2D quantitative imaging of magnetic nanoparticles by an ac biosusceptometry based scanning approach and inverse problem

• Autor(a) principal: Biasotti, Gabriel Gustavo de Albuquerque [UNESP]
• Data de Publicação: 2021
• Outros Autores: Próspero, Andre Gonçalves [UNESP], Alvarez, Marcelo Dante Tacconi [UNESP], Liebl, Maik, Pinto, Leonardo Antonio [UNESP], Soares, Guilherme Augusto [UNESP], Bakuzis, Andris Figueiroa, Baffa, Oswaldo, Wiekhorst, Frank, Miranda, José Ricardo de Arruda [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.3390/s21217063; http://hdl.handle.net/11449/233716
• topic: AC Biosusceptometry; Inverse problem; Magnetic nanoparticles; Quantitative imaging

The use of magnetic nanoparticles (MNPs) in biomedical applications requires the quantitative knowledge of their quantitative distribution within the body. AC Biosusceptometry (ACB) is a biomagnetic technique recently employed to detect MNPs in vivo by measuring the MNPs response when exposed to an alternate magnetic field. The ACB technique presents some interesting characteristics: non-invasiveness, low operational cost, high portability, and no need for magnetic shielding. ACB conventional methods until now provided only qualitative information about the MNPs’ mapping in small animals. We present a theoretical model and experimentally demonstrate the feasibility of ACB reconstructing 2D quantitative images of MNPs’ distributions. We employed an ACB single-channel scanning approach, measuring at 361 sensor positions, to reconstruct MNPs’ spatial distributions. For this, we established a discrete forward problem and solved the ACB sys-tem’s inverse problem. Thus, we were able to determine the positions and quantities of MNPs in a field of view of 5 × 5 × 1 cm3 with good precision and accuracy. The results show the ACB system’s capabilities to reconstruct the quantitative spatial distribution of MNPs with a spatial resolution better than 1 cm, and a sensitivity of 1.17 mg of MNPs fixed in gypsum. These results show the system’s potential for biomedical application of MNPs in several studies, for example, electrochemical-functionalized MNPs for cancer cell targeting, quantitative sensing, and possibly in vivo imaging.