Experimental model of bladder instability in rabbits

Detalhes bibliográficos
Autor(a) principal: Balasteghin, Karina Tuma [UNESP]
Data de Publicação: 2003
Outros Autores: Nardo, A. M. [UNESP], Amaro, J.L. [UNESP], Padovani, C.R. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1677-55382003000100013
http://hdl.handle.net/11449/13498
Resumo: OBJECTIVE: Propose a new experimental model of bladder instability in rabbits after partial bladder obstruction. MATERIALS and METHODS: Thirty North Folk male rabbits, weighting 1,700 to 2,820 g (mean: 2,162 g) were studied. The animals were distributed in 2 experimental groups, formed by 15 rabbits each: Group 1 - clinical control. In this group there was no surgical intervention; Group 2 - bladder outlet obstruction. In this group, after anesthetizing the animal, urethral cannulation with Foley catheter 10F was performed and then an adjustable plastic bracelet was passed around the bladder neck. It was then adjusted in order to not constrict the urethra. The following parameters were studied in M1 - pre-operative period; M2 - 4 weeks post-operatively moments: 1)- urine culture; 2)- cystometric study; 3)- serum creatinine and BUN. RESULTS: Bladder weight was 2.5 times larger in the group with obstruction than in the control group. Cystometric evaluation showed a significant increase in maximal vesical volume in the final moment at Group G2. However, there was no statistically significant difference among the groups studied. There was no statistically significant difference between maximal detrusor pressure and vesical compliance in the different moments or in the studied groups. There was an absence of uninhibited detrusor contractions in all the animals in group 1, and involuntary contractions were detected in 93% of group 2 animals. There was no significant variation in BUN and serum creatinine either among the groups or in the same group. CONCLUSIONS: We observed in the group with obstruction a bladder weight 2.5 higher than normal bladders. We detected involuntary contractions in 93% of the animals in group 2, establishing this experimental model as appropriate to secondary bladder instability and partial bladder outlet obstruction.
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spelling Experimental model of bladder instability in rabbitsbladderneurogenicrabbitsurethral obstructionurodynamicsOBJECTIVE: Propose a new experimental model of bladder instability in rabbits after partial bladder obstruction. MATERIALS and METHODS: Thirty North Folk male rabbits, weighting 1,700 to 2,820 g (mean: 2,162 g) were studied. The animals were distributed in 2 experimental groups, formed by 15 rabbits each: Group 1 - clinical control. In this group there was no surgical intervention; Group 2 - bladder outlet obstruction. In this group, after anesthetizing the animal, urethral cannulation with Foley catheter 10F was performed and then an adjustable plastic bracelet was passed around the bladder neck. It was then adjusted in order to not constrict the urethra. The following parameters were studied in M1 - pre-operative period; M2 - 4 weeks post-operatively moments: 1)- urine culture; 2)- cystometric study; 3)- serum creatinine and BUN. RESULTS: Bladder weight was 2.5 times larger in the group with obstruction than in the control group. Cystometric evaluation showed a significant increase in maximal vesical volume in the final moment at Group G2. However, there was no statistically significant difference among the groups studied. There was no statistically significant difference between maximal detrusor pressure and vesical compliance in the different moments or in the studied groups. There was an absence of uninhibited detrusor contractions in all the animals in group 1, and involuntary contractions were detected in 93% of group 2 animals. There was no significant variation in BUN and serum creatinine either among the groups or in the same group. CONCLUSIONS: We observed in the group with obstruction a bladder weight 2.5 higher than normal bladders. We detected involuntary contractions in 93% of the animals in group 2, establishing this experimental model as appropriate to secondary bladder instability and partial bladder outlet obstruction.UNESP Botucatu School of Medicine Departments of Urology and StatisticsUNESP Botucatu School of Medicine Departments of Urology and StatisticsSociedade Brasileira de UrologiaUniversidade Estadual Paulista (Unesp)Balasteghin, Karina Tuma [UNESP]Nardo, A. M. [UNESP]Amaro, J.L. [UNESP]Padovani, C.R. [UNESP]2014-05-20T13:38:55Z2014-05-20T13:38:55Z2003-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article62-71application/pdfhttp://dx.doi.org/10.1590/S1677-55382003000100013International braz j urol. Sociedade Brasileira de Urologia, v. 29, n. 1, p. 62-71, 2003.1677-5538http://hdl.handle.net/11449/1349810.1590/S1677-55382003000100013S1677-55382003000100013S1677-55382003000100013.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Braz J Urol0.9760,367info:eu-repo/semantics/openAccess2024-09-03T14:30:23Zoai:repositorio.unesp.br:11449/13498Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T14:30:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Experimental model of bladder instability in rabbits
title Experimental model of bladder instability in rabbits
spellingShingle Experimental model of bladder instability in rabbits
Balasteghin, Karina Tuma [UNESP]
bladder
neurogenic
rabbits
urethral obstruction
urodynamics
title_short Experimental model of bladder instability in rabbits
title_full Experimental model of bladder instability in rabbits
title_fullStr Experimental model of bladder instability in rabbits
title_full_unstemmed Experimental model of bladder instability in rabbits
title_sort Experimental model of bladder instability in rabbits
author Balasteghin, Karina Tuma [UNESP]
author_facet Balasteghin, Karina Tuma [UNESP]
Nardo, A. M. [UNESP]
Amaro, J.L. [UNESP]
Padovani, C.R. [UNESP]
author_role author
author2 Nardo, A. M. [UNESP]
Amaro, J.L. [UNESP]
Padovani, C.R. [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Balasteghin, Karina Tuma [UNESP]
Nardo, A. M. [UNESP]
Amaro, J.L. [UNESP]
Padovani, C.R. [UNESP]
dc.subject.por.fl_str_mv bladder
neurogenic
rabbits
urethral obstruction
urodynamics
topic bladder
neurogenic
rabbits
urethral obstruction
urodynamics
description OBJECTIVE: Propose a new experimental model of bladder instability in rabbits after partial bladder obstruction. MATERIALS and METHODS: Thirty North Folk male rabbits, weighting 1,700 to 2,820 g (mean: 2,162 g) were studied. The animals were distributed in 2 experimental groups, formed by 15 rabbits each: Group 1 - clinical control. In this group there was no surgical intervention; Group 2 - bladder outlet obstruction. In this group, after anesthetizing the animal, urethral cannulation with Foley catheter 10F was performed and then an adjustable plastic bracelet was passed around the bladder neck. It was then adjusted in order to not constrict the urethra. The following parameters were studied in M1 - pre-operative period; M2 - 4 weeks post-operatively moments: 1)- urine culture; 2)- cystometric study; 3)- serum creatinine and BUN. RESULTS: Bladder weight was 2.5 times larger in the group with obstruction than in the control group. Cystometric evaluation showed a significant increase in maximal vesical volume in the final moment at Group G2. However, there was no statistically significant difference among the groups studied. There was no statistically significant difference between maximal detrusor pressure and vesical compliance in the different moments or in the studied groups. There was an absence of uninhibited detrusor contractions in all the animals in group 1, and involuntary contractions were detected in 93% of group 2 animals. There was no significant variation in BUN and serum creatinine either among the groups or in the same group. CONCLUSIONS: We observed in the group with obstruction a bladder weight 2.5 higher than normal bladders. We detected involuntary contractions in 93% of the animals in group 2, establishing this experimental model as appropriate to secondary bladder instability and partial bladder outlet obstruction.
publishDate 2003
dc.date.none.fl_str_mv 2003-02-01
2014-05-20T13:38:55Z
2014-05-20T13:38:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1677-55382003000100013
International braz j urol. Sociedade Brasileira de Urologia, v. 29, n. 1, p. 62-71, 2003.
1677-5538
http://hdl.handle.net/11449/13498
10.1590/S1677-55382003000100013
S1677-55382003000100013
S1677-55382003000100013.pdf
url http://dx.doi.org/10.1590/S1677-55382003000100013
http://hdl.handle.net/11449/13498
identifier_str_mv International braz j urol. Sociedade Brasileira de Urologia, v. 29, n. 1, p. 62-71, 2003.
1677-5538
10.1590/S1677-55382003000100013
S1677-55382003000100013
S1677-55382003000100013.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Braz J Urol
0.976
0,367
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 62-71
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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