Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils

Detalhes bibliográficos
Autor(a) principal: Silva, João Paulo Assis
Data de Publicação: 2019
Outros Autores: Ramos, Jordana Gomes, Campos, Mônica Sousa, da Silva Lima, Danilo, de Azevedo Brito, Pedro Vale, Mendes, Elizabeth Pereira, Taboga, Sebastião Roberto [UNESP], Biancardi, Manoel Francisco, Ghedini, Paulo César, Santos, Fernanda Cristina Alcantara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.reprotox.2019.02.009
http://hdl.handle.net/11449/188788
Resumo: This study evaluated the effects of BPS (40 μg/kg/day, during 28 consecutive days) on the male ventral prostate and female prostate of adult gerbils. For comparative purposes, gerbils were also exposed to BPA under the same experimental conditions. The prostates were submitted to biometric, morphometric, histopathological, immunohistochemical and ultrastructural analyses. The results demonstrated that exposure to both types of bisphenol caused no changes in testosterone or estradiol serum levels. Morphologically, the effects of BPS and BPA on female prostates were similar and included changes in prostatic tissue compartments, glandular hyperplasia, AR and ERα up-regulation and increased cell proliferation. In males, BPS and BPA promoted differential effects, since the prostate presented morphological changes and proliferative disorders that were more pronounced in the BPS group. Therefore, this study demonstrates that BPS caused endocrine disruption in the prostate of male and female gerbils.
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spelling Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbilsAndrogen receptorEndocrine-disrupting chemicalsEstrogen receptorMorphologyReproductionThis study evaluated the effects of BPS (40 μg/kg/day, during 28 consecutive days) on the male ventral prostate and female prostate of adult gerbils. For comparative purposes, gerbils were also exposed to BPA under the same experimental conditions. The prostates were submitted to biometric, morphometric, histopathological, immunohistochemical and ultrastructural analyses. The results demonstrated that exposure to both types of bisphenol caused no changes in testosterone or estradiol serum levels. Morphologically, the effects of BPS and BPA on female prostates were similar and included changes in prostatic tissue compartments, glandular hyperplasia, AR and ERα up-regulation and increased cell proliferation. In males, BPS and BPA promoted differential effects, since the prostate presented morphological changes and proliferative disorders that were more pronounced in the BPS group. Therefore, this study demonstrates that BPS caused endocrine disruption in the prostate of male and female gerbils.Fundação de Amparo à Pesquisa do Estado de GoiásDepartment of Histology Embryology and Cell Biology Laboratory of Microscopy Applied to Reproduction Institute of Biological Sciences Federal University of GoiásDepartment of Physiological Sciences Institute of Biological Sciences Federal University of GoiásDepartment of Biology Laboratory of Microscopy and Microanalysis State University of São Paulo – UNESP Rua Cristóvão Colombo, 2265Department of Pharmacology Institute of Biological Sciences Federal University of GoiásDepartment of Biology Laboratory of Microscopy and Microanalysis State University of São Paulo – UNESP Rua Cristóvão Colombo, 2265Universidade Federal de Goiás (UFG)Universidade Estadual Paulista (Unesp)Silva, João Paulo AssisRamos, Jordana GomesCampos, Mônica Sousada Silva Lima, Danilode Azevedo Brito, Pedro ValeMendes, Elizabeth PereiraTaboga, Sebastião Roberto [UNESP]Biancardi, Manoel FranciscoGhedini, Paulo CésarSantos, Fernanda Cristina Alcantara2019-10-06T16:19:15Z2019-10-06T16:19:15Z2019-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article83-92http://dx.doi.org/10.1016/j.reprotox.2019.02.009Reproductive Toxicology, v. 85, p. 83-92.1873-17080890-6238http://hdl.handle.net/11449/18878810.1016/j.reprotox.2019.02.0092-s2.0-85062231264Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengReproductive Toxicologyinfo:eu-repo/semantics/openAccess2024-04-11T19:33:57Zoai:repositorio.unesp.br:11449/188788Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:26:25.631545Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils
title Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils
spellingShingle Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils
Silva, João Paulo Assis
Androgen receptor
Endocrine-disrupting chemicals
Estrogen receptor
Morphology
Reproduction
title_short Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils
title_full Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils
title_fullStr Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils
title_full_unstemmed Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils
title_sort Bisphenol-S promotes endocrine-disrupting effects similar to those promoted by bisphenol-A in the prostate of adult gerbils
author Silva, João Paulo Assis
author_facet Silva, João Paulo Assis
Ramos, Jordana Gomes
Campos, Mônica Sousa
da Silva Lima, Danilo
de Azevedo Brito, Pedro Vale
Mendes, Elizabeth Pereira
Taboga, Sebastião Roberto [UNESP]
Biancardi, Manoel Francisco
Ghedini, Paulo César
Santos, Fernanda Cristina Alcantara
author_role author
author2 Ramos, Jordana Gomes
Campos, Mônica Sousa
da Silva Lima, Danilo
de Azevedo Brito, Pedro Vale
Mendes, Elizabeth Pereira
Taboga, Sebastião Roberto [UNESP]
Biancardi, Manoel Francisco
Ghedini, Paulo César
Santos, Fernanda Cristina Alcantara
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de Goiás (UFG)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Silva, João Paulo Assis
Ramos, Jordana Gomes
Campos, Mônica Sousa
da Silva Lima, Danilo
de Azevedo Brito, Pedro Vale
Mendes, Elizabeth Pereira
Taboga, Sebastião Roberto [UNESP]
Biancardi, Manoel Francisco
Ghedini, Paulo César
Santos, Fernanda Cristina Alcantara
dc.subject.por.fl_str_mv Androgen receptor
Endocrine-disrupting chemicals
Estrogen receptor
Morphology
Reproduction
topic Androgen receptor
Endocrine-disrupting chemicals
Estrogen receptor
Morphology
Reproduction
description This study evaluated the effects of BPS (40 μg/kg/day, during 28 consecutive days) on the male ventral prostate and female prostate of adult gerbils. For comparative purposes, gerbils were also exposed to BPA under the same experimental conditions. The prostates were submitted to biometric, morphometric, histopathological, immunohistochemical and ultrastructural analyses. The results demonstrated that exposure to both types of bisphenol caused no changes in testosterone or estradiol serum levels. Morphologically, the effects of BPS and BPA on female prostates were similar and included changes in prostatic tissue compartments, glandular hyperplasia, AR and ERα up-regulation and increased cell proliferation. In males, BPS and BPA promoted differential effects, since the prostate presented morphological changes and proliferative disorders that were more pronounced in the BPS group. Therefore, this study demonstrates that BPS caused endocrine disruption in the prostate of male and female gerbils.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T16:19:15Z
2019-10-06T16:19:15Z
2019-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.reprotox.2019.02.009
Reproductive Toxicology, v. 85, p. 83-92.
1873-1708
0890-6238
http://hdl.handle.net/11449/188788
10.1016/j.reprotox.2019.02.009
2-s2.0-85062231264
url http://dx.doi.org/10.1016/j.reprotox.2019.02.009
http://hdl.handle.net/11449/188788
identifier_str_mv Reproductive Toxicology, v. 85, p. 83-92.
1873-1708
0890-6238
10.1016/j.reprotox.2019.02.009
2-s2.0-85062231264
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Reproductive Toxicology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 83-92
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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