INFLUÊNCIA DE DIFERENTES PROTOCOLOS DE TREINAMENTO FÍSICO SOBRE A FOSFORILAÇÃO DA PROTEÍNA AKT EM MÚSCULO ESQUELÉTICO E SENSIBILIDADE À INSULINA DE RATOS OBESOS

• Autor(a) principal: Marinho, Rodolfo
• Data de Publicação: 2015
• Outros Autores: Gaspar, Rodrigo Stellzer, Pauli, Luciana Santos Souza, Cintra, Dennys Esper, Ropelle, Eduardo Rochete, Pauli, José Rodrigo
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.4025/reveducfis.v26i1.23718; http://hdl.handle.net/11449/157993
• topic: Physical Training; Obesity; Insulin Signaling; Treinamento Físico; Obesidade; Sinalização da Insulina

ABSTRACTInvestigate the effects of different protocols of physical training (PT) on insulin sensibility (IS) and Akt phosphorylation (p-Akt) in skeletal muscle of obese rats. Animals were distributed in four groups according to the diet and physical training: Control: received standard chow (C); Sedentary obese: received high fat diet (HFD) for 12 weeks (OS); Obese Trained 1: received HFD for 12 weeks and PT without overload for 6 weeks (OT-1); Obese Trained 2: received HFD for 12 weeks and PT with overload of 5% body weight (OT-2). Insulin tolerance test was used to evaluate the IS. Western blotting was performed to evaluate p-Akt and total Akt in gastrocnemius muscle. Results: The PT with overload induced greater p-Akt, however there isn't difference in SI when compared with the training without overload. Conclusion: Differences in p-Akt not induced better responses of IS in obese rats induced by HFD.