Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio)
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.chemosphere.2021.130279 http://hdl.handle.net/11449/210315 |
Resumo: | Although the toxicity of conventional microplastic types (i.e., petroleum derivatives) in different organisms is already known, knowledge about the effects of alternative biopolymers on aquatic vertebrates remains incipient. Thus, the aim of the present study is to test the hypothesis that the exposure of adult Danio rerio individuals to this pollutant for 30 days is enough to cause polylactic acid biomicroplastics (BioMPs of PLA) accumulation in their bodies, which leads to behavioral/neurotoxic, biochemical, and morphological changes. Based on our results, PLA BioMPs at concentrations of 2.5 and 5 mg/L accumulated in the liver, brain, gills and carcass of the assessed animals. However, such an accumulation was not able to cause locomotor damages or to trigger anxiety-like behavior in them. On the other hand, it was enough to cause behavioral changes (in shoal) predictive of co-specific social interaction and antipredatory defensive response deficit likely related to cholinergic changes inferred by increased acetylcholinesterase activity and REDOX imbalance. This imbalance was featured by increased production of reactive species. We observed that the treatments have affected animals' pigmentation pattern. Therefore, our study highlights the toxicological potential of the herein assessed biopolymer, and this finding puts in check the innocuousness of this material, as well as expands our knowledge about how PLA BioMPs can affect the ichthyofauna in freshwater environments. (C) 2021 Elsevier Ltd. All rights reserved. |
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Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio)BiopolymersBiomicroplasticsFishBehavioral toxicologyAlthough the toxicity of conventional microplastic types (i.e., petroleum derivatives) in different organisms is already known, knowledge about the effects of alternative biopolymers on aquatic vertebrates remains incipient. Thus, the aim of the present study is to test the hypothesis that the exposure of adult Danio rerio individuals to this pollutant for 30 days is enough to cause polylactic acid biomicroplastics (BioMPs of PLA) accumulation in their bodies, which leads to behavioral/neurotoxic, biochemical, and morphological changes. Based on our results, PLA BioMPs at concentrations of 2.5 and 5 mg/L accumulated in the liver, brain, gills and carcass of the assessed animals. However, such an accumulation was not able to cause locomotor damages or to trigger anxiety-like behavior in them. On the other hand, it was enough to cause behavioral changes (in shoal) predictive of co-specific social interaction and antipredatory defensive response deficit likely related to cholinergic changes inferred by increased acetylcholinesterase activity and REDOX imbalance. This imbalance was featured by increased production of reactive species. We observed that the treatments have affected animals' pigmentation pattern. Therefore, our study highlights the toxicological potential of the herein assessed biopolymer, and this finding puts in check the innocuousness of this material, as well as expands our knowledge about how PLA BioMPs can affect the ichthyofauna in freshwater environments. (C) 2021 Elsevier Ltd. All rights reserved.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Goiano Federal InstituteGoiano Fed Univ, Postgrad Program Cerrado Nat Resources Conservat, Urutai Campus, Urutai, BrazilGoiano Fed Inst, Biol Res Lab, Urutai Campus, Urutai, BrazilUniv Fed Uberlandia, Postgrad Program Ecol & Nat Resources Conservat, Uberlandia, MG, BrazilSao Paulo State Univ, Morphol Dept, Reprod & Mol Biol Grp, Botucatu, SP, BrazilFed Univ Jatai, Dept Biol Sci, Zebrafish Res & Reprod Lab LABFISH, Jatai, BrazilUniv Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, BrazilUniv Fed Goias, Postgrad Program Biotechnol & Biodivers, Goiania, Go, BrazilSao Paulo State Univ, Morphol Dept, Reprod & Mol Biol Grp, Botucatu, SP, BrazilCNPq: 426531/2018-3Goiano Federal Institute: 23219.001551.2020-92Elsevier B.V.Goiano Fed UnivGoiano Fed InstUniversidade Federal de Uberlândia (UFU)Universidade Estadual Paulista (Unesp)Fed Univ JataiUniversidade de São Paulo (USP)Universidade Federal de Goiás (UFG)Chagas, Thales QuintaoFreitas, Italo NascimentoMontalvao, Mateus FloresNobrega, Rafael Henrique [UNESP]Ferreira Machado, Monica RodriguesCharlie-Silva, IvesCosta Araujo, Amanda Pereira daBatista Guimaraes, Abraao TiagoSilva Alvarez, Tenilce Gabriela daMalafaia, Guilherme2021-06-25T15:04:37Z2021-06-25T15:04:37Z2021-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16http://dx.doi.org/10.1016/j.chemosphere.2021.130279Chemosphere. Oxford: Pergamon-elsevier Science Ltd, v. 277, 16 p., 2021.0045-6535http://hdl.handle.net/11449/21031510.1016/j.chemosphere.2021.130279WOS:000648342100059Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengChemosphereinfo:eu-repo/semantics/openAccess2021-10-23T20:17:26Zoai:repositorio.unesp.br:11449/210315Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:10:57.526602Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio) |
title |
Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio) |
spellingShingle |
Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio) Chagas, Thales Quintao Biopolymers Biomicroplastics Fish Behavioral toxicology |
title_short |
Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio) |
title_full |
Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio) |
title_fullStr |
Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio) |
title_full_unstemmed |
Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio) |
title_sort |
Multiple endpoints of polylactic acid biomicroplastic toxicity in adult zebrafish (Danio rerio) |
author |
Chagas, Thales Quintao |
author_facet |
Chagas, Thales Quintao Freitas, Italo Nascimento Montalvao, Mateus Flores Nobrega, Rafael Henrique [UNESP] Ferreira Machado, Monica Rodrigues Charlie-Silva, Ives Costa Araujo, Amanda Pereira da Batista Guimaraes, Abraao Tiago Silva Alvarez, Tenilce Gabriela da Malafaia, Guilherme |
author_role |
author |
author2 |
Freitas, Italo Nascimento Montalvao, Mateus Flores Nobrega, Rafael Henrique [UNESP] Ferreira Machado, Monica Rodrigues Charlie-Silva, Ives Costa Araujo, Amanda Pereira da Batista Guimaraes, Abraao Tiago Silva Alvarez, Tenilce Gabriela da Malafaia, Guilherme |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Goiano Fed Univ Goiano Fed Inst Universidade Federal de Uberlândia (UFU) Universidade Estadual Paulista (Unesp) Fed Univ Jatai Universidade de São Paulo (USP) Universidade Federal de Goiás (UFG) |
dc.contributor.author.fl_str_mv |
Chagas, Thales Quintao Freitas, Italo Nascimento Montalvao, Mateus Flores Nobrega, Rafael Henrique [UNESP] Ferreira Machado, Monica Rodrigues Charlie-Silva, Ives Costa Araujo, Amanda Pereira da Batista Guimaraes, Abraao Tiago Silva Alvarez, Tenilce Gabriela da Malafaia, Guilherme |
dc.subject.por.fl_str_mv |
Biopolymers Biomicroplastics Fish Behavioral toxicology |
topic |
Biopolymers Biomicroplastics Fish Behavioral toxicology |
description |
Although the toxicity of conventional microplastic types (i.e., petroleum derivatives) in different organisms is already known, knowledge about the effects of alternative biopolymers on aquatic vertebrates remains incipient. Thus, the aim of the present study is to test the hypothesis that the exposure of adult Danio rerio individuals to this pollutant for 30 days is enough to cause polylactic acid biomicroplastics (BioMPs of PLA) accumulation in their bodies, which leads to behavioral/neurotoxic, biochemical, and morphological changes. Based on our results, PLA BioMPs at concentrations of 2.5 and 5 mg/L accumulated in the liver, brain, gills and carcass of the assessed animals. However, such an accumulation was not able to cause locomotor damages or to trigger anxiety-like behavior in them. On the other hand, it was enough to cause behavioral changes (in shoal) predictive of co-specific social interaction and antipredatory defensive response deficit likely related to cholinergic changes inferred by increased acetylcholinesterase activity and REDOX imbalance. This imbalance was featured by increased production of reactive species. We observed that the treatments have affected animals' pigmentation pattern. Therefore, our study highlights the toxicological potential of the herein assessed biopolymer, and this finding puts in check the innocuousness of this material, as well as expands our knowledge about how PLA BioMPs can affect the ichthyofauna in freshwater environments. (C) 2021 Elsevier Ltd. All rights reserved. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T15:04:37Z 2021-06-25T15:04:37Z 2021-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.chemosphere.2021.130279 Chemosphere. Oxford: Pergamon-elsevier Science Ltd, v. 277, 16 p., 2021. 0045-6535 http://hdl.handle.net/11449/210315 10.1016/j.chemosphere.2021.130279 WOS:000648342100059 |
url |
http://dx.doi.org/10.1016/j.chemosphere.2021.130279 http://hdl.handle.net/11449/210315 |
identifier_str_mv |
Chemosphere. Oxford: Pergamon-elsevier Science Ltd, v. 277, 16 p., 2021. 0045-6535 10.1016/j.chemosphere.2021.130279 WOS:000648342100059 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Chemosphere |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
16 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128767908904960 |