Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.prostaglins.2022.106669 http://hdl.handle.net/11449/245469 |
Resumo: | The high-fat diet (HFD) promotes obesity and develops inflammation, causing dysregulation of energy meta-bolism and prostatic neoplastic tissue changes. PPARa deletion leads to loss of homeostasis between the pro and anti-inflammatory response, and dysregulation of lipid metabolism, causing changes in different physiological processes and damage to the prostate. On the other hand, aerobic physical exercise has been suggested as a non-pharmacological tool to improve energy metabolism and cellular metabolism in the prostate, however, the un-derlying molecular mechanism remains unclear. the current study aimed to evaluate PPAR alpha as a possible regulator of the protective effects of aerobic physical exercise in the prostate by examining prostatic alterations in wild-type and PPAR alpha deletion mice fed a standard diet or an HFD. Wild-type and PPAR alpha-null mice were fed a standard or HFD diet for 12 weeks, and submitted to aerobic physical exercise for 8 weeks. The HFD promoted the increase of inflammatory markers IL-6, TNF-alpha, NF-kB, and an increase of inflammatory foci in animals in both genotypes. Although the PPAR alpha deletion animals submitted to the aerobic physical exercise were not able to regulate response pro-inflammatory, but promoted an increase in IL-10 in the prostate. In animals WT, the aerobic physical exercise, reduced all inflammatory markers, improve the inflammatory response, and showed a higher expression of BAX and IL-10 proteins was protective against prostatic tissue lesions. Suggested that PPAR alpha deletion associated with HFD suppressed apoptosis and increased damage prostate. On other hand, aerobic physical exercise improves prostatic tissue by increasing the response to anti-inflammatory and apoptosis protein. |
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Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted micePhysical exercisePeroxisome proliferator-activated receptor ?ApoptosisInflammationHistopathology prostaticThe high-fat diet (HFD) promotes obesity and develops inflammation, causing dysregulation of energy meta-bolism and prostatic neoplastic tissue changes. PPARa deletion leads to loss of homeostasis between the pro and anti-inflammatory response, and dysregulation of lipid metabolism, causing changes in different physiological processes and damage to the prostate. On the other hand, aerobic physical exercise has been suggested as a non-pharmacological tool to improve energy metabolism and cellular metabolism in the prostate, however, the un-derlying molecular mechanism remains unclear. the current study aimed to evaluate PPAR alpha as a possible regulator of the protective effects of aerobic physical exercise in the prostate by examining prostatic alterations in wild-type and PPAR alpha deletion mice fed a standard diet or an HFD. Wild-type and PPAR alpha-null mice were fed a standard or HFD diet for 12 weeks, and submitted to aerobic physical exercise for 8 weeks. The HFD promoted the increase of inflammatory markers IL-6, TNF-alpha, NF-kB, and an increase of inflammatory foci in animals in both genotypes. Although the PPAR alpha deletion animals submitted to the aerobic physical exercise were not able to regulate response pro-inflammatory, but promoted an increase in IL-10 in the prostate. In animals WT, the aerobic physical exercise, reduced all inflammatory markers, improve the inflammatory response, and showed a higher expression of BAX and IL-10 proteins was protective against prostatic tissue lesions. Suggested that PPAR alpha deletion associated with HFD suppressed apoptosis and increased damage prostate. On other hand, aerobic physical exercise improves prostatic tissue by increasing the response to anti-inflammatory and apoptosis protein.Funda��o de Amparo � Pesquisa do Estado de S�o Paulo (FAPESP)Conselho Nacional de Desenvolvimento Cient�fico e Tecnol�gico (CNPq)Sao Paulo State Univ UNESP, Dept Phys Educ, Campus Presidente Prudente, Sao Paulo, SP, BrazilUniv Guelph, Ontario Vet Coll, Dept Biomed Sci, Guelph, ON, CanadaSao Paulo State Univ UNESP, Multictr Grad Program Physiol Sci, SBFis, Aracatuba, SP, BrazilSao Paulo State Univ UNESP, Expt Lab Exercise Biol LEBioEx, Presidente Prudent, SP, BrazilSao Paulo State Univ UNESP, Sch Technol & Sci, Dept Phys Educ, St Roberto Simonsen 305, BR-19060900 Presidente Prudente, SP, BrazilSao Paulo State Univ UNESP, Dept Phys Educ, Campus Presidente Prudente, Sao Paulo, SP, BrazilSao Paulo State Univ UNESP, Multictr Grad Program Physiol Sci, SBFis, Aracatuba, SP, BrazilSao Paulo State Univ UNESP, Expt Lab Exercise Biol LEBioEx, Presidente Prudent, SP, BrazilSao Paulo State Univ UNESP, Sch Technol & Sci, Dept Phys Educ, St Roberto Simonsen 305, BR-19060900 Presidente Prudente, SP, BrazilFAPESP: 2018/05092-4CNPq: 161215/2020-3CNPq: 460332/2014-7Elsevier B.V.Universidade Estadual Paulista (UNESP)Univ GuelphTavares, Maria Eduarda Almeida [UNESP]Veras, Allice Santos Cruz [UNESP]Thorpe, Hayley Hope AllyssaBaptista, Danilo Bianchini [UNESP]Teixeira, Giovana Rampazzo [UNESP]2023-07-29T11:55:52Z2023-07-29T11:55:52Z2022-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article13http://dx.doi.org/10.1016/j.prostaglins.2022.106669Prostaglandins & Other Lipid Mediators. New York: Elsevier Science Inc, v. 163, 13 p., 2022.1098-8823http://hdl.handle.net/11449/24546910.1016/j.prostaglins.2022.106669WOS:000862821300003Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengProstaglandins & Other Lipid Mediatorsinfo:eu-repo/semantics/openAccess2024-06-18T18:18:16Zoai:repositorio.unesp.br:11449/245469Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:44:43.600416Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice |
title |
Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice |
spellingShingle |
Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice Tavares, Maria Eduarda Almeida [UNESP] Physical exercise Peroxisome proliferator-activated receptor ? Apoptosis Inflammation Histopathology prostatic |
title_short |
Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice |
title_full |
Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice |
title_fullStr |
Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice |
title_full_unstemmed |
Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice |
title_sort |
Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice |
author |
Tavares, Maria Eduarda Almeida [UNESP] |
author_facet |
Tavares, Maria Eduarda Almeida [UNESP] Veras, Allice Santos Cruz [UNESP] Thorpe, Hayley Hope Allyssa Baptista, Danilo Bianchini [UNESP] Teixeira, Giovana Rampazzo [UNESP] |
author_role |
author |
author2 |
Veras, Allice Santos Cruz [UNESP] Thorpe, Hayley Hope Allyssa Baptista, Danilo Bianchini [UNESP] Teixeira, Giovana Rampazzo [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Univ Guelph |
dc.contributor.author.fl_str_mv |
Tavares, Maria Eduarda Almeida [UNESP] Veras, Allice Santos Cruz [UNESP] Thorpe, Hayley Hope Allyssa Baptista, Danilo Bianchini [UNESP] Teixeira, Giovana Rampazzo [UNESP] |
dc.subject.por.fl_str_mv |
Physical exercise Peroxisome proliferator-activated receptor ? Apoptosis Inflammation Histopathology prostatic |
topic |
Physical exercise Peroxisome proliferator-activated receptor ? Apoptosis Inflammation Histopathology prostatic |
description |
The high-fat diet (HFD) promotes obesity and develops inflammation, causing dysregulation of energy meta-bolism and prostatic neoplastic tissue changes. PPARa deletion leads to loss of homeostasis between the pro and anti-inflammatory response, and dysregulation of lipid metabolism, causing changes in different physiological processes and damage to the prostate. On the other hand, aerobic physical exercise has been suggested as a non-pharmacological tool to improve energy metabolism and cellular metabolism in the prostate, however, the un-derlying molecular mechanism remains unclear. the current study aimed to evaluate PPAR alpha as a possible regulator of the protective effects of aerobic physical exercise in the prostate by examining prostatic alterations in wild-type and PPAR alpha deletion mice fed a standard diet or an HFD. Wild-type and PPAR alpha-null mice were fed a standard or HFD diet for 12 weeks, and submitted to aerobic physical exercise for 8 weeks. The HFD promoted the increase of inflammatory markers IL-6, TNF-alpha, NF-kB, and an increase of inflammatory foci in animals in both genotypes. Although the PPAR alpha deletion animals submitted to the aerobic physical exercise were not able to regulate response pro-inflammatory, but promoted an increase in IL-10 in the prostate. In animals WT, the aerobic physical exercise, reduced all inflammatory markers, improve the inflammatory response, and showed a higher expression of BAX and IL-10 proteins was protective against prostatic tissue lesions. Suggested that PPAR alpha deletion associated with HFD suppressed apoptosis and increased damage prostate. On other hand, aerobic physical exercise improves prostatic tissue by increasing the response to anti-inflammatory and apoptosis protein. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-01 2023-07-29T11:55:52Z 2023-07-29T11:55:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.prostaglins.2022.106669 Prostaglandins & Other Lipid Mediators. New York: Elsevier Science Inc, v. 163, 13 p., 2022. 1098-8823 http://hdl.handle.net/11449/245469 10.1016/j.prostaglins.2022.106669 WOS:000862821300003 |
url |
http://dx.doi.org/10.1016/j.prostaglins.2022.106669 http://hdl.handle.net/11449/245469 |
identifier_str_mv |
Prostaglandins & Other Lipid Mediators. New York: Elsevier Science Inc, v. 163, 13 p., 2022. 1098-8823 10.1016/j.prostaglins.2022.106669 WOS:000862821300003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Prostaglandins & Other Lipid Mediators |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
13 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129353640312832 |