Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?

Detalhes bibliográficos
Autor(a) principal: Barbosa, Walnei Fernandes [UNESP]
Data de Publicação: 2021
Outros Autores: Andrade, Vanessa Gutierrez [UNESP], Braz, Aline Márcia Marques [UNESP], Winckler, Fernanda Cristina [UNESP], Barbosa, Livia Roma, Golim, Márjorie de Assis [UNESP], Silveira, Liciana Vaz de Arruda [UNESP], Simões, Rafael Plana [UNESP], Silva, Giovanni Faria [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s10238-021-00749-1
http://hdl.handle.net/11449/229261
Resumo: Hepatitis C virus has infected over 71 million people worldwide, and it is the main cause of cirrhosis in the western world. Currently, the treatment involves direct-acting antiviral agents (DAAs) and its main goal is to achieve sustained virologic response (SVR). The aim of this study was to evaluate the impact of SVR using DAAs in the improvement of liver fibrosis using scores evaluation by indirect method, liver function, and inflammation indirect biomarkers. Patients with cirrhosis with SVR after treatment (n = 104) were evaluated using liver function scores, indirect fibrosis methods, alpha-fetoprotein, and ferritin at t-base and t-SVR. Statistically significant positive results in all parameters were observed: 54 patients were classified as 5 in the CP score in t-base, and 77 in t-SVR; a significant decrease was observed in MELD score, alpha-fetoprotein, ferritin, APRI, FIB-4 and liver stiffness in liver elastography. We did not observe difference in the liver function scores between regressors and non-regressors of liver stiffness, as well as in indirect inflammation biomarkers. The measurements of fibrosis using the indirect methods have significantly decreased in patients with cirrhosis treated who achieved SVR associated with decreased indirect inflammation biomarkers and improved liver function scores.
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spelling Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?CirrhosisDAAsFibrosis regressionHCVStiffnessHepatitis C virus has infected over 71 million people worldwide, and it is the main cause of cirrhosis in the western world. Currently, the treatment involves direct-acting antiviral agents (DAAs) and its main goal is to achieve sustained virologic response (SVR). The aim of this study was to evaluate the impact of SVR using DAAs in the improvement of liver fibrosis using scores evaluation by indirect method, liver function, and inflammation indirect biomarkers. Patients with cirrhosis with SVR after treatment (n = 104) were evaluated using liver function scores, indirect fibrosis methods, alpha-fetoprotein, and ferritin at t-base and t-SVR. Statistically significant positive results in all parameters were observed: 54 patients were classified as 5 in the CP score in t-base, and 77 in t-SVR; a significant decrease was observed in MELD score, alpha-fetoprotein, ferritin, APRI, FIB-4 and liver stiffness in liver elastography. We did not observe difference in the liver function scores between regressors and non-regressors of liver stiffness, as well as in indirect inflammation biomarkers. The measurements of fibrosis using the indirect methods have significantly decreased in patients with cirrhosis treated who achieved SVR associated with decreased indirect inflammation biomarkers and improved liver function scores.Department of Clinical Medicine Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n – UNESPUndergraduate Course in Medicine Taubaté Medical School - UNITAUGraduate Program in Research and Development (Medical Biotechnology) Botucatu Medical School São Paulo State University (UNESP)Department of Bioestatistics Institute of Biosciences of Botucatu São Paulo State University (UNESP)Department of Biotechnology and Bioprocess Engineering Faculty of Agronomic Sciences São Paulo State University (UNESP)Department of Clinical Medicine Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n – UNESPGraduate Program in Research and Development (Medical Biotechnology) Botucatu Medical School São Paulo State University (UNESP)Department of Bioestatistics Institute of Biosciences of Botucatu São Paulo State University (UNESP)Department of Biotechnology and Bioprocess Engineering Faculty of Agronomic Sciences São Paulo State University (UNESP)Universidade Estadual Paulista (UNESP)Taubaté Medical School - UNITAUBarbosa, Walnei Fernandes [UNESP]Andrade, Vanessa Gutierrez [UNESP]Braz, Aline Márcia Marques [UNESP]Winckler, Fernanda Cristina [UNESP]Barbosa, Livia RomaGolim, Márjorie de Assis [UNESP]Silveira, Liciana Vaz de Arruda [UNESP]Simões, Rafael Plana [UNESP]Silva, Giovanni Faria [UNESP]2022-04-29T08:31:28Z2022-04-29T08:31:28Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s10238-021-00749-1Clinical and Experimental Medicine.1591-95281591-8890http://hdl.handle.net/11449/22926110.1007/s10238-021-00749-12-s2.0-85111766815Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical and Experimental Medicineinfo:eu-repo/semantics/openAccess2022-04-29T08:31:28Zoai:repositorio.unesp.br:11449/229261Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:06:46.520173Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?
title Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?
spellingShingle Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?
Barbosa, Walnei Fernandes [UNESP]
Cirrhosis
DAAs
Fibrosis regression
HCV
Stiffness
title_short Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?
title_full Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?
title_fullStr Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?
title_full_unstemmed Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?
title_sort Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?
author Barbosa, Walnei Fernandes [UNESP]
author_facet Barbosa, Walnei Fernandes [UNESP]
Andrade, Vanessa Gutierrez [UNESP]
Braz, Aline Márcia Marques [UNESP]
Winckler, Fernanda Cristina [UNESP]
Barbosa, Livia Roma
Golim, Márjorie de Assis [UNESP]
Silveira, Liciana Vaz de Arruda [UNESP]
Simões, Rafael Plana [UNESP]
Silva, Giovanni Faria [UNESP]
author_role author
author2 Andrade, Vanessa Gutierrez [UNESP]
Braz, Aline Márcia Marques [UNESP]
Winckler, Fernanda Cristina [UNESP]
Barbosa, Livia Roma
Golim, Márjorie de Assis [UNESP]
Silveira, Liciana Vaz de Arruda [UNESP]
Simões, Rafael Plana [UNESP]
Silva, Giovanni Faria [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Taubaté Medical School - UNITAU
dc.contributor.author.fl_str_mv Barbosa, Walnei Fernandes [UNESP]
Andrade, Vanessa Gutierrez [UNESP]
Braz, Aline Márcia Marques [UNESP]
Winckler, Fernanda Cristina [UNESP]
Barbosa, Livia Roma
Golim, Márjorie de Assis [UNESP]
Silveira, Liciana Vaz de Arruda [UNESP]
Simões, Rafael Plana [UNESP]
Silva, Giovanni Faria [UNESP]
dc.subject.por.fl_str_mv Cirrhosis
DAAs
Fibrosis regression
HCV
Stiffness
topic Cirrhosis
DAAs
Fibrosis regression
HCV
Stiffness
description Hepatitis C virus has infected over 71 million people worldwide, and it is the main cause of cirrhosis in the western world. Currently, the treatment involves direct-acting antiviral agents (DAAs) and its main goal is to achieve sustained virologic response (SVR). The aim of this study was to evaluate the impact of SVR using DAAs in the improvement of liver fibrosis using scores evaluation by indirect method, liver function, and inflammation indirect biomarkers. Patients with cirrhosis with SVR after treatment (n = 104) were evaluated using liver function scores, indirect fibrosis methods, alpha-fetoprotein, and ferritin at t-base and t-SVR. Statistically significant positive results in all parameters were observed: 54 patients were classified as 5 in the CP score in t-base, and 77 in t-SVR; a significant decrease was observed in MELD score, alpha-fetoprotein, ferritin, APRI, FIB-4 and liver stiffness in liver elastography. We did not observe difference in the liver function scores between regressors and non-regressors of liver stiffness, as well as in indirect inflammation biomarkers. The measurements of fibrosis using the indirect methods have significantly decreased in patients with cirrhosis treated who achieved SVR associated with decreased indirect inflammation biomarkers and improved liver function scores.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
2022-04-29T08:31:28Z
2022-04-29T08:31:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s10238-021-00749-1
Clinical and Experimental Medicine.
1591-9528
1591-8890
http://hdl.handle.net/11449/229261
10.1007/s10238-021-00749-1
2-s2.0-85111766815
url http://dx.doi.org/10.1007/s10238-021-00749-1
http://hdl.handle.net/11449/229261
identifier_str_mv Clinical and Experimental Medicine.
1591-9528
1591-8890
10.1007/s10238-021-00749-1
2-s2.0-85111766815
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical and Experimental Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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