Genetically-determined variations of SELENOP are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1017/S000711452100146X http://hdl.handle.net/11449/207719 |
Resumo: | Several single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biomarkers to the Brazil nut consumption in patients using statins, and if the variation in Se homeostasis could affect antioxidant protection, lipid profile, muscle homeostasis, and selenoproteins mRNA. The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients using statins received one unit of Brazil nut daily for three months. Body composition, blood Se concentrations, erythrocyte glutathione peroxidase (GPX) activity, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), creatine kinase (CK) activity, and gene expression of GPX1 and selenoprotein P (SELENOP) were evaluated before and after Brazil nut consumption. The volunteers were genotyped for SNPs in GPX1 (rs1050450) and SELENOP (rs3877899 and rs7579). SNPs in selenoproteins were not associated with plasma and erythrocyte Se, but SNPs in SELENOP influenced the response of erythrocyte GPX activity and CK activity, triglycerides, and LDL after Brazil nut consumption. Also, Brazil nut consumption increased GPX1 mRNA expression only in subjects with rs1050450 CC genotype. SELENOP mRNA expression was significantly lower in subjects with rs7579 GG genotype before and after the intervention. Thus, SNPs in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasizing the involvement of genetic variability in the response to Se consumption toward health maintenance and disease prevention. |
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Repositório Institucional da UNESP |
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Genetically-determined variations of SELENOP are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statinsOxidative stressSeleniumSelenoproteinsSingle nucleotide polymorphismsStatinSeveral single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biomarkers to the Brazil nut consumption in patients using statins, and if the variation in Se homeostasis could affect antioxidant protection, lipid profile, muscle homeostasis, and selenoproteins mRNA. The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients using statins received one unit of Brazil nut daily for three months. Body composition, blood Se concentrations, erythrocyte glutathione peroxidase (GPX) activity, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), creatine kinase (CK) activity, and gene expression of GPX1 and selenoprotein P (SELENOP) were evaluated before and after Brazil nut consumption. The volunteers were genotyped for SNPs in GPX1 (rs1050450) and SELENOP (rs3877899 and rs7579). SNPs in selenoproteins were not associated with plasma and erythrocyte Se, but SNPs in SELENOP influenced the response of erythrocyte GPX activity and CK activity, triglycerides, and LDL after Brazil nut consumption. Also, Brazil nut consumption increased GPX1 mRNA expression only in subjects with rs1050450 CC genotype. SELENOP mRNA expression was significantly lower in subjects with rs7579 GG genotype before and after the intervention. Thus, SNPs in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasizing the involvement of genetic variability in the response to Se consumption toward health maintenance and disease prevention.Department of Internal Medicine Ribeirão Preto Medical School University of São Paulo - FMRP/USPDepartment of Clinical and Toxicological Analyses and Bromatology Faculty of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo - FCFRP/USPDepartment of Pediatrics Ribeirão Preto Medical School University of São Paulo - FMRP/USPDepartment of Health Sciences Division of Nutrition and Metabolism Ribeirão Preto Medical School University of São Paulo - FMRP/USPDepartment of Food and Nutrition Faculty of Pharmaceutical Sciences São Paulo State University - UNESPDepartment of Food and Nutrition Faculty of Pharmaceutical Sciences São Paulo State University - UNESPUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Watanabe, Lígia MoriguchiBueno, Ana Carolinade Lima, Livia FernandesFerraz-Bannitz, RafaelDessordi, Renata [UNESP]Guimarães, Mariana Palmade Freitas, Maria Cristina FossBarbosa, FernandoNavarro, Anderson Marliere2021-06-25T10:59:51Z2021-06-25T10:59:51Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1017/S000711452100146XBritish Journal of Nutrition.1475-26620007-1145http://hdl.handle.net/11449/20771910.1017/S000711452100146X2-s2.0-85105674916Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBritish Journal of Nutritioninfo:eu-repo/semantics/openAccess2024-06-21T12:46:50Zoai:repositorio.unesp.br:11449/207719Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:41:55.058649Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Genetically-determined variations of SELENOP are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins |
title |
Genetically-determined variations of SELENOP are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins |
spellingShingle |
Genetically-determined variations of SELENOP are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins Watanabe, Lígia Moriguchi Oxidative stress Selenium Selenoproteins Single nucleotide polymorphisms Statin |
title_short |
Genetically-determined variations of SELENOP are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins |
title_full |
Genetically-determined variations of SELENOP are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins |
title_fullStr |
Genetically-determined variations of SELENOP are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins |
title_full_unstemmed |
Genetically-determined variations of SELENOP are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins |
title_sort |
Genetically-determined variations of SELENOP are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins |
author |
Watanabe, Lígia Moriguchi |
author_facet |
Watanabe, Lígia Moriguchi Bueno, Ana Carolina de Lima, Livia Fernandes Ferraz-Bannitz, Rafael Dessordi, Renata [UNESP] Guimarães, Mariana Palma de Freitas, Maria Cristina Foss Barbosa, Fernando Navarro, Anderson Marliere |
author_role |
author |
author2 |
Bueno, Ana Carolina de Lima, Livia Fernandes Ferraz-Bannitz, Rafael Dessordi, Renata [UNESP] Guimarães, Mariana Palma de Freitas, Maria Cristina Foss Barbosa, Fernando Navarro, Anderson Marliere |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Watanabe, Lígia Moriguchi Bueno, Ana Carolina de Lima, Livia Fernandes Ferraz-Bannitz, Rafael Dessordi, Renata [UNESP] Guimarães, Mariana Palma de Freitas, Maria Cristina Foss Barbosa, Fernando Navarro, Anderson Marliere |
dc.subject.por.fl_str_mv |
Oxidative stress Selenium Selenoproteins Single nucleotide polymorphisms Statin |
topic |
Oxidative stress Selenium Selenoproteins Single nucleotide polymorphisms Statin |
description |
Several single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biomarkers to the Brazil nut consumption in patients using statins, and if the variation in Se homeostasis could affect antioxidant protection, lipid profile, muscle homeostasis, and selenoproteins mRNA. The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients using statins received one unit of Brazil nut daily for three months. Body composition, blood Se concentrations, erythrocyte glutathione peroxidase (GPX) activity, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), creatine kinase (CK) activity, and gene expression of GPX1 and selenoprotein P (SELENOP) were evaluated before and after Brazil nut consumption. The volunteers were genotyped for SNPs in GPX1 (rs1050450) and SELENOP (rs3877899 and rs7579). SNPs in selenoproteins were not associated with plasma and erythrocyte Se, but SNPs in SELENOP influenced the response of erythrocyte GPX activity and CK activity, triglycerides, and LDL after Brazil nut consumption. Also, Brazil nut consumption increased GPX1 mRNA expression only in subjects with rs1050450 CC genotype. SELENOP mRNA expression was significantly lower in subjects with rs7579 GG genotype before and after the intervention. Thus, SNPs in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasizing the involvement of genetic variability in the response to Se consumption toward health maintenance and disease prevention. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:59:51Z 2021-06-25T10:59:51Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1017/S000711452100146X British Journal of Nutrition. 1475-2662 0007-1145 http://hdl.handle.net/11449/207719 10.1017/S000711452100146X 2-s2.0-85105674916 |
url |
http://dx.doi.org/10.1017/S000711452100146X http://hdl.handle.net/11449/207719 |
identifier_str_mv |
British Journal of Nutrition. 1475-2662 0007-1145 10.1017/S000711452100146X 2-s2.0-85105674916 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
British Journal of Nutrition |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128846520647680 |