The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bbi.2022.03.014 http://hdl.handle.net/11449/231640 |
Resumo: | Recent evidence has suggested that the carotid bodies might act as immunological sensors, detecting pro-inflammatory mediators and signalling to the central nervous system, which, in turn, orchestrates autonomic responses. Here, we confirmed that the TNF-α receptor type I is expressed in the carotid bodies of rats. The systemic administration of TNF-α increased carotid body afferent discharge and activated glutamatergic neurons in the nucleus tractus solitarius (NTS) that project to the rostral ventrolateral medulla (RVLM), where many pre-sympathetic neurons reside. The activation of these neurons was accompanied by an increase in splanchnic sympathetic nerve activity. Carotid body ablation blunted the TNF-α-induced activation of RVLM-projecting NTS neurons and the increase in splanchnic sympathetic nerve activity. Finally, plasma and spleen levels of cytokines after TNF-α administration were higher in rats subjected to either carotid body ablation or splanchnic sympathetic denervation. Collectively, our findings indicate that the carotid body detects circulating TNF-α to activate a counteracting sympathetic anti-inflammatory mechanism. |
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The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflexCarotid bodyInflammationNeural circuitsNeuroimmune interactionsNeuroimmunomodulationSympathetic nervous systemRecent evidence has suggested that the carotid bodies might act as immunological sensors, detecting pro-inflammatory mediators and signalling to the central nervous system, which, in turn, orchestrates autonomic responses. Here, we confirmed that the TNF-α receptor type I is expressed in the carotid bodies of rats. The systemic administration of TNF-α increased carotid body afferent discharge and activated glutamatergic neurons in the nucleus tractus solitarius (NTS) that project to the rostral ventrolateral medulla (RVLM), where many pre-sympathetic neurons reside. The activation of these neurons was accompanied by an increase in splanchnic sympathetic nerve activity. Carotid body ablation blunted the TNF-α-induced activation of RVLM-projecting NTS neurons and the increase in splanchnic sympathetic nerve activity. Finally, plasma and spleen levels of cytokines after TNF-α administration were higher in rats subjected to either carotid body ablation or splanchnic sympathetic denervation. Collectively, our findings indicate that the carotid body detects circulating TNF-α to activate a counteracting sympathetic anti-inflammatory mechanism.Booz Allen FoundationDepartment of Physiology and Pathology School of Dentistry São Paulo State University, São PauloDepartment of Neurosciences and Behavior Ribeirão Preto Medical School University of São Paulo, São PauloDepartment of Pharmacology Ribeirão Preto Medical School University of São Paulo, São PauloDepartment of Physiology Ribeirão Preto Medical School University of São Paulo, São PauloDepartment of Physiology and Pathology School of Dentistry São Paulo State University, São PauloBooz Allen Foundation: 2015/23467-7Booz Allen Foundation: 2019/11196-0Booz Allen Foundation: PROPE-UNESPUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Katayama, Pedro L. [UNESP]Leirão, Isabela P. [UNESP]Kanashiro, AlexandreLuiz, João P.M.Cunha, Fernando Q.Navegantes, Luiz C.C.Menani, Jose V. [UNESP]Zoccal, Daniel B. [UNESP]Colombari, Débora S.A. [UNESP]Colombari, Eduardo [UNESP]2022-04-29T08:46:43Z2022-04-29T08:46:43Z2022-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article370-386http://dx.doi.org/10.1016/j.bbi.2022.03.014Brain, Behavior, and Immunity, v. 102, p. 370-386.1090-21390889-1591http://hdl.handle.net/11449/23164010.1016/j.bbi.2022.03.0142-s2.0-85126921730Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrain, Behavior, and Immunityinfo:eu-repo/semantics/openAccess2022-04-29T08:46:43Zoai:repositorio.unesp.br:11449/231640Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:46:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex |
title |
The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex |
spellingShingle |
The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex Katayama, Pedro L. [UNESP] Carotid body Inflammation Neural circuits Neuroimmune interactions Neuroimmunomodulation Sympathetic nervous system |
title_short |
The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex |
title_full |
The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex |
title_fullStr |
The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex |
title_full_unstemmed |
The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex |
title_sort |
The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex |
author |
Katayama, Pedro L. [UNESP] |
author_facet |
Katayama, Pedro L. [UNESP] Leirão, Isabela P. [UNESP] Kanashiro, Alexandre Luiz, João P.M. Cunha, Fernando Q. Navegantes, Luiz C.C. Menani, Jose V. [UNESP] Zoccal, Daniel B. [UNESP] Colombari, Débora S.A. [UNESP] Colombari, Eduardo [UNESP] |
author_role |
author |
author2 |
Leirão, Isabela P. [UNESP] Kanashiro, Alexandre Luiz, João P.M. Cunha, Fernando Q. Navegantes, Luiz C.C. Menani, Jose V. [UNESP] Zoccal, Daniel B. [UNESP] Colombari, Débora S.A. [UNESP] Colombari, Eduardo [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Katayama, Pedro L. [UNESP] Leirão, Isabela P. [UNESP] Kanashiro, Alexandre Luiz, João P.M. Cunha, Fernando Q. Navegantes, Luiz C.C. Menani, Jose V. [UNESP] Zoccal, Daniel B. [UNESP] Colombari, Débora S.A. [UNESP] Colombari, Eduardo [UNESP] |
dc.subject.por.fl_str_mv |
Carotid body Inflammation Neural circuits Neuroimmune interactions Neuroimmunomodulation Sympathetic nervous system |
topic |
Carotid body Inflammation Neural circuits Neuroimmune interactions Neuroimmunomodulation Sympathetic nervous system |
description |
Recent evidence has suggested that the carotid bodies might act as immunological sensors, detecting pro-inflammatory mediators and signalling to the central nervous system, which, in turn, orchestrates autonomic responses. Here, we confirmed that the TNF-α receptor type I is expressed in the carotid bodies of rats. The systemic administration of TNF-α increased carotid body afferent discharge and activated glutamatergic neurons in the nucleus tractus solitarius (NTS) that project to the rostral ventrolateral medulla (RVLM), where many pre-sympathetic neurons reside. The activation of these neurons was accompanied by an increase in splanchnic sympathetic nerve activity. Carotid body ablation blunted the TNF-α-induced activation of RVLM-projecting NTS neurons and the increase in splanchnic sympathetic nerve activity. Finally, plasma and spleen levels of cytokines after TNF-α administration were higher in rats subjected to either carotid body ablation or splanchnic sympathetic denervation. Collectively, our findings indicate that the carotid body detects circulating TNF-α to activate a counteracting sympathetic anti-inflammatory mechanism. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-29T08:46:43Z 2022-04-29T08:46:43Z 2022-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bbi.2022.03.014 Brain, Behavior, and Immunity, v. 102, p. 370-386. 1090-2139 0889-1591 http://hdl.handle.net/11449/231640 10.1016/j.bbi.2022.03.014 2-s2.0-85126921730 |
url |
http://dx.doi.org/10.1016/j.bbi.2022.03.014 http://hdl.handle.net/11449/231640 |
identifier_str_mv |
Brain, Behavior, and Immunity, v. 102, p. 370-386. 1090-2139 0889-1591 10.1016/j.bbi.2022.03.014 2-s2.0-85126921730 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brain, Behavior, and Immunity |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
370-386 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965119296307200 |