Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1806-9282.64.02.133 http://hdl.handle.net/11449/176179 |
Resumo: | Objective: The aim of our study was to assess body composition status and its association with inflammatory profile and extent of intestinal damage in ulcerative colitis patients during clinical remission. Method: This is a cross-sectional study in which body composition data (phase angle [PhA], fat mass [FM], triceps skin fold thickness [TSFt], mid-arm circumference [MAC], mid-arm muscle circumference [MAMC], adductor pollicis muscle thickness [APMt]), inflammatory profile (C-reactive protein [CRP], α1-acid glycoprotein, erythrocyte sedimentation rate [ESR]) and disease extent were recorded. Results: The mean age of the 59 patients was 48.1 years; 53.3% were women. Most patients were in clinical remission (94.9%) and 3.4% was malnourished according to body mass index. PhA was inversely correlated with inflammatory markers such as CRP (R=-0.59; p<0.001) and ESR (R=-0.46; p<0.001) and directly correlated with lean mass: MAMC (R=0.31; p=0.01) and APMt (R=0.47; p<0.001). Lean mass was inversely correlated with non-specific inflammation marker (APMt vs. ESR) and directly correlated with hemoglobin values (MAMC vs. hemoglobin). Logistic regression analysis revealed that body cell mass was associated with disease extent (OR 0.92; 95CI 0.87-0.97; p<0.01). Conclusion: PhA was inversely correlated with inflammatory markers and directly correlated with lean mass. Acute inflammatory markers were correlated with disease extent. Body cell mass was associated with disease extent. |
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Repositório Institucional da UNESP |
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Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patientsBiomarkersBody compositionC-reactive proteinSeverity of illness indexUlcerative colitisObjective: The aim of our study was to assess body composition status and its association with inflammatory profile and extent of intestinal damage in ulcerative colitis patients during clinical remission. Method: This is a cross-sectional study in which body composition data (phase angle [PhA], fat mass [FM], triceps skin fold thickness [TSFt], mid-arm circumference [MAC], mid-arm muscle circumference [MAMC], adductor pollicis muscle thickness [APMt]), inflammatory profile (C-reactive protein [CRP], α1-acid glycoprotein, erythrocyte sedimentation rate [ESR]) and disease extent were recorded. Results: The mean age of the 59 patients was 48.1 years; 53.3% were women. Most patients were in clinical remission (94.9%) and 3.4% was malnourished according to body mass index. PhA was inversely correlated with inflammatory markers such as CRP (R=-0.59; p<0.001) and ESR (R=-0.46; p<0.001) and directly correlated with lean mass: MAMC (R=0.31; p=0.01) and APMt (R=0.47; p<0.001). Lean mass was inversely correlated with non-specific inflammation marker (APMt vs. ESR) and directly correlated with hemoglobin values (MAMC vs. hemoglobin). Logistic regression analysis revealed that body cell mass was associated with disease extent (OR 0.92; 95CI 0.87-0.97; p<0.01). Conclusion: PhA was inversely correlated with inflammatory markers and directly correlated with lean mass. Acute inflammatory markers were correlated with disease extent. Body cell mass was associated with disease extent.Department of Internal Medicine Universidade Estadual Paulista (Unesp) Faculdade de Medicina, Unesp Distrito de Rubião Junior, s/nNursing Department Universidade Estadual Paulista (Unesp) Faculdade de MedicinaDepartment of Nutrition Faculdade de Saúde Pública Universidade de São Paulo (FSP-USP)Department of Internal Medicine Universidade Estadual Paulista (Unesp) Faculdade de Medicina, Unesp Distrito de Rubião Junior, s/nNursing Department Universidade Estadual Paulista (Unesp) Faculdade de MedicinaUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Urbano, Ana Paula Signori [UNESP]Sassaki, Ligia Yukie [UNESP]De Souza Dorna, Mariana [UNESP]Presti, Paula Torres [UNESP]De Barros Leite Carvalhaes, Maria Antonieta [UNESP]Martini, Ligia AraújoFerreira, Ana Lucia Anjos [UNESP]2018-12-11T17:19:30Z2018-12-11T17:19:30Z2018-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article133-139application/pdfhttp://dx.doi.org/10.1590/1806-9282.64.02.133Revista da Associacao Medica Brasileira, v. 64, n. 2, p. 133-139, 2018.0104-4230http://hdl.handle.net/11449/17617910.1590/1806-9282.64.02.1332-s2.0-850453191672-s2.0-85045319167.pdf4734747821898178Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista da Associacao Medica Brasileira0,265info:eu-repo/semantics/openAccess2023-12-04T06:12:24Zoai:repositorio.unesp.br:11449/176179Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-04T06:12:24Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients |
title |
Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients |
spellingShingle |
Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients Urbano, Ana Paula Signori [UNESP] Biomarkers Body composition C-reactive protein Severity of illness index Ulcerative colitis |
title_short |
Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients |
title_full |
Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients |
title_fullStr |
Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients |
title_full_unstemmed |
Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients |
title_sort |
Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients |
author |
Urbano, Ana Paula Signori [UNESP] |
author_facet |
Urbano, Ana Paula Signori [UNESP] Sassaki, Ligia Yukie [UNESP] De Souza Dorna, Mariana [UNESP] Presti, Paula Torres [UNESP] De Barros Leite Carvalhaes, Maria Antonieta [UNESP] Martini, Ligia Araújo Ferreira, Ana Lucia Anjos [UNESP] |
author_role |
author |
author2 |
Sassaki, Ligia Yukie [UNESP] De Souza Dorna, Mariana [UNESP] Presti, Paula Torres [UNESP] De Barros Leite Carvalhaes, Maria Antonieta [UNESP] Martini, Ligia Araújo Ferreira, Ana Lucia Anjos [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Urbano, Ana Paula Signori [UNESP] Sassaki, Ligia Yukie [UNESP] De Souza Dorna, Mariana [UNESP] Presti, Paula Torres [UNESP] De Barros Leite Carvalhaes, Maria Antonieta [UNESP] Martini, Ligia Araújo Ferreira, Ana Lucia Anjos [UNESP] |
dc.subject.por.fl_str_mv |
Biomarkers Body composition C-reactive protein Severity of illness index Ulcerative colitis |
topic |
Biomarkers Body composition C-reactive protein Severity of illness index Ulcerative colitis |
description |
Objective: The aim of our study was to assess body composition status and its association with inflammatory profile and extent of intestinal damage in ulcerative colitis patients during clinical remission. Method: This is a cross-sectional study in which body composition data (phase angle [PhA], fat mass [FM], triceps skin fold thickness [TSFt], mid-arm circumference [MAC], mid-arm muscle circumference [MAMC], adductor pollicis muscle thickness [APMt]), inflammatory profile (C-reactive protein [CRP], α1-acid glycoprotein, erythrocyte sedimentation rate [ESR]) and disease extent were recorded. Results: The mean age of the 59 patients was 48.1 years; 53.3% were women. Most patients were in clinical remission (94.9%) and 3.4% was malnourished according to body mass index. PhA was inversely correlated with inflammatory markers such as CRP (R=-0.59; p<0.001) and ESR (R=-0.46; p<0.001) and directly correlated with lean mass: MAMC (R=0.31; p=0.01) and APMt (R=0.47; p<0.001). Lean mass was inversely correlated with non-specific inflammation marker (APMt vs. ESR) and directly correlated with hemoglobin values (MAMC vs. hemoglobin). Logistic regression analysis revealed that body cell mass was associated with disease extent (OR 0.92; 95CI 0.87-0.97; p<0.01). Conclusion: PhA was inversely correlated with inflammatory markers and directly correlated with lean mass. Acute inflammatory markers were correlated with disease extent. Body cell mass was associated with disease extent. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:19:30Z 2018-12-11T17:19:30Z 2018-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1806-9282.64.02.133 Revista da Associacao Medica Brasileira, v. 64, n. 2, p. 133-139, 2018. 0104-4230 http://hdl.handle.net/11449/176179 10.1590/1806-9282.64.02.133 2-s2.0-85045319167 2-s2.0-85045319167.pdf 4734747821898178 |
url |
http://dx.doi.org/10.1590/1806-9282.64.02.133 http://hdl.handle.net/11449/176179 |
identifier_str_mv |
Revista da Associacao Medica Brasileira, v. 64, n. 2, p. 133-139, 2018. 0104-4230 10.1590/1806-9282.64.02.133 2-s2.0-85045319167 2-s2.0-85045319167.pdf 4734747821898178 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista da Associacao Medica Brasileira 0,265 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
133-139 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965166105788416 |