Modulatory effect of polyphenolic compounds from the mangrove tree rhizophora mangle l. On non-alcoholic fatty liver disease and insulin resistance in high-fat diet obese mice

Detalhes bibliográficos
Autor(a) principal: De Souza Mesquita, Leonardo Mendes [UNESP]
Data de Publicação: 2018
Outros Autores: e Paiva Caria, Cíntia Rabelo, Santos, Paola Souza, Ruy, Caio Cesar, Da Silva Lima, Natalia, Taketa Moreira, Débora Kono, Da Rocha, Claudia Quintino [UNESP], Murador, Daniella Carisa, De Rosso, Veridiana Vera, Gambero, Alessandra, Vilegas, Wagner [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/molecules23092114
http://hdl.handle.net/11449/176792
Resumo: No scientific report proves the action of the phytochemicals from the mangrove tree Rhizophora mangle in the treatment of diabetes. The aim of this work is to evaluate the effects of the acetonic extract of R. mangle barks (AERM) on type 2 diabetes. The main chemical constituents of the extract were analyzed by high-performance liquid chromatography (HPLC) and flow injection analysis electrospray-iontrap mass spectrometry (FIA-ESI-IT-MS/MS). High-fat diet (HFD)-fed mice were used as model of type 2 diabetes associated with obesity. After 4 weeks of AERM 5 or 50 mg/kg/day orally, glucose homeostasis was evaluated by insulin tolerance test (kiTT). Hepatic steatosis, triglycerides and gene expression were also evaluated. AERM consists of catechin, quercetin and chlorogenic acids derivatives. These metabolites have nutritional importance, obese mice treated with AERM (50 mg/kg) presented improvements in insulin resistance resulting in hepatic steatosis reductions associated with a strong inhibition of hepatic mRNA levels of CD36. The beneficial effects of AERM in an obesity model could be associated with its inhibitory α-amylase activity detected in vitro. Rhizophora mangle partially reverses insulin resistance and hepatic steatosis associated with obesity, supporting previous claims in traditional knowledge.
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spelling Modulatory effect of polyphenolic compounds from the mangrove tree rhizophora mangle l. On non-alcoholic fatty liver disease and insulin resistance in high-fat diet obese miceCatechinsCD36Non-alcoholic fatty liver diseasePolyphenolsType 2 diabetesNo scientific report proves the action of the phytochemicals from the mangrove tree Rhizophora mangle in the treatment of diabetes. The aim of this work is to evaluate the effects of the acetonic extract of R. mangle barks (AERM) on type 2 diabetes. The main chemical constituents of the extract were analyzed by high-performance liquid chromatography (HPLC) and flow injection analysis electrospray-iontrap mass spectrometry (FIA-ESI-IT-MS/MS). High-fat diet (HFD)-fed mice were used as model of type 2 diabetes associated with obesity. After 4 weeks of AERM 5 or 50 mg/kg/day orally, glucose homeostasis was evaluated by insulin tolerance test (kiTT). Hepatic steatosis, triglycerides and gene expression were also evaluated. AERM consists of catechin, quercetin and chlorogenic acids derivatives. These metabolites have nutritional importance, obese mice treated with AERM (50 mg/kg) presented improvements in insulin resistance resulting in hepatic steatosis reductions associated with a strong inhibition of hepatic mRNA levels of CD36. The beneficial effects of AERM in an obesity model could be associated with its inhibitory α-amylase activity detected in vitro. Rhizophora mangle partially reverses insulin resistance and hepatic steatosis associated with obesity, supporting previous claims in traditional knowledge.UNESP São Paulo State University Coastal Campus of São Vicente Laboratory of Bioprospection of Natural Products (LBPN) Pça Infante Dom Henrique S/NClinical Pharmacology and Gastroenterology Unit USF—São Francisco University, Av. São Francisco de Assis, 218Laboratório de Estudos Avançados em Fitomedicamentos (LEAF) UFMA Federal University of Maranhão, Av. dos Portugueses, 1966-BacangaDepartment of Biosciences Federal University of São Paulo (UNIFESP), Silva Jardim Street, 136, Vila MathiasUNESP São Paulo State University Coastal Campus of São Vicente Laboratory of Bioprospection of Natural Products (LBPN) Pça Infante Dom Henrique S/NUniversidade Estadual Paulista (Unesp)USF—São Francisco UniversityFederal University of MaranhãoUniversidade de São Paulo (USP)De Souza Mesquita, Leonardo Mendes [UNESP]e Paiva Caria, Cíntia RabeloSantos, Paola SouzaRuy, Caio CesarDa Silva Lima, NataliaTaketa Moreira, Débora KonoDa Rocha, Claudia Quintino [UNESP]Murador, Daniella CarisaDe Rosso, Veridiana VeraGambero, AlessandraVilegas, Wagner [UNESP]2018-12-11T17:22:31Z2018-12-11T17:22:31Z2018-08-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.3390/molecules23092114Molecules, v. 23, n. 9, 2018.1420-3049http://hdl.handle.net/11449/17679210.3390/molecules230921142-s2.0-850528065002-s2.0-85052806500.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMolecules0,855info:eu-repo/semantics/openAccess2023-10-04T06:04:03Zoai:repositorio.unesp.br:11449/176792Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-04T06:04:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Modulatory effect of polyphenolic compounds from the mangrove tree rhizophora mangle l. On non-alcoholic fatty liver disease and insulin resistance in high-fat diet obese mice
title Modulatory effect of polyphenolic compounds from the mangrove tree rhizophora mangle l. On non-alcoholic fatty liver disease and insulin resistance in high-fat diet obese mice
spellingShingle Modulatory effect of polyphenolic compounds from the mangrove tree rhizophora mangle l. On non-alcoholic fatty liver disease and insulin resistance in high-fat diet obese mice
De Souza Mesquita, Leonardo Mendes [UNESP]
Catechins
CD36
Non-alcoholic fatty liver disease
Polyphenols
Type 2 diabetes
title_short Modulatory effect of polyphenolic compounds from the mangrove tree rhizophora mangle l. On non-alcoholic fatty liver disease and insulin resistance in high-fat diet obese mice
title_full Modulatory effect of polyphenolic compounds from the mangrove tree rhizophora mangle l. On non-alcoholic fatty liver disease and insulin resistance in high-fat diet obese mice
title_fullStr Modulatory effect of polyphenolic compounds from the mangrove tree rhizophora mangle l. On non-alcoholic fatty liver disease and insulin resistance in high-fat diet obese mice
title_full_unstemmed Modulatory effect of polyphenolic compounds from the mangrove tree rhizophora mangle l. On non-alcoholic fatty liver disease and insulin resistance in high-fat diet obese mice
title_sort Modulatory effect of polyphenolic compounds from the mangrove tree rhizophora mangle l. On non-alcoholic fatty liver disease and insulin resistance in high-fat diet obese mice
author De Souza Mesquita, Leonardo Mendes [UNESP]
author_facet De Souza Mesquita, Leonardo Mendes [UNESP]
e Paiva Caria, Cíntia Rabelo
Santos, Paola Souza
Ruy, Caio Cesar
Da Silva Lima, Natalia
Taketa Moreira, Débora Kono
Da Rocha, Claudia Quintino [UNESP]
Murador, Daniella Carisa
De Rosso, Veridiana Vera
Gambero, Alessandra
Vilegas, Wagner [UNESP]
author_role author
author2 e Paiva Caria, Cíntia Rabelo
Santos, Paola Souza
Ruy, Caio Cesar
Da Silva Lima, Natalia
Taketa Moreira, Débora Kono
Da Rocha, Claudia Quintino [UNESP]
Murador, Daniella Carisa
De Rosso, Veridiana Vera
Gambero, Alessandra
Vilegas, Wagner [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
USF—São Francisco University
Federal University of Maranhão
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv De Souza Mesquita, Leonardo Mendes [UNESP]
e Paiva Caria, Cíntia Rabelo
Santos, Paola Souza
Ruy, Caio Cesar
Da Silva Lima, Natalia
Taketa Moreira, Débora Kono
Da Rocha, Claudia Quintino [UNESP]
Murador, Daniella Carisa
De Rosso, Veridiana Vera
Gambero, Alessandra
Vilegas, Wagner [UNESP]
dc.subject.por.fl_str_mv Catechins
CD36
Non-alcoholic fatty liver disease
Polyphenols
Type 2 diabetes
topic Catechins
CD36
Non-alcoholic fatty liver disease
Polyphenols
Type 2 diabetes
description No scientific report proves the action of the phytochemicals from the mangrove tree Rhizophora mangle in the treatment of diabetes. The aim of this work is to evaluate the effects of the acetonic extract of R. mangle barks (AERM) on type 2 diabetes. The main chemical constituents of the extract were analyzed by high-performance liquid chromatography (HPLC) and flow injection analysis electrospray-iontrap mass spectrometry (FIA-ESI-IT-MS/MS). High-fat diet (HFD)-fed mice were used as model of type 2 diabetes associated with obesity. After 4 weeks of AERM 5 or 50 mg/kg/day orally, glucose homeostasis was evaluated by insulin tolerance test (kiTT). Hepatic steatosis, triglycerides and gene expression were also evaluated. AERM consists of catechin, quercetin and chlorogenic acids derivatives. These metabolites have nutritional importance, obese mice treated with AERM (50 mg/kg) presented improvements in insulin resistance resulting in hepatic steatosis reductions associated with a strong inhibition of hepatic mRNA levels of CD36. The beneficial effects of AERM in an obesity model could be associated with its inhibitory α-amylase activity detected in vitro. Rhizophora mangle partially reverses insulin resistance and hepatic steatosis associated with obesity, supporting previous claims in traditional knowledge.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:22:31Z
2018-12-11T17:22:31Z
2018-08-22
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/molecules23092114
Molecules, v. 23, n. 9, 2018.
1420-3049
http://hdl.handle.net/11449/176792
10.3390/molecules23092114
2-s2.0-85052806500
2-s2.0-85052806500.pdf
url http://dx.doi.org/10.3390/molecules23092114
http://hdl.handle.net/11449/176792
identifier_str_mv Molecules, v. 23, n. 9, 2018.
1420-3049
10.3390/molecules23092114
2-s2.0-85052806500
2-s2.0-85052806500.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Molecules
0,855
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964428303597568

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