The influence of hydroxyurea on oxidative stress in sickle cell anemia
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000600010 http://hdl.handle.net/11449/21452 |
Resumo: | OBJECTIVE: The oxidative stress in 20 sickle cell anemia patients taking hydroxyurea and 13 sickle cell anemia patients who did not take hydroxyurea was compared with a control group of 96 individuals without any hemoglobinopathy. METHODS: Oxidative stress was assessed by thiobarbituric acid reactive species production, the Trolox-equivalent antioxidant capacity and plasma glutathione levels. RESULTS: Thiobarbituric acid reactive species values were higher in patients without specific medication, followed by patients taking hydroxyurea and the Control Group (p < 0.0001). The antioxidant capacity was higher in patients taking hydroxyurea and lower in the Control Group (p = 0.0002 for Trolox-equivalent antioxidant capacity and p < 0.0292 for plasma glutathione). Thiobarbituric acid reactive species levels were correlated with higher hemoglobin S levels (r = 0.55; p = 0.0040) and lower hemoglobin F concentrations(r = -0.52; p = 0.0067). on the other hand, plasma glutathione levels were negatively correlated with hemoglobin S levels (r = -0.49; p = 0.0111) and positively associated with hemoglobin F values (r = 0.56; p = 0.0031). CONCLUSION: Sickle cell anemia patients have high oxidative stress and, conversely, increased antioxidant activity. The increase in hemoglobin F levels provided by hydroxyurea and its antioxidant action may explain the reduction in lipid peroxidation and increased antioxidant defenses in these individuals. |
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The influence of hydroxyurea on oxidative stress in sickle cell anemiaHemoglobinopathiesOxidative stressSickle cell anemiaHydroxyureaOBJECTIVE: The oxidative stress in 20 sickle cell anemia patients taking hydroxyurea and 13 sickle cell anemia patients who did not take hydroxyurea was compared with a control group of 96 individuals without any hemoglobinopathy. METHODS: Oxidative stress was assessed by thiobarbituric acid reactive species production, the Trolox-equivalent antioxidant capacity and plasma glutathione levels. RESULTS: Thiobarbituric acid reactive species values were higher in patients without specific medication, followed by patients taking hydroxyurea and the Control Group (p < 0.0001). The antioxidant capacity was higher in patients taking hydroxyurea and lower in the Control Group (p = 0.0002 for Trolox-equivalent antioxidant capacity and p < 0.0292 for plasma glutathione). Thiobarbituric acid reactive species levels were correlated with higher hemoglobin S levels (r = 0.55; p = 0.0040) and lower hemoglobin F concentrations(r = -0.52; p = 0.0067). on the other hand, plasma glutathione levels were negatively correlated with hemoglobin S levels (r = -0.49; p = 0.0111) and positively associated with hemoglobin F values (r = 0.56; p = 0.0031). CONCLUSION: Sickle cell anemia patients have high oxidative stress and, conversely, increased antioxidant activity. The increase in hemoglobin F levels provided by hydroxyurea and its antioxidant action may explain the reduction in lipid peroxidation and increased antioxidant defenses in these individuals.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual PaulistaInstituto de Hematologia Arthur de Siqueira CavalcantiSanta Casa de São Paulo Faculdade de Ciências MédicasUniversidade de São PauloUniversidade Estadual PaulistaAssociação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula ÓsseaUniversidade Estadual Paulista (Unesp)Instituto de Hematologia Arthur de Siqueira CavalcantiSanta Casa de São Paulo Faculdade de Ciências MédicasUniversidade de São Paulo (USP)Torres, Lidiane de Souza [UNESP]Silva, Danilo Grünig Humberto da [UNESP]Belini Junior, Edis [UNESP]Almeida, Eduardo Alves de [UNESP]Lobo, Clarisse Lopes de CastroCançado, Rodolfo DelfiniRuiz, Milton ArturBonini-Domingos, Claudia Regina [UNESP]2014-05-20T14:00:43Z2014-05-20T14:00:43Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article421-425application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000600010Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, v. 34, n. 6, p. 421-425, 2012.1516-8484http://hdl.handle.net/11449/2145210.5581/1516-8484.20120106S1516-84842012000600010S1516-84842012000600010.pdf67134008663822553279428066176719SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Hematologia e Hemoterapia0,335info:eu-repo/semantics/openAccess2023-11-27T06:10:50Zoai:repositorio.unesp.br:11449/21452Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:49:38.537916Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The influence of hydroxyurea on oxidative stress in sickle cell anemia |
title |
The influence of hydroxyurea on oxidative stress in sickle cell anemia |
spellingShingle |
The influence of hydroxyurea on oxidative stress in sickle cell anemia Torres, Lidiane de Souza [UNESP] Hemoglobinopathies Oxidative stress Sickle cell anemia Hydroxyurea |
title_short |
The influence of hydroxyurea on oxidative stress in sickle cell anemia |
title_full |
The influence of hydroxyurea on oxidative stress in sickle cell anemia |
title_fullStr |
The influence of hydroxyurea on oxidative stress in sickle cell anemia |
title_full_unstemmed |
The influence of hydroxyurea on oxidative stress in sickle cell anemia |
title_sort |
The influence of hydroxyurea on oxidative stress in sickle cell anemia |
author |
Torres, Lidiane de Souza [UNESP] |
author_facet |
Torres, Lidiane de Souza [UNESP] Silva, Danilo Grünig Humberto da [UNESP] Belini Junior, Edis [UNESP] Almeida, Eduardo Alves de [UNESP] Lobo, Clarisse Lopes de Castro Cançado, Rodolfo Delfini Ruiz, Milton Artur Bonini-Domingos, Claudia Regina [UNESP] |
author_role |
author |
author2 |
Silva, Danilo Grünig Humberto da [UNESP] Belini Junior, Edis [UNESP] Almeida, Eduardo Alves de [UNESP] Lobo, Clarisse Lopes de Castro Cançado, Rodolfo Delfini Ruiz, Milton Artur Bonini-Domingos, Claudia Regina [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Instituto de Hematologia Arthur de Siqueira Cavalcanti Santa Casa de São Paulo Faculdade de Ciências Médicas Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Torres, Lidiane de Souza [UNESP] Silva, Danilo Grünig Humberto da [UNESP] Belini Junior, Edis [UNESP] Almeida, Eduardo Alves de [UNESP] Lobo, Clarisse Lopes de Castro Cançado, Rodolfo Delfini Ruiz, Milton Artur Bonini-Domingos, Claudia Regina [UNESP] |
dc.subject.por.fl_str_mv |
Hemoglobinopathies Oxidative stress Sickle cell anemia Hydroxyurea |
topic |
Hemoglobinopathies Oxidative stress Sickle cell anemia Hydroxyurea |
description |
OBJECTIVE: The oxidative stress in 20 sickle cell anemia patients taking hydroxyurea and 13 sickle cell anemia patients who did not take hydroxyurea was compared with a control group of 96 individuals without any hemoglobinopathy. METHODS: Oxidative stress was assessed by thiobarbituric acid reactive species production, the Trolox-equivalent antioxidant capacity and plasma glutathione levels. RESULTS: Thiobarbituric acid reactive species values were higher in patients without specific medication, followed by patients taking hydroxyurea and the Control Group (p < 0.0001). The antioxidant capacity was higher in patients taking hydroxyurea and lower in the Control Group (p = 0.0002 for Trolox-equivalent antioxidant capacity and p < 0.0292 for plasma glutathione). Thiobarbituric acid reactive species levels were correlated with higher hemoglobin S levels (r = 0.55; p = 0.0040) and lower hemoglobin F concentrations(r = -0.52; p = 0.0067). on the other hand, plasma glutathione levels were negatively correlated with hemoglobin S levels (r = -0.49; p = 0.0111) and positively associated with hemoglobin F values (r = 0.56; p = 0.0031). CONCLUSION: Sickle cell anemia patients have high oxidative stress and, conversely, increased antioxidant activity. The increase in hemoglobin F levels provided by hydroxyurea and its antioxidant action may explain the reduction in lipid peroxidation and increased antioxidant defenses in these individuals. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2014-05-20T14:00:43Z 2014-05-20T14:00:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000600010 Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, v. 34, n. 6, p. 421-425, 2012. 1516-8484 http://hdl.handle.net/11449/21452 10.5581/1516-8484.20120106 S1516-84842012000600010 S1516-84842012000600010.pdf 6713400866382255 3279428066176719 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000600010 http://hdl.handle.net/11449/21452 |
identifier_str_mv |
Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, v. 34, n. 6, p. 421-425, 2012. 1516-8484 10.5581/1516-8484.20120106 S1516-84842012000600010 S1516-84842012000600010.pdf 6713400866382255 3279428066176719 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia 0,335 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
421-425 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea |
publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128986488766464 |