Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttrium

Detalhes bibliográficos
Autor(a) principal: Holanda, Bruno B.C. [UNESP]
Data de Publicação: 2017
Outros Autores: Guerra, Renan B. [UNESP], Legendre, Alexandre O. [UNESP], Almeida, Débora F. [UNESP], Fraga-Silva, Thais F.C. [UNESP], Finato, Ângela C. [UNESP], Venturini, James [UNESP], Bannach, Gilbert [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.tca.2016.11.007
http://hdl.handle.net/11449/173837
Resumo: Heavy lanthanide complexes (Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) and yttrium (III) complexes with ibuprofen ligands (Hibu) were synthesized and characterized by simultaneous thermogravimetric and differential thermal analysis (TG-DTA), differential scanning calorimetry (DSC), attenuated total reflection mid-infrared spectroscopy (ATR-MIR), complexometric titration, X-ray powder diffraction (XRD) in order to determine stoichiometry, thermal stability and the ligand coordination modes of the compounds. The volatiles released were also analyzed by online coupled thermogravimetry-infrared spectroscopy evolved gas analysis (TG-EGA-MIR), to identify the main product resulting from the heating of terbium complex. In addition, ibuprofen and the synthesized compounds were tested to assess cytotoxic/proliferative and anti-inflammatory activity. The results of the cytotoxicity assays showed that compounds [Yb(ibu)3], [Lu(ibu)3] and [Y(ibu)3] decreased the cytotoxic activity of ibuprofen. Furthermore, [Yb(ibu)3] and [Lu(ibu)3] exhibited a significant anti-inflammatory profile, superior to that of ibuprofen. Under the stimulatory effect of lipopolysaccharide, these compounds displayed anti-inflammatory activity characterized by low TNF-α and H2O2 production and high IL-10 production, emerging as interesting alternatives for further biological applications.
id UNSP_70205b1e4efc20c5a16317dbcea82733
oai_identifier_str oai:repositorio.unesp.br:11449/173837
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttriumBiological studiesLanthanidesMetallodrugMiddle infrared spectroscopyTG-EGA-MIRThermal behaviorHeavy lanthanide complexes (Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) and yttrium (III) complexes with ibuprofen ligands (Hibu) were synthesized and characterized by simultaneous thermogravimetric and differential thermal analysis (TG-DTA), differential scanning calorimetry (DSC), attenuated total reflection mid-infrared spectroscopy (ATR-MIR), complexometric titration, X-ray powder diffraction (XRD) in order to determine stoichiometry, thermal stability and the ligand coordination modes of the compounds. The volatiles released were also analyzed by online coupled thermogravimetry-infrared spectroscopy evolved gas analysis (TG-EGA-MIR), to identify the main product resulting from the heating of terbium complex. In addition, ibuprofen and the synthesized compounds were tested to assess cytotoxic/proliferative and anti-inflammatory activity. The results of the cytotoxicity assays showed that compounds [Yb(ibu)3], [Lu(ibu)3] and [Y(ibu)3] decreased the cytotoxic activity of ibuprofen. Furthermore, [Yb(ibu)3] and [Lu(ibu)3] exhibited a significant anti-inflammatory profile, superior to that of ibuprofen. Under the stimulatory effect of lipopolysaccharide, these compounds displayed anti-inflammatory activity characterized by low TNF-α and H2O2 production and high IL-10 production, emerging as interesting alternatives for further biological applications.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Faculdade de Ciências Departamento de Química UNESP—Univ. Estadual Paulista, BauruFaculdade de Ciências Departamento de Ciências Biológicas UNESP—Univ. Estadual Paulista, BauruFaculdade de Ciências Departamento de Química UNESP—Univ. Estadual Paulista, BauruFaculdade de Ciências Departamento de Ciências Biológicas UNESP—Univ. Estadual Paulista, BauruCAPES: 024/2012FAPESP: 2012/21450-1FAPESP: 2013/09022-7Universidade Estadual Paulista (Unesp)Holanda, Bruno B.C. [UNESP]Guerra, Renan B. [UNESP]Legendre, Alexandre O. [UNESP]Almeida, Débora F. [UNESP]Fraga-Silva, Thais F.C. [UNESP]Finato, Ângela C. [UNESP]Venturini, James [UNESP]Bannach, Gilbert [UNESP]2018-12-11T17:07:59Z2018-12-11T17:07:59Z2017-01-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article47-54application/pdfhttp://dx.doi.org/10.1016/j.tca.2016.11.007Thermochimica Acta, v. 647, p. 47-54.0040-6031http://hdl.handle.net/11449/17383710.1016/j.tca.2016.11.0072-s2.0-849978345912-s2.0-84997834591.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengThermochimica Acta0,605info:eu-repo/semantics/openAccess2024-04-29T18:17:11Zoai:repositorio.unesp.br:11449/173837Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:21:51.090931Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttrium
title Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttrium
spellingShingle Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttrium
Holanda, Bruno B.C. [UNESP]
Biological studies
Lanthanides
Metallodrug
Middle infrared spectroscopy
TG-EGA-MIR
Thermal behavior
title_short Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttrium
title_full Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttrium
title_fullStr Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttrium
title_full_unstemmed Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttrium
title_sort Thermal, spectroscopic and biological studies on solid ibuprofen complexes of heavy trivalent lanthanides and yttrium
author Holanda, Bruno B.C. [UNESP]
author_facet Holanda, Bruno B.C. [UNESP]
Guerra, Renan B. [UNESP]
Legendre, Alexandre O. [UNESP]
Almeida, Débora F. [UNESP]
Fraga-Silva, Thais F.C. [UNESP]
Finato, Ângela C. [UNESP]
Venturini, James [UNESP]
Bannach, Gilbert [UNESP]
author_role author
author2 Guerra, Renan B. [UNESP]
Legendre, Alexandre O. [UNESP]
Almeida, Débora F. [UNESP]
Fraga-Silva, Thais F.C. [UNESP]
Finato, Ângela C. [UNESP]
Venturini, James [UNESP]
Bannach, Gilbert [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Holanda, Bruno B.C. [UNESP]
Guerra, Renan B. [UNESP]
Legendre, Alexandre O. [UNESP]
Almeida, Débora F. [UNESP]
Fraga-Silva, Thais F.C. [UNESP]
Finato, Ângela C. [UNESP]
Venturini, James [UNESP]
Bannach, Gilbert [UNESP]
dc.subject.por.fl_str_mv Biological studies
Lanthanides
Metallodrug
Middle infrared spectroscopy
TG-EGA-MIR
Thermal behavior
topic Biological studies
Lanthanides
Metallodrug
Middle infrared spectroscopy
TG-EGA-MIR
Thermal behavior
description Heavy lanthanide complexes (Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) and yttrium (III) complexes with ibuprofen ligands (Hibu) were synthesized and characterized by simultaneous thermogravimetric and differential thermal analysis (TG-DTA), differential scanning calorimetry (DSC), attenuated total reflection mid-infrared spectroscopy (ATR-MIR), complexometric titration, X-ray powder diffraction (XRD) in order to determine stoichiometry, thermal stability and the ligand coordination modes of the compounds. The volatiles released were also analyzed by online coupled thermogravimetry-infrared spectroscopy evolved gas analysis (TG-EGA-MIR), to identify the main product resulting from the heating of terbium complex. In addition, ibuprofen and the synthesized compounds were tested to assess cytotoxic/proliferative and anti-inflammatory activity. The results of the cytotoxicity assays showed that compounds [Yb(ibu)3], [Lu(ibu)3] and [Y(ibu)3] decreased the cytotoxic activity of ibuprofen. Furthermore, [Yb(ibu)3] and [Lu(ibu)3] exhibited a significant anti-inflammatory profile, superior to that of ibuprofen. Under the stimulatory effect of lipopolysaccharide, these compounds displayed anti-inflammatory activity characterized by low TNF-α and H2O2 production and high IL-10 production, emerging as interesting alternatives for further biological applications.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-10
2018-12-11T17:07:59Z
2018-12-11T17:07:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.tca.2016.11.007
Thermochimica Acta, v. 647, p. 47-54.
0040-6031
http://hdl.handle.net/11449/173837
10.1016/j.tca.2016.11.007
2-s2.0-84997834591
2-s2.0-84997834591.pdf
url http://dx.doi.org/10.1016/j.tca.2016.11.007
http://hdl.handle.net/11449/173837
identifier_str_mv Thermochimica Acta, v. 647, p. 47-54.
0040-6031
10.1016/j.tca.2016.11.007
2-s2.0-84997834591
2-s2.0-84997834591.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Thermochimica Acta
0,605
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 47-54
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129193389588480

Registros relacionados