Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings
Autor(a) principal: | |
---|---|
Data de Publicação: | 2004 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3998/ark.5550190.0005.616 http://hdl.handle.net/11449/32714 |
Resumo: | The bioassay directed fractionation of the EtOH extract from leaves of Cryptocarya ashersoniana seedlings led to the isolation of two flavonol glucosides: iso-quercitrin and hyperin, which exhibited free radical scavenging activity towards DPPH (IC50 34.4 muM and 32.7 muM, respectively) and were compared to standard compounds rutin (IC50 27.0 muM) and catechin (IC50 41.4 muM). Investigation of extracts from the seedlings roots and stems afforded one antifungal styrylpyrone: goniothalamine, and two dihydropyrones: 6-propyl-5,6-dihydro-2-pyrone and the new 6-[(4'-ethyl-9'-oxabicyclo[3.3.1]non-6'-en-3'-yl)methyl]-5,6-dihydro-2H-pyran-2-one, which had its structure determined by detailed analysis of MS and NMR data, including 2D experiments. |
id |
UNSP_70238378a1046309f945a205f1c74c45 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/32714 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlingsCryptocarya ashersonianaLauraceaepyroneflavonoidantioxidantfree radical scavengerDPPHThe bioassay directed fractionation of the EtOH extract from leaves of Cryptocarya ashersoniana seedlings led to the isolation of two flavonol glucosides: iso-quercitrin and hyperin, which exhibited free radical scavenging activity towards DPPH (IC50 34.4 muM and 32.7 muM, respectively) and were compared to standard compounds rutin (IC50 27.0 muM) and catechin (IC50 41.4 muM). Investigation of extracts from the seedlings roots and stems afforded one antifungal styrylpyrone: goniothalamine, and two dihydropyrones: 6-propyl-5,6-dihydro-2-pyrone and the new 6-[(4'-ethyl-9'-oxabicyclo[3.3.1]non-6'-en-3'-yl)methyl]-5,6-dihydro-2H-pyran-2-one, which had its structure determined by detailed analysis of MS and NMR data, including 2D experiments.Univ Estadual Paulista, Inst Quim, BR-14800900 São Paulo, BrazilUniv Estadual Paulista, Inst Quim, BR-14800900 São Paulo, BrazilArkat Usa IncUniversidade Estadual Paulista (Unesp)Ricardo, MAGAndreo, M. A.Cavalheiro, Alberto José [UNESP]Gamboa, Ian Castro [UNESP]Bolzani, Vanderlan da Silva [UNESP]Silva, DHS2014-05-20T15:21:35Z2014-05-20T15:21:35Z2004-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article127-136application/pdfhttp://dx.doi.org/10.3998/ark.5550190.0005.616Arkivoc. Gainesville: Arkat Usa Inc., p. 127-136, 2004.http://hdl.handle.net/11449/3271410.3998/ark.5550190.0005.616WOS:000224153100016WOS000224153100016.pdf2518006820764120903297370520432044840836852516734702004904231248Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArkivocinfo:eu-repo/semantics/openAccess2023-12-19T06:23:01Zoai:repositorio.unesp.br:11449/32714Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:45:44.434484Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings |
title |
Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings |
spellingShingle |
Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings Ricardo, MAG Cryptocarya ashersoniana Lauraceae pyrone flavonoid antioxidant free radical scavenger DPPH |
title_short |
Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings |
title_full |
Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings |
title_fullStr |
Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings |
title_full_unstemmed |
Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings |
title_sort |
Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings |
author |
Ricardo, MAG |
author_facet |
Ricardo, MAG Andreo, M. A. Cavalheiro, Alberto José [UNESP] Gamboa, Ian Castro [UNESP] Bolzani, Vanderlan da Silva [UNESP] Silva, DHS |
author_role |
author |
author2 |
Andreo, M. A. Cavalheiro, Alberto José [UNESP] Gamboa, Ian Castro [UNESP] Bolzani, Vanderlan da Silva [UNESP] Silva, DHS |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ricardo, MAG Andreo, M. A. Cavalheiro, Alberto José [UNESP] Gamboa, Ian Castro [UNESP] Bolzani, Vanderlan da Silva [UNESP] Silva, DHS |
dc.subject.por.fl_str_mv |
Cryptocarya ashersoniana Lauraceae pyrone flavonoid antioxidant free radical scavenger DPPH |
topic |
Cryptocarya ashersoniana Lauraceae pyrone flavonoid antioxidant free radical scavenger DPPH |
description |
The bioassay directed fractionation of the EtOH extract from leaves of Cryptocarya ashersoniana seedlings led to the isolation of two flavonol glucosides: iso-quercitrin and hyperin, which exhibited free radical scavenging activity towards DPPH (IC50 34.4 muM and 32.7 muM, respectively) and were compared to standard compounds rutin (IC50 27.0 muM) and catechin (IC50 41.4 muM). Investigation of extracts from the seedlings roots and stems afforded one antifungal styrylpyrone: goniothalamine, and two dihydropyrones: 6-propyl-5,6-dihydro-2-pyrone and the new 6-[(4'-ethyl-9'-oxabicyclo[3.3.1]non-6'-en-3'-yl)methyl]-5,6-dihydro-2H-pyran-2-one, which had its structure determined by detailed analysis of MS and NMR data, including 2D experiments. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-01-01 2014-05-20T15:21:35Z 2014-05-20T15:21:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3998/ark.5550190.0005.616 Arkivoc. Gainesville: Arkat Usa Inc., p. 127-136, 2004. http://hdl.handle.net/11449/32714 10.3998/ark.5550190.0005.616 WOS:000224153100016 WOS000224153100016.pdf 2518006820764120 9032973705204320 4484083685251673 4702004904231248 |
url |
http://dx.doi.org/10.3998/ark.5550190.0005.616 http://hdl.handle.net/11449/32714 |
identifier_str_mv |
Arkivoc. Gainesville: Arkat Usa Inc., p. 127-136, 2004. 10.3998/ark.5550190.0005.616 WOS:000224153100016 WOS000224153100016.pdf 2518006820764120 9032973705204320 4484083685251673 4702004904231248 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arkivoc |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
127-136 application/pdf |
dc.publisher.none.fl_str_mv |
Arkat Usa Inc |
publisher.none.fl_str_mv |
Arkat Usa Inc |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129243453849600 |