Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation

Detalhes bibliográficos
Autor(a) principal: Mota, Alessandro D.
Data de Publicação: 2015
Outros Autores: Cestari, Andre M., Oliveira, Andre O. de, Oliveira, Anselmo G. [UNESP], Terruggi, Cristina H. B. [UNESP], Rossi, Giuliano, Castro, Jarbas C., Ligabo, Joao P. B., Ortega, Tiago A., Rosa, Tiago, Kane, M. H., Jiao, J., Dietz, N., Huang, J. J.
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1117/12.2187265
http://hdl.handle.net/11449/164699
Resumo: This work presents an innovative cross-linking procedure to keratoconus treatment, a corneal disease. It includes the development of an ultraviolet controlled emission portable device based on LED source and a new formulation of a photosensitive drug called riboflavin. This new formulation improves drug administration by its transepithelial property. The UV reaction with riboflavin in corneal tissue leads to a modification of corneal collagen fibers, turning them more rigid and denser, and consequently restraining the advance of the disease. We present the control procedures to maintain UV output power stable up to 45mw/cm(2), the optical architecture that leads to a homogeneous UV spot and the new formulation of Riboflavin.
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spelling Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiationUltraviolet LEDCross-linkingKeratoconusRiboflavinTransepithelialPID control system for LEDsClose loop system for LEDUV based Optical systemThis work presents an innovative cross-linking procedure to keratoconus treatment, a corneal disease. It includes the development of an ultraviolet controlled emission portable device based on LED source and a new formulation of a photosensitive drug called riboflavin. This new formulation improves drug administration by its transepithelial property. The UV reaction with riboflavin in corneal tissue leads to a modification of corneal collagen fibers, turning them more rigid and denser, and consequently restraining the advance of the disease. We present the control procedures to maintain UV output power stable up to 45mw/cm(2), the optical architecture that leads to a homogeneous UV spot and the new formulation of Riboflavin.Opto Eletron SA, BR-13560330 Sao Carlos, SP, BrazilUniv Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, BrazilSpie-int Soc Optical EngineeringOpto Eletron SAUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Mota, Alessandro D.Cestari, Andre M.Oliveira, Andre O. deOliveira, Anselmo G. [UNESP]Terruggi, Cristina H. B. [UNESP]Rossi, GiulianoCastro, Jarbas C.Ligabo, Joao P. B.Ortega, Tiago A.Rosa, TiagoKane, M. H.Jiao, J.Dietz, N.Huang, J. J.2018-11-26T17:55:40Z2018-11-26T17:55:40Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject13application/pdfhttp://dx.doi.org/10.1117/12.2187265Fourteenth International Conference On Solid State Lighting And Led-based Illumination Systems. Bellingham: Spie-int Soc Optical Engineering, v. 9571, 13 p., 2015.0277-786Xhttp://hdl.handle.net/11449/16469910.1117/12.2187265WOS:000365760600020WOS000365760600020.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFourteenth International Conference On Solid State Lighting And Led-based Illumination Systemsinfo:eu-repo/semantics/openAccess2023-11-24T06:12:44Zoai:repositorio.unesp.br:11449/164699Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:34:40.217693Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation
title Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation
spellingShingle Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation
Mota, Alessandro D.
Ultraviolet LED
Cross-linking
Keratoconus
Riboflavin
Transepithelial
PID control system for LEDs
Close loop system for LED
UV based Optical system
title_short Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation
title_full Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation
title_fullStr Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation
title_full_unstemmed Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation
title_sort Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation
author Mota, Alessandro D.
author_facet Mota, Alessandro D.
Cestari, Andre M.
Oliveira, Andre O. de
Oliveira, Anselmo G. [UNESP]
Terruggi, Cristina H. B. [UNESP]
Rossi, Giuliano
Castro, Jarbas C.
Ligabo, Joao P. B.
Ortega, Tiago A.
Rosa, Tiago
Kane, M. H.
Jiao, J.
Dietz, N.
Huang, J. J.
author_role author
author2 Cestari, Andre M.
Oliveira, Andre O. de
Oliveira, Anselmo G. [UNESP]
Terruggi, Cristina H. B. [UNESP]
Rossi, Giuliano
Castro, Jarbas C.
Ligabo, Joao P. B.
Ortega, Tiago A.
Rosa, Tiago
Kane, M. H.
Jiao, J.
Dietz, N.
Huang, J. J.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Opto Eletron SA
Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Mota, Alessandro D.
Cestari, Andre M.
Oliveira, Andre O. de
Oliveira, Anselmo G. [UNESP]
Terruggi, Cristina H. B. [UNESP]
Rossi, Giuliano
Castro, Jarbas C.
Ligabo, Joao P. B.
Ortega, Tiago A.
Rosa, Tiago
Kane, M. H.
Jiao, J.
Dietz, N.
Huang, J. J.
dc.subject.por.fl_str_mv Ultraviolet LED
Cross-linking
Keratoconus
Riboflavin
Transepithelial
PID control system for LEDs
Close loop system for LED
UV based Optical system
topic Ultraviolet LED
Cross-linking
Keratoconus
Riboflavin
Transepithelial
PID control system for LEDs
Close loop system for LED
UV based Optical system
description This work presents an innovative cross-linking procedure to keratoconus treatment, a corneal disease. It includes the development of an ultraviolet controlled emission portable device based on LED source and a new formulation of a photosensitive drug called riboflavin. This new formulation improves drug administration by its transepithelial property. The UV reaction with riboflavin in corneal tissue leads to a modification of corneal collagen fibers, turning them more rigid and denser, and consequently restraining the advance of the disease. We present the control procedures to maintain UV output power stable up to 45mw/cm(2), the optical architecture that leads to a homogeneous UV spot and the new formulation of Riboflavin.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01
2018-11-26T17:55:40Z
2018-11-26T17:55:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1117/12.2187265
Fourteenth International Conference On Solid State Lighting And Led-based Illumination Systems. Bellingham: Spie-int Soc Optical Engineering, v. 9571, 13 p., 2015.
0277-786X
http://hdl.handle.net/11449/164699
10.1117/12.2187265
WOS:000365760600020
WOS000365760600020.pdf
url http://dx.doi.org/10.1117/12.2187265
http://hdl.handle.net/11449/164699
identifier_str_mv Fourteenth International Conference On Solid State Lighting And Led-based Illumination Systems. Bellingham: Spie-int Soc Optical Engineering, v. 9571, 13 p., 2015.
0277-786X
10.1117/12.2187265
WOS:000365760600020
WOS000365760600020.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fourteenth International Conference On Solid State Lighting And Led-based Illumination Systems
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13
application/pdf
dc.publisher.none.fl_str_mv Spie-int Soc Optical Engineering
publisher.none.fl_str_mv Spie-int Soc Optical Engineering
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128951273390080

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