Calcium-independent membrane damage by venom phospholipases A2

Detalhes bibliográficos
Autor(a) principal: De Oliveira, A. H.C.
Data de Publicação: 2009
Outros Autores: Aragão, E. A., Sá, J. M., Chioato, L., Bugs-Bortoleto, R. [UNESP], Ruller, R., Ferreira, T. L., Ward, R. J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2174/092986609788923392
http://hdl.handle.net/11449/219518
Resumo: Many snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA 2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins. © 2009 Bentham Science Publishers Ltd.
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spelling Calcium-independent membrane damage by venom phospholipases A2Membrane permeabilizationMicelle nucleationMolecular mechanismMany snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA 2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins. © 2009 Bentham Science Publishers Ltd.Departamento de Química FFCLRP-USP Universidade de São PauloDepartamento de Bioquímica e Immunologia FMRP-USP Universidade de São PauloDepartamento de Física IBILICE-UNESP Universidade Estadual de São PauloDepartamento de Física IBILICE-UNESP Universidade Estadual de São PauloUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)De Oliveira, A. H.C.Aragão, E. A.Sá, J. M.Chioato, L.Bugs-Bortoleto, R. [UNESP]Ruller, R.Ferreira, T. L.Ward, R. J.2022-04-28T18:56:06Z2022-04-28T18:56:06Z2009-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article877-886http://dx.doi.org/10.2174/092986609788923392Protein and Peptide Letters, v. 16, n. 8, p. 877-886, 2009.0929-8665http://hdl.handle.net/11449/21951810.2174/0929866097889233922-s2.0-68849106813Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengProtein and Peptide Lettersinfo:eu-repo/semantics/openAccess2022-04-28T18:56:06Zoai:repositorio.unesp.br:11449/219518Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:53:37.646752Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Calcium-independent membrane damage by venom phospholipases A2
title Calcium-independent membrane damage by venom phospholipases A2
spellingShingle Calcium-independent membrane damage by venom phospholipases A2
De Oliveira, A. H.C.
Membrane permeabilization
Micelle nucleation
Molecular mechanism
title_short Calcium-independent membrane damage by venom phospholipases A2
title_full Calcium-independent membrane damage by venom phospholipases A2
title_fullStr Calcium-independent membrane damage by venom phospholipases A2
title_full_unstemmed Calcium-independent membrane damage by venom phospholipases A2
title_sort Calcium-independent membrane damage by venom phospholipases A2
author De Oliveira, A. H.C.
author_facet De Oliveira, A. H.C.
Aragão, E. A.
Sá, J. M.
Chioato, L.
Bugs-Bortoleto, R. [UNESP]
Ruller, R.
Ferreira, T. L.
Ward, R. J.
author_role author
author2 Aragão, E. A.
Sá, J. M.
Chioato, L.
Bugs-Bortoleto, R. [UNESP]
Ruller, R.
Ferreira, T. L.
Ward, R. J.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv De Oliveira, A. H.C.
Aragão, E. A.
Sá, J. M.
Chioato, L.
Bugs-Bortoleto, R. [UNESP]
Ruller, R.
Ferreira, T. L.
Ward, R. J.
dc.subject.por.fl_str_mv Membrane permeabilization
Micelle nucleation
Molecular mechanism
topic Membrane permeabilization
Micelle nucleation
Molecular mechanism
description Many snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA 2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins. © 2009 Bentham Science Publishers Ltd.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
2022-04-28T18:56:06Z
2022-04-28T18:56:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2174/092986609788923392
Protein and Peptide Letters, v. 16, n. 8, p. 877-886, 2009.
0929-8665
http://hdl.handle.net/11449/219518
10.2174/092986609788923392
2-s2.0-68849106813
url http://dx.doi.org/10.2174/092986609788923392
http://hdl.handle.net/11449/219518
identifier_str_mv Protein and Peptide Letters, v. 16, n. 8, p. 877-886, 2009.
0929-8665
10.2174/092986609788923392
2-s2.0-68849106813
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Protein and Peptide Letters
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 877-886
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129135295332352

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