Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits

Detalhes bibliográficos
Autor(a) principal: Cavallini, Daniela C.U. [UNESP]
Data de Publicação: 2010
Outros Autores: Abdalla, Dulcinéia S.P., Pauly-Silveira, Nadiége D. [UNESP], Rossi, Elizeu A. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/226210
Resumo: Oxidized Low-Density Lipoproteins (oxLDL) and autoantibodies against oxLDL are important in the development of atherosclerotic lesions. Statins are efficacious in the control of dyslipidemia and prevention of atherosclerosis; however, many questions concerning the mechanism of action of such drugs remain unknown. This work investigated the effect of simvastatin on generation of autoantibodies against oxLDL and development of atherosclerosis in rabbits. The animals were divided into three groups: control, hypercholesterolemic, and hypercholesterolemic simvastatin (3.0 mg simvastatin/ kg body weight). Concentrations of autoantibodies against oxLDL were determined on days 0, 30 and 60 of the experiment and the atherosclerotic lesions were evaluated at the end of the study. Simvastatin reduced intimal proliferation in the thoracic region, prevented arterial calcification and inhibited the generation of autoantibodies against oxLDL. In conclusion, daily administration of simvastatin slows down atherosclerotic lesion development in rabbits with induced hypercholesterolemia and inhibition on generation of autoantibodies against oxLDL contributes to the cardioprotective effect observed.
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spelling Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbitsAtherosclerosisAutoantibodies against oxidized LDLSimvastatinOxidized Low-Density Lipoproteins (oxLDL) and autoantibodies against oxLDL are important in the development of atherosclerotic lesions. Statins are efficacious in the control of dyslipidemia and prevention of atherosclerosis; however, many questions concerning the mechanism of action of such drugs remain unknown. This work investigated the effect of simvastatin on generation of autoantibodies against oxLDL and development of atherosclerosis in rabbits. The animals were divided into three groups: control, hypercholesterolemic, and hypercholesterolemic simvastatin (3.0 mg simvastatin/ kg body weight). Concentrations of autoantibodies against oxLDL were determined on days 0, 30 and 60 of the experiment and the atherosclerotic lesions were evaluated at the end of the study. Simvastatin reduced intimal proliferation in the thoracic region, prevented arterial calcification and inhibited the generation of autoantibodies against oxLDL. In conclusion, daily administration of simvastatin slows down atherosclerotic lesion development in rabbits with induced hypercholesterolemia and inhibition on generation of autoantibodies against oxLDL contributes to the cardioprotective effect observed.Department of Food and Nutrition Faculty of Pharmaceutical Sciences Sao Paulo State University, Araraquara, SPDepartment of Clinical and Toxicological Analyses Faculty of Pharmaceutical Sciences University of Sao Paulo, Sao PauloDepartment of Food and Nutrition Faculty of Pharmaceutical Sciences Sao Paulo State University, Araraquara, SPUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Cavallini, Daniela C.U. [UNESP]Abdalla, Dulcinéia S.P.Pauly-Silveira, Nadiége D. [UNESP]Rossi, Elizeu A. [UNESP]2022-04-28T22:02:09Z2022-04-28T22:02:09Z2010-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1419-1424Latin American Journal of Pharmacy, v. 29, n. 8, p. 1419-1424, 2010.0326-2383http://hdl.handle.net/11449/2262102-s2.0-78751486891Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLatin American Journal of Pharmacyinfo:eu-repo/semantics/openAccess2024-06-21T12:47:13Zoai:repositorio.unesp.br:11449/226210Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:03:51.848382Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
title Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
spellingShingle Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
Cavallini, Daniela C.U. [UNESP]
Atherosclerosis
Autoantibodies against oxidized LDL
Simvastatin
title_short Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
title_full Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
title_fullStr Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
title_full_unstemmed Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
title_sort Effect of simvastatin on the generation of autoantibodies against oxidized LDL and progression of atherosclerosis in rabbits
author Cavallini, Daniela C.U. [UNESP]
author_facet Cavallini, Daniela C.U. [UNESP]
Abdalla, Dulcinéia S.P.
Pauly-Silveira, Nadiége D. [UNESP]
Rossi, Elizeu A. [UNESP]
author_role author
author2 Abdalla, Dulcinéia S.P.
Pauly-Silveira, Nadiége D. [UNESP]
Rossi, Elizeu A. [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Cavallini, Daniela C.U. [UNESP]
Abdalla, Dulcinéia S.P.
Pauly-Silveira, Nadiége D. [UNESP]
Rossi, Elizeu A. [UNESP]
dc.subject.por.fl_str_mv Atherosclerosis
Autoantibodies against oxidized LDL
Simvastatin
topic Atherosclerosis
Autoantibodies against oxidized LDL
Simvastatin
description Oxidized Low-Density Lipoproteins (oxLDL) and autoantibodies against oxLDL are important in the development of atherosclerotic lesions. Statins are efficacious in the control of dyslipidemia and prevention of atherosclerosis; however, many questions concerning the mechanism of action of such drugs remain unknown. This work investigated the effect of simvastatin on generation of autoantibodies against oxLDL and development of atherosclerosis in rabbits. The animals were divided into three groups: control, hypercholesterolemic, and hypercholesterolemic simvastatin (3.0 mg simvastatin/ kg body weight). Concentrations of autoantibodies against oxLDL were determined on days 0, 30 and 60 of the experiment and the atherosclerotic lesions were evaluated at the end of the study. Simvastatin reduced intimal proliferation in the thoracic region, prevented arterial calcification and inhibited the generation of autoantibodies against oxLDL. In conclusion, daily administration of simvastatin slows down atherosclerotic lesion development in rabbits with induced hypercholesterolemia and inhibition on generation of autoantibodies against oxLDL contributes to the cardioprotective effect observed.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
2022-04-28T22:02:09Z
2022-04-28T22:02:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Latin American Journal of Pharmacy, v. 29, n. 8, p. 1419-1424, 2010.
0326-2383
http://hdl.handle.net/11449/226210
2-s2.0-78751486891
identifier_str_mv Latin American Journal of Pharmacy, v. 29, n. 8, p. 1419-1424, 2010.
0326-2383
2-s2.0-78751486891
url http://hdl.handle.net/11449/226210
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Latin American Journal of Pharmacy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1419-1424
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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