The action of oxytocin on the bone of senescent female rats

Detalhes bibliográficos
Autor(a) principal: Santos, Luís Fernando Gadioli [UNESP]
Data de Publicação: 2022
Outros Autores: Fernandes-Breitenbach, Fernanda [UNESP], Silva, Rafael Augusto Santos [UNESP], Santos, Damáris Raíssa [UNESP], Peres-Ueno, Melise Jacon [UNESP], Ervolino, Edilson [UNESP], Chaves-Neto, Antonio Hernandes [UNESP], Dornelles, Rita Cássia Menegati [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.lfs.2022.120484
http://hdl.handle.net/11449/234280
Resumo: Aims: This study verified the action of oxytocin (OT) as a preventive measure to control bone damage during aging in female rats. Main methods: Wistar rats received saline (0.15 mol/L/IP; Vehicle Group), Atosiban/AT (300 μg/Kg/IP; At Group), OT (134 μg/Kg/IP; Ot Group), or AT+OT (OT injections 5 min after AT; At+Ot Group), at 19 and 20 months of age. A functional test was performed immediately before and 30 days after the injections to analyze the animals' gait. Key findings: Animals in the At group had higher alkaline phosphatase (ALP) activity, lower cortical and trabecular thickness, fewer trabeculae, higher expression of tartrate-resistant acid phosphatase (TRAP) and lower osteocalcin (OCN), higher cortical porosity, and lower moment of inertia and bone strength at the femoral neck. OT administration increased lipidic peroxidation and plasma superoxide dismutase (SOD), and provided, in the femoral neck, lower expression of TRAP and higher OCN, greater cortical and trabecular thickness, a greater number of trabeculae, bone mineral density (BMD), higher inertia bone strength, and lower cortical porosity. At + Ot group showed great similarity with the vehicle group, higher SOD, and BMD. An increase in stride length and no increase in base width of 21-month-old animals were observed after OT, unlike animal's vehicle or AT. Significance: Endogenous OT plays an important role in the regulation of bone remodeling during periestropause, and exogenous OT stands out as a potential preventive intervention in this period to improve bone quality with functional repercussions, possibly providing better gait activity.
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spelling The action of oxytocin on the bone of senescent female ratsAgingAtosibanFemaleFemur neckOsteoporosisOxytocinPerimenopauseAims: This study verified the action of oxytocin (OT) as a preventive measure to control bone damage during aging in female rats. Main methods: Wistar rats received saline (0.15 mol/L/IP; Vehicle Group), Atosiban/AT (300 μg/Kg/IP; At Group), OT (134 μg/Kg/IP; Ot Group), or AT+OT (OT injections 5 min after AT; At+Ot Group), at 19 and 20 months of age. A functional test was performed immediately before and 30 days after the injections to analyze the animals' gait. Key findings: Animals in the At group had higher alkaline phosphatase (ALP) activity, lower cortical and trabecular thickness, fewer trabeculae, higher expression of tartrate-resistant acid phosphatase (TRAP) and lower osteocalcin (OCN), higher cortical porosity, and lower moment of inertia and bone strength at the femoral neck. OT administration increased lipidic peroxidation and plasma superoxide dismutase (SOD), and provided, in the femoral neck, lower expression of TRAP and higher OCN, greater cortical and trabecular thickness, a greater number of trabeculae, bone mineral density (BMD), higher inertia bone strength, and lower cortical porosity. At + Ot group showed great similarity with the vehicle group, higher SOD, and BMD. An increase in stride length and no increase in base width of 21-month-old animals were observed after OT, unlike animal's vehicle or AT. Significance: Endogenous OT plays an important role in the regulation of bone remodeling during periestropause, and exogenous OT stands out as a potential preventive intervention in this period to improve bone quality with functional repercussions, possibly providing better gait activity.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas/SBFis/UNESPDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), São PauloPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas/SBFis/UNESPDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), São PauloFAPESP: 013/26779-4FAPESP: 2012/14464-6Universidade Estadual Paulista (UNESP)Santos, Luís Fernando Gadioli [UNESP]Fernandes-Breitenbach, Fernanda [UNESP]Silva, Rafael Augusto Santos [UNESP]Santos, Damáris Raíssa [UNESP]Peres-Ueno, Melise Jacon [UNESP]Ervolino, Edilson [UNESP]Chaves-Neto, Antonio Hernandes [UNESP]Dornelles, Rita Cássia Menegati [UNESP]2022-05-01T15:46:12Z2022-05-01T15:46:12Z2022-05-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.lfs.2022.120484Life Sciences, v. 297.1879-06310024-3205http://hdl.handle.net/11449/23428010.1016/j.lfs.2022.1204842-s2.0-85126560742Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLife Sciencesinfo:eu-repo/semantics/openAccess2024-09-19T14:02:27Zoai:repositorio.unesp.br:11449/234280Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T14:02:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The action of oxytocin on the bone of senescent female rats
title The action of oxytocin on the bone of senescent female rats
spellingShingle The action of oxytocin on the bone of senescent female rats
Santos, Luís Fernando Gadioli [UNESP]
Aging
Atosiban
Female
Femur neck
Osteoporosis
Oxytocin
Perimenopause
title_short The action of oxytocin on the bone of senescent female rats
title_full The action of oxytocin on the bone of senescent female rats
title_fullStr The action of oxytocin on the bone of senescent female rats
title_full_unstemmed The action of oxytocin on the bone of senescent female rats
title_sort The action of oxytocin on the bone of senescent female rats
author Santos, Luís Fernando Gadioli [UNESP]
author_facet Santos, Luís Fernando Gadioli [UNESP]
Fernandes-Breitenbach, Fernanda [UNESP]
Silva, Rafael Augusto Santos [UNESP]
Santos, Damáris Raíssa [UNESP]
Peres-Ueno, Melise Jacon [UNESP]
Ervolino, Edilson [UNESP]
Chaves-Neto, Antonio Hernandes [UNESP]
Dornelles, Rita Cássia Menegati [UNESP]
author_role author
author2 Fernandes-Breitenbach, Fernanda [UNESP]
Silva, Rafael Augusto Santos [UNESP]
Santos, Damáris Raíssa [UNESP]
Peres-Ueno, Melise Jacon [UNESP]
Ervolino, Edilson [UNESP]
Chaves-Neto, Antonio Hernandes [UNESP]
Dornelles, Rita Cássia Menegati [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Santos, Luís Fernando Gadioli [UNESP]
Fernandes-Breitenbach, Fernanda [UNESP]
Silva, Rafael Augusto Santos [UNESP]
Santos, Damáris Raíssa [UNESP]
Peres-Ueno, Melise Jacon [UNESP]
Ervolino, Edilson [UNESP]
Chaves-Neto, Antonio Hernandes [UNESP]
Dornelles, Rita Cássia Menegati [UNESP]
dc.subject.por.fl_str_mv Aging
Atosiban
Female
Femur neck
Osteoporosis
Oxytocin
Perimenopause
topic Aging
Atosiban
Female
Femur neck
Osteoporosis
Oxytocin
Perimenopause
description Aims: This study verified the action of oxytocin (OT) as a preventive measure to control bone damage during aging in female rats. Main methods: Wistar rats received saline (0.15 mol/L/IP; Vehicle Group), Atosiban/AT (300 μg/Kg/IP; At Group), OT (134 μg/Kg/IP; Ot Group), or AT+OT (OT injections 5 min after AT; At+Ot Group), at 19 and 20 months of age. A functional test was performed immediately before and 30 days after the injections to analyze the animals' gait. Key findings: Animals in the At group had higher alkaline phosphatase (ALP) activity, lower cortical and trabecular thickness, fewer trabeculae, higher expression of tartrate-resistant acid phosphatase (TRAP) and lower osteocalcin (OCN), higher cortical porosity, and lower moment of inertia and bone strength at the femoral neck. OT administration increased lipidic peroxidation and plasma superoxide dismutase (SOD), and provided, in the femoral neck, lower expression of TRAP and higher OCN, greater cortical and trabecular thickness, a greater number of trabeculae, bone mineral density (BMD), higher inertia bone strength, and lower cortical porosity. At + Ot group showed great similarity with the vehicle group, higher SOD, and BMD. An increase in stride length and no increase in base width of 21-month-old animals were observed after OT, unlike animal's vehicle or AT. Significance: Endogenous OT plays an important role in the regulation of bone remodeling during periestropause, and exogenous OT stands out as a potential preventive intervention in this period to improve bone quality with functional repercussions, possibly providing better gait activity.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-01T15:46:12Z
2022-05-01T15:46:12Z
2022-05-15
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.lfs.2022.120484
Life Sciences, v. 297.
1879-0631
0024-3205
http://hdl.handle.net/11449/234280
10.1016/j.lfs.2022.120484
2-s2.0-85126560742
url http://dx.doi.org/10.1016/j.lfs.2022.120484
http://hdl.handle.net/11449/234280
identifier_str_mv Life Sciences, v. 297.
1879-0631
0024-3205
10.1016/j.lfs.2022.120484
2-s2.0-85126560742
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Life Sciences
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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