Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1111/eci.13219 http://hdl.handle.net/11449/198662 |
Resumo: | Background: Inflammatory/immunological serum markers are useful for the early detection of organ dysfunction, helping the diagnosis of sepsis. Although the detection of blood biomarkers is a standard practice, the use of noninvasive samples (eg saliva) would be beneficial. Aim: To investigate the saliva of hospitalized patients with and without sepsis and identify the levels of inflammatory markers such as C-reactive protein (CRP), procalcitonin (PCT), interleukin 6 (IL-6) and nitric oxide (NO). Methods: Saliva samples were collected from 26 patients in intensive care unit with diagnosis of sepsis and from 26 without sepsis (control). The levels of CRP were determined by using latex agglutination test, whereas those of procalcitonin and IL-6 by ELISA and NO by the Griess reaction. Results: Of 26 patients with sepsis, 14 were males (54%) with a mean age of 63.81 ± 3.48 years. The control group had the same distribution for gender, with mean age 65.04 ± 4.07 years. Sepsis group showed higher salivary concentrations of CRP, PCT, IL-6 and NO, with only levels of IL-6 being statistically different (P =.0001). Conclusions: Patients with sepsis had significantly higher levels of IL-6 in their saliva, suggesting that this biological sample could be useful in the diagnosis of this condition. |
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Repositório Institucional da UNESP |
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Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patientsbiomarkersintensive care unitsalivasepsisBackground: Inflammatory/immunological serum markers are useful for the early detection of organ dysfunction, helping the diagnosis of sepsis. Although the detection of blood biomarkers is a standard practice, the use of noninvasive samples (eg saliva) would be beneficial. Aim: To investigate the saliva of hospitalized patients with and without sepsis and identify the levels of inflammatory markers such as C-reactive protein (CRP), procalcitonin (PCT), interleukin 6 (IL-6) and nitric oxide (NO). Methods: Saliva samples were collected from 26 patients in intensive care unit with diagnosis of sepsis and from 26 without sepsis (control). The levels of CRP were determined by using latex agglutination test, whereas those of procalcitonin and IL-6 by ELISA and NO by the Griess reaction. Results: Of 26 patients with sepsis, 14 were males (54%) with a mean age of 63.81 ± 3.48 years. The control group had the same distribution for gender, with mean age 65.04 ± 4.07 years. Sepsis group showed higher salivary concentrations of CRP, PCT, IL-6 and NO, with only levels of IL-6 being statistically different (P =.0001). Conclusions: Patients with sepsis had significantly higher levels of IL-6 in their saliva, suggesting that this biological sample could be useful in the diagnosis of this condition.UNITAU - University of TaubatéUNESP – State of São Paulo UniversityUNISA - University of Santo AmaroHUMANITAS - School of Medical Sciences of São José dos CamposUNESP – State of São Paulo UniversityUNITAU - University of TaubatéUniversidade Estadual Paulista (Unesp)UNISA - University of Santo AmaroHUMANITAS - School of Medical Sciences of São José dos CamposGalhardo, Luciana FreitasRuivo, Gilson Fernandesde Oliveira, Luciane Dias [UNESP]Parize, GrazieleSantos, Silvana Soléo Ferreira DosPallos, DeboraLeão, Mariella Vieira Pereira2020-12-12T01:18:48Z2020-12-12T01:18:48Z2020-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1111/eci.13219European Journal of Clinical Investigation, v. 50, n. 5, 2020.1365-23620014-2972http://hdl.handle.net/11449/19866210.1111/eci.132192-s2.0-85082187740Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Journal of Clinical Investigationinfo:eu-repo/semantics/openAccess2021-10-22T18:27:23Zoai:repositorio.unesp.br:11449/198662Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:36:49.125828Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients |
title |
Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients |
spellingShingle |
Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients Galhardo, Luciana Freitas biomarkers intensive care unit saliva sepsis |
title_short |
Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients |
title_full |
Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients |
title_fullStr |
Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients |
title_full_unstemmed |
Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients |
title_sort |
Inflammatory markers in saliva for diagnosis of sepsis of hospitalizes patients |
author |
Galhardo, Luciana Freitas |
author_facet |
Galhardo, Luciana Freitas Ruivo, Gilson Fernandes de Oliveira, Luciane Dias [UNESP] Parize, Graziele Santos, Silvana Soléo Ferreira Dos Pallos, Debora Leão, Mariella Vieira Pereira |
author_role |
author |
author2 |
Ruivo, Gilson Fernandes de Oliveira, Luciane Dias [UNESP] Parize, Graziele Santos, Silvana Soléo Ferreira Dos Pallos, Debora Leão, Mariella Vieira Pereira |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
UNITAU - University of Taubaté Universidade Estadual Paulista (Unesp) UNISA - University of Santo Amaro HUMANITAS - School of Medical Sciences of São José dos Campos |
dc.contributor.author.fl_str_mv |
Galhardo, Luciana Freitas Ruivo, Gilson Fernandes de Oliveira, Luciane Dias [UNESP] Parize, Graziele Santos, Silvana Soléo Ferreira Dos Pallos, Debora Leão, Mariella Vieira Pereira |
dc.subject.por.fl_str_mv |
biomarkers intensive care unit saliva sepsis |
topic |
biomarkers intensive care unit saliva sepsis |
description |
Background: Inflammatory/immunological serum markers are useful for the early detection of organ dysfunction, helping the diagnosis of sepsis. Although the detection of blood biomarkers is a standard practice, the use of noninvasive samples (eg saliva) would be beneficial. Aim: To investigate the saliva of hospitalized patients with and without sepsis and identify the levels of inflammatory markers such as C-reactive protein (CRP), procalcitonin (PCT), interleukin 6 (IL-6) and nitric oxide (NO). Methods: Saliva samples were collected from 26 patients in intensive care unit with diagnosis of sepsis and from 26 without sepsis (control). The levels of CRP were determined by using latex agglutination test, whereas those of procalcitonin and IL-6 by ELISA and NO by the Griess reaction. Results: Of 26 patients with sepsis, 14 were males (54%) with a mean age of 63.81 ± 3.48 years. The control group had the same distribution for gender, with mean age 65.04 ± 4.07 years. Sepsis group showed higher salivary concentrations of CRP, PCT, IL-6 and NO, with only levels of IL-6 being statistically different (P =.0001). Conclusions: Patients with sepsis had significantly higher levels of IL-6 in their saliva, suggesting that this biological sample could be useful in the diagnosis of this condition. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:18:48Z 2020-12-12T01:18:48Z 2020-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/eci.13219 European Journal of Clinical Investigation, v. 50, n. 5, 2020. 1365-2362 0014-2972 http://hdl.handle.net/11449/198662 10.1111/eci.13219 2-s2.0-85082187740 |
url |
http://dx.doi.org/10.1111/eci.13219 http://hdl.handle.net/11449/198662 |
identifier_str_mv |
European Journal of Clinical Investigation, v. 50, n. 5, 2020. 1365-2362 0014-2972 10.1111/eci.13219 2-s2.0-85082187740 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
European Journal of Clinical Investigation |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128387971022848 |