Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.cimid.2015.09.005 http://hdl.handle.net/11449/161136 |
Resumo: | The aim of this study was to evaluate the role of butyrylcholinesterase (BChE) as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis. Forty-two serum samples of dogs naturally infected with Ehrlichia canis were used, of which 24 were from animals with the acute phase of the disease and 18 with subclinical disease. In addition, sera from 17 healthy dogs were used as negative controls. The hematocrit, BChE activity, hepatic injury (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), nitric oxide, and cytokines levels were evaluated. The BChE activity was significantly elevated (P < 0.05) in dogs with the acute phase of the disease when compared to healthy animals. However, there was a reduction on BChE activity on dogs with subclinical disease compared to the other two groups. AST and ALT levels were significantly higher (P < 0.05) in the acute phase, as well as the inflammatory mediators (NO chi, TNF-alpha, INF-gamma, IL-4, IL-6) when compared to the control group. On the other hand, IL-10 levels were lower in the acute phase. Based on these results, we are able to conclude that the acute infection caused by E. canis in dogs leads to an increase on seric BChE activity and some inflammatory mediators. Therefore, this enzyme might be used as a marker of acute inflammatory response in dogs naturally infected by this bacterium. (C) 2015 Elsevier Ltd. All rights reserved. |
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Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosisBChEEhrlichia canisInflammation markerThe aim of this study was to evaluate the role of butyrylcholinesterase (BChE) as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis. Forty-two serum samples of dogs naturally infected with Ehrlichia canis were used, of which 24 were from animals with the acute phase of the disease and 18 with subclinical disease. In addition, sera from 17 healthy dogs were used as negative controls. The hematocrit, BChE activity, hepatic injury (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), nitric oxide, and cytokines levels were evaluated. The BChE activity was significantly elevated (P < 0.05) in dogs with the acute phase of the disease when compared to healthy animals. However, there was a reduction on BChE activity on dogs with subclinical disease compared to the other two groups. AST and ALT levels were significantly higher (P < 0.05) in the acute phase, as well as the inflammatory mediators (NO chi, TNF-alpha, INF-gamma, IL-4, IL-6) when compared to the control group. On the other hand, IL-10 levels were lower in the acute phase. Based on these results, we are able to conclude that the acute infection caused by E. canis in dogs leads to an increase on seric BChE activity and some inflammatory mediators. Therefore, this enzyme might be used as a marker of acute inflammatory response in dogs naturally infected by this bacterium. (C) 2015 Elsevier Ltd. All rights reserved.Univ Fed Santa Maria, Programa Posgrad Bioquim Toxicol, BR-97119900 Santa Maria, RS, BrazilUniv Estadual Paulista, Dept Vet Clin & Surg, Jaboticabal, SP, BrazilUniv Franca, Dept Vet Clin & Surg, Franca, SP, BrazilUniv Fed Rio Grande do Sul, Fac Vet, Lab Vet Epidemiol, Porto Alegre, RS, BrazilUniv Fed Santa Maria, Dept Clin & Toxicol Anal, BR-97119900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Programa Pos Grad Farmacol, BR-97119900 Santa Maria, RS, BrazilUniv Luteranda Brasil ULBRA, Santa Maria, RS, BrazilUniv Estado Santa Catarina UDESC, Dept Anim Sci, Chapeco, SC, BrazilUniv Estadual Paulista, Dept Vet Clin & Surg, Jaboticabal, SP, BrazilElsevier B.V.Universidade Federal de Sergipe (UFS)Universidade Estadual Paulista (Unesp)Univ FrancaUniv Fed Rio Grande do SulUniv Luteranda Brasil ULBRAUniv Estado Santa Catarina UDESCCarmo, Guilherme M. doCrivellenti, Leandro Z. [UNESP]Bottari, Nathieli B.Machado, GustavoBorin-Crivellenti, Sofia [UNESP]Moresco, Rafael N.Duarte, ThiagoDuarte, MartaTinucci-Costa, Mirela [UNESP]Morsch, Vera M.Schetinger, Maria Rosa C.Stefani, Lenita M.Da Silva, Aleksandro S.2018-11-26T16:19:17Z2018-11-26T16:19:17Z2015-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16-21application/pdfhttp://dx.doi.org/10.1016/j.cimid.2015.09.005Comparative Immunology Microbiology And Infectious Diseases. Oxford: Elsevier Sci Ltd, v. 43, p. 16-21, 2015.0147-9571http://hdl.handle.net/11449/16113610.1016/j.cimid.2015.09.005WOS:000368353900003WOS000368353900003.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengComparative Immunology Microbiology And Infectious Diseases0,877info:eu-repo/semantics/openAccess2024-06-06T14:10:48Zoai:repositorio.unesp.br:11449/161136Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:42:14.145217Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis |
title |
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis |
spellingShingle |
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis Carmo, Guilherme M. do BChE Ehrlichia canis Inflammation marker |
title_short |
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis |
title_full |
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis |
title_fullStr |
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis |
title_full_unstemmed |
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis |
title_sort |
Butyrylcholinesterase as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis |
author |
Carmo, Guilherme M. do |
author_facet |
Carmo, Guilherme M. do Crivellenti, Leandro Z. [UNESP] Bottari, Nathieli B. Machado, Gustavo Borin-Crivellenti, Sofia [UNESP] Moresco, Rafael N. Duarte, Thiago Duarte, Marta Tinucci-Costa, Mirela [UNESP] Morsch, Vera M. Schetinger, Maria Rosa C. Stefani, Lenita M. Da Silva, Aleksandro S. |
author_role |
author |
author2 |
Crivellenti, Leandro Z. [UNESP] Bottari, Nathieli B. Machado, Gustavo Borin-Crivellenti, Sofia [UNESP] Moresco, Rafael N. Duarte, Thiago Duarte, Marta Tinucci-Costa, Mirela [UNESP] Morsch, Vera M. Schetinger, Maria Rosa C. Stefani, Lenita M. Da Silva, Aleksandro S. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Sergipe (UFS) Universidade Estadual Paulista (Unesp) Univ Franca Univ Fed Rio Grande do Sul Univ Luteranda Brasil ULBRA Univ Estado Santa Catarina UDESC |
dc.contributor.author.fl_str_mv |
Carmo, Guilherme M. do Crivellenti, Leandro Z. [UNESP] Bottari, Nathieli B. Machado, Gustavo Borin-Crivellenti, Sofia [UNESP] Moresco, Rafael N. Duarte, Thiago Duarte, Marta Tinucci-Costa, Mirela [UNESP] Morsch, Vera M. Schetinger, Maria Rosa C. Stefani, Lenita M. Da Silva, Aleksandro S. |
dc.subject.por.fl_str_mv |
BChE Ehrlichia canis Inflammation marker |
topic |
BChE Ehrlichia canis Inflammation marker |
description |
The aim of this study was to evaluate the role of butyrylcholinesterase (BChE) as a marker of inflammation and liver injury in the acute and subclinical phases of canine ehrlichiosis. Forty-two serum samples of dogs naturally infected with Ehrlichia canis were used, of which 24 were from animals with the acute phase of the disease and 18 with subclinical disease. In addition, sera from 17 healthy dogs were used as negative controls. The hematocrit, BChE activity, hepatic injury (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), nitric oxide, and cytokines levels were evaluated. The BChE activity was significantly elevated (P < 0.05) in dogs with the acute phase of the disease when compared to healthy animals. However, there was a reduction on BChE activity on dogs with subclinical disease compared to the other two groups. AST and ALT levels were significantly higher (P < 0.05) in the acute phase, as well as the inflammatory mediators (NO chi, TNF-alpha, INF-gamma, IL-4, IL-6) when compared to the control group. On the other hand, IL-10 levels were lower in the acute phase. Based on these results, we are able to conclude that the acute infection caused by E. canis in dogs leads to an increase on seric BChE activity and some inflammatory mediators. Therefore, this enzyme might be used as a marker of acute inflammatory response in dogs naturally infected by this bacterium. (C) 2015 Elsevier Ltd. All rights reserved. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-01 2018-11-26T16:19:17Z 2018-11-26T16:19:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.cimid.2015.09.005 Comparative Immunology Microbiology And Infectious Diseases. Oxford: Elsevier Sci Ltd, v. 43, p. 16-21, 2015. 0147-9571 http://hdl.handle.net/11449/161136 10.1016/j.cimid.2015.09.005 WOS:000368353900003 WOS000368353900003.pdf |
url |
http://dx.doi.org/10.1016/j.cimid.2015.09.005 http://hdl.handle.net/11449/161136 |
identifier_str_mv |
Comparative Immunology Microbiology And Infectious Diseases. Oxford: Elsevier Sci Ltd, v. 43, p. 16-21, 2015. 0147-9571 10.1016/j.cimid.2015.09.005 WOS:000368353900003 WOS000368353900003.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Comparative Immunology Microbiology And Infectious Diseases 0,877 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
16-21 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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_version_ |
1808129348455104512 |