Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy

Detalhes bibliográficos
Autor(a) principal: Maschio, Eva Liliane dos Santos Silva [UNESP]
Data de Publicação: 2023
Outros Autores: Narciso, Luis Gustavo [UNESP], Trevizan, Juliane Teramachi [UNESP], Bovino, Fernanda [UNESP], Vieira, Dielson da Silva [UNESP], Mendes, Luiz Cláudio Nogueira [UNESP], Peiró, Juliana Regina [UNESP], Alcindo, Jefferson Filgueira, de Almeida, Breno Fernando Martins, Feitosa, Francisco Leydson Formiga [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.smallrumres.2022.106883
http://hdl.handle.net/11449/248139
Resumo: The objective of this study was to evaluate the influence of different corticosteroid protocols performed in pregnant does on oxidative stress markers of newborn kids born with 141 days of gestation and does. Reactive oxygen metabolites (D-ROMs) and biological antioxidant potential (BAP) were examine in response to the following four protocols: GI (does: n = 4; newborns kids: n = 7) with a single dose of 20 mg dexamethasone, 2 days prior to elective surgery (139 days of gestation); GII (does: n = 4; newborns kids: n = 6) 2 mg dexamethasone (133–136 days); 4 mg (137−139); and 20 mg at 140 days; GIII (does: n = 4; newborns kids: n = 7) with a dose of 16 mg of dexamethasone (139 days), with repeated doses at 12-h interval until elective surgery; and GIV (does: n = 4; newborns kids: n = 6) using doses of 4, 8, 16, and 20 mg dexamethasone (137, 138, 139, and 140 days). Samples were collected from does 15 min (DM15) after birth and from newborn kids 15 min (M15), 24 h (M24), and 48 h (M48) after birth. When verifying the effect of time in each group, newborn kids from GII, GIII, and GIV presented lower concentrations of D-ROMs at M15 when compared to M48. Newborn kids from GIII and GIV showed increased BAP values at M24 and M48 when compared to M15, respectively. Comparisons between treatments revealed that newborn kids from GI presented higher D-ROMs than those of GII at M15 and GIV at M48. GIV presented higher BAP values than GI, GII, and GII at M48. No significant differences among does were observed considering D-ROMs or BAP values. The protocol for the administration of corticosteroids in does influence the oxidative stress response in newborn kids.
id UNSP_6de48e21b8b1a6b303e59853f2d75bf2
oai_identifier_str oai:repositorio.unesp.br:11449/248139
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapyAntioxidantDexamethasoneGoatsOxidantPrematureThe objective of this study was to evaluate the influence of different corticosteroid protocols performed in pregnant does on oxidative stress markers of newborn kids born with 141 days of gestation and does. Reactive oxygen metabolites (D-ROMs) and biological antioxidant potential (BAP) were examine in response to the following four protocols: GI (does: n = 4; newborns kids: n = 7) with a single dose of 20 mg dexamethasone, 2 days prior to elective surgery (139 days of gestation); GII (does: n = 4; newborns kids: n = 6) 2 mg dexamethasone (133–136 days); 4 mg (137−139); and 20 mg at 140 days; GIII (does: n = 4; newborns kids: n = 7) with a dose of 16 mg of dexamethasone (139 days), with repeated doses at 12-h interval until elective surgery; and GIV (does: n = 4; newborns kids: n = 6) using doses of 4, 8, 16, and 20 mg dexamethasone (137, 138, 139, and 140 days). Samples were collected from does 15 min (DM15) after birth and from newborn kids 15 min (M15), 24 h (M24), and 48 h (M48) after birth. When verifying the effect of time in each group, newborn kids from GII, GIII, and GIV presented lower concentrations of D-ROMs at M15 when compared to M48. Newborn kids from GIII and GIV showed increased BAP values at M24 and M48 when compared to M15, respectively. Comparisons between treatments revealed that newborn kids from GI presented higher D-ROMs than those of GII at M15 and GIV at M48. GIV presented higher BAP values than GI, GII, and GII at M48. No significant differences among does were observed considering D-ROMs or BAP values. The protocol for the administration of corticosteroids in does influence the oxidative stress response in newborn kids.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista (UNESP) Campus de Araçatuba Faculdade de Medicina Veterinária (FMVA) Departamento de Clínica Cirurgia e Reprodução Animal SPUniversidade Estadual Paulista (UNESP) Campus de Jaboticabal Faculdade de Ciências Agrárias e Veterinárias (FCAV) Departamento de Reprodução AnimalEmbrapa Pecuaria Sudeste, Sao PauloCentro Universitário das Faculdades Integradas de Ourinhos (Unifio) Departamento de Medicina Veterinária, São PauloUniversidade Federal Rural do Semi-Árido (UFERSA) Departamento de Ciência Animal, Rio Grande do NorteSection of Infectious Diseases Department of Internal Medicine Yale University School of MedicineUniversidade Estadual Paulista (UNESP) Campus de Araçatuba Faculdade de Medicina Veterinária (FMVA) Departamento de Clínica Cirurgia e Reprodução Animal SPUniversidade Estadual Paulista (UNESP) Campus de Jaboticabal Faculdade de Ciências Agrárias e Veterinárias (FCAV) Departamento de Reprodução AnimalFAPESP: 16/00808-6Universidade Estadual Paulista (UNESP)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Centro Universitário das Faculdades Integradas de Ourinhos (Unifio)Universidade Federal Rural do Semi-Árido (UFERSA)Yale University School of MedicineMaschio, Eva Liliane dos Santos Silva [UNESP]Narciso, Luis Gustavo [UNESP]Trevizan, Juliane Teramachi [UNESP]Bovino, Fernanda [UNESP]Vieira, Dielson da Silva [UNESP]Mendes, Luiz Cláudio Nogueira [UNESP]Peiró, Juliana Regina [UNESP]Alcindo, Jefferson Filgueirade Almeida, Breno Fernando MartinsFeitosa, Francisco Leydson Formiga [UNESP]2023-07-29T13:35:34Z2023-07-29T13:35:34Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.smallrumres.2022.106883Small Ruminant Research, v. 218.0921-4488http://hdl.handle.net/11449/24813910.1016/j.smallrumres.2022.1068832-s2.0-85145609449Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSmall Ruminant Researchinfo:eu-repo/semantics/openAccess2024-09-04T18:03:25Zoai:repositorio.unesp.br:11449/248139Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T18:03:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy
title Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy
spellingShingle Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy
Maschio, Eva Liliane dos Santos Silva [UNESP]
Antioxidant
Dexamethasone
Goats
Oxidant
Premature
title_short Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy
title_full Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy
title_fullStr Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy
title_full_unstemmed Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy
title_sort Oxidative stress in newborn kids and does submitted to different antenatal corticosteroid therapy
author Maschio, Eva Liliane dos Santos Silva [UNESP]
author_facet Maschio, Eva Liliane dos Santos Silva [UNESP]
Narciso, Luis Gustavo [UNESP]
Trevizan, Juliane Teramachi [UNESP]
Bovino, Fernanda [UNESP]
Vieira, Dielson da Silva [UNESP]
Mendes, Luiz Cláudio Nogueira [UNESP]
Peiró, Juliana Regina [UNESP]
Alcindo, Jefferson Filgueira
de Almeida, Breno Fernando Martins
Feitosa, Francisco Leydson Formiga [UNESP]
author_role author
author2 Narciso, Luis Gustavo [UNESP]
Trevizan, Juliane Teramachi [UNESP]
Bovino, Fernanda [UNESP]
Vieira, Dielson da Silva [UNESP]
Mendes, Luiz Cláudio Nogueira [UNESP]
Peiró, Juliana Regina [UNESP]
Alcindo, Jefferson Filgueira
de Almeida, Breno Fernando Martins
Feitosa, Francisco Leydson Formiga [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
Centro Universitário das Faculdades Integradas de Ourinhos (Unifio)
Universidade Federal Rural do Semi-Árido (UFERSA)
Yale University School of Medicine
dc.contributor.author.fl_str_mv Maschio, Eva Liliane dos Santos Silva [UNESP]
Narciso, Luis Gustavo [UNESP]
Trevizan, Juliane Teramachi [UNESP]
Bovino, Fernanda [UNESP]
Vieira, Dielson da Silva [UNESP]
Mendes, Luiz Cláudio Nogueira [UNESP]
Peiró, Juliana Regina [UNESP]
Alcindo, Jefferson Filgueira
de Almeida, Breno Fernando Martins
Feitosa, Francisco Leydson Formiga [UNESP]
dc.subject.por.fl_str_mv Antioxidant
Dexamethasone
Goats
Oxidant
Premature
topic Antioxidant
Dexamethasone
Goats
Oxidant
Premature
description The objective of this study was to evaluate the influence of different corticosteroid protocols performed in pregnant does on oxidative stress markers of newborn kids born with 141 days of gestation and does. Reactive oxygen metabolites (D-ROMs) and biological antioxidant potential (BAP) were examine in response to the following four protocols: GI (does: n = 4; newborns kids: n = 7) with a single dose of 20 mg dexamethasone, 2 days prior to elective surgery (139 days of gestation); GII (does: n = 4; newborns kids: n = 6) 2 mg dexamethasone (133–136 days); 4 mg (137−139); and 20 mg at 140 days; GIII (does: n = 4; newborns kids: n = 7) with a dose of 16 mg of dexamethasone (139 days), with repeated doses at 12-h interval until elective surgery; and GIV (does: n = 4; newborns kids: n = 6) using doses of 4, 8, 16, and 20 mg dexamethasone (137, 138, 139, and 140 days). Samples were collected from does 15 min (DM15) after birth and from newborn kids 15 min (M15), 24 h (M24), and 48 h (M48) after birth. When verifying the effect of time in each group, newborn kids from GII, GIII, and GIV presented lower concentrations of D-ROMs at M15 when compared to M48. Newborn kids from GIII and GIV showed increased BAP values at M24 and M48 when compared to M15, respectively. Comparisons between treatments revealed that newborn kids from GI presented higher D-ROMs than those of GII at M15 and GIV at M48. GIV presented higher BAP values than GI, GII, and GII at M48. No significant differences among does were observed considering D-ROMs or BAP values. The protocol for the administration of corticosteroids in does influence the oxidative stress response in newborn kids.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-29T13:35:34Z
2023-07-29T13:35:34Z
2023-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.smallrumres.2022.106883
Small Ruminant Research, v. 218.
0921-4488
http://hdl.handle.net/11449/248139
10.1016/j.smallrumres.2022.106883
2-s2.0-85145609449
url http://dx.doi.org/10.1016/j.smallrumres.2022.106883
http://hdl.handle.net/11449/248139
identifier_str_mv Small Ruminant Research, v. 218.
0921-4488
10.1016/j.smallrumres.2022.106883
2-s2.0-85145609449
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Small Ruminant Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1810021361026859008