Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.7324/JAPS.2020.101213 http://hdl.handle.net/11449/206408 |
Resumo: | Constant efforts to discover new antileishmanial agents are important because there are only a few available drugs for the treatment of leishmaniasis, which present several drawbacks including high toxicity and difficult route of administration. In this scenario, different sources of natural products have been explored regarding their potential to treat infectious diseases. Following this initiative, our research team has been analyzing the bioactive potential of Himantothallus grandifolius, an endemic macroalga of the Antarctic region, with the hypothesis that the hostile environment imposed on these organisms has shaped its arsenal of chemical constituents, thus consequently bringing new opportunities to discover bioactive compounds that might be useful against leishmaniasis. Herein, we report the antileishmanial property of the fatty acid 13E-docosenamide, identified during the fractionation of the hexanic extract of H. grandifolius after semipreparative high performance liquid chromatography separation and ultrafast liquid chromatography coupled with mass spectrometry analyses to track its antileishmanial constituents. 13E-docosenamide was found in HSG11and HSG12 fractions, presented promising antileishmanial activity (IC50 = 9.6 μg ml-1) and is 10 times more selective to the parasite rather than to the host cells (SI > 10.4). |
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Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent13E-docosenamideantarctic macroalgaeantileishmanial activitydesmarestiaceaefatty acidConstant efforts to discover new antileishmanial agents are important because there are only a few available drugs for the treatment of leishmaniasis, which present several drawbacks including high toxicity and difficult route of administration. In this scenario, different sources of natural products have been explored regarding their potential to treat infectious diseases. Following this initiative, our research team has been analyzing the bioactive potential of Himantothallus grandifolius, an endemic macroalga of the Antarctic region, with the hypothesis that the hostile environment imposed on these organisms has shaped its arsenal of chemical constituents, thus consequently bringing new opportunities to discover bioactive compounds that might be useful against leishmaniasis. Herein, we report the antileishmanial property of the fatty acid 13E-docosenamide, identified during the fractionation of the hexanic extract of H. grandifolius after semipreparative high performance liquid chromatography separation and ultrafast liquid chromatography coupled with mass spectrometry analyses to track its antileishmanial constituents. 13E-docosenamide was found in HSG11and HSG12 fractions, presented promising antileishmanial activity (IC50 = 9.6 μg ml-1) and is 10 times more selective to the parasite rather than to the host cells (SI > 10.4).Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)São Paulo State University (UNESP) Chemistry InstituteSchool of Pharmaceutical Sciences São Paulo State University (UNESP)Chemistry Institute University of São Paulo (USP)Institute of Botany (IBt)São Paulo State University (UNESP) Chemistry InstituteSchool of Pharmaceutical Sciences São Paulo State University (UNESP)FAPESP: 2013/08248-1 and 2016/06931CNPq: 407588/2013-2Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Institute of Botany (IBt)Clementino, Leandro Costa [UNESP]Torres, Fabio Aurelio Esteves [UNESP]Velasquez, Angela Maria Arenas [UNESP]Villela, LeonardoMutue, Toyota FujiiColepicolo, PioGraminha, Marcia A.S. [UNESP]2021-06-25T10:31:36Z2021-06-25T10:31:36Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article98-103http://dx.doi.org/10.7324/JAPS.2020.101213Journal of Applied Pharmaceutical Science, v. 10, n. 12, p. 98-103, 2020.2231-3354http://hdl.handle.net/11449/20640810.7324/JAPS.2020.1012132-s2.0-85106777961Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Pharmaceutical Scienceinfo:eu-repo/semantics/openAccess2021-10-23T02:54:18Zoai:repositorio.unesp.br:11449/206408Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:58:53.981573Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
title |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
spellingShingle |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent Clementino, Leandro Costa [UNESP] 13E-docosenamide antarctic macroalgae antileishmanial activity desmarestiaceae fatty acid |
title_short |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
title_full |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
title_fullStr |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
title_full_unstemmed |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
title_sort |
Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent |
author |
Clementino, Leandro Costa [UNESP] |
author_facet |
Clementino, Leandro Costa [UNESP] Torres, Fabio Aurelio Esteves [UNESP] Velasquez, Angela Maria Arenas [UNESP] Villela, Leonardo Mutue, Toyota Fujii Colepicolo, Pio Graminha, Marcia A.S. [UNESP] |
author_role |
author |
author2 |
Torres, Fabio Aurelio Esteves [UNESP] Velasquez, Angela Maria Arenas [UNESP] Villela, Leonardo Mutue, Toyota Fujii Colepicolo, Pio Graminha, Marcia A.S. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) Institute of Botany (IBt) |
dc.contributor.author.fl_str_mv |
Clementino, Leandro Costa [UNESP] Torres, Fabio Aurelio Esteves [UNESP] Velasquez, Angela Maria Arenas [UNESP] Villela, Leonardo Mutue, Toyota Fujii Colepicolo, Pio Graminha, Marcia A.S. [UNESP] |
dc.subject.por.fl_str_mv |
13E-docosenamide antarctic macroalgae antileishmanial activity desmarestiaceae fatty acid |
topic |
13E-docosenamide antarctic macroalgae antileishmanial activity desmarestiaceae fatty acid |
description |
Constant efforts to discover new antileishmanial agents are important because there are only a few available drugs for the treatment of leishmaniasis, which present several drawbacks including high toxicity and difficult route of administration. In this scenario, different sources of natural products have been explored regarding their potential to treat infectious diseases. Following this initiative, our research team has been analyzing the bioactive potential of Himantothallus grandifolius, an endemic macroalga of the Antarctic region, with the hypothesis that the hostile environment imposed on these organisms has shaped its arsenal of chemical constituents, thus consequently bringing new opportunities to discover bioactive compounds that might be useful against leishmaniasis. Herein, we report the antileishmanial property of the fatty acid 13E-docosenamide, identified during the fractionation of the hexanic extract of H. grandifolius after semipreparative high performance liquid chromatography separation and ultrafast liquid chromatography coupled with mass spectrometry analyses to track its antileishmanial constituents. 13E-docosenamide was found in HSG11and HSG12 fractions, presented promising antileishmanial activity (IC50 = 9.6 μg ml-1) and is 10 times more selective to the parasite rather than to the host cells (SI > 10.4). |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 2021-06-25T10:31:36Z 2021-06-25T10:31:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.7324/JAPS.2020.101213 Journal of Applied Pharmaceutical Science, v. 10, n. 12, p. 98-103, 2020. 2231-3354 http://hdl.handle.net/11449/206408 10.7324/JAPS.2020.101213 2-s2.0-85106777961 |
url |
http://dx.doi.org/10.7324/JAPS.2020.101213 http://hdl.handle.net/11449/206408 |
identifier_str_mv |
Journal of Applied Pharmaceutical Science, v. 10, n. 12, p. 98-103, 2020. 2231-3354 10.7324/JAPS.2020.101213 2-s2.0-85106777961 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Applied Pharmaceutical Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
98-103 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128300350963712 |