Evidence for temporal population replacement and the signature of ecological adaptation in a major Neotropical malaria vector in Amazonian Peru
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/s12936-015-0863-4 http://hdl.handle.net/11449/131446 |
Resumo: | The major Neotropical malaria vector, Anopheles darlingi, was reintroduced into the Iquitos, Loreto, Peru area during the early 1990s, where it displaced other anophelines and caused a major malaria epidemic. Since then, case numbers in Loreto have fluctuated, but annual increases have been reported since 2012. The population genetic structure of An. darlingi sampled before and after the introduction of long-lasting insecticidal nets (LLINs) was investigated to test the hypothesis of temporal population change (2006 vs. 2012). Current samples of An. darlingi were used to test the hypothesis of ecological adaptation to human modified (highway) compared with wild (riverine) habitat, linked to forest cover. In total, 693 An. darlingi from nine localities in Loreto, Peru area were genotyped using 13 microsatellite loci. To test the hypothesis of habitat differentiation in An. darlingi biting time patterns, HBR and EIR, four collections of An. darlingi from five localities (two riverine and three highway) were analysed. Analyses of microsatellite loci from seven (2006) and nine settlements (2012-2014) in the Iquitos area detected two distinctive populations with little overlap, although it is unclear whether this population replacement event is associated with LLIN distribution or climate. Within the 2012-2014 population two admixed subpopulations, A and B, were differentiated by habitat, with B significantly overrepresented in highway, and both in near-equal proportions in riverine. Both subpopulations had a signature of expansion and there was moderate genetic differentiation between them. Habitat and forest cover level had significant effects on HBR, such that Plasmodium transmission risk, as measured by EIR, in peridomestic riverine settlements was threefold higher than in peridomestic highway settlements. HBR was directly associated with available host biomass rather than forest cover. A population replacement event occurred between 2006 and 2012-2014, concurrently with LLIN distribution and a moderate El Niño event, and prior to an increase in malaria incidence. The likely drivers of this replacement cannot be determined with current data. The present-day An. darlingi population is composed of two highly admixed subpopulations, which appear to be in an early stage of differentiation, triggered by anthropogenic alterations to local habitat. |
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Evidence for temporal population replacement and the signature of ecological adaptation in a major Neotropical malaria vector in Amazonian PeruPopulation replacementEcological adaptationAnopheles darlingiMalariaHuman biting rateMicrosatellitesThe major Neotropical malaria vector, Anopheles darlingi, was reintroduced into the Iquitos, Loreto, Peru area during the early 1990s, where it displaced other anophelines and caused a major malaria epidemic. Since then, case numbers in Loreto have fluctuated, but annual increases have been reported since 2012. The population genetic structure of An. darlingi sampled before and after the introduction of long-lasting insecticidal nets (LLINs) was investigated to test the hypothesis of temporal population change (2006 vs. 2012). Current samples of An. darlingi were used to test the hypothesis of ecological adaptation to human modified (highway) compared with wild (riverine) habitat, linked to forest cover. In total, 693 An. darlingi from nine localities in Loreto, Peru area were genotyped using 13 microsatellite loci. To test the hypothesis of habitat differentiation in An. darlingi biting time patterns, HBR and EIR, four collections of An. darlingi from five localities (two riverine and three highway) were analysed. Analyses of microsatellite loci from seven (2006) and nine settlements (2012-2014) in the Iquitos area detected two distinctive populations with little overlap, although it is unclear whether this population replacement event is associated with LLIN distribution or climate. Within the 2012-2014 population two admixed subpopulations, A and B, were differentiated by habitat, with B significantly overrepresented in highway, and both in near-equal proportions in riverine. Both subpopulations had a signature of expansion and there was moderate genetic differentiation between them. Habitat and forest cover level had significant effects on HBR, such that Plasmodium transmission risk, as measured by EIR, in peridomestic riverine settlements was threefold higher than in peridomestic highway settlements. HBR was directly associated with available host biomass rather than forest cover. A population replacement event occurred between 2006 and 2012-2014, concurrently with LLIN distribution and a moderate El Niño event, and prior to an increase in malaria incidence. The likely drivers of this replacement cannot be determined with current data. The present-day An. darlingi population is composed of two highly admixed subpopulations, which appear to be in an early stage of differentiation, triggered by anthropogenic alterations to local habitat.Department of Biomedical Sciences, School of Public Health, State University of New York at Albany, Albany, NY, USAWadsworth Center, New York State Department of Health, Griffin Laboratory, 5669 State Farm Road, Building 1, Room 101, Slingerlands 12159, NY, USADivision of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA, USAAsociación Benéfica PRISMA, Iquitos, PeruUniversidade Estadual Paulista, São Paulo, BrazilInstituto de Medicine Tropical “Alexander von Humboldt”, Universidad Peruana Cayetano Heredia, Lima, Peru.Universidade Estadual Paulista, São Paulo, Brazil.BioMed CentralUniversity of New YorkWadsworth CenterUniversity of CaliforniaAsociación Benéfica PRISMAUniversidade Estadual Paulista (Unesp)Universidad Peruana Cayetano HerediaLainhart, WilliamBickersmith, Sara A.Nadler, Kyle J.Moreno, MartaSaavedra, Marlon P.Chu, Virginia M.Ribolla, Paulo Eduardo Martins [UNESP]Vinetz, Joseph M.Conn, Jan E.2015-12-07T15:35:36Z2015-12-07T15:35:36Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-17application/pdfhttp://dx.doi.org/10.1186/s12936-015-0863-4Malaria Journal, v. 14, p. 1-17, 2015.1475-2875http://hdl.handle.net/11449/13144610.1186/s12936-015-0863-4PMC4587789.pdf357714974845688026415942PMC45877890000-0001-8735-6090PubMedreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMalaria Journal2.8452,082info:eu-repo/semantics/openAccess2023-10-10T06:06:47Zoai:repositorio.unesp.br:11449/131446Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-10T06:06:47Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evidence for temporal population replacement and the signature of ecological adaptation in a major Neotropical malaria vector in Amazonian Peru |
title |
Evidence for temporal population replacement and the signature of ecological adaptation in a major Neotropical malaria vector in Amazonian Peru |
spellingShingle |
Evidence for temporal population replacement and the signature of ecological adaptation in a major Neotropical malaria vector in Amazonian Peru Lainhart, William Population replacement Ecological adaptation Anopheles darlingi Malaria Human biting rate Microsatellites |
title_short |
Evidence for temporal population replacement and the signature of ecological adaptation in a major Neotropical malaria vector in Amazonian Peru |
title_full |
Evidence for temporal population replacement and the signature of ecological adaptation in a major Neotropical malaria vector in Amazonian Peru |
title_fullStr |
Evidence for temporal population replacement and the signature of ecological adaptation in a major Neotropical malaria vector in Amazonian Peru |
title_full_unstemmed |
Evidence for temporal population replacement and the signature of ecological adaptation in a major Neotropical malaria vector in Amazonian Peru |
title_sort |
Evidence for temporal population replacement and the signature of ecological adaptation in a major Neotropical malaria vector in Amazonian Peru |
author |
Lainhart, William |
author_facet |
Lainhart, William Bickersmith, Sara A. Nadler, Kyle J. Moreno, Marta Saavedra, Marlon P. Chu, Virginia M. Ribolla, Paulo Eduardo Martins [UNESP] Vinetz, Joseph M. Conn, Jan E. |
author_role |
author |
author2 |
Bickersmith, Sara A. Nadler, Kyle J. Moreno, Marta Saavedra, Marlon P. Chu, Virginia M. Ribolla, Paulo Eduardo Martins [UNESP] Vinetz, Joseph M. Conn, Jan E. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
University of New York Wadsworth Center University of California Asociación Benéfica PRISMA Universidade Estadual Paulista (Unesp) Universidad Peruana Cayetano Heredia |
dc.contributor.author.fl_str_mv |
Lainhart, William Bickersmith, Sara A. Nadler, Kyle J. Moreno, Marta Saavedra, Marlon P. Chu, Virginia M. Ribolla, Paulo Eduardo Martins [UNESP] Vinetz, Joseph M. Conn, Jan E. |
dc.subject.por.fl_str_mv |
Population replacement Ecological adaptation Anopheles darlingi Malaria Human biting rate Microsatellites |
topic |
Population replacement Ecological adaptation Anopheles darlingi Malaria Human biting rate Microsatellites |
description |
The major Neotropical malaria vector, Anopheles darlingi, was reintroduced into the Iquitos, Loreto, Peru area during the early 1990s, where it displaced other anophelines and caused a major malaria epidemic. Since then, case numbers in Loreto have fluctuated, but annual increases have been reported since 2012. The population genetic structure of An. darlingi sampled before and after the introduction of long-lasting insecticidal nets (LLINs) was investigated to test the hypothesis of temporal population change (2006 vs. 2012). Current samples of An. darlingi were used to test the hypothesis of ecological adaptation to human modified (highway) compared with wild (riverine) habitat, linked to forest cover. In total, 693 An. darlingi from nine localities in Loreto, Peru area were genotyped using 13 microsatellite loci. To test the hypothesis of habitat differentiation in An. darlingi biting time patterns, HBR and EIR, four collections of An. darlingi from five localities (two riverine and three highway) were analysed. Analyses of microsatellite loci from seven (2006) and nine settlements (2012-2014) in the Iquitos area detected two distinctive populations with little overlap, although it is unclear whether this population replacement event is associated with LLIN distribution or climate. Within the 2012-2014 population two admixed subpopulations, A and B, were differentiated by habitat, with B significantly overrepresented in highway, and both in near-equal proportions in riverine. Both subpopulations had a signature of expansion and there was moderate genetic differentiation between them. Habitat and forest cover level had significant effects on HBR, such that Plasmodium transmission risk, as measured by EIR, in peridomestic riverine settlements was threefold higher than in peridomestic highway settlements. HBR was directly associated with available host biomass rather than forest cover. A population replacement event occurred between 2006 and 2012-2014, concurrently with LLIN distribution and a moderate El Niño event, and prior to an increase in malaria incidence. The likely drivers of this replacement cannot be determined with current data. The present-day An. darlingi population is composed of two highly admixed subpopulations, which appear to be in an early stage of differentiation, triggered by anthropogenic alterations to local habitat. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-07T15:35:36Z 2015-12-07T15:35:36Z 2015 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/s12936-015-0863-4 Malaria Journal, v. 14, p. 1-17, 2015. 1475-2875 http://hdl.handle.net/11449/131446 10.1186/s12936-015-0863-4 PMC4587789.pdf 3577149748456880 26415942 PMC4587789 0000-0001-8735-6090 |
url |
http://dx.doi.org/10.1186/s12936-015-0863-4 http://hdl.handle.net/11449/131446 |
identifier_str_mv |
Malaria Journal, v. 14, p. 1-17, 2015. 1475-2875 10.1186/s12936-015-0863-4 PMC4587789.pdf 3577149748456880 26415942 PMC4587789 0000-0001-8735-6090 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Malaria Journal 2.845 2,082 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-17 application/pdf |
dc.publisher.none.fl_str_mv |
BioMed Central |
publisher.none.fl_str_mv |
BioMed Central |
dc.source.none.fl_str_mv |
PubMed reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799964509848207360 |