Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorial

Detalhes bibliográficos
Autor(a) principal: Sabes, Amanda Festa [UNESP]
Data de Publicação: 2015
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/136729
http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/22-03-2016/000860307.pdf
Resumo: The sheep meet industry is constantly rising in Brazil and this fact leads to an increase on the number of confined animals, looking for greater weight gain in short period of time. This situation predisposes to disorders such as acute lactic ruminal acidosis (ARLA) and, consequently, acute laminitis, which causes economic problems by the treatment costs, reduced productivity and disposal of animals. Ten adult sheep were induced to ALRA by oral administration of sucrose; were further evaluated to physical examination, arterial blood gas analysis, hematological parameters, glucose and lactate plasma, serum protein profile and zymography for detection of metalloproteinases 2 and 9. All animals had clinical signs of ARLA, the respiratory rate remained high up to 36 hours, returning to normal in 48 hours. Five animals showed typical clinical signs of acute laminitis, however clinical treatment was not necessary. The values of the red blood cell count, packed cell volume, hemoglobin, total leukocytes and neutrophils and segmented rod rases in 24 hours. Glucose content increased up to eight hours by increasing the synthesis of volatile fatty acids and subsequent blood absorption; lactate has increased to 24 hours, with a subsequent decrease. From four hours there was an increase of pH, bicarbonate and base excess. After 12 hours, the animals had metabolic acidosis. At 28 hours there was normalization of the hemogasometry parameters without need of treatment. In serum protein were identified 13 proteins: immunoglobulins A (IgA) and G (IgG), ceruloplasmin (Cp), transferrin (Tf), albumin (Ab), 1-antitrypsin ( 1AT), haptoglobin (Hp), 1- acid glycoprotein ( 1GA), 95 (MWP95), 46 (MWP46), 36 (MWP36) and 31 (MWP31) kDa molecular weight protein In all animals with ARLA the total protein showed changes from 08 hours, coinciding with clinical signs of dehydration, which occurred up to 36 hours after induction. Although five animals shown clinical ...
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spelling Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorialOvinoOvelhaGasometriaLaminiteMetaloproteinase 2 da matrizMetaloproteinase 9 da MatrizAcidoseSheepThe sheep meet industry is constantly rising in Brazil and this fact leads to an increase on the number of confined animals, looking for greater weight gain in short period of time. This situation predisposes to disorders such as acute lactic ruminal acidosis (ARLA) and, consequently, acute laminitis, which causes economic problems by the treatment costs, reduced productivity and disposal of animals. Ten adult sheep were induced to ALRA by oral administration of sucrose; were further evaluated to physical examination, arterial blood gas analysis, hematological parameters, glucose and lactate plasma, serum protein profile and zymography for detection of metalloproteinases 2 and 9. All animals had clinical signs of ARLA, the respiratory rate remained high up to 36 hours, returning to normal in 48 hours. Five animals showed typical clinical signs of acute laminitis, however clinical treatment was not necessary. The values of the red blood cell count, packed cell volume, hemoglobin, total leukocytes and neutrophils and segmented rod rases in 24 hours. Glucose content increased up to eight hours by increasing the synthesis of volatile fatty acids and subsequent blood absorption; lactate has increased to 24 hours, with a subsequent decrease. From four hours there was an increase of pH, bicarbonate and base excess. After 12 hours, the animals had metabolic acidosis. At 28 hours there was normalization of the hemogasometry parameters without need of treatment. In serum protein were identified 13 proteins: immunoglobulins A (IgA) and G (IgG), ceruloplasmin (Cp), transferrin (Tf), albumin (Ab), 1-antitrypsin ( 1AT), haptoglobin (Hp), 1- acid glycoprotein ( 1GA), 95 (MWP95), 46 (MWP46), 36 (MWP36) and 31 (MWP31) kDa molecular weight protein In all animals with ARLA the total protein showed changes from 08 hours, coinciding with clinical signs of dehydration, which occurred up to 36 hours after induction. Although five animals shown clinical ...A ovinocultura de corte está em constante ascensão no Brasil e tal fato leva ao aumento do número de animais confinados, visando maior ganho de peso em curto período de tempo. Tal situação predispõe os ovinos a desordens como acidose láctica ruminal aguda (ALRA) e, consequentemente, laminite aguda, as quais geram problemas econômicos pelos custos do tratamento, menor produtividade do rebanho e descarte de animais. Dez ovelhas adultas foram induzidas à ALRA através da administração oral de sacarose; posteriormente foram avaliadas quando ao exame físico além das análises hemogasométricas arteriais, hematológicas, avaliação da glicose e lactato plasmáticos, proteinograma sérico e zimografia para detecção das metaloproteinases 2 e 9. Todos os animais tiveram sinais clínicos de ALRA, a frequência respiratória permaneceu elevada até às 36 horas, retornando à normalidade com 48 horas. Cinco animais apresentam sinais clínicos característicos de laminite aguda, porém não foi necessária a realização de tratamento clínico. Os valores da contagem de hemácias, volume globular, hemoglobina, leucócitos totais e neutrófilos bastonetes e segmentados elevaram-se nas 24 horas. Os teores de glicose aumentaram até as 8 horas pelo aumento da síntese dos ácidos graxos voláteis e posterior absorção sanguínea; o lactato apresentou aumento até as 24 horas, com posterior diminuição dos valores. A partir de 4 horas ocorreu elevação do pH, bicarbonato e excesso de base. Após 12 horas, os animais apresentaram acidose metabólica. Com 28 horas houve normalização dos parâmetros hemogasimétricos, sem necessidade de tratamento. No proteinograma sérico foram identificadas 13 proteínas: imunoglobulinas A (IgA) e G (IgG), ceruloplasmina (Cp), transferrina (Tf), albumina (Ab), 1-antitripsina ( 1AT), haptoglobina (Hp), 1-glicoproteína ácida ( 1GA), 95 (PPM95), 46 (PPM46), 36 (PPM36) e 31 (PMM31) kDa proteínas de...Universidade Estadual Paulista (Unesp)Marques, Luiz Carlos [UNESP]Universidade Estadual Paulista (Unesp)Sabes, Amanda Festa [UNESP]2016-04-01T17:54:59Z2016-04-01T17:54:59Z2015-11-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisxii, 87 p. : il.application/pdfSABES, Amanda Festa. Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorial. 2015. xii, 87 p. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, 2015.http://hdl.handle.net/11449/136729000860307http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/22-03-2016/000860307.pdf33004102072P93281538474011979Alephreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporinfo:eu-repo/semantics/openAccess2024-06-05T13:47:28Zoai:repositorio.unesp.br:11449/136729Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:25:46.670181Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorial
title Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorial
spellingShingle Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorial
Sabes, Amanda Festa [UNESP]
Ovino
Ovelha
Gasometria
Laminite
Metaloproteinase 2 da matriz
Metaloproteinase 9 da Matriz
Acidose
Sheep
title_short Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorial
title_full Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorial
title_fullStr Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorial
title_full_unstemmed Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorial
title_sort Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorial
author Sabes, Amanda Festa [UNESP]
author_facet Sabes, Amanda Festa [UNESP]
author_role author
dc.contributor.none.fl_str_mv Marques, Luiz Carlos [UNESP]
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Sabes, Amanda Festa [UNESP]
dc.subject.por.fl_str_mv Ovino
Ovelha
Gasometria
Laminite
Metaloproteinase 2 da matriz
Metaloproteinase 9 da Matriz
Acidose
Sheep
topic Ovino
Ovelha
Gasometria
Laminite
Metaloproteinase 2 da matriz
Metaloproteinase 9 da Matriz
Acidose
Sheep
description The sheep meet industry is constantly rising in Brazil and this fact leads to an increase on the number of confined animals, looking for greater weight gain in short period of time. This situation predisposes to disorders such as acute lactic ruminal acidosis (ARLA) and, consequently, acute laminitis, which causes economic problems by the treatment costs, reduced productivity and disposal of animals. Ten adult sheep were induced to ALRA by oral administration of sucrose; were further evaluated to physical examination, arterial blood gas analysis, hematological parameters, glucose and lactate plasma, serum protein profile and zymography for detection of metalloproteinases 2 and 9. All animals had clinical signs of ARLA, the respiratory rate remained high up to 36 hours, returning to normal in 48 hours. Five animals showed typical clinical signs of acute laminitis, however clinical treatment was not necessary. The values of the red blood cell count, packed cell volume, hemoglobin, total leukocytes and neutrophils and segmented rod rases in 24 hours. Glucose content increased up to eight hours by increasing the synthesis of volatile fatty acids and subsequent blood absorption; lactate has increased to 24 hours, with a subsequent decrease. From four hours there was an increase of pH, bicarbonate and base excess. After 12 hours, the animals had metabolic acidosis. At 28 hours there was normalization of the hemogasometry parameters without need of treatment. In serum protein were identified 13 proteins: immunoglobulins A (IgA) and G (IgG), ceruloplasmin (Cp), transferrin (Tf), albumin (Ab), 1-antitrypsin ( 1AT), haptoglobin (Hp), 1- acid glycoprotein ( 1GA), 95 (MWP95), 46 (MWP46), 36 (MWP36) and 31 (MWP31) kDa molecular weight protein In all animals with ARLA the total protein showed changes from 08 hours, coinciding with clinical signs of dehydration, which occurred up to 36 hours after induction. Although five animals shown clinical ...
publishDate 2015
dc.date.none.fl_str_mv 2015-11-06
2016-04-01T17:54:59Z
2016-04-01T17:54:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv SABES, Amanda Festa. Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorial. 2015. xii, 87 p. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, 2015.
http://hdl.handle.net/11449/136729
000860307
http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/22-03-2016/000860307.pdf
33004102072P9
3281538474011979
identifier_str_mv SABES, Amanda Festa. Acidose láctica ruminal aguda induzida experimentalmente em ovinos: estudo clínico e laboratorial. 2015. xii, 87 p. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, 2015.
000860307
33004102072P9
3281538474011979
url http://hdl.handle.net/11449/136729
http://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/22-03-2016/000860307.pdf
dc.language.iso.fl_str_mv por
language por
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dc.format.none.fl_str_mv xii, 87 p. : il.
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dc.publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
publisher.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.source.none.fl_str_mv Aleph
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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