The action of oxytocin on the bone of senescent female rats
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.lfs.2022.120484 http://hdl.handle.net/11449/234280 |
Resumo: | Aims: This study verified the action of oxytocin (OT) as a preventive measure to control bone damage during aging in female rats. Main methods: Wistar rats received saline (0.15 mol/L/IP; Vehicle Group), Atosiban/AT (300 μg/Kg/IP; At Group), OT (134 μg/Kg/IP; Ot Group), or AT+OT (OT injections 5 min after AT; At+Ot Group), at 19 and 20 months of age. A functional test was performed immediately before and 30 days after the injections to analyze the animals' gait. Key findings: Animals in the At group had higher alkaline phosphatase (ALP) activity, lower cortical and trabecular thickness, fewer trabeculae, higher expression of tartrate-resistant acid phosphatase (TRAP) and lower osteocalcin (OCN), higher cortical porosity, and lower moment of inertia and bone strength at the femoral neck. OT administration increased lipidic peroxidation and plasma superoxide dismutase (SOD), and provided, in the femoral neck, lower expression of TRAP and higher OCN, greater cortical and trabecular thickness, a greater number of trabeculae, bone mineral density (BMD), higher inertia bone strength, and lower cortical porosity. At + Ot group showed great similarity with the vehicle group, higher SOD, and BMD. An increase in stride length and no increase in base width of 21-month-old animals were observed after OT, unlike animal's vehicle or AT. Significance: Endogenous OT plays an important role in the regulation of bone remodeling during periestropause, and exogenous OT stands out as a potential preventive intervention in this period to improve bone quality with functional repercussions, possibly providing better gait activity. |
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The action of oxytocin on the bone of senescent female ratsAgingAtosibanFemaleFemur neckOsteoporosisOxytocinPerimenopauseAims: This study verified the action of oxytocin (OT) as a preventive measure to control bone damage during aging in female rats. Main methods: Wistar rats received saline (0.15 mol/L/IP; Vehicle Group), Atosiban/AT (300 μg/Kg/IP; At Group), OT (134 μg/Kg/IP; Ot Group), or AT+OT (OT injections 5 min after AT; At+Ot Group), at 19 and 20 months of age. A functional test was performed immediately before and 30 days after the injections to analyze the animals' gait. Key findings: Animals in the At group had higher alkaline phosphatase (ALP) activity, lower cortical and trabecular thickness, fewer trabeculae, higher expression of tartrate-resistant acid phosphatase (TRAP) and lower osteocalcin (OCN), higher cortical porosity, and lower moment of inertia and bone strength at the femoral neck. OT administration increased lipidic peroxidation and plasma superoxide dismutase (SOD), and provided, in the femoral neck, lower expression of TRAP and higher OCN, greater cortical and trabecular thickness, a greater number of trabeculae, bone mineral density (BMD), higher inertia bone strength, and lower cortical porosity. At + Ot group showed great similarity with the vehicle group, higher SOD, and BMD. An increase in stride length and no increase in base width of 21-month-old animals were observed after OT, unlike animal's vehicle or AT. Significance: Endogenous OT plays an important role in the regulation of bone remodeling during periestropause, and exogenous OT stands out as a potential preventive intervention in this period to improve bone quality with functional repercussions, possibly providing better gait activity.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas/SBFis/UNESPDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), São PauloPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas/SBFis/UNESPDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP), São PauloFAPESP: 013/26779-4FAPESP: 2012/14464-6Universidade Estadual Paulista (UNESP)Santos, Luís Fernando Gadioli [UNESP]Fernandes-Breitenbach, Fernanda [UNESP]Silva, Rafael Augusto Santos [UNESP]Santos, Damáris Raíssa [UNESP]Peres-Ueno, Melise Jacon [UNESP]Ervolino, Edilson [UNESP]Chaves-Neto, Antonio Hernandes [UNESP]Dornelles, Rita Cássia Menegati [UNESP]2022-05-01T15:46:12Z2022-05-01T15:46:12Z2022-05-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.lfs.2022.120484Life Sciences, v. 297.1879-06310024-3205http://hdl.handle.net/11449/23428010.1016/j.lfs.2022.1204842-s2.0-85126560742Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLife Sciencesinfo:eu-repo/semantics/openAccess2024-09-19T14:02:27Zoai:repositorio.unesp.br:11449/234280Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T14:02:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The action of oxytocin on the bone of senescent female rats |
title |
The action of oxytocin on the bone of senescent female rats |
spellingShingle |
The action of oxytocin on the bone of senescent female rats Santos, Luís Fernando Gadioli [UNESP] Aging Atosiban Female Femur neck Osteoporosis Oxytocin Perimenopause |
title_short |
The action of oxytocin on the bone of senescent female rats |
title_full |
The action of oxytocin on the bone of senescent female rats |
title_fullStr |
The action of oxytocin on the bone of senescent female rats |
title_full_unstemmed |
The action of oxytocin on the bone of senescent female rats |
title_sort |
The action of oxytocin on the bone of senescent female rats |
author |
Santos, Luís Fernando Gadioli [UNESP] |
author_facet |
Santos, Luís Fernando Gadioli [UNESP] Fernandes-Breitenbach, Fernanda [UNESP] Silva, Rafael Augusto Santos [UNESP] Santos, Damáris Raíssa [UNESP] Peres-Ueno, Melise Jacon [UNESP] Ervolino, Edilson [UNESP] Chaves-Neto, Antonio Hernandes [UNESP] Dornelles, Rita Cássia Menegati [UNESP] |
author_role |
author |
author2 |
Fernandes-Breitenbach, Fernanda [UNESP] Silva, Rafael Augusto Santos [UNESP] Santos, Damáris Raíssa [UNESP] Peres-Ueno, Melise Jacon [UNESP] Ervolino, Edilson [UNESP] Chaves-Neto, Antonio Hernandes [UNESP] Dornelles, Rita Cássia Menegati [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Santos, Luís Fernando Gadioli [UNESP] Fernandes-Breitenbach, Fernanda [UNESP] Silva, Rafael Augusto Santos [UNESP] Santos, Damáris Raíssa [UNESP] Peres-Ueno, Melise Jacon [UNESP] Ervolino, Edilson [UNESP] Chaves-Neto, Antonio Hernandes [UNESP] Dornelles, Rita Cássia Menegati [UNESP] |
dc.subject.por.fl_str_mv |
Aging Atosiban Female Femur neck Osteoporosis Oxytocin Perimenopause |
topic |
Aging Atosiban Female Femur neck Osteoporosis Oxytocin Perimenopause |
description |
Aims: This study verified the action of oxytocin (OT) as a preventive measure to control bone damage during aging in female rats. Main methods: Wistar rats received saline (0.15 mol/L/IP; Vehicle Group), Atosiban/AT (300 μg/Kg/IP; At Group), OT (134 μg/Kg/IP; Ot Group), or AT+OT (OT injections 5 min after AT; At+Ot Group), at 19 and 20 months of age. A functional test was performed immediately before and 30 days after the injections to analyze the animals' gait. Key findings: Animals in the At group had higher alkaline phosphatase (ALP) activity, lower cortical and trabecular thickness, fewer trabeculae, higher expression of tartrate-resistant acid phosphatase (TRAP) and lower osteocalcin (OCN), higher cortical porosity, and lower moment of inertia and bone strength at the femoral neck. OT administration increased lipidic peroxidation and plasma superoxide dismutase (SOD), and provided, in the femoral neck, lower expression of TRAP and higher OCN, greater cortical and trabecular thickness, a greater number of trabeculae, bone mineral density (BMD), higher inertia bone strength, and lower cortical porosity. At + Ot group showed great similarity with the vehicle group, higher SOD, and BMD. An increase in stride length and no increase in base width of 21-month-old animals were observed after OT, unlike animal's vehicle or AT. Significance: Endogenous OT plays an important role in the regulation of bone remodeling during periestropause, and exogenous OT stands out as a potential preventive intervention in this period to improve bone quality with functional repercussions, possibly providing better gait activity. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-01T15:46:12Z 2022-05-01T15:46:12Z 2022-05-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.lfs.2022.120484 Life Sciences, v. 297. 1879-0631 0024-3205 http://hdl.handle.net/11449/234280 10.1016/j.lfs.2022.120484 2-s2.0-85126560742 |
url |
http://dx.doi.org/10.1016/j.lfs.2022.120484 http://hdl.handle.net/11449/234280 |
identifier_str_mv |
Life Sciences, v. 297. 1879-0631 0024-3205 10.1016/j.lfs.2022.120484 2-s2.0-85126560742 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Life Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546385069309952 |