Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.smallrumres.2022.106883 http://hdl.handle.net/11449/248139 |
Resumo: | The objective of this study was to evaluate the influence of different corticosteroid protocols performed in pregnant does on oxidative stress markers of newborn kids born with 141 days of gestation and does. Reactive oxygen metabolites (D-ROMs) and biological antioxidant potential (BAP) were examine in response to the following four protocols: GI (does: n = 4; newborns kids: n = 7) with a single dose of 20 mg dexamethasone, 2 days prior to elective surgery (139 days of gestation); GII (does: n = 4; newborns kids: n = 6) 2 mg dexamethasone (133–136 days); 4 mg (137−139); and 20 mg at 140 days; GIII (does: n = 4; newborns kids: n = 7) with a dose of 16 mg of dexamethasone (139 days), with repeated doses at 12-h interval until elective surgery; and GIV (does: n = 4; newborns kids: n = 6) using doses of 4, 8, 16, and 20 mg dexamethasone (137, 138, 139, and 140 days). Samples were collected from does 15 min (DM15) after birth and from newborn kids 15 min (M15), 24 h (M24), and 48 h (M48) after birth. When verifying the effect of time in each group, newborn kids from GII, GIII, and GIV presented lower concentrations of D-ROMs at M15 when compared to M48. Newborn kids from GIII and GIV showed increased BAP values at M24 and M48 when compared to M15, respectively. Comparisons between treatments revealed that newborn kids from GI presented higher D-ROMs than those of GII at M15 and GIV at M48. GIV presented higher BAP values than GI, GII, and GII at M48. No significant differences among does were observed considering D-ROMs or BAP values. The protocol for the administration of corticosteroids in does influence the oxidative stress response in newborn kids. |
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Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapyAntioxidantDexamethasoneGoatsOxidantPrematureThe objective of this study was to evaluate the influence of different corticosteroid protocols performed in pregnant does on oxidative stress markers of newborn kids born with 141 days of gestation and does. Reactive oxygen metabolites (D-ROMs) and biological antioxidant potential (BAP) were examine in response to the following four protocols: GI (does: n = 4; newborns kids: n = 7) with a single dose of 20 mg dexamethasone, 2 days prior to elective surgery (139 days of gestation); GII (does: n = 4; newborns kids: n = 6) 2 mg dexamethasone (133–136 days); 4 mg (137−139); and 20 mg at 140 days; GIII (does: n = 4; newborns kids: n = 7) with a dose of 16 mg of dexamethasone (139 days), with repeated doses at 12-h interval until elective surgery; and GIV (does: n = 4; newborns kids: n = 6) using doses of 4, 8, 16, and 20 mg dexamethasone (137, 138, 139, and 140 days). Samples were collected from does 15 min (DM15) after birth and from newborn kids 15 min (M15), 24 h (M24), and 48 h (M48) after birth. When verifying the effect of time in each group, newborn kids from GII, GIII, and GIV presented lower concentrations of D-ROMs at M15 when compared to M48. Newborn kids from GIII and GIV showed increased BAP values at M24 and M48 when compared to M15, respectively. Comparisons between treatments revealed that newborn kids from GI presented higher D-ROMs than those of GII at M15 and GIV at M48. GIV presented higher BAP values than GI, GII, and GII at M48. No significant differences among does were observed considering D-ROMs or BAP values. The protocol for the administration of corticosteroids in does influence the oxidative stress response in newborn kids.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista (UNESP) Campus de Araçatuba Faculdade de Medicina Veterinária (FMVA) Departamento de Clínica Cirurgia e Reprodução Animal SPUniversidade Estadual Paulista (UNESP) Campus de Jaboticabal Faculdade de Ciências Agrárias e Veterinárias (FCAV) Departamento de Reprodução AnimalEmbrapa Pecuaria Sudeste, Sao PauloCentro Universitário das Faculdades Integradas de Ourinhos (Unifio) Departamento de Medicina Veterinária, São PauloUniversidade Federal Rural do Semi-Árido (UFERSA) Departamento de Ciência Animal, Rio Grande do NorteSection of Infectious Diseases Department of Internal Medicine Yale University School of MedicineUniversidade Estadual Paulista (UNESP) Campus de Araçatuba Faculdade de Medicina Veterinária (FMVA) Departamento de Clínica Cirurgia e Reprodução Animal SPUniversidade Estadual Paulista (UNESP) Campus de Jaboticabal Faculdade de Ciências Agrárias e Veterinárias (FCAV) Departamento de Reprodução AnimalFAPESP: 16/00808-6Universidade Estadual Paulista (UNESP)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Centro Universitário das Faculdades Integradas de Ourinhos (Unifio)Universidade Federal Rural do Semi-Árido (UFERSA)Yale University School of MedicineMaschio, Eva Liliane dos Santos Silva [UNESP]Narciso, Luis Gustavo [UNESP]Trevizan, Juliane Teramachi [UNESP]Bovino, Fernanda [UNESP]Vieira, Dielson da Silva [UNESP]Mendes, Luiz Cláudio Nogueira [UNESP]Peiró, Juliana Regina [UNESP]Alcindo, Jefferson Filgueirade Almeida, Breno Fernando MartinsFeitosa, Francisco Leydson Formiga [UNESP]2023-07-29T13:35:34Z2023-07-29T13:35:34Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.smallrumres.2022.106883Small Ruminant Research, v. 218.0921-4488http://hdl.handle.net/11449/24813910.1016/j.smallrumres.2022.1068832-s2.0-85145609449Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSmall Ruminant Researchinfo:eu-repo/semantics/openAccess2024-09-04T18:03:25Zoai:repositorio.unesp.br:11449/248139Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T18:03:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy |
title |
Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy |
spellingShingle |
Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy Maschio, Eva Liliane dos Santos Silva [UNESP] Antioxidant Dexamethasone Goats Oxidant Premature |
title_short |
Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy |
title_full |
Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy |
title_fullStr |
Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy |
title_full_unstemmed |
Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy |
title_sort |
Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy |
author |
Maschio, Eva Liliane dos Santos Silva [UNESP] |
author_facet |
Maschio, Eva Liliane dos Santos Silva [UNESP] Narciso, Luis Gustavo [UNESP] Trevizan, Juliane Teramachi [UNESP] Bovino, Fernanda [UNESP] Vieira, Dielson da Silva [UNESP] Mendes, Luiz Cláudio Nogueira [UNESP] Peiró, Juliana Regina [UNESP] Alcindo, Jefferson Filgueira de Almeida, Breno Fernando Martins Feitosa, Francisco Leydson Formiga [UNESP] |
author_role |
author |
author2 |
Narciso, Luis Gustavo [UNESP] Trevizan, Juliane Teramachi [UNESP] Bovino, Fernanda [UNESP] Vieira, Dielson da Silva [UNESP] Mendes, Luiz Cláudio Nogueira [UNESP] Peiró, Juliana Regina [UNESP] Alcindo, Jefferson Filgueira de Almeida, Breno Fernando Martins Feitosa, Francisco Leydson Formiga [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Centro Universitário das Faculdades Integradas de Ourinhos (Unifio) Universidade Federal Rural do Semi-Árido (UFERSA) Yale University School of Medicine |
dc.contributor.author.fl_str_mv |
Maschio, Eva Liliane dos Santos Silva [UNESP] Narciso, Luis Gustavo [UNESP] Trevizan, Juliane Teramachi [UNESP] Bovino, Fernanda [UNESP] Vieira, Dielson da Silva [UNESP] Mendes, Luiz Cláudio Nogueira [UNESP] Peiró, Juliana Regina [UNESP] Alcindo, Jefferson Filgueira de Almeida, Breno Fernando Martins Feitosa, Francisco Leydson Formiga [UNESP] |
dc.subject.por.fl_str_mv |
Antioxidant Dexamethasone Goats Oxidant Premature |
topic |
Antioxidant Dexamethasone Goats Oxidant Premature |
description |
The objective of this study was to evaluate the influence of different corticosteroid protocols performed in pregnant does on oxidative stress markers of newborn kids born with 141 days of gestation and does. Reactive oxygen metabolites (D-ROMs) and biological antioxidant potential (BAP) were examine in response to the following four protocols: GI (does: n = 4; newborns kids: n = 7) with a single dose of 20 mg dexamethasone, 2 days prior to elective surgery (139 days of gestation); GII (does: n = 4; newborns kids: n = 6) 2 mg dexamethasone (133–136 days); 4 mg (137−139); and 20 mg at 140 days; GIII (does: n = 4; newborns kids: n = 7) with a dose of 16 mg of dexamethasone (139 days), with repeated doses at 12-h interval until elective surgery; and GIV (does: n = 4; newborns kids: n = 6) using doses of 4, 8, 16, and 20 mg dexamethasone (137, 138, 139, and 140 days). Samples were collected from does 15 min (DM15) after birth and from newborn kids 15 min (M15), 24 h (M24), and 48 h (M48) after birth. When verifying the effect of time in each group, newborn kids from GII, GIII, and GIV presented lower concentrations of D-ROMs at M15 when compared to M48. Newborn kids from GIII and GIV showed increased BAP values at M24 and M48 when compared to M15, respectively. Comparisons between treatments revealed that newborn kids from GI presented higher D-ROMs than those of GII at M15 and GIV at M48. GIV presented higher BAP values than GI, GII, and GII at M48. No significant differences among does were observed considering D-ROMs or BAP values. The protocol for the administration of corticosteroids in does influence the oxidative stress response in newborn kids. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:35:34Z 2023-07-29T13:35:34Z 2023-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.smallrumres.2022.106883 Small Ruminant Research, v. 218. 0921-4488 http://hdl.handle.net/11449/248139 10.1016/j.smallrumres.2022.106883 2-s2.0-85145609449 |
url |
http://dx.doi.org/10.1016/j.smallrumres.2022.106883 http://hdl.handle.net/11449/248139 |
identifier_str_mv |
Small Ruminant Research, v. 218. 0921-4488 10.1016/j.smallrumres.2022.106883 2-s2.0-85145609449 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Small Ruminant Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021361026859008 |