Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium

Detalhes bibliográficos
Autor(a) principal: de Lima, Eliene Cezario
Data de Publicação: 2020
Outros Autores: de Moura, Carolina Foot Gomes, Silva, Marcelo Jose Dias [UNESP], Vilegas, Wagner [UNESP], Santamarina, Aline Boveto, Pisani, Luciana Pellegrini, de Oliveira, Flavia, Ribeiro, Daniel Araki
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s11356-019-07455-2
http://hdl.handle.net/11449/201489
Resumo: The aim of this study was to evaluate the therapeutic properties of Mimosa caesalpiniifolia in liver of rats exposed to cadmium under morphological, oxidative, inflammatory, and mutagenic parameters. A total of 40 Wistar rats (90 days, ~ 250 g) were distributed into eight groups (n = 5) as follows: (i) control; (ii) cadmium: cadmium chloride injection at 1.2 mg/kg; (iii) Mimosa extract: treatment with Mimosa extract at 250 mg/kg; (iv) Mimosa fraction: treatment with Mimosa acetate fraction at 62.5 mg/kg; (v) cadmium and Mimosa extract 62.5: submitted to cadmium chloride at 1.2 mg/kg injection and treatment with Mimosa extract at 62.5 mg/kg; (vi) cadmium and Mimosa extract 125: subjected to cadmium chloride at 1.2 mg/kg injection and treatment with Mimosa extract at 125 mg/kg; (vii) cadmium and Mimosa 250 extract: submitted to cadmium chloride 1.2 mg/kg injection and treatment with Mimosa extract at 250 mg/kg; (viii) cadmium treated with fraction of Mimosa acetate: submitted to cadmium chloride 1.2 mg/kg injection and treatment with acetate fraction of Mimosa extract at 62.5 mg/kg. In the animals intoxicated with cadmium and treated with fraction [62.5], increased expression of SOD-Mn reduced frequency of binucleated hepatocytes, karyolysis, and karyorrhexis, besides the antimutagenic and antioxidant action. The extract [62.5] was cytoprotective, antimutagenic, and reduced karyolysis. The extract [125] was cytoprotective, antioxidant, antifibrotic, anti-inflammatory, and reduced frequency of binucleated hepatocytes, while extract [250] was cytotoxic and mutagenic. In summary, the extract of Mimosa exerts some therapeutic properties in hepatic tissue after Cd intoxication, but only when it is administrated at intermediate doses. Probably, a high content of polyphenols in the EHM [250] and Fr-EtOAc groups exert pro-oxidant activities in the liver particularly when associated with Cd.
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spelling Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmiumAntioxidantsCadmiumCytotoxicity and micronucleusMimosa caesalpiniifoliaThe aim of this study was to evaluate the therapeutic properties of Mimosa caesalpiniifolia in liver of rats exposed to cadmium under morphological, oxidative, inflammatory, and mutagenic parameters. A total of 40 Wistar rats (90 days, ~ 250 g) were distributed into eight groups (n = 5) as follows: (i) control; (ii) cadmium: cadmium chloride injection at 1.2 mg/kg; (iii) Mimosa extract: treatment with Mimosa extract at 250 mg/kg; (iv) Mimosa fraction: treatment with Mimosa acetate fraction at 62.5 mg/kg; (v) cadmium and Mimosa extract 62.5: submitted to cadmium chloride at 1.2 mg/kg injection and treatment with Mimosa extract at 62.5 mg/kg; (vi) cadmium and Mimosa extract 125: subjected to cadmium chloride at 1.2 mg/kg injection and treatment with Mimosa extract at 125 mg/kg; (vii) cadmium and Mimosa 250 extract: submitted to cadmium chloride 1.2 mg/kg injection and treatment with Mimosa extract at 250 mg/kg; (viii) cadmium treated with fraction of Mimosa acetate: submitted to cadmium chloride 1.2 mg/kg injection and treatment with acetate fraction of Mimosa extract at 62.5 mg/kg. In the animals intoxicated with cadmium and treated with fraction [62.5], increased expression of SOD-Mn reduced frequency of binucleated hepatocytes, karyolysis, and karyorrhexis, besides the antimutagenic and antioxidant action. The extract [62.5] was cytoprotective, antimutagenic, and reduced karyolysis. The extract [125] was cytoprotective, antioxidant, antifibrotic, anti-inflammatory, and reduced frequency of binucleated hepatocytes, while extract [250] was cytotoxic and mutagenic. In summary, the extract of Mimosa exerts some therapeutic properties in hepatic tissue after Cd intoxication, but only when it is administrated at intermediate doses. Probably, a high content of polyphenols in the EHM [250] and Fr-EtOAc groups exert pro-oxidant activities in the liver particularly when associated with Cd.Department of Biosciences Federal University of Sao Paulo UNIFESP, Rua Silva Jardim, 136UNESP São Paulo State University, Coastal CampusUNESP São Paulo State University, Coastal CampusUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)de Lima, Eliene Cezariode Moura, Carolina Foot GomesSilva, Marcelo Jose Dias [UNESP]Vilegas, Wagner [UNESP]Santamarina, Aline BovetoPisani, Luciana Pellegrinide Oliveira, FlaviaRibeiro, Daniel Araki2020-12-12T02:33:52Z2020-12-12T02:33:52Z2020-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10981-10989http://dx.doi.org/10.1007/s11356-019-07455-2Environmental Science and Pollution Research, v. 27, n. 10, p. 10981-10989, 2020.1614-74990944-1344http://hdl.handle.net/11449/20148910.1007/s11356-019-07455-22-s2.0-85078300747Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEnvironmental Science and Pollution Researchinfo:eu-repo/semantics/openAccess2021-10-22T20:04:03Zoai:repositorio.unesp.br:11449/201489Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:59:13.535432Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium
title Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium
spellingShingle Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium
de Lima, Eliene Cezario
Antioxidants
Cadmium
Cytotoxicity and micronucleus
Mimosa caesalpiniifolia
title_short Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium
title_full Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium
title_fullStr Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium
title_full_unstemmed Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium
title_sort Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium
author de Lima, Eliene Cezario
author_facet de Lima, Eliene Cezario
de Moura, Carolina Foot Gomes
Silva, Marcelo Jose Dias [UNESP]
Vilegas, Wagner [UNESP]
Santamarina, Aline Boveto
Pisani, Luciana Pellegrini
de Oliveira, Flavia
Ribeiro, Daniel Araki
author_role author
author2 de Moura, Carolina Foot Gomes
Silva, Marcelo Jose Dias [UNESP]
Vilegas, Wagner [UNESP]
Santamarina, Aline Boveto
Pisani, Luciana Pellegrini
de Oliveira, Flavia
Ribeiro, Daniel Araki
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv de Lima, Eliene Cezario
de Moura, Carolina Foot Gomes
Silva, Marcelo Jose Dias [UNESP]
Vilegas, Wagner [UNESP]
Santamarina, Aline Boveto
Pisani, Luciana Pellegrini
de Oliveira, Flavia
Ribeiro, Daniel Araki
dc.subject.por.fl_str_mv Antioxidants
Cadmium
Cytotoxicity and micronucleus
Mimosa caesalpiniifolia
topic Antioxidants
Cadmium
Cytotoxicity and micronucleus
Mimosa caesalpiniifolia
description The aim of this study was to evaluate the therapeutic properties of Mimosa caesalpiniifolia in liver of rats exposed to cadmium under morphological, oxidative, inflammatory, and mutagenic parameters. A total of 40 Wistar rats (90 days, ~ 250 g) were distributed into eight groups (n = 5) as follows: (i) control; (ii) cadmium: cadmium chloride injection at 1.2 mg/kg; (iii) Mimosa extract: treatment with Mimosa extract at 250 mg/kg; (iv) Mimosa fraction: treatment with Mimosa acetate fraction at 62.5 mg/kg; (v) cadmium and Mimosa extract 62.5: submitted to cadmium chloride at 1.2 mg/kg injection and treatment with Mimosa extract at 62.5 mg/kg; (vi) cadmium and Mimosa extract 125: subjected to cadmium chloride at 1.2 mg/kg injection and treatment with Mimosa extract at 125 mg/kg; (vii) cadmium and Mimosa 250 extract: submitted to cadmium chloride 1.2 mg/kg injection and treatment with Mimosa extract at 250 mg/kg; (viii) cadmium treated with fraction of Mimosa acetate: submitted to cadmium chloride 1.2 mg/kg injection and treatment with acetate fraction of Mimosa extract at 62.5 mg/kg. In the animals intoxicated with cadmium and treated with fraction [62.5], increased expression of SOD-Mn reduced frequency of binucleated hepatocytes, karyolysis, and karyorrhexis, besides the antimutagenic and antioxidant action. The extract [62.5] was cytoprotective, antimutagenic, and reduced karyolysis. The extract [125] was cytoprotective, antioxidant, antifibrotic, anti-inflammatory, and reduced frequency of binucleated hepatocytes, while extract [250] was cytotoxic and mutagenic. In summary, the extract of Mimosa exerts some therapeutic properties in hepatic tissue after Cd intoxication, but only when it is administrated at intermediate doses. Probably, a high content of polyphenols in the EHM [250] and Fr-EtOAc groups exert pro-oxidant activities in the liver particularly when associated with Cd.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:33:52Z
2020-12-12T02:33:52Z
2020-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s11356-019-07455-2
Environmental Science and Pollution Research, v. 27, n. 10, p. 10981-10989, 2020.
1614-7499
0944-1344
http://hdl.handle.net/11449/201489
10.1007/s11356-019-07455-2
2-s2.0-85078300747
url http://dx.doi.org/10.1007/s11356-019-07455-2
http://hdl.handle.net/11449/201489
identifier_str_mv Environmental Science and Pollution Research, v. 27, n. 10, p. 10981-10989, 2020.
1614-7499
0944-1344
10.1007/s11356-019-07455-2
2-s2.0-85078300747
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Environmental Science and Pollution Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10981-10989
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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