Sedative and cardiopulmonary effects of dexmedetomidine infusions randomly receiving, or not, butorphanol in standing horses
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1136/vr.104359 http://hdl.handle.net/11449/175353 |
Resumo: | Dexmedetomidine (DEX) alone, or combined with butorphanol (BUT), may be administered by constant rate infusions (CRIs) in standing horses. This blinded, randomised, crossover study in six healthy adult horses aimed to determine the sedative and cardiopulmonary effects of DEX (dexmedetomidine (3.5 μg/kg+5 μg/kg/hour CRI) and DEX/BUT (dexmedetomidine (3.5 μg/kg+3.5 μg/kg/hour CRI) and butorphanol (20 μg/kg+24 μg/kg/hour CRI)). Head height above ground (HHAG), ataxia, responses to tactile/auditory stimuli and cardiopulmonary variables were recorded before, at 5/15/30/60/90 minutes and after CRIs terminated (15/30/60 minutes). Repeated measures analysis of variance with Tukey-Kramer test were used for cardiopulmonary values (mean±SD) and HHAG reduction (per cent), and Friedman's and Dunn's for non-parametric data (P<0.05). Maximum HHAG reductions of 54 per cent (DEX) and 58 per cent (DEX/BUT) occurred at 15 minutes, with ataxia for 15 minutes in both treatments. Responses to stimuli were reduced for 30 minutes in both treatments, and auditory up to 60 minutes in DEX. Cardiopulmonary effects typical of α 2 -agonists were observed, with no differences between treatments. At the doses and rates reported here, both regimens provided clinically sufficient sedation for only 30 minutes. |
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Sedative and cardiopulmonary effects of dexmedetomidine infusions randomly receiving, or not, butorphanol in standing horsesbutorphanolconstant rate infusiondexmedetomidineequinestanding horseDexmedetomidine (DEX) alone, or combined with butorphanol (BUT), may be administered by constant rate infusions (CRIs) in standing horses. This blinded, randomised, crossover study in six healthy adult horses aimed to determine the sedative and cardiopulmonary effects of DEX (dexmedetomidine (3.5 μg/kg+5 μg/kg/hour CRI) and DEX/BUT (dexmedetomidine (3.5 μg/kg+3.5 μg/kg/hour CRI) and butorphanol (20 μg/kg+24 μg/kg/hour CRI)). Head height above ground (HHAG), ataxia, responses to tactile/auditory stimuli and cardiopulmonary variables were recorded before, at 5/15/30/60/90 minutes and after CRIs terminated (15/30/60 minutes). Repeated measures analysis of variance with Tukey-Kramer test were used for cardiopulmonary values (mean±SD) and HHAG reduction (per cent), and Friedman's and Dunn's for non-parametric data (P<0.05). Maximum HHAG reductions of 54 per cent (DEX) and 58 per cent (DEX/BUT) occurred at 15 minutes, with ataxia for 15 minutes in both treatments. Responses to stimuli were reduced for 30 minutes in both treatments, and auditory up to 60 minutes in DEX. Cardiopulmonary effects typical of α 2 -agonists were observed, with no differences between treatments. At the doses and rates reported here, both regimens provided clinically sufficient sedation for only 30 minutes.Graduate Program in Anaesthesiology Medical School of Botucatu UNESP - Univ Estadual PaulistaDepartment of Veterinary Surgery and Anaestesiology Faculty of Veterinary Medicine and Animal Science UNESP - Univ Estadual PaulistaTaylor MonroeGraduate Program in Anaesthesiology Medical School of Botucatu UNESP - Univ Estadual PaulistaDepartment of Veterinary Surgery and Anaestesiology Faculty of Veterinary Medicine and Animal Science UNESP - Univ Estadual PaulistaUniversidade Estadual Paulista (Unesp)Taylor MonroeMedeiros, Luíza Quintão [UNESP]Gozalo-Marcilla, Miguel [UNESP]Taylor, Polly M.Campagnol, Daniela [UNESP]De Oliveira, Flávia Augusta [UNESP]Watanabe, Marcos Jun [UNESP]De Araujo Aguiar, Antonio José [UNESP]2018-12-11T17:15:27Z2018-12-11T17:15:27Z2017-10-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1136/vr.104359Veterinary Record, v. 181, n. 15, 2017.0042-4900http://hdl.handle.net/11449/17535310.1136/vr.1043592-s2.0-850316678662-s2.0-85031667866.pdf7989397951395253Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengVeterinary Record0,464info:eu-repo/semantics/openAccess2024-08-14T13:20:25Zoai:repositorio.unesp.br:11449/175353Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T13:20:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Sedative and cardiopulmonary effects of dexmedetomidine infusions randomly receiving, or not, butorphanol in standing horses |
title |
Sedative and cardiopulmonary effects of dexmedetomidine infusions randomly receiving, or not, butorphanol in standing horses |
spellingShingle |
Sedative and cardiopulmonary effects of dexmedetomidine infusions randomly receiving, or not, butorphanol in standing horses Medeiros, Luíza Quintão [UNESP] butorphanol constant rate infusion dexmedetomidine equine standing horse |
title_short |
Sedative and cardiopulmonary effects of dexmedetomidine infusions randomly receiving, or not, butorphanol in standing horses |
title_full |
Sedative and cardiopulmonary effects of dexmedetomidine infusions randomly receiving, or not, butorphanol in standing horses |
title_fullStr |
Sedative and cardiopulmonary effects of dexmedetomidine infusions randomly receiving, or not, butorphanol in standing horses |
title_full_unstemmed |
Sedative and cardiopulmonary effects of dexmedetomidine infusions randomly receiving, or not, butorphanol in standing horses |
title_sort |
Sedative and cardiopulmonary effects of dexmedetomidine infusions randomly receiving, or not, butorphanol in standing horses |
author |
Medeiros, Luíza Quintão [UNESP] |
author_facet |
Medeiros, Luíza Quintão [UNESP] Gozalo-Marcilla, Miguel [UNESP] Taylor, Polly M. Campagnol, Daniela [UNESP] De Oliveira, Flávia Augusta [UNESP] Watanabe, Marcos Jun [UNESP] De Araujo Aguiar, Antonio José [UNESP] |
author_role |
author |
author2 |
Gozalo-Marcilla, Miguel [UNESP] Taylor, Polly M. Campagnol, Daniela [UNESP] De Oliveira, Flávia Augusta [UNESP] Watanabe, Marcos Jun [UNESP] De Araujo Aguiar, Antonio José [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Taylor Monroe |
dc.contributor.author.fl_str_mv |
Medeiros, Luíza Quintão [UNESP] Gozalo-Marcilla, Miguel [UNESP] Taylor, Polly M. Campagnol, Daniela [UNESP] De Oliveira, Flávia Augusta [UNESP] Watanabe, Marcos Jun [UNESP] De Araujo Aguiar, Antonio José [UNESP] |
dc.subject.por.fl_str_mv |
butorphanol constant rate infusion dexmedetomidine equine standing horse |
topic |
butorphanol constant rate infusion dexmedetomidine equine standing horse |
description |
Dexmedetomidine (DEX) alone, or combined with butorphanol (BUT), may be administered by constant rate infusions (CRIs) in standing horses. This blinded, randomised, crossover study in six healthy adult horses aimed to determine the sedative and cardiopulmonary effects of DEX (dexmedetomidine (3.5 μg/kg+5 μg/kg/hour CRI) and DEX/BUT (dexmedetomidine (3.5 μg/kg+3.5 μg/kg/hour CRI) and butorphanol (20 μg/kg+24 μg/kg/hour CRI)). Head height above ground (HHAG), ataxia, responses to tactile/auditory stimuli and cardiopulmonary variables were recorded before, at 5/15/30/60/90 minutes and after CRIs terminated (15/30/60 minutes). Repeated measures analysis of variance with Tukey-Kramer test were used for cardiopulmonary values (mean±SD) and HHAG reduction (per cent), and Friedman's and Dunn's for non-parametric data (P<0.05). Maximum HHAG reductions of 54 per cent (DEX) and 58 per cent (DEX/BUT) occurred at 15 minutes, with ataxia for 15 minutes in both treatments. Responses to stimuli were reduced for 30 minutes in both treatments, and auditory up to 60 minutes in DEX. Cardiopulmonary effects typical of α 2 -agonists were observed, with no differences between treatments. At the doses and rates reported here, both regimens provided clinically sufficient sedation for only 30 minutes. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-14 2018-12-11T17:15:27Z 2018-12-11T17:15:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1136/vr.104359 Veterinary Record, v. 181, n. 15, 2017. 0042-4900 http://hdl.handle.net/11449/175353 10.1136/vr.104359 2-s2.0-85031667866 2-s2.0-85031667866.pdf 7989397951395253 |
url |
http://dx.doi.org/10.1136/vr.104359 http://hdl.handle.net/11449/175353 |
identifier_str_mv |
Veterinary Record, v. 181, n. 15, 2017. 0042-4900 10.1136/vr.104359 2-s2.0-85031667866 2-s2.0-85031667866.pdf 7989397951395253 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Veterinary Record 0,464 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128131987406848 |