Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0157584 http://hdl.handle.net/11449/161621 |
Resumo: | Preeclampsia (PE) is considered the leading cause of maternal and perinatal morbidity and mortality. The placenta seems to play an essential role in this disease, probably due to factors involved in its formation and development. The present study aimed to investigate the association between placental lesions, cytokines and angiogenic factors in pregnant women with preeclampsia (PE). We evaluated 20 normotensive pregnant women, 40 with early-onset PE and 80 with late-onset PE. Placental samples were analyzed for histopathology, immunohistochemistry and determination of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-10 (IL-10), transforming growth factor-beta 1 (TGF-beta 1), tumor necrosis factor-alpha (TNF-alpha), placental growth factor (PlGF), vascular endothelial growth factor (VEGF), fms-like tyrosine-kinase-1 (Flt-1) and endoglin (Eng) levels. Higher percentages of increased syncytial knots and increased perivillous fibrin deposits, and greater levels of TNF-alpha, TGF-beta 1 and Flt-1 were detected in placentas from early-onset PE. Levels of IL-10, VEGF and PlGF were decreased in PE versus normotensive placentas. Both the TNF-alpha/IL-10 and sFlt-1/PlGF ratios were higher in placental homogenate of early-onset PE than late-onset PE and control groups. The more severe lesions and the imbalance between TNF-alpha/IL-10 and PlGF/sFlt-1 in placentas from early-onset PE allows differentiation of early and late-onset PE and suggests higher placental impairment in early-onset PE. |
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Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with PreeclampsiaPreeclampsia (PE) is considered the leading cause of maternal and perinatal morbidity and mortality. The placenta seems to play an essential role in this disease, probably due to factors involved in its formation and development. The present study aimed to investigate the association between placental lesions, cytokines and angiogenic factors in pregnant women with preeclampsia (PE). We evaluated 20 normotensive pregnant women, 40 with early-onset PE and 80 with late-onset PE. Placental samples were analyzed for histopathology, immunohistochemistry and determination of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-10 (IL-10), transforming growth factor-beta 1 (TGF-beta 1), tumor necrosis factor-alpha (TNF-alpha), placental growth factor (PlGF), vascular endothelial growth factor (VEGF), fms-like tyrosine-kinase-1 (Flt-1) and endoglin (Eng) levels. Higher percentages of increased syncytial knots and increased perivillous fibrin deposits, and greater levels of TNF-alpha, TGF-beta 1 and Flt-1 were detected in placentas from early-onset PE. Levels of IL-10, VEGF and PlGF were decreased in PE versus normotensive placentas. Both the TNF-alpha/IL-10 and sFlt-1/PlGF ratios were higher in placental homogenate of early-onset PE than late-onset PE and control groups. The more severe lesions and the imbalance between TNF-alpha/IL-10 and PlGF/sFlt-1 in placentas from early-onset PE allows differentiation of early and late-onset PE and suggests higher placental impairment in early-onset PE.Sao Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynaecol, BR-18618970 Botucatu, SP, BrazilNew York Presbyterian Hosp, Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY USAWeill Cornell Med Coll, Dept Obstet & Gynecol, New York, NY USASao Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, BR-18618970 Botucatu, SP, BrazilSao Paulo State Univ, Botucatu Med Sch, Dept Obstet & Gynaecol, BR-18618970 Botucatu, SP, BrazilSao Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, BR-18618970 Botucatu, SP, BrazilPublic Library ScienceUniversidade Estadual Paulista (Unesp)New York Presbyterian HospWeill Cornell Med CollWeel, Ingrid C. [UNESP]Baergen, Rebecca N.Romao-Veiga, Mariana [UNESP]Borges, Vera T. [UNESP]Ribeiro, Vanessa R. [UNESP]Witkin, Steven S.Bannwart-Castro, Camila [UNESP]Peracoli, Jose C. [UNESP]De Oliveira, Leandro [UNESP]Peracoli, Maria T. [UNESP]2018-11-26T16:40:42Z2018-11-26T16:40:42Z2016-06-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article15application/pdfhttp://dx.doi.org/10.1371/journal.pone.0157584Plos One. San Francisco: Public Library Science, v. 11, n. 6, 15 p., 2016.1932-6203http://hdl.handle.net/11449/16162110.1371/journal.pone.0157584WOS:000378030000039WOS000378030000039.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPlos One1,164info:eu-repo/semantics/openAccess2024-08-16T14:12:36Zoai:repositorio.unesp.br:11449/161621Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:12:36Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia |
title |
Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia |
spellingShingle |
Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia Weel, Ingrid C. [UNESP] |
title_short |
Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia |
title_full |
Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia |
title_fullStr |
Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia |
title_full_unstemmed |
Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia |
title_sort |
Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia |
author |
Weel, Ingrid C. [UNESP] |
author_facet |
Weel, Ingrid C. [UNESP] Baergen, Rebecca N. Romao-Veiga, Mariana [UNESP] Borges, Vera T. [UNESP] Ribeiro, Vanessa R. [UNESP] Witkin, Steven S. Bannwart-Castro, Camila [UNESP] Peracoli, Jose C. [UNESP] De Oliveira, Leandro [UNESP] Peracoli, Maria T. [UNESP] |
author_role |
author |
author2 |
Baergen, Rebecca N. Romao-Veiga, Mariana [UNESP] Borges, Vera T. [UNESP] Ribeiro, Vanessa R. [UNESP] Witkin, Steven S. Bannwart-Castro, Camila [UNESP] Peracoli, Jose C. [UNESP] De Oliveira, Leandro [UNESP] Peracoli, Maria T. [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) New York Presbyterian Hosp Weill Cornell Med Coll |
dc.contributor.author.fl_str_mv |
Weel, Ingrid C. [UNESP] Baergen, Rebecca N. Romao-Veiga, Mariana [UNESP] Borges, Vera T. [UNESP] Ribeiro, Vanessa R. [UNESP] Witkin, Steven S. Bannwart-Castro, Camila [UNESP] Peracoli, Jose C. [UNESP] De Oliveira, Leandro [UNESP] Peracoli, Maria T. [UNESP] |
description |
Preeclampsia (PE) is considered the leading cause of maternal and perinatal morbidity and mortality. The placenta seems to play an essential role in this disease, probably due to factors involved in its formation and development. The present study aimed to investigate the association between placental lesions, cytokines and angiogenic factors in pregnant women with preeclampsia (PE). We evaluated 20 normotensive pregnant women, 40 with early-onset PE and 80 with late-onset PE. Placental samples were analyzed for histopathology, immunohistochemistry and determination of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-10 (IL-10), transforming growth factor-beta 1 (TGF-beta 1), tumor necrosis factor-alpha (TNF-alpha), placental growth factor (PlGF), vascular endothelial growth factor (VEGF), fms-like tyrosine-kinase-1 (Flt-1) and endoglin (Eng) levels. Higher percentages of increased syncytial knots and increased perivillous fibrin deposits, and greater levels of TNF-alpha, TGF-beta 1 and Flt-1 were detected in placentas from early-onset PE. Levels of IL-10, VEGF and PlGF were decreased in PE versus normotensive placentas. Both the TNF-alpha/IL-10 and sFlt-1/PlGF ratios were higher in placental homogenate of early-onset PE than late-onset PE and control groups. The more severe lesions and the imbalance between TNF-alpha/IL-10 and PlGF/sFlt-1 in placentas from early-onset PE allows differentiation of early and late-onset PE and suggests higher placental impairment in early-onset PE. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-17 2018-11-26T16:40:42Z 2018-11-26T16:40:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0157584 Plos One. San Francisco: Public Library Science, v. 11, n. 6, 15 p., 2016. 1932-6203 http://hdl.handle.net/11449/161621 10.1371/journal.pone.0157584 WOS:000378030000039 WOS000378030000039.pdf |
url |
http://dx.doi.org/10.1371/journal.pone.0157584 http://hdl.handle.net/11449/161621 |
identifier_str_mv |
Plos One. San Francisco: Public Library Science, v. 11, n. 6, 15 p., 2016. 1932-6203 10.1371/journal.pone.0157584 WOS:000378030000039 WOS000378030000039.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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Plos One 1,164 |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
15 application/pdf |
dc.publisher.none.fl_str_mv |
Public Library Science |
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Public Library Science |
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Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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