Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients

Detalhes bibliográficos
Autor(a) principal: Urbano, Ana Paula Signori [UNESP]
Data de Publicação: 2018
Outros Autores: Sassaki, Ligia Yukie [UNESP], De Souza Dorna, Mariana [UNESP], Presti, Paula Torres [UNESP], De Barros Leite Carvalhaes, Maria Antonieta [UNESP], Martini, Ligia Araújo, Ferreira, Ana Lucia Anjos [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1806-9282.64.02.133
http://hdl.handle.net/11449/176179
Resumo: Objective: The aim of our study was to assess body composition status and its association with inflammatory profile and extent of intestinal damage in ulcerative colitis patients during clinical remission. Method: This is a cross-sectional study in which body composition data (phase angle [PhA], fat mass [FM], triceps skin fold thickness [TSFt], mid-arm circumference [MAC], mid-arm muscle circumference [MAMC], adductor pollicis muscle thickness [APMt]), inflammatory profile (C-reactive protein [CRP], α1-acid glycoprotein, erythrocyte sedimentation rate [ESR]) and disease extent were recorded. Results: The mean age of the 59 patients was 48.1 years; 53.3% were women. Most patients were in clinical remission (94.9%) and 3.4% was malnourished according to body mass index. PhA was inversely correlated with inflammatory markers such as CRP (R=-0.59; p<0.001) and ESR (R=-0.46; p<0.001) and directly correlated with lean mass: MAMC (R=0.31; p=0.01) and APMt (R=0.47; p<0.001). Lean mass was inversely correlated with non-specific inflammation marker (APMt vs. ESR) and directly correlated with hemoglobin values (MAMC vs. hemoglobin). Logistic regression analysis revealed that body cell mass was associated with disease extent (OR 0.92; 95CI 0.87-0.97; p<0.01). Conclusion: PhA was inversely correlated with inflammatory markers and directly correlated with lean mass. Acute inflammatory markers were correlated with disease extent. Body cell mass was associated with disease extent.
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spelling Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patientsBiomarkersBody compositionC-reactive proteinSeverity of illness indexUlcerative colitisObjective: The aim of our study was to assess body composition status and its association with inflammatory profile and extent of intestinal damage in ulcerative colitis patients during clinical remission. Method: This is a cross-sectional study in which body composition data (phase angle [PhA], fat mass [FM], triceps skin fold thickness [TSFt], mid-arm circumference [MAC], mid-arm muscle circumference [MAMC], adductor pollicis muscle thickness [APMt]), inflammatory profile (C-reactive protein [CRP], α1-acid glycoprotein, erythrocyte sedimentation rate [ESR]) and disease extent were recorded. Results: The mean age of the 59 patients was 48.1 years; 53.3% were women. Most patients were in clinical remission (94.9%) and 3.4% was malnourished according to body mass index. PhA was inversely correlated with inflammatory markers such as CRP (R=-0.59; p<0.001) and ESR (R=-0.46; p<0.001) and directly correlated with lean mass: MAMC (R=0.31; p=0.01) and APMt (R=0.47; p<0.001). Lean mass was inversely correlated with non-specific inflammation marker (APMt vs. ESR) and directly correlated with hemoglobin values (MAMC vs. hemoglobin). Logistic regression analysis revealed that body cell mass was associated with disease extent (OR 0.92; 95CI 0.87-0.97; p<0.01). Conclusion: PhA was inversely correlated with inflammatory markers and directly correlated with lean mass. Acute inflammatory markers were correlated with disease extent. Body cell mass was associated with disease extent.Department of Internal Medicine Universidade Estadual Paulista (Unesp) Faculdade de Medicina, Unesp Distrito de Rubião Junior, s/nNursing Department Universidade Estadual Paulista (Unesp) Faculdade de MedicinaDepartment of Nutrition Faculdade de Saúde Pública Universidade de São Paulo (FSP-USP)Department of Internal Medicine Universidade Estadual Paulista (Unesp) Faculdade de Medicina, Unesp Distrito de Rubião Junior, s/nNursing Department Universidade Estadual Paulista (Unesp) Faculdade de MedicinaUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Urbano, Ana Paula Signori [UNESP]Sassaki, Ligia Yukie [UNESP]De Souza Dorna, Mariana [UNESP]Presti, Paula Torres [UNESP]De Barros Leite Carvalhaes, Maria Antonieta [UNESP]Martini, Ligia AraújoFerreira, Ana Lucia Anjos [UNESP]2018-12-11T17:19:30Z2018-12-11T17:19:30Z2018-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article133-139application/pdfhttp://dx.doi.org/10.1590/1806-9282.64.02.133Revista da Associacao Medica Brasileira, v. 64, n. 2, p. 133-139, 2018.0104-4230http://hdl.handle.net/11449/17617910.1590/1806-9282.64.02.1332-s2.0-850453191672-s2.0-85045319167.pdf4734747821898178Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista da Associacao Medica Brasileira0,265info:eu-repo/semantics/openAccess2023-12-04T06:12:24Zoai:repositorio.unesp.br:11449/176179Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-04T06:12:24Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients
title Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients
spellingShingle Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients
Urbano, Ana Paula Signori [UNESP]
Biomarkers
Body composition
C-reactive protein
Severity of illness index
Ulcerative colitis
title_short Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients
title_full Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients
title_fullStr Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients
title_full_unstemmed Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients
title_sort Associations among body composition, inflammatory profile and disease extent in ulcerative colitis patients
author Urbano, Ana Paula Signori [UNESP]
author_facet Urbano, Ana Paula Signori [UNESP]
Sassaki, Ligia Yukie [UNESP]
De Souza Dorna, Mariana [UNESP]
Presti, Paula Torres [UNESP]
De Barros Leite Carvalhaes, Maria Antonieta [UNESP]
Martini, Ligia Araújo
Ferreira, Ana Lucia Anjos [UNESP]
author_role author
author2 Sassaki, Ligia Yukie [UNESP]
De Souza Dorna, Mariana [UNESP]
Presti, Paula Torres [UNESP]
De Barros Leite Carvalhaes, Maria Antonieta [UNESP]
Martini, Ligia Araújo
Ferreira, Ana Lucia Anjos [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Urbano, Ana Paula Signori [UNESP]
Sassaki, Ligia Yukie [UNESP]
De Souza Dorna, Mariana [UNESP]
Presti, Paula Torres [UNESP]
De Barros Leite Carvalhaes, Maria Antonieta [UNESP]
Martini, Ligia Araújo
Ferreira, Ana Lucia Anjos [UNESP]
dc.subject.por.fl_str_mv Biomarkers
Body composition
C-reactive protein
Severity of illness index
Ulcerative colitis
topic Biomarkers
Body composition
C-reactive protein
Severity of illness index
Ulcerative colitis
description Objective: The aim of our study was to assess body composition status and its association with inflammatory profile and extent of intestinal damage in ulcerative colitis patients during clinical remission. Method: This is a cross-sectional study in which body composition data (phase angle [PhA], fat mass [FM], triceps skin fold thickness [TSFt], mid-arm circumference [MAC], mid-arm muscle circumference [MAMC], adductor pollicis muscle thickness [APMt]), inflammatory profile (C-reactive protein [CRP], α1-acid glycoprotein, erythrocyte sedimentation rate [ESR]) and disease extent were recorded. Results: The mean age of the 59 patients was 48.1 years; 53.3% were women. Most patients were in clinical remission (94.9%) and 3.4% was malnourished according to body mass index. PhA was inversely correlated with inflammatory markers such as CRP (R=-0.59; p<0.001) and ESR (R=-0.46; p<0.001) and directly correlated with lean mass: MAMC (R=0.31; p=0.01) and APMt (R=0.47; p<0.001). Lean mass was inversely correlated with non-specific inflammation marker (APMt vs. ESR) and directly correlated with hemoglobin values (MAMC vs. hemoglobin). Logistic regression analysis revealed that body cell mass was associated with disease extent (OR 0.92; 95CI 0.87-0.97; p<0.01). Conclusion: PhA was inversely correlated with inflammatory markers and directly correlated with lean mass. Acute inflammatory markers were correlated with disease extent. Body cell mass was associated with disease extent.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:19:30Z
2018-12-11T17:19:30Z
2018-02-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1806-9282.64.02.133
Revista da Associacao Medica Brasileira, v. 64, n. 2, p. 133-139, 2018.
0104-4230
http://hdl.handle.net/11449/176179
10.1590/1806-9282.64.02.133
2-s2.0-85045319167
2-s2.0-85045319167.pdf
4734747821898178
url http://dx.doi.org/10.1590/1806-9282.64.02.133
http://hdl.handle.net/11449/176179
identifier_str_mv Revista da Associacao Medica Brasileira, v. 64, n. 2, p. 133-139, 2018.
0104-4230
10.1590/1806-9282.64.02.133
2-s2.0-85045319167
2-s2.0-85045319167.pdf
4734747821898178
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista da Associacao Medica Brasileira
0,265
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 133-139
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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