Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3748/wjg.v19.i13.2060 http://hdl.handle.net/11449/75077 |
Resumo: | AIM: To study the association between atrophic gastritis (AG) and esophageal squamous cell carcinoma (ESCC) in a Latin-America population. METHODS: A case-control study was performed at two reference Brazilian hospitals including patients diagnosed with advanced ESCC and dyspeptic patients who had been subjected to upper gastrointestinal endoscopy, with biopsies of the gastric antrum and body. All cases with ESCC were reviewed by a single pathologist, who applied standard criteria for the diagnosis of mucosal atrophy, intestinal metaplasia, and dysplasia, all classified as AG. The data on the patients' age, sex, smoking status, and alcohol consumption were collected from clinical records, and any missing information was completed by telephone interview. The association between AG and ESCC was assessed by means of univariate and multiple conditional logistic regressions. RESULTS: Most patients were male, and the median age was 59 years (range: 37-79 years) in both the ESCC and control groups. Univariate analysis showed that an intake of ethanol greater than 32 g/d was an independent risk factor that increased the odds of ESCC 7.57 times (P = 0.014); upon multiple analysis, alcohol intake of ethanol greater than 32 g/d exhibited a risk of 4.54 (P = 0.081), as adjusted for AG and smoking. Smoking was shown to be an independent risk factor that increased the odds of ESCC 14.55 times (P = 0.011) for individuals who smoked 0 to 51 packs/year and 21.40 times (P = 0.006) for those who smoked more than 51 packs/year. Upon multiple analyses, those who smoked up to 51 packs/year exhibited a risk of 7.85 (P = 0.058), and those who smoked more than 51 packs/year had a risk 11.57 times higher (P = 0.04), as adjusted for AG and alcohol consumption. AG proved to be a risk factor that increased the odds of ESCC 5.33 times (95%CI: 1.55-18.30, P = 0.008) according to the results of univariate conditional logistic regression. CONCLUSION: There was an association by univariate conditional logistic regression between AG and ECSS in this sample of Latin-American population. © 2013 Baishideng. |
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Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American populationAlcoholAtrophic gastritisEsophagusRisk factorSquamous cell carcinomaTobaccoadultagedatrophic gastritiscase control studycontrolled studydisease associationesophageal squamous cell carcinomafemalegastrointestinal endoscopyhistopathologyhumanhuman tissuelogistic regression analysismalemultivariate logistic regression analysisreviewrisk factorSouth and Central AmericaAIM: To study the association between atrophic gastritis (AG) and esophageal squamous cell carcinoma (ESCC) in a Latin-America population. METHODS: A case-control study was performed at two reference Brazilian hospitals including patients diagnosed with advanced ESCC and dyspeptic patients who had been subjected to upper gastrointestinal endoscopy, with biopsies of the gastric antrum and body. All cases with ESCC were reviewed by a single pathologist, who applied standard criteria for the diagnosis of mucosal atrophy, intestinal metaplasia, and dysplasia, all classified as AG. The data on the patients' age, sex, smoking status, and alcohol consumption were collected from clinical records, and any missing information was completed by telephone interview. The association between AG and ESCC was assessed by means of univariate and multiple conditional logistic regressions. RESULTS: Most patients were male, and the median age was 59 years (range: 37-79 years) in both the ESCC and control groups. Univariate analysis showed that an intake of ethanol greater than 32 g/d was an independent risk factor that increased the odds of ESCC 7.57 times (P = 0.014); upon multiple analysis, alcohol intake of ethanol greater than 32 g/d exhibited a risk of 4.54 (P = 0.081), as adjusted for AG and smoking. Smoking was shown to be an independent risk factor that increased the odds of ESCC 14.55 times (P = 0.011) for individuals who smoked 0 to 51 packs/year and 21.40 times (P = 0.006) for those who smoked more than 51 packs/year. Upon multiple analyses, those who smoked up to 51 packs/year exhibited a risk of 7.85 (P = 0.058), and those who smoked more than 51 packs/year had a risk 11.57 times higher (P = 0.04), as adjusted for AG and alcohol consumption. AG proved to be a risk factor that increased the odds of ESCC 5.33 times (95%CI: 1.55-18.30, P = 0.008) according to the results of univariate conditional logistic regression. CONCLUSION: There was an association by univariate conditional logistic regression between AG and ECSS in this sample of Latin-American population. © 2013 Baishideng.Endoscopy Department Cancer Hospital of Barretos, Barretos, São Paulo 147830-066Surgery Post Graduate Course Botucatu Medical School State of Sao Paulo University, Botucatu, São Paulo 18600-000Surgery and Orthopedics Department Botucatu Medical School State of Sao Paulo University, Botucatu, São Paulo 18600-000Pathology Department Cancer Hospital of Barretos, Barretos, São Paulo 147830-066Endoscopy Department Botucatu Medical School State of Sao Paulo University, Botucatu, São Paulo 18600-000Surgery Post Graduate Course Botucatu Medical School State of Sao Paulo University, Botucatu, São Paulo 18600-000Surgery and Orthopedics Department Botucatu Medical School State of Sao Paulo University, Botucatu, São Paulo 18600-000Endoscopy Department Botucatu Medical School State of Sao Paulo University, Botucatu, São Paulo 18600-000Cancer Hospital of BarretosUniversidade Estadual Paulista (Unesp)Almodova, Emiliano de Carvalho [UNESP]Oliveira, Walmar Kerche de [UNESP]Machado, Lucas Faria AbrahãoGrejo, Juliana Rigotto [UNESP]da Cunha, Thiago RabeloColaiacovo, WagnerOrtolan, Érika Veruska Paiva [UNESP]2014-05-27T11:28:53Z2014-05-27T11:28:53Z2013-04-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2060-2064application/pdfhttp://dx.doi.org/10.3748/wjg.v19.i13.2060World Journal of Gastroenterology, v. 19, n. 13, p. 2060-2064, 2013.1007-93272219-2840http://hdl.handle.net/11449/7507710.3748/wjg.v19.i13.20602-s2.0-848764033232-s2.0-84876403323.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengWorld Journal of Gastroenterology3.3001,4091,409info:eu-repo/semantics/openAccess2024-08-14T14:18:55Zoai:repositorio.unesp.br:11449/75077Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T14:18:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population |
title |
Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population |
spellingShingle |
Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population Almodova, Emiliano de Carvalho [UNESP] Alcohol Atrophic gastritis Esophagus Risk factor Squamous cell carcinoma Tobacco adult aged atrophic gastritis case control study controlled study disease association esophageal squamous cell carcinoma female gastrointestinal endoscopy histopathology human human tissue logistic regression analysis male multivariate logistic regression analysis review risk factor South and Central America |
title_short |
Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population |
title_full |
Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population |
title_fullStr |
Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population |
title_full_unstemmed |
Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population |
title_sort |
Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population |
author |
Almodova, Emiliano de Carvalho [UNESP] |
author_facet |
Almodova, Emiliano de Carvalho [UNESP] Oliveira, Walmar Kerche de [UNESP] Machado, Lucas Faria Abrahão Grejo, Juliana Rigotto [UNESP] da Cunha, Thiago Rabelo Colaiacovo, Wagner Ortolan, Érika Veruska Paiva [UNESP] |
author_role |
author |
author2 |
Oliveira, Walmar Kerche de [UNESP] Machado, Lucas Faria Abrahão Grejo, Juliana Rigotto [UNESP] da Cunha, Thiago Rabelo Colaiacovo, Wagner Ortolan, Érika Veruska Paiva [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Cancer Hospital of Barretos Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Almodova, Emiliano de Carvalho [UNESP] Oliveira, Walmar Kerche de [UNESP] Machado, Lucas Faria Abrahão Grejo, Juliana Rigotto [UNESP] da Cunha, Thiago Rabelo Colaiacovo, Wagner Ortolan, Érika Veruska Paiva [UNESP] |
dc.subject.por.fl_str_mv |
Alcohol Atrophic gastritis Esophagus Risk factor Squamous cell carcinoma Tobacco adult aged atrophic gastritis case control study controlled study disease association esophageal squamous cell carcinoma female gastrointestinal endoscopy histopathology human human tissue logistic regression analysis male multivariate logistic regression analysis review risk factor South and Central America |
topic |
Alcohol Atrophic gastritis Esophagus Risk factor Squamous cell carcinoma Tobacco adult aged atrophic gastritis case control study controlled study disease association esophageal squamous cell carcinoma female gastrointestinal endoscopy histopathology human human tissue logistic regression analysis male multivariate logistic regression analysis review risk factor South and Central America |
description |
AIM: To study the association between atrophic gastritis (AG) and esophageal squamous cell carcinoma (ESCC) in a Latin-America population. METHODS: A case-control study was performed at two reference Brazilian hospitals including patients diagnosed with advanced ESCC and dyspeptic patients who had been subjected to upper gastrointestinal endoscopy, with biopsies of the gastric antrum and body. All cases with ESCC were reviewed by a single pathologist, who applied standard criteria for the diagnosis of mucosal atrophy, intestinal metaplasia, and dysplasia, all classified as AG. The data on the patients' age, sex, smoking status, and alcohol consumption were collected from clinical records, and any missing information was completed by telephone interview. The association between AG and ESCC was assessed by means of univariate and multiple conditional logistic regressions. RESULTS: Most patients were male, and the median age was 59 years (range: 37-79 years) in both the ESCC and control groups. Univariate analysis showed that an intake of ethanol greater than 32 g/d was an independent risk factor that increased the odds of ESCC 7.57 times (P = 0.014); upon multiple analysis, alcohol intake of ethanol greater than 32 g/d exhibited a risk of 4.54 (P = 0.081), as adjusted for AG and smoking. Smoking was shown to be an independent risk factor that increased the odds of ESCC 14.55 times (P = 0.011) for individuals who smoked 0 to 51 packs/year and 21.40 times (P = 0.006) for those who smoked more than 51 packs/year. Upon multiple analyses, those who smoked up to 51 packs/year exhibited a risk of 7.85 (P = 0.058), and those who smoked more than 51 packs/year had a risk 11.57 times higher (P = 0.04), as adjusted for AG and alcohol consumption. AG proved to be a risk factor that increased the odds of ESCC 5.33 times (95%CI: 1.55-18.30, P = 0.008) according to the results of univariate conditional logistic regression. CONCLUSION: There was an association by univariate conditional logistic regression between AG and ECSS in this sample of Latin-American population. © 2013 Baishideng. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04-07 2014-05-27T11:28:53Z 2014-05-27T11:28:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3748/wjg.v19.i13.2060 World Journal of Gastroenterology, v. 19, n. 13, p. 2060-2064, 2013. 1007-9327 2219-2840 http://hdl.handle.net/11449/75077 10.3748/wjg.v19.i13.2060 2-s2.0-84876403323 2-s2.0-84876403323.pdf |
url |
http://dx.doi.org/10.3748/wjg.v19.i13.2060 http://hdl.handle.net/11449/75077 |
identifier_str_mv |
World Journal of Gastroenterology, v. 19, n. 13, p. 2060-2064, 2013. 1007-9327 2219-2840 10.3748/wjg.v19.i13.2060 2-s2.0-84876403323 2-s2.0-84876403323.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
World Journal of Gastroenterology 3.300 1,409 1,409 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2060-2064 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128149374894080 |