Eficácia da ciclosporina no controle da dermatite atópica em cães

Detalhes bibliográficos
Autor(a) principal: Neto, Adriano Souza
Data de Publicação: 2017
Outros Autores: de Farias, Marconi R., Pimpão, Claudia T., Quitzan, Juliany G. [UNESP], Anater, Amanda
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/s0100-736x2017000700013
http://hdl.handle.net/11449/170322
Resumo: Atopic dermatitis is an itchy, chronic inflammatory skin disease of genetic origin, resulting from loss of the physical barrier function of the skin and hyper-reactivity to environmental allergens, trofoallergens, microbial allergens and to primary irritants. The efficacy of cyclosporine in the control of pruritus and lesions associated with atopic dermatitis in dogs was evaluated. Twenty-four dogs with atopic dermatitis were selected, based on Favrot et al.'s criteria (2010). They were divided into two groups of 12 dogs, where Group 1 received cyclosporine (5mg/kg/vo/24h), and Group 2 was treated with prednisone (0.5mg/kg/ vo/24h) in decreasing doses, both for 60 days. The animals were continuously evaluated, and theirits lesional symptomatology scores were based on a Cadesi-03 scale, set on days 0, 30 and 60. Pruritus scores of each dog, based on Rybnicek's criteria, were weekly evaluated, from day 0 to day 63. All collected data were analyzed by the nonparametric Kruskal- -Wallis' test, followed by Dunn's test, and for the analysis between the groups, considered the minimum significance level of 5%, t-test was used. Cyclosporin had similar efficacy in lesional control in the group which received prednisone on day (+30) (p < 0.05) and on the day (+60) (p < 0.001) of treatment, compared with day zero. A significant difference of the itching score was observed on days +28, +35, +42, +49, +56 and +63 (p < 0.001), and on day +21 (p < 0.01) when compared to initial treatment. However, its efficacy was lower than Group 2, from 42 days of evaluation on, keeping such difference on days +49, +56 and +63 (p > 0.05). Although cyclosporin have been less effective in controlling itching, it remained at acceptable levels, and its continued use was not associated with significant side effects.
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spelling Eficácia da ciclosporina no controle da dermatite atópica em cãesEfficacy of cyclosporine in the control of atopic dermatitis in dogsCADESICorticoidCyclosporineDermatitisDogsGenodermatosisPruritusRybnicekAtopic dermatitis is an itchy, chronic inflammatory skin disease of genetic origin, resulting from loss of the physical barrier function of the skin and hyper-reactivity to environmental allergens, trofoallergens, microbial allergens and to primary irritants. The efficacy of cyclosporine in the control of pruritus and lesions associated with atopic dermatitis in dogs was evaluated. Twenty-four dogs with atopic dermatitis were selected, based on Favrot et al.'s criteria (2010). They were divided into two groups of 12 dogs, where Group 1 received cyclosporine (5mg/kg/vo/24h), and Group 2 was treated with prednisone (0.5mg/kg/ vo/24h) in decreasing doses, both for 60 days. The animals were continuously evaluated, and theirits lesional symptomatology scores were based on a Cadesi-03 scale, set on days 0, 30 and 60. Pruritus scores of each dog, based on Rybnicek's criteria, were weekly evaluated, from day 0 to day 63. All collected data were analyzed by the nonparametric Kruskal- -Wallis' test, followed by Dunn's test, and for the analysis between the groups, considered the minimum significance level of 5%, t-test was used. Cyclosporin had similar efficacy in lesional control in the group which received prednisone on day (+30) (p < 0.05) and on the day (+60) (p < 0.001) of treatment, compared with day zero. A significant difference of the itching score was observed on days +28, +35, +42, +49, +56 and +63 (p < 0.001), and on day +21 (p < 0.01) when compared to initial treatment. However, its efficacy was lower than Group 2, from 42 days of evaluation on, keeping such difference on days +49, +56 and +63 (p > 0.05). Although cyclosporin have been less effective in controlling itching, it remained at acceptable levels, and its continued use was not associated with significant side effects.Escola de Ciências Agrarias e Ambientais Pontificia Universidade Catolica do Parana (PUC), BR-376 Km 14Departamento de Clinica Médica Veterinária Escola de Ciências Agrárias e Ambientais PUC, BR-376 Km 14Departmento de Farmacologia e Toxicologia Veterinária Escola de Ciências Agrárias e Ambientais Pontifícia Universidade Católica do Paraná (PUC), BR-376 Km 14Departyamento de Clinica Médica e Cirurgia Veterinária Universidade Estadual Paulista Júlio de Mesquita Filho (Unesp), Cx. Postal 237PIBITI PUC, BR-376 Km 14Departyamento de Clinica Médica e Cirurgia Veterinária Universidade Estadual Paulista Júlio de Mesquita Filho (Unesp), Cx. Postal 237Pontificia Universidade Catolica do Parana (PUC)PUCPontifícia Universidade Católica do Paraná (PUC)Universidade Estadual Paulista (Unesp)Neto, Adriano Souzade Farias, Marconi R.Pimpão, Claudia T.Quitzan, Juliany G. [UNESP]Anater, Amanda2018-12-11T16:50:16Z2018-12-11T16:50:16Z2017-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article729-733application/pdfhttp://dx.doi.org/10.1590/s0100-736x2017000700013Pesquisa Veterinaria Brasileira, v. 37, n. 7, p. 729-733, 2017.1678-51500100-736Xhttp://hdl.handle.net/11449/17032210.1590/s0100-736x2017000700013S0100-736X20170007007292-s2.0-85032493509S0100-736X2017000700729.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2023-12-01T06:14:39Zoai:repositorio.unesp.br:11449/170322Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:13:33.538755Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Eficácia da ciclosporina no controle da dermatite atópica em cães
Efficacy of cyclosporine in the control of atopic dermatitis in dogs
title Eficácia da ciclosporina no controle da dermatite atópica em cães
spellingShingle Eficácia da ciclosporina no controle da dermatite atópica em cães
Neto, Adriano Souza
CADESI
Corticoid
Cyclosporine
Dermatitis
Dogs
Genodermatosis
Pruritus
Rybnicek
title_short Eficácia da ciclosporina no controle da dermatite atópica em cães
title_full Eficácia da ciclosporina no controle da dermatite atópica em cães
title_fullStr Eficácia da ciclosporina no controle da dermatite atópica em cães
title_full_unstemmed Eficácia da ciclosporina no controle da dermatite atópica em cães
title_sort Eficácia da ciclosporina no controle da dermatite atópica em cães
author Neto, Adriano Souza
author_facet Neto, Adriano Souza
de Farias, Marconi R.
Pimpão, Claudia T.
Quitzan, Juliany G. [UNESP]
Anater, Amanda
author_role author
author2 de Farias, Marconi R.
Pimpão, Claudia T.
Quitzan, Juliany G. [UNESP]
Anater, Amanda
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Pontificia Universidade Catolica do Parana (PUC)
PUC
Pontifícia Universidade Católica do Paraná (PUC)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Neto, Adriano Souza
de Farias, Marconi R.
Pimpão, Claudia T.
Quitzan, Juliany G. [UNESP]
Anater, Amanda
dc.subject.por.fl_str_mv CADESI
Corticoid
Cyclosporine
Dermatitis
Dogs
Genodermatosis
Pruritus
Rybnicek
topic CADESI
Corticoid
Cyclosporine
Dermatitis
Dogs
Genodermatosis
Pruritus
Rybnicek
description Atopic dermatitis is an itchy, chronic inflammatory skin disease of genetic origin, resulting from loss of the physical barrier function of the skin and hyper-reactivity to environmental allergens, trofoallergens, microbial allergens and to primary irritants. The efficacy of cyclosporine in the control of pruritus and lesions associated with atopic dermatitis in dogs was evaluated. Twenty-four dogs with atopic dermatitis were selected, based on Favrot et al.'s criteria (2010). They were divided into two groups of 12 dogs, where Group 1 received cyclosporine (5mg/kg/vo/24h), and Group 2 was treated with prednisone (0.5mg/kg/ vo/24h) in decreasing doses, both for 60 days. The animals were continuously evaluated, and theirits lesional symptomatology scores were based on a Cadesi-03 scale, set on days 0, 30 and 60. Pruritus scores of each dog, based on Rybnicek's criteria, were weekly evaluated, from day 0 to day 63. All collected data were analyzed by the nonparametric Kruskal- -Wallis' test, followed by Dunn's test, and for the analysis between the groups, considered the minimum significance level of 5%, t-test was used. Cyclosporin had similar efficacy in lesional control in the group which received prednisone on day (+30) (p < 0.05) and on the day (+60) (p < 0.001) of treatment, compared with day zero. A significant difference of the itching score was observed on days +28, +35, +42, +49, +56 and +63 (p < 0.001), and on day +21 (p < 0.01) when compared to initial treatment. However, its efficacy was lower than Group 2, from 42 days of evaluation on, keeping such difference on days +49, +56 and +63 (p > 0.05). Although cyclosporin have been less effective in controlling itching, it remained at acceptable levels, and its continued use was not associated with significant side effects.
publishDate 2017
dc.date.none.fl_str_mv 2017-07-01
2018-12-11T16:50:16Z
2018-12-11T16:50:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/s0100-736x2017000700013
Pesquisa Veterinaria Brasileira, v. 37, n. 7, p. 729-733, 2017.
1678-5150
0100-736X
http://hdl.handle.net/11449/170322
10.1590/s0100-736x2017000700013
S0100-736X2017000700729
2-s2.0-85032493509
S0100-736X2017000700729.pdf
url http://dx.doi.org/10.1590/s0100-736x2017000700013
http://hdl.handle.net/11449/170322
identifier_str_mv Pesquisa Veterinaria Brasileira, v. 37, n. 7, p. 729-733, 2017.
1678-5150
0100-736X
10.1590/s0100-736x2017000700013
S0100-736X2017000700729
2-s2.0-85032493509
S0100-736X2017000700729.pdf
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Pesquisa Veterinaria Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 729-733
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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