A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1984-82502015000400007 http://hdl.handle.net/11449/177940 |
Resumo: | Daptomycin is the first approved drug from a new class of antimicrobials, the cyclic lipopeptides, and is a very important antimicrobial agent in current clinical practice. Currently, there are no “green” analytical methods described in the literature to analyze the typical pharmaceutical dosage form of daptomycin. Thus, the aim of this work was to validate an environment-friendly spectrophotometric method in the UV region, for the analysis of daptomycin as a lyophilized powder. Water was used as diluent and the analyses were carried out on a spectrophotometer at 221 nm. The method met all validation requirements of the ICH guidelines, over a concentration range of 6-21 μg mL-1. A Student’s t-test demonstrated that the proposed method was comparable to an HPLC method previously validated. Thus, the validated spectrophotometric method could quantify daptomycin in a powder form for injectable solutions, while being an economical, rapid, and “green” alternative for routine analysis in quality control. |
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A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometryAntimicrobials/quality controlDaptomycin/determinationSpectrophotometry/green analytical methodSpectrophotometry/UV region/ quantitative analysisDaptomycin is the first approved drug from a new class of antimicrobials, the cyclic lipopeptides, and is a very important antimicrobial agent in current clinical practice. Currently, there are no “green” analytical methods described in the literature to analyze the typical pharmaceutical dosage form of daptomycin. Thus, the aim of this work was to validate an environment-friendly spectrophotometric method in the UV region, for the analysis of daptomycin as a lyophilized powder. Water was used as diluent and the analyses were carried out on a spectrophotometer at 221 nm. The method met all validation requirements of the ICH guidelines, over a concentration range of 6-21 μg mL-1. A Student’s t-test demonstrated that the proposed method was comparable to an HPLC method previously validated. Thus, the validated spectrophotometric method could quantify daptomycin in a powder form for injectable solutions, while being an economical, rapid, and “green” alternative for routine analysis in quality control.School of Pharmaceutical Sciences Universidade Estadual Paulista “Júlio de Mesquita Filho” UNESPSchool of Pharmaceutical Sciences Universidade Estadual Paulista “Júlio de Mesquita Filho” UNESPUniversidade Estadual Paulista (Unesp)Tótoli, Eliane Gandolpho [UNESP]Salgado, Hérida Regina Nunes [UNESP]2018-12-11T17:27:47Z2018-12-11T17:27:47Z2015-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article811-821application/pdfhttp://dx.doi.org/10.1590/S1984-82502015000400007Brazilian Journal of Pharmaceutical Sciences, v. 51, n. 4, p. 811-821, 2015.2175-97901984-8250http://hdl.handle.net/11449/17794010.1590/S1984-82502015000400007S1984-825020150004008112-s2.0-84962757590S1984-82502015000400811.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Pharmaceutical Sciences0,2140,214info:eu-repo/semantics/openAccess2024-06-24T13:45:18Zoai:repositorio.unesp.br:11449/177940Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-06-24T13:45:18Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry |
title |
A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry |
spellingShingle |
A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry Tótoli, Eliane Gandolpho [UNESP] Antimicrobials/quality control Daptomycin/determination Spectrophotometry/green analytical method Spectrophotometry/UV region/ quantitative analysis |
title_short |
A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry |
title_full |
A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry |
title_fullStr |
A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry |
title_full_unstemmed |
A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry |
title_sort |
A green approach for the quantification of daptomycin in pharmaceutical formulation by UV spectrophotometry |
author |
Tótoli, Eliane Gandolpho [UNESP] |
author_facet |
Tótoli, Eliane Gandolpho [UNESP] Salgado, Hérida Regina Nunes [UNESP] |
author_role |
author |
author2 |
Salgado, Hérida Regina Nunes [UNESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Tótoli, Eliane Gandolpho [UNESP] Salgado, Hérida Regina Nunes [UNESP] |
dc.subject.por.fl_str_mv |
Antimicrobials/quality control Daptomycin/determination Spectrophotometry/green analytical method Spectrophotometry/UV region/ quantitative analysis |
topic |
Antimicrobials/quality control Daptomycin/determination Spectrophotometry/green analytical method Spectrophotometry/UV region/ quantitative analysis |
description |
Daptomycin is the first approved drug from a new class of antimicrobials, the cyclic lipopeptides, and is a very important antimicrobial agent in current clinical practice. Currently, there are no “green” analytical methods described in the literature to analyze the typical pharmaceutical dosage form of daptomycin. Thus, the aim of this work was to validate an environment-friendly spectrophotometric method in the UV region, for the analysis of daptomycin as a lyophilized powder. Water was used as diluent and the analyses were carried out on a spectrophotometer at 221 nm. The method met all validation requirements of the ICH guidelines, over a concentration range of 6-21 μg mL-1. A Student’s t-test demonstrated that the proposed method was comparable to an HPLC method previously validated. Thus, the validated spectrophotometric method could quantify daptomycin in a powder form for injectable solutions, while being an economical, rapid, and “green” alternative for routine analysis in quality control. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-01 2018-12-11T17:27:47Z 2018-12-11T17:27:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1984-82502015000400007 Brazilian Journal of Pharmaceutical Sciences, v. 51, n. 4, p. 811-821, 2015. 2175-9790 1984-8250 http://hdl.handle.net/11449/177940 10.1590/S1984-82502015000400007 S1984-82502015000400811 2-s2.0-84962757590 S1984-82502015000400811.pdf |
url |
http://dx.doi.org/10.1590/S1984-82502015000400007 http://hdl.handle.net/11449/177940 |
identifier_str_mv |
Brazilian Journal of Pharmaceutical Sciences, v. 51, n. 4, p. 811-821, 2015. 2175-9790 1984-8250 10.1590/S1984-82502015000400007 S1984-82502015000400811 2-s2.0-84962757590 S1984-82502015000400811.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences 0,214 0,214 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
811-821 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803045236009598976 |