A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 immune response against a highly virulent sporothrix schenckii by toluene exposure

Detalhes bibliográficos
Autor(a) principal: Téllez-Martínez, Damiana [UNESP]
Data de Publicação: 2019
Outros Autores: Portuondo, Deivys Leandro [UNESP], Loesch, Maria Luiza [UNESP], Batista-Duharte, Alexander [UNESP], Carlos, Iracilda Zeppone [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/pharmaceutics11030144
http://hdl.handle.net/11449/189025
Resumo: The effect of vaccination in fungal strains that suffered changes in their virulence by exposure to environmental contaminants is largely known. Growing reports of resistance to antifungal drugs and the emergence of new highly virulent strains, possibly acquired in the environment, prompt the design of new vaccines able to prevent and combat emerging mycotic diseases. In this study, we evaluated the protective capacity of an enolase-based vaccine and Montanide PetGel A (PGA) as an adjuvant against S. schenckii with increased virulence by exposure to toluene. The adjuvanted vaccine induced a strong specific Th1 response and protective immunity against a challenge with either wildtype or toluene-adapted S. schenckii in Balb/c mice. This study highlights the role of the adjuvant PGA driving the quality of the anti-sporothrix immunity and the key component in the vaccine efficacy.
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spelling A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 immune response against a highly virulent sporothrix schenckii by toluene exposureAdjuvantsEnolaseMontanide PetGel ASporothrix schenckiiTolueneVaccineVirulenceThe effect of vaccination in fungal strains that suffered changes in their virulence by exposure to environmental contaminants is largely known. Growing reports of resistance to antifungal drugs and the emergence of new highly virulent strains, possibly acquired in the environment, prompt the design of new vaccines able to prevent and combat emerging mycotic diseases. In this study, we evaluated the protective capacity of an enolase-based vaccine and Montanide PetGel A (PGA) as an adjuvant against S. schenckii with increased virulence by exposure to toluene. The adjuvanted vaccine induced a strong specific Th1 response and protective immunity against a challenge with either wildtype or toluene-adapted S. schenckii in Balb/c mice. This study highlights the role of the adjuvant PGA driving the quality of the anti-sporothrix immunity and the key component in the vaccine efficacy.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP)Department of Clinical Analysis School of Pharmaceutical Sciences São Paulo State University (UNESP)FAPESP: 2017/26774-3Universidade Estadual Paulista (Unesp)Téllez-Martínez, Damiana [UNESP]Portuondo, Deivys Leandro [UNESP]Loesch, Maria Luiza [UNESP]Batista-Duharte, Alexander [UNESP]Carlos, Iracilda Zeppone [UNESP]2019-10-06T16:27:21Z2019-10-06T16:27:21Z2019-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-13http://dx.doi.org/10.3390/pharmaceutics11030144Pharmaceutics, v. 11, n. 3, p. 1-13, 2019.1999-4923http://hdl.handle.net/11449/18902510.3390/pharmaceutics110301442-s2.0-85064739891Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmaceuticsinfo:eu-repo/semantics/openAccess2024-06-21T15:18:46Zoai:repositorio.unesp.br:11449/189025Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:22:38.131851Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 immune response against a highly virulent sporothrix schenckii by toluene exposure
title A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 immune response against a highly virulent sporothrix schenckii by toluene exposure
spellingShingle A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 immune response against a highly virulent sporothrix schenckii by toluene exposure
Téllez-Martínez, Damiana [UNESP]
Adjuvants
Enolase
Montanide PetGel A
Sporothrix schenckii
Toluene
Vaccine
Virulence
title_short A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 immune response against a highly virulent sporothrix schenckii by toluene exposure
title_full A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 immune response against a highly virulent sporothrix schenckii by toluene exposure
title_fullStr A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 immune response against a highly virulent sporothrix schenckii by toluene exposure
title_full_unstemmed A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 immune response against a highly virulent sporothrix schenckii by toluene exposure
title_sort A recombinant enolase-montanide™ petgel a vaccine promotes a protective th1 immune response against a highly virulent sporothrix schenckii by toluene exposure
author Téllez-Martínez, Damiana [UNESP]
author_facet Téllez-Martínez, Damiana [UNESP]
Portuondo, Deivys Leandro [UNESP]
Loesch, Maria Luiza [UNESP]
Batista-Duharte, Alexander [UNESP]
Carlos, Iracilda Zeppone [UNESP]
author_role author
author2 Portuondo, Deivys Leandro [UNESP]
Loesch, Maria Luiza [UNESP]
Batista-Duharte, Alexander [UNESP]
Carlos, Iracilda Zeppone [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Téllez-Martínez, Damiana [UNESP]
Portuondo, Deivys Leandro [UNESP]
Loesch, Maria Luiza [UNESP]
Batista-Duharte, Alexander [UNESP]
Carlos, Iracilda Zeppone [UNESP]
dc.subject.por.fl_str_mv Adjuvants
Enolase
Montanide PetGel A
Sporothrix schenckii
Toluene
Vaccine
Virulence
topic Adjuvants
Enolase
Montanide PetGel A
Sporothrix schenckii
Toluene
Vaccine
Virulence
description The effect of vaccination in fungal strains that suffered changes in their virulence by exposure to environmental contaminants is largely known. Growing reports of resistance to antifungal drugs and the emergence of new highly virulent strains, possibly acquired in the environment, prompt the design of new vaccines able to prevent and combat emerging mycotic diseases. In this study, we evaluated the protective capacity of an enolase-based vaccine and Montanide PetGel A (PGA) as an adjuvant against S. schenckii with increased virulence by exposure to toluene. The adjuvanted vaccine induced a strong specific Th1 response and protective immunity against a challenge with either wildtype or toluene-adapted S. schenckii in Balb/c mice. This study highlights the role of the adjuvant PGA driving the quality of the anti-sporothrix immunity and the key component in the vaccine efficacy.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T16:27:21Z
2019-10-06T16:27:21Z
2019-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/pharmaceutics11030144
Pharmaceutics, v. 11, n. 3, p. 1-13, 2019.
1999-4923
http://hdl.handle.net/11449/189025
10.3390/pharmaceutics11030144
2-s2.0-85064739891
url http://dx.doi.org/10.3390/pharmaceutics11030144
http://hdl.handle.net/11449/189025
identifier_str_mv Pharmaceutics, v. 11, n. 3, p. 1-13, 2019.
1999-4923
10.3390/pharmaceutics11030144
2-s2.0-85064739891
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmaceutics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-13
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128800991477760

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