Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAs
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3748/wjg.v20.i6.1424 http://hdl.handle.net/11449/112843 |
Resumo: | Helicobacter pylori (H. pylori) infection is the most common bacterial infection worldwide. Persistent infection of the gastric mucosa leads to inflammatory processes and may remain silent for decades or progress causing more severe diseases, such as gastric adenocarcinoma. The clinical consequences of H. pylori infection are determined by multiple factors, including host genetic predisposition, gene regulation, environmental factors and heterogeneity of H. pylori virulence factors. After decades of studies of this successful relationship between pathogen and human host, various mechanisms have been elucidated. In this review, we have made an introduction on H. pylori infection and its virulence factors, and focused mainly on modulation of host immune response triggered by bacteria, changes in the pattern of gene expression in H. pylori-infected gastric mucosa, with activation of gene transcription involved in defense mechanisms, inflammatory and immunological response, cell proliferation and apoptosis. We also highlighted the role of bacteria eradication on gene expression levels. In addition, we addressed the recent involvement of different microRNAs in precancerous lesions, gastric cancer, and inflammatory processes induced by bacteria. New discoveries in this field may allow a better understanding of the role of major factors involved in the pathogenic mechanisms of H. pylori. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved. |
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Repositório Institucional da UNESP |
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Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAsHelicobacter pyloriInflammationVirulence factorsImmune responseGastric lesionsGastric cancerGene expressionMicroRNAsHelicobacter pylori (H. pylori) infection is the most common bacterial infection worldwide. Persistent infection of the gastric mucosa leads to inflammatory processes and may remain silent for decades or progress causing more severe diseases, such as gastric adenocarcinoma. The clinical consequences of H. pylori infection are determined by multiple factors, including host genetic predisposition, gene regulation, environmental factors and heterogeneity of H. pylori virulence factors. After decades of studies of this successful relationship between pathogen and human host, various mechanisms have been elucidated. In this review, we have made an introduction on H. pylori infection and its virulence factors, and focused mainly on modulation of host immune response triggered by bacteria, changes in the pattern of gene expression in H. pylori-infected gastric mucosa, with activation of gene transcription involved in defense mechanisms, inflammatory and immunological response, cell proliferation and apoptosis. We also highlighted the role of bacteria eradication on gene expression levels. In addition, we addressed the recent involvement of different microRNAs in precancerous lesions, gastric cancer, and inflammatory processes induced by bacteria. New discoveries in this field may allow a better understanding of the role of major factors involved in the pathogenic mechanisms of H. pylori. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.UNESP Sao Paulo State Univ, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP, BrazilUNESP Sao Paulo State Univ, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP, BrazilBaishideng Publ Grp Co LtdUniversidade Estadual Paulista (Unesp)Targa Cadamuro, Aline Cristina [UNESP]Teixeira Rossi, Ana Flavia [UNESP]Maniezzo, Nathalia Maciel [UNESP]Silva, Ana Elizabete [UNESP]2014-12-03T13:11:06Z2014-12-03T13:11:06Z2014-02-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1424-1437application/pdfhttp://dx.doi.org/10.3748/wjg.v20.i6.1424World Journal Of Gastroenterology. Wanchai: Baishideng Publ Grp Co Ltd, v. 20, n. 6, p. 1424-1437, 2014.1007-9327http://hdl.handle.net/11449/11284310.3748/wjg.v20.i6.1424WOS:000331613300003WOS000331613300003.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengWorld Journal of Gastroenterology3.3001,409info:eu-repo/semantics/openAccess2023-11-14T06:12:28Zoai:repositorio.unesp.br:11449/112843Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:40:20.614448Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAs |
title |
Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAs |
spellingShingle |
Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAs Targa Cadamuro, Aline Cristina [UNESP] Helicobacter pylori Inflammation Virulence factors Immune response Gastric lesions Gastric cancer Gene expression MicroRNAs |
title_short |
Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAs |
title_full |
Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAs |
title_fullStr |
Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAs |
title_full_unstemmed |
Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAs |
title_sort |
Helicobacter pylori infection: Host immune response, implications on gene expression and microRNAs |
author |
Targa Cadamuro, Aline Cristina [UNESP] |
author_facet |
Targa Cadamuro, Aline Cristina [UNESP] Teixeira Rossi, Ana Flavia [UNESP] Maniezzo, Nathalia Maciel [UNESP] Silva, Ana Elizabete [UNESP] |
author_role |
author |
author2 |
Teixeira Rossi, Ana Flavia [UNESP] Maniezzo, Nathalia Maciel [UNESP] Silva, Ana Elizabete [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Targa Cadamuro, Aline Cristina [UNESP] Teixeira Rossi, Ana Flavia [UNESP] Maniezzo, Nathalia Maciel [UNESP] Silva, Ana Elizabete [UNESP] |
dc.subject.por.fl_str_mv |
Helicobacter pylori Inflammation Virulence factors Immune response Gastric lesions Gastric cancer Gene expression MicroRNAs |
topic |
Helicobacter pylori Inflammation Virulence factors Immune response Gastric lesions Gastric cancer Gene expression MicroRNAs |
description |
Helicobacter pylori (H. pylori) infection is the most common bacterial infection worldwide. Persistent infection of the gastric mucosa leads to inflammatory processes and may remain silent for decades or progress causing more severe diseases, such as gastric adenocarcinoma. The clinical consequences of H. pylori infection are determined by multiple factors, including host genetic predisposition, gene regulation, environmental factors and heterogeneity of H. pylori virulence factors. After decades of studies of this successful relationship between pathogen and human host, various mechanisms have been elucidated. In this review, we have made an introduction on H. pylori infection and its virulence factors, and focused mainly on modulation of host immune response triggered by bacteria, changes in the pattern of gene expression in H. pylori-infected gastric mucosa, with activation of gene transcription involved in defense mechanisms, inflammatory and immunological response, cell proliferation and apoptosis. We also highlighted the role of bacteria eradication on gene expression levels. In addition, we addressed the recent involvement of different microRNAs in precancerous lesions, gastric cancer, and inflammatory processes induced by bacteria. New discoveries in this field may allow a better understanding of the role of major factors involved in the pathogenic mechanisms of H. pylori. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-03T13:11:06Z 2014-12-03T13:11:06Z 2014-02-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3748/wjg.v20.i6.1424 World Journal Of Gastroenterology. Wanchai: Baishideng Publ Grp Co Ltd, v. 20, n. 6, p. 1424-1437, 2014. 1007-9327 http://hdl.handle.net/11449/112843 10.3748/wjg.v20.i6.1424 WOS:000331613300003 WOS000331613300003.pdf |
url |
http://dx.doi.org/10.3748/wjg.v20.i6.1424 http://hdl.handle.net/11449/112843 |
identifier_str_mv |
World Journal Of Gastroenterology. Wanchai: Baishideng Publ Grp Co Ltd, v. 20, n. 6, p. 1424-1437, 2014. 1007-9327 10.3748/wjg.v20.i6.1424 WOS:000331613300003 WOS000331613300003.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
World Journal of Gastroenterology 3.300 1,409 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1424-1437 application/pdf |
dc.publisher.none.fl_str_mv |
Baishideng Publ Grp Co Ltd |
publisher.none.fl_str_mv |
Baishideng Publ Grp Co Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128840857288704 |