Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata Juice

Detalhes bibliográficos
Autor(a) principal: Barbalho, Sandra M.
Data de Publicação: 2011
Outros Autores: Damasceno, Débora Cristina [UNESP], Machado Spada, Ana Paula, Palhares, Mireia, Martuchi, Karla Aparecida, Oshiiwa, Marie, Sazaki, Viviane, da Silva, Vanessa Sellis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2011/173647
http://hdl.handle.net/11449/12343
Resumo: Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, and increased HDL-c. The use of acerola juice is a potential strategy to aid in the prevention of DM and dyslipidemia and its complications or to act as an auxiliary in the treatment of these diseases.
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spelling Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata JuiceKnowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, and increased HDL-c. The use of acerola juice is a potential strategy to aid in the prevention of DM and dyslipidemia and its complications or to act as an auxiliary in the treatment of these diseases.Fac Technol & Foods Marilia, Med Sch Med Marilia UNIMAR, BR-17525902 Marilia, SP, BrazilUNESP, Lab Expt Res Gynecol & Obstet, Botucatu Med Sch, BR-18618000 Botucatu, SP, BrazilUniv São Paulo, Dept Biochem, Fac UNINOVE, BR-01041000 São Paulo, BrazilUniv São Paulo, SENAC, BR-01041000 São Paulo, BrazilUniv Metodista Piracicaba, Dept Nutr, UNIMEP, BR-16400680 Lins, SP, BrazilFrigorificos Bertin SA, Dept Nutr, BR-16400000 Lins, SP, BrazilFATEC, Fac Technol & Foods Marilia, BR-17506000 Marilia, SP, BrazilUNESP, Lab Expt Res Gynecol & Obstet, Botucatu Med Sch, BR-18618000 Botucatu, SP, BrazilHindawi Publishing CorporationFac Technol & Foods MariliaUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Univ Metodista PiracicabaFrigorificos Bertin SAFaculdade de Tecnologia do Estado de São Paulo (FATEC)Barbalho, Sandra M.Damasceno, Débora Cristina [UNESP]Machado Spada, Ana PaulaPalhares, MireiaMartuchi, Karla AparecidaOshiiwa, MarieSazaki, Vivianeda Silva, Vanessa Sellis2014-05-20T13:35:53Z2014-05-20T13:35:53Z2011-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://dx.doi.org/10.1155/2011/173647Experimental Diabetes Research. New York: Hindawi Publishing Corporation, p. 6, 2011.1687-5214http://hdl.handle.net/11449/1234310.1155/2011/173647WOS:000289086700001WOS000289086700001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengExperimental Diabetes Researchinfo:eu-repo/semantics/openAccess2024-08-16T14:07:07Zoai:repositorio.unesp.br:11449/12343Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:07:07Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata Juice
title Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata Juice
spellingShingle Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata Juice
Barbalho, Sandra M.
title_short Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata Juice
title_full Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata Juice
title_fullStr Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata Juice
title_full_unstemmed Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata Juice
title_sort Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata Juice
author Barbalho, Sandra M.
author_facet Barbalho, Sandra M.
Damasceno, Débora Cristina [UNESP]
Machado Spada, Ana Paula
Palhares, Mireia
Martuchi, Karla Aparecida
Oshiiwa, Marie
Sazaki, Viviane
da Silva, Vanessa Sellis
author_role author
author2 Damasceno, Débora Cristina [UNESP]
Machado Spada, Ana Paula
Palhares, Mireia
Martuchi, Karla Aparecida
Oshiiwa, Marie
Sazaki, Viviane
da Silva, Vanessa Sellis
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fac Technol & Foods Marilia
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
Univ Metodista Piracicaba
Frigorificos Bertin SA
Faculdade de Tecnologia do Estado de São Paulo (FATEC)
dc.contributor.author.fl_str_mv Barbalho, Sandra M.
Damasceno, Débora Cristina [UNESP]
Machado Spada, Ana Paula
Palhares, Mireia
Martuchi, Karla Aparecida
Oshiiwa, Marie
Sazaki, Viviane
da Silva, Vanessa Sellis
description Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, and increased HDL-c. The use of acerola juice is a potential strategy to aid in the prevention of DM and dyslipidemia and its complications or to act as an auxiliary in the treatment of these diseases.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
2014-05-20T13:35:53Z
2014-05-20T13:35:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2011/173647
Experimental Diabetes Research. New York: Hindawi Publishing Corporation, p. 6, 2011.
1687-5214
http://hdl.handle.net/11449/12343
10.1155/2011/173647
WOS:000289086700001
WOS000289086700001.pdf
url http://dx.doi.org/10.1155/2011/173647
http://hdl.handle.net/11449/12343
identifier_str_mv Experimental Diabetes Research. New York: Hindawi Publishing Corporation, p. 6, 2011.
1687-5214
10.1155/2011/173647
WOS:000289086700001
WOS000289086700001.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Experimental Diabetes Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128150430810112

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