Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.hindawi.com/journals/jir/2015/635052/ http://hdl.handle.net/11449/128618 |
Resumo: | Multiple sclerosis (MS) is an inflammatory/autoimmune disease of the central nervous system (CNS) mainly mediated by myelin specific T cells. It is widely believed that environmental factors, including fungal infections, contribute to disease induction or evolution. Even though Candida infection among MS patients has been described, the participation of this fungus in this pathology is not clear. The purpose of this work was to evaluate the effect of a Candida albicans infection on experimental autoimmune encephalomyelitis (EAE) that is a widely accepted model to study MS. Female C57BL/6 mice were infected with C. albicans and 3 days later, animals were submitted to EAE induction by immunization with myelin oligodendrocyte glycoprotein. Previous infection increased the clinical score and also the body weight loss. EAE aggravation was associated with expansion of peripheral CD4(+) T cells and production of high levels of TNF-alpha, IFN-gamma IL-6, and IL-17 by spleen and CNS cells. In addition to yeast and hyphae, fungus specific T cells were found in the CNS. These findings suggest that C. albicans infection before EAE induction aggravates EAE, and possibly MS, mainly by CNS dissemination and local induction of encephalitogenic cytokines. Peripheral production of encephalitogenic cytokines could also contribute to disease aggravation. |
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Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans InfectionMultiple sclerosis (MS) is an inflammatory/autoimmune disease of the central nervous system (CNS) mainly mediated by myelin specific T cells. It is widely believed that environmental factors, including fungal infections, contribute to disease induction or evolution. Even though Candida infection among MS patients has been described, the participation of this fungus in this pathology is not clear. The purpose of this work was to evaluate the effect of a Candida albicans infection on experimental autoimmune encephalomyelitis (EAE) that is a widely accepted model to study MS. Female C57BL/6 mice were infected with C. albicans and 3 days later, animals were submitted to EAE induction by immunization with myelin oligodendrocyte glycoprotein. Previous infection increased the clinical score and also the body weight loss. EAE aggravation was associated with expansion of peripheral CD4(+) T cells and production of high levels of TNF-alpha, IFN-gamma IL-6, and IL-17 by spleen and CNS cells. In addition to yeast and hyphae, fungus specific T cells were found in the CNS. These findings suggest that C. albicans infection before EAE induction aggravates EAE, and possibly MS, mainly by CNS dissemination and local induction of encephalitogenic cytokines. Peripheral production of encephalitogenic cytokines could also contribute to disease aggravation.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Sao Paulo State Univ UNESP, Biosci Inst, Dept Microbiol &Immunol, BR-18618000 Botucatu, SP, BrazilSao Paulo State Univ UNESP, Dept Biol Sci, Sch Sci, BR-17033360 Bauru, SP, BrazilSao Paulo State Univ UNESP, Biosci Inst, Dept Microbiol &Immunol, BR-18618000 Botucatu, SP, BrazilSao Paulo State Univ UNESP, Dept Biol Sci, Sch Sci, BR-17033360 Bauru, SP, BrazilFAPESP: 2013/14353-2FAPESP: 2012/12540-7Hindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)Fraga-Silva, Thais F. C. [UNESP]Mimura, Luiza A. N. [UNESP]Marchetti, Camila M. [UNESP]Chiuso-Minicucci, Fernanda [UNESP]Franca, Thais G. D. [UNESP]Zorzella-Pezavento, Sofia F. G. [UNESP]Venturini, James [UNESP]Arruda, Maria S. P. [UNESP]Sartori, Alexandrina [UNESP]2015-10-21T13:11:34Z2015-10-21T13:11:34Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-11application/pdfhttp://www.hindawi.com/journals/jir/2015/635052/Journal Of Immunology Research. New York: Hindawi Publishing Corporation, p. 1-11, 2015.2314-8861http://hdl.handle.net/11449/12861810.1155/2015/635052WOS:000353777700001WOS000353777700001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Immunology Research3.2981,352info:eu-repo/semantics/openAccess2024-04-23T15:23:04Zoai:repositorio.unesp.br:11449/128618Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:18:15.286259Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection |
title |
Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection |
spellingShingle |
Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection Fraga-Silva, Thais F. C. [UNESP] |
title_short |
Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection |
title_full |
Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection |
title_fullStr |
Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection |
title_full_unstemmed |
Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection |
title_sort |
Experimental Autoimmune Encephalomyelitis Development Is Aggravated by Candida albicans Infection |
author |
Fraga-Silva, Thais F. C. [UNESP] |
author_facet |
Fraga-Silva, Thais F. C. [UNESP] Mimura, Luiza A. N. [UNESP] Marchetti, Camila M. [UNESP] Chiuso-Minicucci, Fernanda [UNESP] Franca, Thais G. D. [UNESP] Zorzella-Pezavento, Sofia F. G. [UNESP] Venturini, James [UNESP] Arruda, Maria S. P. [UNESP] Sartori, Alexandrina [UNESP] |
author_role |
author |
author2 |
Mimura, Luiza A. N. [UNESP] Marchetti, Camila M. [UNESP] Chiuso-Minicucci, Fernanda [UNESP] Franca, Thais G. D. [UNESP] Zorzella-Pezavento, Sofia F. G. [UNESP] Venturini, James [UNESP] Arruda, Maria S. P. [UNESP] Sartori, Alexandrina [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Fraga-Silva, Thais F. C. [UNESP] Mimura, Luiza A. N. [UNESP] Marchetti, Camila M. [UNESP] Chiuso-Minicucci, Fernanda [UNESP] Franca, Thais G. D. [UNESP] Zorzella-Pezavento, Sofia F. G. [UNESP] Venturini, James [UNESP] Arruda, Maria S. P. [UNESP] Sartori, Alexandrina [UNESP] |
description |
Multiple sclerosis (MS) is an inflammatory/autoimmune disease of the central nervous system (CNS) mainly mediated by myelin specific T cells. It is widely believed that environmental factors, including fungal infections, contribute to disease induction or evolution. Even though Candida infection among MS patients has been described, the participation of this fungus in this pathology is not clear. The purpose of this work was to evaluate the effect of a Candida albicans infection on experimental autoimmune encephalomyelitis (EAE) that is a widely accepted model to study MS. Female C57BL/6 mice were infected with C. albicans and 3 days later, animals were submitted to EAE induction by immunization with myelin oligodendrocyte glycoprotein. Previous infection increased the clinical score and also the body weight loss. EAE aggravation was associated with expansion of peripheral CD4(+) T cells and production of high levels of TNF-alpha, IFN-gamma IL-6, and IL-17 by spleen and CNS cells. In addition to yeast and hyphae, fungus specific T cells were found in the CNS. These findings suggest that C. albicans infection before EAE induction aggravates EAE, and possibly MS, mainly by CNS dissemination and local induction of encephalitogenic cytokines. Peripheral production of encephalitogenic cytokines could also contribute to disease aggravation. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-21T13:11:34Z 2015-10-21T13:11:34Z 2015-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.hindawi.com/journals/jir/2015/635052/ Journal Of Immunology Research. New York: Hindawi Publishing Corporation, p. 1-11, 2015. 2314-8861 http://hdl.handle.net/11449/128618 10.1155/2015/635052 WOS:000353777700001 WOS000353777700001.pdf |
url |
http://www.hindawi.com/journals/jir/2015/635052/ http://hdl.handle.net/11449/128618 |
identifier_str_mv |
Journal Of Immunology Research. New York: Hindawi Publishing Corporation, p. 1-11, 2015. 2314-8861 10.1155/2015/635052 WOS:000353777700001 WOS000353777700001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Immunology Research 3.298 1,352 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-11 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128493907607552 |