Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings

Detalhes bibliográficos
Autor(a) principal: Ricardo, MAG
Data de Publicação: 2004
Outros Autores: Andreo, M. A., Cavalheiro, Alberto José [UNESP], Gamboa, Ian Castro [UNESP], Bolzani, Vanderlan da Silva [UNESP], Silva, DHS
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3998/ark.5550190.0005.616
http://hdl.handle.net/11449/32714
Resumo: The bioassay directed fractionation of the EtOH extract from leaves of Cryptocarya ashersoniana seedlings led to the isolation of two flavonol glucosides: iso-quercitrin and hyperin, which exhibited free radical scavenging activity towards DPPH (IC50 34.4 muM and 32.7 muM, respectively) and were compared to standard compounds rutin (IC50 27.0 muM) and catechin (IC50 41.4 muM). Investigation of extracts from the seedlings roots and stems afforded one antifungal styrylpyrone: goniothalamine, and two dihydropyrones: 6-propyl-5,6-dihydro-2-pyrone and the new 6-[(4'-ethyl-9'-oxabicyclo[3.3.1]non-6'-en-3'-yl)methyl]-5,6-dihydro-2H-pyran-2-one, which had its structure determined by detailed analysis of MS and NMR data, including 2D experiments.
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spelling Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlingsCryptocarya ashersonianaLauraceaepyroneflavonoidantioxidantfree radical scavengerDPPHThe bioassay directed fractionation of the EtOH extract from leaves of Cryptocarya ashersoniana seedlings led to the isolation of two flavonol glucosides: iso-quercitrin and hyperin, which exhibited free radical scavenging activity towards DPPH (IC50 34.4 muM and 32.7 muM, respectively) and were compared to standard compounds rutin (IC50 27.0 muM) and catechin (IC50 41.4 muM). Investigation of extracts from the seedlings roots and stems afforded one antifungal styrylpyrone: goniothalamine, and two dihydropyrones: 6-propyl-5,6-dihydro-2-pyrone and the new 6-[(4'-ethyl-9'-oxabicyclo[3.3.1]non-6'-en-3'-yl)methyl]-5,6-dihydro-2H-pyran-2-one, which had its structure determined by detailed analysis of MS and NMR data, including 2D experiments.Univ Estadual Paulista, Inst Quim, BR-14800900 São Paulo, BrazilUniv Estadual Paulista, Inst Quim, BR-14800900 São Paulo, BrazilArkat Usa IncUniversidade Estadual Paulista (Unesp)Ricardo, MAGAndreo, M. A.Cavalheiro, Alberto José [UNESP]Gamboa, Ian Castro [UNESP]Bolzani, Vanderlan da Silva [UNESP]Silva, DHS2014-05-20T15:21:35Z2014-05-20T15:21:35Z2004-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article127-136application/pdfhttp://dx.doi.org/10.3998/ark.5550190.0005.616Arkivoc. Gainesville: Arkat Usa Inc., p. 127-136, 2004.http://hdl.handle.net/11449/3271410.3998/ark.5550190.0005.616WOS:000224153100016WOS000224153100016.pdf2518006820764120903297370520432044840836852516734702004904231248Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArkivocinfo:eu-repo/semantics/openAccess2023-12-19T06:23:01Zoai:repositorio.unesp.br:11449/32714Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:45:44.434484Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings
title Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings
spellingShingle Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings
Ricardo, MAG
Cryptocarya ashersoniana
Lauraceae
pyrone
flavonoid
antioxidant
free radical scavenger
DPPH
title_short Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings
title_full Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings
title_fullStr Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings
title_full_unstemmed Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings
title_sort Bioactive pyrones and flavonoids from Cryptocarya ashersoniana seedlings
author Ricardo, MAG
author_facet Ricardo, MAG
Andreo, M. A.
Cavalheiro, Alberto José [UNESP]
Gamboa, Ian Castro [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Silva, DHS
author_role author
author2 Andreo, M. A.
Cavalheiro, Alberto José [UNESP]
Gamboa, Ian Castro [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Silva, DHS
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ricardo, MAG
Andreo, M. A.
Cavalheiro, Alberto José [UNESP]
Gamboa, Ian Castro [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Silva, DHS
dc.subject.por.fl_str_mv Cryptocarya ashersoniana
Lauraceae
pyrone
flavonoid
antioxidant
free radical scavenger
DPPH
topic Cryptocarya ashersoniana
Lauraceae
pyrone
flavonoid
antioxidant
free radical scavenger
DPPH
description The bioassay directed fractionation of the EtOH extract from leaves of Cryptocarya ashersoniana seedlings led to the isolation of two flavonol glucosides: iso-quercitrin and hyperin, which exhibited free radical scavenging activity towards DPPH (IC50 34.4 muM and 32.7 muM, respectively) and were compared to standard compounds rutin (IC50 27.0 muM) and catechin (IC50 41.4 muM). Investigation of extracts from the seedlings roots and stems afforded one antifungal styrylpyrone: goniothalamine, and two dihydropyrones: 6-propyl-5,6-dihydro-2-pyrone and the new 6-[(4'-ethyl-9'-oxabicyclo[3.3.1]non-6'-en-3'-yl)methyl]-5,6-dihydro-2H-pyran-2-one, which had its structure determined by detailed analysis of MS and NMR data, including 2D experiments.
publishDate 2004
dc.date.none.fl_str_mv 2004-01-01
2014-05-20T15:21:35Z
2014-05-20T15:21:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3998/ark.5550190.0005.616
Arkivoc. Gainesville: Arkat Usa Inc., p. 127-136, 2004.
http://hdl.handle.net/11449/32714
10.3998/ark.5550190.0005.616
WOS:000224153100016
WOS000224153100016.pdf
2518006820764120
9032973705204320
4484083685251673
4702004904231248
url http://dx.doi.org/10.3998/ark.5550190.0005.616
http://hdl.handle.net/11449/32714
identifier_str_mv Arkivoc. Gainesville: Arkat Usa Inc., p. 127-136, 2004.
10.3998/ark.5550190.0005.616
WOS:000224153100016
WOS000224153100016.pdf
2518006820764120
9032973705204320
4484083685251673
4702004904231248
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arkivoc
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 127-136
application/pdf
dc.publisher.none.fl_str_mv Arkat Usa Inc
publisher.none.fl_str_mv Arkat Usa Inc
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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