Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10238-021-00749-1 http://hdl.handle.net/11449/229261 |
Resumo: | Hepatitis C virus has infected over 71 million people worldwide, and it is the main cause of cirrhosis in the western world. Currently, the treatment involves direct-acting antiviral agents (DAAs) and its main goal is to achieve sustained virologic response (SVR). The aim of this study was to evaluate the impact of SVR using DAAs in the improvement of liver fibrosis using scores evaluation by indirect method, liver function, and inflammation indirect biomarkers. Patients with cirrhosis with SVR after treatment (n = 104) were evaluated using liver function scores, indirect fibrosis methods, alpha-fetoprotein, and ferritin at t-base and t-SVR. Statistically significant positive results in all parameters were observed: 54 patients were classified as 5 in the CP score in t-base, and 77 in t-SVR; a significant decrease was observed in MELD score, alpha-fetoprotein, ferritin, APRI, FIB-4 and liver stiffness in liver elastography. We did not observe difference in the liver function scores between regressors and non-regressors of liver stiffness, as well as in indirect inflammation biomarkers. The measurements of fibrosis using the indirect methods have significantly decreased in patients with cirrhosis treated who achieved SVR associated with decreased indirect inflammation biomarkers and improved liver function scores. |
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Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real?CirrhosisDAAsFibrosis regressionHCVStiffnessHepatitis C virus has infected over 71 million people worldwide, and it is the main cause of cirrhosis in the western world. Currently, the treatment involves direct-acting antiviral agents (DAAs) and its main goal is to achieve sustained virologic response (SVR). The aim of this study was to evaluate the impact of SVR using DAAs in the improvement of liver fibrosis using scores evaluation by indirect method, liver function, and inflammation indirect biomarkers. Patients with cirrhosis with SVR after treatment (n = 104) were evaluated using liver function scores, indirect fibrosis methods, alpha-fetoprotein, and ferritin at t-base and t-SVR. Statistically significant positive results in all parameters were observed: 54 patients were classified as 5 in the CP score in t-base, and 77 in t-SVR; a significant decrease was observed in MELD score, alpha-fetoprotein, ferritin, APRI, FIB-4 and liver stiffness in liver elastography. We did not observe difference in the liver function scores between regressors and non-regressors of liver stiffness, as well as in indirect inflammation biomarkers. The measurements of fibrosis using the indirect methods have significantly decreased in patients with cirrhosis treated who achieved SVR associated with decreased indirect inflammation biomarkers and improved liver function scores.Department of Clinical Medicine Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n – UNESPUndergraduate Course in Medicine Taubaté Medical School - UNITAUGraduate Program in Research and Development (Medical Biotechnology) Botucatu Medical School São Paulo State University (UNESP)Department of Bioestatistics Institute of Biosciences of Botucatu São Paulo State University (UNESP)Department of Biotechnology and Bioprocess Engineering Faculty of Agronomic Sciences São Paulo State University (UNESP)Department of Clinical Medicine Botucatu Medical School São Paulo State University (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n – UNESPGraduate Program in Research and Development (Medical Biotechnology) Botucatu Medical School São Paulo State University (UNESP)Department of Bioestatistics Institute of Biosciences of Botucatu São Paulo State University (UNESP)Department of Biotechnology and Bioprocess Engineering Faculty of Agronomic Sciences São Paulo State University (UNESP)Universidade Estadual Paulista (UNESP)Taubaté Medical School - UNITAUBarbosa, Walnei Fernandes [UNESP]Andrade, Vanessa Gutierrez [UNESP]Braz, Aline Márcia Marques [UNESP]Winckler, Fernanda Cristina [UNESP]Barbosa, Livia RomaGolim, Márjorie de Assis [UNESP]Silveira, Liciana Vaz de Arruda [UNESP]Simões, Rafael Plana [UNESP]Silva, Giovanni Faria [UNESP]2022-04-29T08:31:28Z2022-04-29T08:31:28Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s10238-021-00749-1Clinical and Experimental Medicine.1591-95281591-8890http://hdl.handle.net/11449/22926110.1007/s10238-021-00749-12-s2.0-85111766815Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical and Experimental Medicineinfo:eu-repo/semantics/openAccess2022-04-29T08:31:28Zoai:repositorio.unesp.br:11449/229261Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:06:46.520173Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real? |
title |
Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real? |
spellingShingle |
Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real? Barbosa, Walnei Fernandes [UNESP] Cirrhosis DAAs Fibrosis regression HCV Stiffness |
title_short |
Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real? |
title_full |
Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real? |
title_fullStr |
Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real? |
title_full_unstemmed |
Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real? |
title_sort |
Cirrhosis regression after SVR with indirect methods of fibrosis analysis: How far is it real? |
author |
Barbosa, Walnei Fernandes [UNESP] |
author_facet |
Barbosa, Walnei Fernandes [UNESP] Andrade, Vanessa Gutierrez [UNESP] Braz, Aline Márcia Marques [UNESP] Winckler, Fernanda Cristina [UNESP] Barbosa, Livia Roma Golim, Márjorie de Assis [UNESP] Silveira, Liciana Vaz de Arruda [UNESP] Simões, Rafael Plana [UNESP] Silva, Giovanni Faria [UNESP] |
author_role |
author |
author2 |
Andrade, Vanessa Gutierrez [UNESP] Braz, Aline Márcia Marques [UNESP] Winckler, Fernanda Cristina [UNESP] Barbosa, Livia Roma Golim, Márjorie de Assis [UNESP] Silveira, Liciana Vaz de Arruda [UNESP] Simões, Rafael Plana [UNESP] Silva, Giovanni Faria [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Taubaté Medical School - UNITAU |
dc.contributor.author.fl_str_mv |
Barbosa, Walnei Fernandes [UNESP] Andrade, Vanessa Gutierrez [UNESP] Braz, Aline Márcia Marques [UNESP] Winckler, Fernanda Cristina [UNESP] Barbosa, Livia Roma Golim, Márjorie de Assis [UNESP] Silveira, Liciana Vaz de Arruda [UNESP] Simões, Rafael Plana [UNESP] Silva, Giovanni Faria [UNESP] |
dc.subject.por.fl_str_mv |
Cirrhosis DAAs Fibrosis regression HCV Stiffness |
topic |
Cirrhosis DAAs Fibrosis regression HCV Stiffness |
description |
Hepatitis C virus has infected over 71 million people worldwide, and it is the main cause of cirrhosis in the western world. Currently, the treatment involves direct-acting antiviral agents (DAAs) and its main goal is to achieve sustained virologic response (SVR). The aim of this study was to evaluate the impact of SVR using DAAs in the improvement of liver fibrosis using scores evaluation by indirect method, liver function, and inflammation indirect biomarkers. Patients with cirrhosis with SVR after treatment (n = 104) were evaluated using liver function scores, indirect fibrosis methods, alpha-fetoprotein, and ferritin at t-base and t-SVR. Statistically significant positive results in all parameters were observed: 54 patients were classified as 5 in the CP score in t-base, and 77 in t-SVR; a significant decrease was observed in MELD score, alpha-fetoprotein, ferritin, APRI, FIB-4 and liver stiffness in liver elastography. We did not observe difference in the liver function scores between regressors and non-regressors of liver stiffness, as well as in indirect inflammation biomarkers. The measurements of fibrosis using the indirect methods have significantly decreased in patients with cirrhosis treated who achieved SVR associated with decreased indirect inflammation biomarkers and improved liver function scores. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-29T08:31:28Z 2022-04-29T08:31:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10238-021-00749-1 Clinical and Experimental Medicine. 1591-9528 1591-8890 http://hdl.handle.net/11449/229261 10.1007/s10238-021-00749-1 2-s2.0-85111766815 |
url |
http://dx.doi.org/10.1007/s10238-021-00749-1 http://hdl.handle.net/11449/229261 |
identifier_str_mv |
Clinical and Experimental Medicine. 1591-9528 1591-8890 10.1007/s10238-021-00749-1 2-s2.0-85111766815 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical and Experimental Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128897324154880 |