Physicochemical Stability of Poly(lactide-co-glycolide) Nanocapsules Containing the Local Anesthetic Bupivacaine

Detalhes bibliográficos
Autor(a) principal: Moraes, Carolina M.
Data de Publicação: 2010
Outros Autores: De Paula, Eneida, Rosa, Andre H. [UNESP], Fraceto, Leonardo F. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0103-50532010000600008
http://hdl.handle.net/11449/186
Resumo: This paper describes the preparation of poly(DL-lactide-co-glicolide) (PLGA) nanocapsules as a drug carrier system for the local anesthetic bupivacaine. The system was characterized and its stability investigated. The results showed a size distribution with a polydispersity index of 0.12, an average diameter of 148 nm, a zeta potential of -43.5 mV and an entrapment efficiency of 75.8%. The physicochemical properties of polymeric nanocapsule suspensions (average diameter, polydispersity, zeta potential and drug association efficiency) were evaluated as a function of time to determine the formulation stability. The formulation did not display major changes in these properties over the time, and it was considered stable up to 120 days of storage at room temperature. The results reported here which refer to the initial characterization of these new formulations for the local anesthetic bupivacaine show a promising potential for future in vivo studies.
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spelling Physicochemical Stability of Poly(lactide-co-glycolide) Nanocapsules Containing the Local Anesthetic Bupivacainebupivacainelocal anestheticpolymeric nanocapsulesPLGAphysical-chemical stabilityThis paper describes the preparation of poly(DL-lactide-co-glicolide) (PLGA) nanocapsules as a drug carrier system for the local anesthetic bupivacaine. The system was characterized and its stability investigated. The results showed a size distribution with a polydispersity index of 0.12, an average diameter of 148 nm, a zeta potential of -43.5 mV and an entrapment efficiency of 75.8%. The physicochemical properties of polymeric nanocapsule suspensions (average diameter, polydispersity, zeta potential and drug association efficiency) were evaluated as a function of time to determine the formulation stability. The formulation did not display major changes in these properties over the time, and it was considered stable up to 120 days of storage at room temperature. The results reported here which refer to the initial characterization of these new formulations for the local anesthetic bupivacaine show a promising potential for future in vivo studies.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação para o Desenvolvimento da UNESP (FUNDUNESP)Univ Estadual Campinas, Inst Biol, BR-13083970 Campinas, SP, BrazilUniv Estadual Paulista, Dept Engn Ambiental, BR-18087180 Sorocaba, SP, BrazilUniv Estadual Paulista, Dept Engn Ambiental, BR-18087180 Sorocaba, SP, BrazilFAPESP: 06/00121-9FAPESP: 07/00127-0Soc Brasileira QuimicaUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Moraes, Carolina M.De Paula, EneidaRosa, Andre H. [UNESP]Fraceto, Leonardo F. [UNESP]2014-05-20T13:12:12Z2014-05-20T13:12:12Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article995-1000http://dx.doi.org/10.1590/S0103-50532010000600008Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 21, n. 6, p. 995-1000, 2010.0103-5053http://hdl.handle.net/11449/18610.1590/S0103-50532010000600008S0103-50532010000600008WOS:000278745400008S0103-50532010000600008.pdf0000-0002-2042-018XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of the Brazilian Chemical Society1.4440,357info:eu-repo/semantics/openAccess2021-10-23T17:45:56Zoai:repositorio.unesp.br:11449/186Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:14:01.652006Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Physicochemical Stability of Poly(lactide-co-glycolide) Nanocapsules Containing the Local Anesthetic Bupivacaine
title Physicochemical Stability of Poly(lactide-co-glycolide) Nanocapsules Containing the Local Anesthetic Bupivacaine
spellingShingle Physicochemical Stability of Poly(lactide-co-glycolide) Nanocapsules Containing the Local Anesthetic Bupivacaine
Moraes, Carolina M.
bupivacaine
local anesthetic
polymeric nanocapsules
PLGA
physical-chemical stability
title_short Physicochemical Stability of Poly(lactide-co-glycolide) Nanocapsules Containing the Local Anesthetic Bupivacaine
title_full Physicochemical Stability of Poly(lactide-co-glycolide) Nanocapsules Containing the Local Anesthetic Bupivacaine
title_fullStr Physicochemical Stability of Poly(lactide-co-glycolide) Nanocapsules Containing the Local Anesthetic Bupivacaine
title_full_unstemmed Physicochemical Stability of Poly(lactide-co-glycolide) Nanocapsules Containing the Local Anesthetic Bupivacaine
title_sort Physicochemical Stability of Poly(lactide-co-glycolide) Nanocapsules Containing the Local Anesthetic Bupivacaine
author Moraes, Carolina M.
author_facet Moraes, Carolina M.
De Paula, Eneida
Rosa, Andre H. [UNESP]
Fraceto, Leonardo F. [UNESP]
author_role author
author2 De Paula, Eneida
Rosa, Andre H. [UNESP]
Fraceto, Leonardo F. [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Moraes, Carolina M.
De Paula, Eneida
Rosa, Andre H. [UNESP]
Fraceto, Leonardo F. [UNESP]
dc.subject.por.fl_str_mv bupivacaine
local anesthetic
polymeric nanocapsules
PLGA
physical-chemical stability
topic bupivacaine
local anesthetic
polymeric nanocapsules
PLGA
physical-chemical stability
description This paper describes the preparation of poly(DL-lactide-co-glicolide) (PLGA) nanocapsules as a drug carrier system for the local anesthetic bupivacaine. The system was characterized and its stability investigated. The results showed a size distribution with a polydispersity index of 0.12, an average diameter of 148 nm, a zeta potential of -43.5 mV and an entrapment efficiency of 75.8%. The physicochemical properties of polymeric nanocapsule suspensions (average diameter, polydispersity, zeta potential and drug association efficiency) were evaluated as a function of time to determine the formulation stability. The formulation did not display major changes in these properties over the time, and it was considered stable up to 120 days of storage at room temperature. The results reported here which refer to the initial characterization of these new formulations for the local anesthetic bupivacaine show a promising potential for future in vivo studies.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
2014-05-20T13:12:12Z
2014-05-20T13:12:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0103-50532010000600008
Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 21, n. 6, p. 995-1000, 2010.
0103-5053
http://hdl.handle.net/11449/186
10.1590/S0103-50532010000600008
S0103-50532010000600008
WOS:000278745400008
S0103-50532010000600008.pdf
0000-0002-2042-018X
url http://dx.doi.org/10.1590/S0103-50532010000600008
http://hdl.handle.net/11449/186
identifier_str_mv Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 21, n. 6, p. 995-1000, 2010.
0103-5053
10.1590/S0103-50532010000600008
S0103-50532010000600008
WOS:000278745400008
S0103-50532010000600008.pdf
0000-0002-2042-018X
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of the Brazilian Chemical Society
1.444
0,357
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 995-1000
dc.publisher.none.fl_str_mv Soc Brasileira Quimica
publisher.none.fl_str_mv Soc Brasileira Quimica
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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