Development and Characterization of Natural Rubber Latex and Polylactic Acid Membranes for Biomedical Application

Detalhes bibliográficos
Autor(a) principal: Cesar, Mariana Biondi [UNESP]
Data de Publicação: 2020
Outros Autores: Borges, Felipe Azevedo [UNESP], Bilck, Ana Paula, Yamashita, Fábio, Paulino, Cristiane Garcia [UNESP], Herculano, Rondinelli Donizetti [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s10924-019-01596-8
http://hdl.handle.net/11449/201311
Resumo: Natural rubber latex from the Hevea brasiliensis has been of great importance in areas such as medicine and bioengineering, due to its angiogenic and wound healing activity. However, the biodegradability of natural rubber latex is not significant when compared to other polymers used for the development of materials with biomedical applications, which is important to avoid medical intervention to remove them. Thus, the aim of this work was to improve the biodegradability and subsequent bioabsorption of natural rubber latex membranes associating them with the polylactic acid, a biodegradable, bioreabsorbable and biocompatible polymer, besides being the most studied in biomedical, pharmaceutical and environmental fields. The membranes were prepared with different mass proportions of the polymers with dichloromethane as solvent. The material were submitted to mechanical test, infrared spectroscopy, scanning electron microscopy, water vapor transmission, swelling, in vitro degradation and hemolysis assay. The different polymer proportions influenced the membrane properties. The infrared spectroscopy indicating that no new chemical interactions were formed, and the scanning electron microscopy showed a polymer network formed in membranes with the highest natural rubber latex mass proportion. With the increase of polylactic acid in the membranes, there was an improvement in the degradation of the material of up to 130% and no hemolytic effect was observed, making it interesting for biomedical application.
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spelling Development and Characterization of Natural Rubber Latex and Polylactic Acid Membranes for Biomedical ApplicationBiodegradabilityMembranesNatural rubber latexPolylactic acidPolymer blendNatural rubber latex from the Hevea brasiliensis has been of great importance in areas such as medicine and bioengineering, due to its angiogenic and wound healing activity. However, the biodegradability of natural rubber latex is not significant when compared to other polymers used for the development of materials with biomedical applications, which is important to avoid medical intervention to remove them. Thus, the aim of this work was to improve the biodegradability and subsequent bioabsorption of natural rubber latex membranes associating them with the polylactic acid, a biodegradable, bioreabsorbable and biocompatible polymer, besides being the most studied in biomedical, pharmaceutical and environmental fields. The membranes were prepared with different mass proportions of the polymers with dichloromethane as solvent. The material were submitted to mechanical test, infrared spectroscopy, scanning electron microscopy, water vapor transmission, swelling, in vitro degradation and hemolysis assay. The different polymer proportions influenced the membrane properties. The infrared spectroscopy indicating that no new chemical interactions were formed, and the scanning electron microscopy showed a polymer network formed in membranes with the highest natural rubber latex mass proportion. With the increase of polylactic acid in the membranes, there was an improvement in the degradation of the material of up to 130% and no hemolytic effect was observed, making it interesting for biomedical application.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)School of Pharmaceutical Sciences São Paulo State University (UNESP), Km 01, Araraquara-Jaú RoadInstitute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni StreetDepartment of Food Science and Technology State University of Londrina (UEL), Km 380, Celso Garcia Cid Road (PR 445)School of Pharmaceutical Sciences São Paulo State University (UNESP), Km 01, Araraquara-Jaú RoadInstitute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni StreetFAPESP: 2016/09736-8FAPESP: 2017/19603-8Universidade Estadual Paulista (Unesp)Universidade Estadual de Londrina (UEL)Cesar, Mariana Biondi [UNESP]Borges, Felipe Azevedo [UNESP]Bilck, Ana PaulaYamashita, FábioPaulino, Cristiane Garcia [UNESP]Herculano, Rondinelli Donizetti [UNESP]2020-12-12T02:29:22Z2020-12-12T02:29:22Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article220-230http://dx.doi.org/10.1007/s10924-019-01596-8Journal of Polymers and the Environment, v. 28, n. 1, p. 220-230, 2020.1572-89191566-2543http://hdl.handle.net/11449/20131110.1007/s10924-019-01596-82-s2.0-85074698760Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Polymers and the Environmentinfo:eu-repo/semantics/openAccess2024-06-13T17:38:54Zoai:repositorio.unesp.br:11449/201311Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:29:51.109493Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Development and Characterization of Natural Rubber Latex and Polylactic Acid Membranes for Biomedical Application
title Development and Characterization of Natural Rubber Latex and Polylactic Acid Membranes for Biomedical Application
spellingShingle Development and Characterization of Natural Rubber Latex and Polylactic Acid Membranes for Biomedical Application
Cesar, Mariana Biondi [UNESP]
Biodegradability
Membranes
Natural rubber latex
Polylactic acid
Polymer blend
title_short Development and Characterization of Natural Rubber Latex and Polylactic Acid Membranes for Biomedical Application
title_full Development and Characterization of Natural Rubber Latex and Polylactic Acid Membranes for Biomedical Application
title_fullStr Development and Characterization of Natural Rubber Latex and Polylactic Acid Membranes for Biomedical Application
title_full_unstemmed Development and Characterization of Natural Rubber Latex and Polylactic Acid Membranes for Biomedical Application
title_sort Development and Characterization of Natural Rubber Latex and Polylactic Acid Membranes for Biomedical Application
author Cesar, Mariana Biondi [UNESP]
author_facet Cesar, Mariana Biondi [UNESP]
Borges, Felipe Azevedo [UNESP]
Bilck, Ana Paula
Yamashita, Fábio
Paulino, Cristiane Garcia [UNESP]
Herculano, Rondinelli Donizetti [UNESP]
author_role author
author2 Borges, Felipe Azevedo [UNESP]
Bilck, Ana Paula
Yamashita, Fábio
Paulino, Cristiane Garcia [UNESP]
Herculano, Rondinelli Donizetti [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Londrina (UEL)
dc.contributor.author.fl_str_mv Cesar, Mariana Biondi [UNESP]
Borges, Felipe Azevedo [UNESP]
Bilck, Ana Paula
Yamashita, Fábio
Paulino, Cristiane Garcia [UNESP]
Herculano, Rondinelli Donizetti [UNESP]
dc.subject.por.fl_str_mv Biodegradability
Membranes
Natural rubber latex
Polylactic acid
Polymer blend
topic Biodegradability
Membranes
Natural rubber latex
Polylactic acid
Polymer blend
description Natural rubber latex from the Hevea brasiliensis has been of great importance in areas such as medicine and bioengineering, due to its angiogenic and wound healing activity. However, the biodegradability of natural rubber latex is not significant when compared to other polymers used for the development of materials with biomedical applications, which is important to avoid medical intervention to remove them. Thus, the aim of this work was to improve the biodegradability and subsequent bioabsorption of natural rubber latex membranes associating them with the polylactic acid, a biodegradable, bioreabsorbable and biocompatible polymer, besides being the most studied in biomedical, pharmaceutical and environmental fields. The membranes were prepared with different mass proportions of the polymers with dichloromethane as solvent. The material were submitted to mechanical test, infrared spectroscopy, scanning electron microscopy, water vapor transmission, swelling, in vitro degradation and hemolysis assay. The different polymer proportions influenced the membrane properties. The infrared spectroscopy indicating that no new chemical interactions were formed, and the scanning electron microscopy showed a polymer network formed in membranes with the highest natural rubber latex mass proportion. With the increase of polylactic acid in the membranes, there was an improvement in the degradation of the material of up to 130% and no hemolytic effect was observed, making it interesting for biomedical application.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:29:22Z
2020-12-12T02:29:22Z
2020-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s10924-019-01596-8
Journal of Polymers and the Environment, v. 28, n. 1, p. 220-230, 2020.
1572-8919
1566-2543
http://hdl.handle.net/11449/201311
10.1007/s10924-019-01596-8
2-s2.0-85074698760
url http://dx.doi.org/10.1007/s10924-019-01596-8
http://hdl.handle.net/11449/201311
identifier_str_mv Journal of Polymers and the Environment, v. 28, n. 1, p. 220-230, 2020.
1572-8919
1566-2543
10.1007/s10924-019-01596-8
2-s2.0-85074698760
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Polymers and the Environment
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 220-230
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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