K+ATP channels-independent analgesic action of Crotalus durissus cumanensis venom

• Autor(a) principal: Pereira, Ticiana Praciano
• Data de Publicação: 2010
• Outros Autores: Campos, Adriana Rolim, Leal, Luzia Kalyne A. M., Pierdoná, Taiana Magalhães, Toyama, Marcos H. [UNESP], Monteiro, Helena Serra Azul, Martins, Alice Maria Costa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1177/1934578x1000500725; http://hdl.handle.net/11449/226032
• topic: Crotalus durissus cumanensis venom; Glibenclamide; Nociception

The effect was investigated of the K+ channel blocker, glibenclamide, on the ability of Crotalus durissus cumanensis venom (CDCM) to promote peripheral antinociception. This was measured by formalin-induced nociception in male Swiss mice. CDCM (200 and 300 μg/kg) produced an antinociceptive effect during phase 2 in the formalin test. The effect of CDCM (200 μg/kg) was unaffected by the ATP-sensitive K+ channel blocker glibenclamide (2 mg/kg). These results suggest that CDCM is effective against acute pain. However, the ATP-sensitive K+ channels pathway is not contributable to the antinociceptive mechanism of CDCM.