurotoxicity of subarachnoid hyperbaric bupivacaine in dogs
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/224024 |
Resumo: | Background and Objectives. The study investigated possible neurotoxic effects of increasing concentrations and doses of bupivacaine administered into the subarachnoid space in dogs. Methods. Fifty animals were allocated to five experimental groups: G1, control; G2, 5 mg 0.5 bupivacaine in 10% glucose solution; G3, 10 mg of 1% bupivacaine in 10% glucose solution; G4, 20 mg 2% bupivacaine in 10% glucose solution, and G5, 20 mg 2% bupivacaine in water. After 72 hours of observation, the animals were killed and the spinal cords removed for histologic examination by light microscopy. Results. None of the animals showed any neurologic clinical disturbance following recovery from spinal anesthesia. One case of necrosis of nerve tissue was observed in G3 and four in G4. Conclusions. Increasing concentrations and doses of hyperbaric bupivacaine solutions increased the incidence of nerve tissue damage, which did not occur with hypobaric solutions. These results should contribute to the further understanding of neurologic complications following spinal anesthesia when large doses of local anesthetics in hyperbaric solutions are used. |
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Repositório Institucional da UNESP |
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Neurotoxicity of subarachnoid hyperbaric bupivacaine in dogsbupivacainecauda equina syndromeneurologic damagespinal anesthesiaBackground and Objectives. The study investigated possible neurotoxic effects of increasing concentrations and doses of bupivacaine administered into the subarachnoid space in dogs. Methods. Fifty animals were allocated to five experimental groups: G1, control; G2, 5 mg 0.5 bupivacaine in 10% glucose solution; G3, 10 mg of 1% bupivacaine in 10% glucose solution; G4, 20 mg 2% bupivacaine in 10% glucose solution, and G5, 20 mg 2% bupivacaine in water. After 72 hours of observation, the animals were killed and the spinal cords removed for histologic examination by light microscopy. Results. None of the animals showed any neurologic clinical disturbance following recovery from spinal anesthesia. One case of necrosis of nerve tissue was observed in G3 and four in G4. Conclusions. Increasing concentrations and doses of hyperbaric bupivacaine solutions increased the incidence of nerve tissue damage, which did not occur with hypobaric solutions. These results should contribute to the further understanding of neurologic complications following spinal anesthesia when large doses of local anesthetics in hyperbaric solutions are used.Department of Anesthesiology Faculty of Medicine University Estadual Paulista, Botucatu, SPDepartamento de Anestesiologia Faculdade de Medicina UNESP, 18618-000 Botucatu, SPDepartment of Anesthesiology Faculty of Medicine University Estadual Paulista, Botucatu, SPDepartamento de Anestesiologia Faculdade de Medicina UNESP, 18618-000 Botucatu, SPUniversidade Estadual Paulista (UNESP)Ganem, Eliana Marisa [UNESP]Vianna, Pedro Thadeu G. [UNESP]Marques, Mariangela [UNESP]Castiglia, Yara M. M. [UNESP]Vane, Luis Antonio [UNESP]2022-04-28T19:54:21Z2022-04-28T19:54:21Z1996-05-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article234-238Regional Anesthesia, v. 21, n. 3, p. 234-238, 1996.0146-521Xhttp://hdl.handle.net/11449/2240242-s2.0-0029879155Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRegional Anesthesiainfo:eu-repo/semantics/openAccess2022-04-28T19:54:21Zoai:repositorio.unesp.br:11449/224024Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:54:21Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Neurotoxicity of subarachnoid hyperbaric bupivacaine in dogs |
title |
Neurotoxicity of subarachnoid hyperbaric bupivacaine in dogs |
spellingShingle |
Neurotoxicity of subarachnoid hyperbaric bupivacaine in dogs Ganem, Eliana Marisa [UNESP] bupivacaine cauda equina syndrome neurologic damage spinal anesthesia |
title_short |
Neurotoxicity of subarachnoid hyperbaric bupivacaine in dogs |
title_full |
Neurotoxicity of subarachnoid hyperbaric bupivacaine in dogs |
title_fullStr |
Neurotoxicity of subarachnoid hyperbaric bupivacaine in dogs |
title_full_unstemmed |
Neurotoxicity of subarachnoid hyperbaric bupivacaine in dogs |
title_sort |
Neurotoxicity of subarachnoid hyperbaric bupivacaine in dogs |
author |
Ganem, Eliana Marisa [UNESP] |
author_facet |
Ganem, Eliana Marisa [UNESP] Vianna, Pedro Thadeu G. [UNESP] Marques, Mariangela [UNESP] Castiglia, Yara M. M. [UNESP] Vane, Luis Antonio [UNESP] |
author_role |
author |
author2 |
Vianna, Pedro Thadeu G. [UNESP] Marques, Mariangela [UNESP] Castiglia, Yara M. M. [UNESP] Vane, Luis Antonio [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Ganem, Eliana Marisa [UNESP] Vianna, Pedro Thadeu G. [UNESP] Marques, Mariangela [UNESP] Castiglia, Yara M. M. [UNESP] Vane, Luis Antonio [UNESP] |
dc.subject.por.fl_str_mv |
bupivacaine cauda equina syndrome neurologic damage spinal anesthesia |
topic |
bupivacaine cauda equina syndrome neurologic damage spinal anesthesia |
description |
Background and Objectives. The study investigated possible neurotoxic effects of increasing concentrations and doses of bupivacaine administered into the subarachnoid space in dogs. Methods. Fifty animals were allocated to five experimental groups: G1, control; G2, 5 mg 0.5 bupivacaine in 10% glucose solution; G3, 10 mg of 1% bupivacaine in 10% glucose solution; G4, 20 mg 2% bupivacaine in 10% glucose solution, and G5, 20 mg 2% bupivacaine in water. After 72 hours of observation, the animals were killed and the spinal cords removed for histologic examination by light microscopy. Results. None of the animals showed any neurologic clinical disturbance following recovery from spinal anesthesia. One case of necrosis of nerve tissue was observed in G3 and four in G4. Conclusions. Increasing concentrations and doses of hyperbaric bupivacaine solutions increased the incidence of nerve tissue damage, which did not occur with hypobaric solutions. These results should contribute to the further understanding of neurologic complications following spinal anesthesia when large doses of local anesthetics in hyperbaric solutions are used. |
publishDate |
1996 |
dc.date.none.fl_str_mv |
1996-05-29 2022-04-28T19:54:21Z 2022-04-28T19:54:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Regional Anesthesia, v. 21, n. 3, p. 234-238, 1996. 0146-521X http://hdl.handle.net/11449/224024 2-s2.0-0029879155 |
identifier_str_mv |
Regional Anesthesia, v. 21, n. 3, p. 234-238, 1996. 0146-521X 2-s2.0-0029879155 |
url |
http://hdl.handle.net/11449/224024 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Regional Anesthesia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
234-238 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803047443942604800 |