Aluminum exposure promotes histopathological and pro-oxidant damage to the prostate and gonads of male and female adult gerbils
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.yexmp.2020.104486 http://hdl.handle.net/11449/200631 |
Resumo: | Since the industrial revolution, all living beings have become susceptible to numerous sources of aluminum (Al) exposure. In addition to causing proven toxicity in many organs and systems, Al can also have estrogenic activity when absorbed by the body. The reproductive organs are commonly affected by environmental pollutants with estrogenic activity, but little is known about the effects of Al on the prostate and gonads. Therefore, the aim of this study was to evaluate the effects of subchronic Al exposure on the prostate and gonads of male and female adult gerbils. After 30 days of oral exposure to aluminum chloride (10 mg/kg/day), the animals were euthanized and the organs processed for cytochemical, ultrastructural, and biochemical assays. Ventral male prostates exposed to Al became hyperplastic and showed signs of cell aging. In addition, the male prostate showed decreased catalase (CAT) and superoxide dismutase (SOD) activity. The female prostate was structurally more affected than the ventral male prostate, since it presented hyperplasia and punctual foci of inflammation and prostatic intraepithelial neoplasia. However, CAT and SOD activities did not change in this gland. In the testis, Al promoted immature germ cell detachment and degeneration, as well as reduced CAT activity. In the ovaries, Al caused reduction in folliculogenesis and decreased SOD activity. Together, these results indicate that Al is toxic to the prostate and gonads of adult gerbils and that continuous exposure to this metal can impair the fertility of individuals of both sexes. |
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Aluminum exposure promotes histopathological and pro-oxidant damage to the prostate and gonads of male and female adult gerbilsEnvironmental pollutantsFemale prostateMetalloestrogensOxidative stressUltrastructureVentral male prostateSince the industrial revolution, all living beings have become susceptible to numerous sources of aluminum (Al) exposure. In addition to causing proven toxicity in many organs and systems, Al can also have estrogenic activity when absorbed by the body. The reproductive organs are commonly affected by environmental pollutants with estrogenic activity, but little is known about the effects of Al on the prostate and gonads. Therefore, the aim of this study was to evaluate the effects of subchronic Al exposure on the prostate and gonads of male and female adult gerbils. After 30 days of oral exposure to aluminum chloride (10 mg/kg/day), the animals were euthanized and the organs processed for cytochemical, ultrastructural, and biochemical assays. Ventral male prostates exposed to Al became hyperplastic and showed signs of cell aging. In addition, the male prostate showed decreased catalase (CAT) and superoxide dismutase (SOD) activity. The female prostate was structurally more affected than the ventral male prostate, since it presented hyperplasia and punctual foci of inflammation and prostatic intraepithelial neoplasia. However, CAT and SOD activities did not change in this gland. In the testis, Al promoted immature germ cell detachment and degeneration, as well as reduced CAT activity. In the ovaries, Al caused reduction in folliculogenesis and decreased SOD activity. Together, these results indicate that Al is toxic to the prostate and gonads of adult gerbils and that continuous exposure to this metal can impair the fertility of individuals of both sexes.ASCRS Research FoundationDepartment of Histology Embryology and Cell Biology Laboratory of Microscopy Applied to Reproduction Institute of Biological Sciences Federal University of Goiás GoiâniaDepartment of Pharmacology Laboratory of Molecular and Biochemistry Pharmacology Institute of Biological Sciences Federal University of Goiás GoiâniaDepartment of Biology Laboratory of Microscopy and Microanalysis State University of São Paulo – UNESP, Rua Cristóvão Colombo, 2265, São José do Rio PretoDepartment of Biology Laboratory of Microscopy and Microanalysis State University of São Paulo – UNESP, Rua Cristóvão Colombo, 2265, São José do Rio PretoASCRS Research Foundation: 08/2018Universidade Federal de Goiás (UFG)Universidade Estadual Paulista (Unesp)da Silva Lima, Daniloda Silva Gomes, Lianade Sousa Figueredo, Estherde Godoi, Murion MonteiroSilva, Edvaldo Mendesda Silva Neri, Hiasmin FrancielyTaboga, Sebastião Roberto [UNESP]Biancardi, Manoel FranciscoGhedini, Paulo Césardos Santos, Fernanda Cristina Alcantara2020-12-12T02:11:50Z2020-12-12T02:11:50Z2020-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.yexmp.2020.104486Experimental and Molecular Pathology, v. 116.1096-09450014-4800http://hdl.handle.net/11449/20063110.1016/j.yexmp.2020.1044862-s2.0-85086846486Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengExperimental and Molecular Pathologyinfo:eu-repo/semantics/openAccess2024-04-11T19:33:51Zoai:repositorio.unesp.br:11449/200631Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:03:35.867617Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Aluminum exposure promotes histopathological and pro-oxidant damage to the prostate and gonads of male and female adult gerbils |
title |
Aluminum exposure promotes histopathological and pro-oxidant damage to the prostate and gonads of male and female adult gerbils |
spellingShingle |
Aluminum exposure promotes histopathological and pro-oxidant damage to the prostate and gonads of male and female adult gerbils da Silva Lima, Danilo Environmental pollutants Female prostate Metalloestrogens Oxidative stress Ultrastructure Ventral male prostate |
title_short |
Aluminum exposure promotes histopathological and pro-oxidant damage to the prostate and gonads of male and female adult gerbils |
title_full |
Aluminum exposure promotes histopathological and pro-oxidant damage to the prostate and gonads of male and female adult gerbils |
title_fullStr |
Aluminum exposure promotes histopathological and pro-oxidant damage to the prostate and gonads of male and female adult gerbils |
title_full_unstemmed |
Aluminum exposure promotes histopathological and pro-oxidant damage to the prostate and gonads of male and female adult gerbils |
title_sort |
Aluminum exposure promotes histopathological and pro-oxidant damage to the prostate and gonads of male and female adult gerbils |
author |
da Silva Lima, Danilo |
author_facet |
da Silva Lima, Danilo da Silva Gomes, Liana de Sousa Figueredo, Esther de Godoi, Murion Monteiro Silva, Edvaldo Mendes da Silva Neri, Hiasmin Franciely Taboga, Sebastião Roberto [UNESP] Biancardi, Manoel Francisco Ghedini, Paulo César dos Santos, Fernanda Cristina Alcantara |
author_role |
author |
author2 |
da Silva Gomes, Liana de Sousa Figueredo, Esther de Godoi, Murion Monteiro Silva, Edvaldo Mendes da Silva Neri, Hiasmin Franciely Taboga, Sebastião Roberto [UNESP] Biancardi, Manoel Francisco Ghedini, Paulo César dos Santos, Fernanda Cristina Alcantara |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Goiás (UFG) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
da Silva Lima, Danilo da Silva Gomes, Liana de Sousa Figueredo, Esther de Godoi, Murion Monteiro Silva, Edvaldo Mendes da Silva Neri, Hiasmin Franciely Taboga, Sebastião Roberto [UNESP] Biancardi, Manoel Francisco Ghedini, Paulo César dos Santos, Fernanda Cristina Alcantara |
dc.subject.por.fl_str_mv |
Environmental pollutants Female prostate Metalloestrogens Oxidative stress Ultrastructure Ventral male prostate |
topic |
Environmental pollutants Female prostate Metalloestrogens Oxidative stress Ultrastructure Ventral male prostate |
description |
Since the industrial revolution, all living beings have become susceptible to numerous sources of aluminum (Al) exposure. In addition to causing proven toxicity in many organs and systems, Al can also have estrogenic activity when absorbed by the body. The reproductive organs are commonly affected by environmental pollutants with estrogenic activity, but little is known about the effects of Al on the prostate and gonads. Therefore, the aim of this study was to evaluate the effects of subchronic Al exposure on the prostate and gonads of male and female adult gerbils. After 30 days of oral exposure to aluminum chloride (10 mg/kg/day), the animals were euthanized and the organs processed for cytochemical, ultrastructural, and biochemical assays. Ventral male prostates exposed to Al became hyperplastic and showed signs of cell aging. In addition, the male prostate showed decreased catalase (CAT) and superoxide dismutase (SOD) activity. The female prostate was structurally more affected than the ventral male prostate, since it presented hyperplasia and punctual foci of inflammation and prostatic intraepithelial neoplasia. However, CAT and SOD activities did not change in this gland. In the testis, Al promoted immature germ cell detachment and degeneration, as well as reduced CAT activity. In the ovaries, Al caused reduction in folliculogenesis and decreased SOD activity. Together, these results indicate that Al is toxic to the prostate and gonads of adult gerbils and that continuous exposure to this metal can impair the fertility of individuals of both sexes. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:11:50Z 2020-12-12T02:11:50Z 2020-10-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.yexmp.2020.104486 Experimental and Molecular Pathology, v. 116. 1096-0945 0014-4800 http://hdl.handle.net/11449/200631 10.1016/j.yexmp.2020.104486 2-s2.0-85086846486 |
url |
http://dx.doi.org/10.1016/j.yexmp.2020.104486 http://hdl.handle.net/11449/200631 |
identifier_str_mv |
Experimental and Molecular Pathology, v. 116. 1096-0945 0014-4800 10.1016/j.yexmp.2020.104486 2-s2.0-85086846486 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Experimental and Molecular Pathology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128747793022976 |