Subacute toxicity assessment of biobased ionic liquids in rats
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.foodres.2020.109125 http://hdl.handle.net/11449/195432 |
Resumo: | Ionic liquids (ILs) derived from compounds obtained from natural sources, such as fatty acids (FAs) have attracted the interest of the scientific and industrial communities because of their sustainable appeal and possible low toxic effects or nontoxicity. These aspects open new perspective of applications in other fields, which demands a better comprehension of their toxicity. This work evaluated the subacute toxicity of bis(2-hydroxyethyl) ammonium carboxylates in Wistar rats, considering the alkyl chain length of FAs (capric and oleic acids), and the concentration (0.16%, 1.6% or 3.2%, w(IL)/w(Oil)) of ILs added in diets. The blood serum of the rats was evaluated in relation to total cholesterol, triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and.-glutamyl transferase. Lipid peroxidation was determined in plasma, liver and kidney tissues by determining the level of thiobarbituric acid reactive substances. Histological analyses of the liver and kidney tissues were performed in order to evaluate morphological changes. No signal of toxicity was observed according to lipid peroxidation. Triglycerides increased with the increasing of the concentration and alkyl chain length of the IL, but no difference in serum level of lipid peroxidation was observed. This behavior may be attributed to the amphiphilic nature of FAs based ILs, which might facilitate lipid digestion. However, more studies are necessary in order to understand such behavior. Therefore, the synthesis of ILs from FAs, has been evaluated as a strategy to produce compounds with low or without toxicity for the agro-food, pharmaceutical or cosmetic industries. |
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Subacute toxicity assessment of biobased ionic liquids in ratsIonic liquidToxicityRatFatty acidIonic liquids (ILs) derived from compounds obtained from natural sources, such as fatty acids (FAs) have attracted the interest of the scientific and industrial communities because of their sustainable appeal and possible low toxic effects or nontoxicity. These aspects open new perspective of applications in other fields, which demands a better comprehension of their toxicity. This work evaluated the subacute toxicity of bis(2-hydroxyethyl) ammonium carboxylates in Wistar rats, considering the alkyl chain length of FAs (capric and oleic acids), and the concentration (0.16%, 1.6% or 3.2%, w(IL)/w(Oil)) of ILs added in diets. The blood serum of the rats was evaluated in relation to total cholesterol, triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and.-glutamyl transferase. Lipid peroxidation was determined in plasma, liver and kidney tissues by determining the level of thiobarbituric acid reactive substances. Histological analyses of the liver and kidney tissues were performed in order to evaluate morphological changes. No signal of toxicity was observed according to lipid peroxidation. Triglycerides increased with the increasing of the concentration and alkyl chain length of the IL, but no difference in serum level of lipid peroxidation was observed. This behavior may be attributed to the amphiphilic nature of FAs based ILs, which might facilitate lipid digestion. However, more studies are necessary in order to understand such behavior. Therefore, the synthesis of ILs from FAs, has been evaluated as a strategy to produce compounds with low or without toxicity for the agro-food, pharmaceutical or cosmetic industries.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Campinas, Sch Food Engn, Lab Extract Appl Thermodynam & Equilibrium EXTRAE, R Monteiro Lobato 80, BR-13083862 Campinas, SP, BrazilUniv Estadual Campinas, Sch Food Engn, Lab Biol Assays LEB, R Monteiro Lobato 80, BR-13083862 Campinas, SP, BrazilUniv Estadual Campinas, Sch Med Sci, R Tessalia Vieira de Camargo 126, BR-13083887 Campinas, SP, BrazilUniv Estadual Paulista, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP, BrazilUniv Estadual Paulista, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP, BrazilFAPESP: 2016/24461-5FAPESP: 2014/21252-0FAPESP: 2016/08566-1FAPESP: 2017/04231-8CNPq: 305870/2014-9CNPq: 406963/2016-9CNPq: 406918/2016-3CNPq: 301108/2016-1FAPESP: 2014/16424-7Elsevier B.V.Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Toledo Hijo, Ariel A. C.Barros, Helena D. F. Q.Maximo, Guilherme J.Cazarin, Cinthia B. B.Costa, Larissa B. E. daPereira, Jorge F. B. [UNESP]Marostica Junior, Mario R.Meirelles, Antonio J. A.2020-12-10T17:34:29Z2020-12-10T17:34:29Z2020-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9http://dx.doi.org/10.1016/j.foodres.2020.109125Food Research International. Amsterdam: Elsevier, v. 134, 9 p., 2020.0963-9969http://hdl.handle.net/11449/19543210.1016/j.foodres.2020.109125WOS:000539366100058Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFood Research Internationalinfo:eu-repo/semantics/openAccess2021-10-23T08:05:27Zoai:repositorio.unesp.br:11449/195432Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T08:05:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Subacute toxicity assessment of biobased ionic liquids in rats |
title |
Subacute toxicity assessment of biobased ionic liquids in rats |
spellingShingle |
Subacute toxicity assessment of biobased ionic liquids in rats Toledo Hijo, Ariel A. C. Ionic liquid Toxicity Rat Fatty acid |
title_short |
Subacute toxicity assessment of biobased ionic liquids in rats |
title_full |
Subacute toxicity assessment of biobased ionic liquids in rats |
title_fullStr |
Subacute toxicity assessment of biobased ionic liquids in rats |
title_full_unstemmed |
Subacute toxicity assessment of biobased ionic liquids in rats |
title_sort |
Subacute toxicity assessment of biobased ionic liquids in rats |
author |
Toledo Hijo, Ariel A. C. |
author_facet |
Toledo Hijo, Ariel A. C. Barros, Helena D. F. Q. Maximo, Guilherme J. Cazarin, Cinthia B. B. Costa, Larissa B. E. da Pereira, Jorge F. B. [UNESP] Marostica Junior, Mario R. Meirelles, Antonio J. A. |
author_role |
author |
author2 |
Barros, Helena D. F. Q. Maximo, Guilherme J. Cazarin, Cinthia B. B. Costa, Larissa B. E. da Pereira, Jorge F. B. [UNESP] Marostica Junior, Mario R. Meirelles, Antonio J. A. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Toledo Hijo, Ariel A. C. Barros, Helena D. F. Q. Maximo, Guilherme J. Cazarin, Cinthia B. B. Costa, Larissa B. E. da Pereira, Jorge F. B. [UNESP] Marostica Junior, Mario R. Meirelles, Antonio J. A. |
dc.subject.por.fl_str_mv |
Ionic liquid Toxicity Rat Fatty acid |
topic |
Ionic liquid Toxicity Rat Fatty acid |
description |
Ionic liquids (ILs) derived from compounds obtained from natural sources, such as fatty acids (FAs) have attracted the interest of the scientific and industrial communities because of their sustainable appeal and possible low toxic effects or nontoxicity. These aspects open new perspective of applications in other fields, which demands a better comprehension of their toxicity. This work evaluated the subacute toxicity of bis(2-hydroxyethyl) ammonium carboxylates in Wistar rats, considering the alkyl chain length of FAs (capric and oleic acids), and the concentration (0.16%, 1.6% or 3.2%, w(IL)/w(Oil)) of ILs added in diets. The blood serum of the rats was evaluated in relation to total cholesterol, triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and.-glutamyl transferase. Lipid peroxidation was determined in plasma, liver and kidney tissues by determining the level of thiobarbituric acid reactive substances. Histological analyses of the liver and kidney tissues were performed in order to evaluate morphological changes. No signal of toxicity was observed according to lipid peroxidation. Triglycerides increased with the increasing of the concentration and alkyl chain length of the IL, but no difference in serum level of lipid peroxidation was observed. This behavior may be attributed to the amphiphilic nature of FAs based ILs, which might facilitate lipid digestion. However, more studies are necessary in order to understand such behavior. Therefore, the synthesis of ILs from FAs, has been evaluated as a strategy to produce compounds with low or without toxicity for the agro-food, pharmaceutical or cosmetic industries. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-10T17:34:29Z 2020-12-10T17:34:29Z 2020-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.foodres.2020.109125 Food Research International. Amsterdam: Elsevier, v. 134, 9 p., 2020. 0963-9969 http://hdl.handle.net/11449/195432 10.1016/j.foodres.2020.109125 WOS:000539366100058 |
url |
http://dx.doi.org/10.1016/j.foodres.2020.109125 http://hdl.handle.net/11449/195432 |
identifier_str_mv |
Food Research International. Amsterdam: Elsevier, v. 134, 9 p., 2020. 0963-9969 10.1016/j.foodres.2020.109125 WOS:000539366100058 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Food Research International |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965286225412096 |