Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.18632/oncotarget.27551 http://hdl.handle.net/11449/200585 |
Resumo: | Clinical investigations suggest that melatonin suppression and circadian dysfunction may be related to cancer development in shift workers. Studies also show that melatonin suppression after pinealectomy increases cancer incidence in preclinical models. However, no study evaluated the influence of pinealectomy on oral cancer development. In the current study, we investigated the effects of pinealectomy on oral squamous cell carcinoma (OSCC) occurrence and progression in rats. Rats submitted to sham surgery were used as control. Pinealectomy promoted an increase of 140% in OSCC occurrence when compared to sham animals. Tumors from pinealectomized rats displayed a higher volume and thickness than the tumors from sham-operated animals. Pinealectomy induced atrophy of the epithelium adjacent to the oral lesions. Pinealectomized rats showed higher mean number of tumor-associated macrophages and eosinophils in the invasive front of OSCC. In addition, nuclear overexpression of ERK1/2 and p53 was also observed in the front of carcinomas from pinealectomized rats. These results reveal that pineal gland plays a protective role against oral carcinogenesis. The melatonin suppression caused by the pinealectomy might contribute to oral cancer development by acting on ERK1/2 and p53 pathways and regulating tumor inflammation. |
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Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in ratsCancerCarcinogenesisMelatoninOral cancerPineal glandClinical investigations suggest that melatonin suppression and circadian dysfunction may be related to cancer development in shift workers. Studies also show that melatonin suppression after pinealectomy increases cancer incidence in preclinical models. However, no study evaluated the influence of pinealectomy on oral cancer development. In the current study, we investigated the effects of pinealectomy on oral squamous cell carcinoma (OSCC) occurrence and progression in rats. Rats submitted to sham surgery were used as control. Pinealectomy promoted an increase of 140% in OSCC occurrence when compared to sham animals. Tumors from pinealectomized rats displayed a higher volume and thickness than the tumors from sham-operated animals. Pinealectomy induced atrophy of the epithelium adjacent to the oral lesions. Pinealectomized rats showed higher mean number of tumor-associated macrophages and eosinophils in the invasive front of OSCC. In addition, nuclear overexpression of ERK1/2 and p53 was also observed in the front of carcinomas from pinealectomized rats. These results reveal that pineal gland plays a protective role against oral carcinogenesis. The melatonin suppression caused by the pinealectomy might contribute to oral cancer development by acting on ERK1/2 and p53 pathways and regulating tumor inflammation.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Psychoneuroimmunology Laboratory Psychosomatic Research Center Oral Oncology Center São Paulo State University (Unesp) School of DentistryDepartment of Diagnosis and Surgery São Paulo State University (Unesp) School of DentistryLaboratory of Immunopharmacology Department of Basic Sciences São Paulo State University (Unesp) School of DentistryPsychoneuroimmunology Laboratory Psychosomatic Research Center Oral Oncology Center São Paulo State University (Unesp) School of DentistryDepartment of Diagnosis and Surgery São Paulo State University (Unesp) School of DentistryLaboratory of Immunopharmacology Department of Basic Sciences São Paulo State University (Unesp) School of DentistryFAPESP: 2016/25255-0Universidade Estadual Paulista (Unesp)Kayahara, Giseli Mitsuy [UNESP]Valente, Vitor Bonetti [UNESP]Pereira, Rosani Belzunces [UNESP]Lopes, Felipe Yudi Kabeya [UNESP]Crivelini, Marcelo Macedo [UNESP]Miyahara, Glauco Issamu [UNESP]Biasoli, Éder Ricardo [UNESP]Oliveira, Sandra Helena Penha [UNESP]Bernabé, Daniel Galera [UNESP]2020-12-12T02:10:30Z2020-12-12T02:10:30Z2020-05-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1816-1831http://dx.doi.org/10.18632/oncotarget.27551Oncotarget, v. 11, n. 20, p. 1816-1831, 2020.1949-2553http://hdl.handle.net/11449/20058510.18632/oncotarget.275512-s2.0-85086108325Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengOncotargetinfo:eu-repo/semantics/openAccess2024-04-11T20:16:33Zoai:repositorio.unesp.br:11449/200585Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-11T20:16:33Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats |
title |
Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats |
spellingShingle |
Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats Kayahara, Giseli Mitsuy [UNESP] Cancer Carcinogenesis Melatonin Oral cancer Pineal gland |
title_short |
Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats |
title_full |
Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats |
title_fullStr |
Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats |
title_full_unstemmed |
Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats |
title_sort |
Pineal gland protects against chemically induced oral carcinogenesis and inhibits tumor progression in rats |
author |
Kayahara, Giseli Mitsuy [UNESP] |
author_facet |
Kayahara, Giseli Mitsuy [UNESP] Valente, Vitor Bonetti [UNESP] Pereira, Rosani Belzunces [UNESP] Lopes, Felipe Yudi Kabeya [UNESP] Crivelini, Marcelo Macedo [UNESP] Miyahara, Glauco Issamu [UNESP] Biasoli, Éder Ricardo [UNESP] Oliveira, Sandra Helena Penha [UNESP] Bernabé, Daniel Galera [UNESP] |
author_role |
author |
author2 |
Valente, Vitor Bonetti [UNESP] Pereira, Rosani Belzunces [UNESP] Lopes, Felipe Yudi Kabeya [UNESP] Crivelini, Marcelo Macedo [UNESP] Miyahara, Glauco Issamu [UNESP] Biasoli, Éder Ricardo [UNESP] Oliveira, Sandra Helena Penha [UNESP] Bernabé, Daniel Galera [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Kayahara, Giseli Mitsuy [UNESP] Valente, Vitor Bonetti [UNESP] Pereira, Rosani Belzunces [UNESP] Lopes, Felipe Yudi Kabeya [UNESP] Crivelini, Marcelo Macedo [UNESP] Miyahara, Glauco Issamu [UNESP] Biasoli, Éder Ricardo [UNESP] Oliveira, Sandra Helena Penha [UNESP] Bernabé, Daniel Galera [UNESP] |
dc.subject.por.fl_str_mv |
Cancer Carcinogenesis Melatonin Oral cancer Pineal gland |
topic |
Cancer Carcinogenesis Melatonin Oral cancer Pineal gland |
description |
Clinical investigations suggest that melatonin suppression and circadian dysfunction may be related to cancer development in shift workers. Studies also show that melatonin suppression after pinealectomy increases cancer incidence in preclinical models. However, no study evaluated the influence of pinealectomy on oral cancer development. In the current study, we investigated the effects of pinealectomy on oral squamous cell carcinoma (OSCC) occurrence and progression in rats. Rats submitted to sham surgery were used as control. Pinealectomy promoted an increase of 140% in OSCC occurrence when compared to sham animals. Tumors from pinealectomized rats displayed a higher volume and thickness than the tumors from sham-operated animals. Pinealectomy induced atrophy of the epithelium adjacent to the oral lesions. Pinealectomized rats showed higher mean number of tumor-associated macrophages and eosinophils in the invasive front of OSCC. In addition, nuclear overexpression of ERK1/2 and p53 was also observed in the front of carcinomas from pinealectomized rats. These results reveal that pineal gland plays a protective role against oral carcinogenesis. The melatonin suppression caused by the pinealectomy might contribute to oral cancer development by acting on ERK1/2 and p53 pathways and regulating tumor inflammation. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:10:30Z 2020-12-12T02:10:30Z 2020-05-19 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.18632/oncotarget.27551 Oncotarget, v. 11, n. 20, p. 1816-1831, 2020. 1949-2553 http://hdl.handle.net/11449/200585 10.18632/oncotarget.27551 2-s2.0-85086108325 |
url |
http://dx.doi.org/10.18632/oncotarget.27551 http://hdl.handle.net/11449/200585 |
identifier_str_mv |
Oncotarget, v. 11, n. 20, p. 1816-1831, 2020. 1949-2553 10.18632/oncotarget.27551 2-s2.0-85086108325 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Oncotarget |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1816-1831 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046061503152128 |