Potencial de regeneração óssea guiada de membrana de colágeno porcino (Collprotect Straumann®): estudo histométrico e de perfil inflamatório em defeitos ósseos de calvária de ratos.

• Autor(a) principal: Silva, Mirela Caroline [UNESP]
• Data de Publicação: 2020
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/213835
• topic: Collagen; Regeneração óssea guiada; Colágeno; Ossos

Guided bone regeneration (ROG) has become a common and important practice in Implantology. To perform the regeneration of bone defects it is necessary to use membranes that assist in this process, since they are barriers that prevent the growth of undesirable tissues in the areas of bone defects. Absorbable membranes have shown advantages over non-absorbable membranes, among the most relevant characteristics of absorbable membranes are: blood support (directly related to the porosity of the material) and bone mechanical support that depends on the membrane resorption time, being a strand of biomaterials studies that assist in this repair process. In this way, the search for appropriate materials continues. The purpose of this analysis was to evaluate and compare, through histological, histomorphometric study, of the guided bone regeneration process using the porcine dermis collagen membrane (Collprotect Straumann®) in critical defects created in rat calvaria. For this, 72 Albinus Wistar rats were used, divided into 3 groups, 24 for each group: Control group with clot only; Porcine dermis collagen membrane group (Collprotect Straumann®) and Porcine collagen membrane group. Each group consisted of 4 subgroups according to the study times: 7, 15, 30 and 60 days. After the experimental periods, the pieces were processed in laboratories and submitted to histological and histomorphometric analyzes, for comparative statistical analysis of the data found. From the results obtained, it can be seen in the inflammatory profile that the CS membrane showed a biological behavior inferior to the BG membrane, with less angiogenesis and greater amount of inflammatory cells. As well as in the analysis of the newly formed bone area, not obtaining complete closure of the defect at the end of the experimental periods, no matter how much it behaved superiorly to the GC group at 30 and 60 days. Thus, it is concluded that there is a need for further studies associating the membrane of the CS group with osteoinductive/osteoconductive biomaterials, which enhance the results obtained in this study.