Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome

Detalhes bibliográficos
Autor(a) principal: Orsatti, Claudio Lera
Data de Publicação: 2022
Outros Autores: Orsatti, Fabio Lera, Bezerra, Thaiz Geovana, Quevedo, Ana, Nahas, Eliana Aguiar Petri [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/09513590.2022.2105832
http://hdl.handle.net/11449/241448
Resumo: Objective: To determine if higher levels of circulating interleukin (IL)-15 are positively associated with improvement in insulin resistance in postmenopausal women (PW) with metabolic syndrome (MS). Methods: According to the median value of IL-15 at baseline, PW older than or equal to 45 years were divided into two groups: higher (n = 43) and lower (n = 42) IL-15. There was a 9-month follow-up period with clinical assessments at baseline and at 9 months (criteria of metabolic syndrome, body fat, and insulin resistance). Insulin resistance (IR) was calculated according to the Homeostasis Model Assessment-estimated insulin resistance (HOMA-IR). For IL-1β, IL-6, IL-10, IL-13, IL-33, IL-15, and TNF-α was determined using immunoassay Magnetic Bead Panel. Results: There was an interaction between the time and group only for insulin (p =.008) and HOMA-IR (p =.024). After adjusting for confounding variables (clinical and ILs), the HOMA-IR (p =.006) and insulin (p =.003) were lower in the higher-IL-15 group [HOMA-IR: 2.2 (95% CI: 1.9–2.5) and insulin: 9.1 µIU/mL (95% CI: 7.9–10.3)] when compared to the lower-IL-15 group [HOMA-IR: 3.1 (95% CI: 2.6–3.6) and insulin: 12.9 (95% CI: 11.1–14.9)] after 9 months of follow-up. Conclusion: Higher levels of circulating IL-15 are positively associated with improvements in IR in PW with MS.
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spelling Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndromecytokineInsulin resistanceinterleukin-15metabolic syndromepostmenopausalObjective: To determine if higher levels of circulating interleukin (IL)-15 are positively associated with improvement in insulin resistance in postmenopausal women (PW) with metabolic syndrome (MS). Methods: According to the median value of IL-15 at baseline, PW older than or equal to 45 years were divided into two groups: higher (n = 43) and lower (n = 42) IL-15. There was a 9-month follow-up period with clinical assessments at baseline and at 9 months (criteria of metabolic syndrome, body fat, and insulin resistance). Insulin resistance (IR) was calculated according to the Homeostasis Model Assessment-estimated insulin resistance (HOMA-IR). For IL-1β, IL-6, IL-10, IL-13, IL-33, IL-15, and TNF-α was determined using immunoassay Magnetic Bead Panel. Results: There was an interaction between the time and group only for insulin (p =.008) and HOMA-IR (p =.024). After adjusting for confounding variables (clinical and ILs), the HOMA-IR (p =.006) and insulin (p =.003) were lower in the higher-IL-15 group [HOMA-IR: 2.2 (95% CI: 1.9–2.5) and insulin: 9.1 µIU/mL (95% CI: 7.9–10.3)] when compared to the lower-IL-15 group [HOMA-IR: 3.1 (95% CI: 2.6–3.6) and insulin: 12.9 (95% CI: 11.1–14.9)] after 9 months of follow-up. Conclusion: Higher levels of circulating IL-15 are positively associated with improvements in IR in PW with MS.Department Health Science Oeste Paulista University–UNOESTE, SPApplied Physiology Nutrition and Exercise Research Group–PhyNEr Institute of Health Sciences Federal University of Triangulo Mineiro–UFTM, Minas GeraisDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University-UNESP, São PauloDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University-UNESP, São PauloOeste Paulista University–UNOESTEFederal University of Triangulo Mineiro–UFTMUniversidade Estadual Paulista (UNESP)Orsatti, Claudio LeraOrsatti, Fabio LeraBezerra, Thaiz GeovanaQuevedo, AnaNahas, Eliana Aguiar Petri [UNESP]2023-03-01T21:03:36Z2023-03-01T21:03:36Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/09513590.2022.2105832Gynecological Endocrinology.1473-07660951-3590http://hdl.handle.net/11449/24144810.1080/09513590.2022.21058322-s2.0-85135260883Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGynecological Endocrinologyinfo:eu-repo/semantics/openAccess2024-08-16T14:06:30Zoai:repositorio.unesp.br:11449/241448Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:06:30Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome
title Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome
spellingShingle Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome
Orsatti, Claudio Lera
cytokine
Insulin resistance
interleukin-15
metabolic syndrome
postmenopausal
title_short Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome
title_full Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome
title_fullStr Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome
title_full_unstemmed Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome
title_sort Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome
author Orsatti, Claudio Lera
author_facet Orsatti, Claudio Lera
Orsatti, Fabio Lera
Bezerra, Thaiz Geovana
Quevedo, Ana
Nahas, Eliana Aguiar Petri [UNESP]
author_role author
author2 Orsatti, Fabio Lera
Bezerra, Thaiz Geovana
Quevedo, Ana
Nahas, Eliana Aguiar Petri [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Oeste Paulista University–UNOESTE
Federal University of Triangulo Mineiro–UFTM
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Orsatti, Claudio Lera
Orsatti, Fabio Lera
Bezerra, Thaiz Geovana
Quevedo, Ana
Nahas, Eliana Aguiar Petri [UNESP]
dc.subject.por.fl_str_mv cytokine
Insulin resistance
interleukin-15
metabolic syndrome
postmenopausal
topic cytokine
Insulin resistance
interleukin-15
metabolic syndrome
postmenopausal
description Objective: To determine if higher levels of circulating interleukin (IL)-15 are positively associated with improvement in insulin resistance in postmenopausal women (PW) with metabolic syndrome (MS). Methods: According to the median value of IL-15 at baseline, PW older than or equal to 45 years were divided into two groups: higher (n = 43) and lower (n = 42) IL-15. There was a 9-month follow-up period with clinical assessments at baseline and at 9 months (criteria of metabolic syndrome, body fat, and insulin resistance). Insulin resistance (IR) was calculated according to the Homeostasis Model Assessment-estimated insulin resistance (HOMA-IR). For IL-1β, IL-6, IL-10, IL-13, IL-33, IL-15, and TNF-α was determined using immunoassay Magnetic Bead Panel. Results: There was an interaction between the time and group only for insulin (p =.008) and HOMA-IR (p =.024). After adjusting for confounding variables (clinical and ILs), the HOMA-IR (p =.006) and insulin (p =.003) were lower in the higher-IL-15 group [HOMA-IR: 2.2 (95% CI: 1.9–2.5) and insulin: 9.1 µIU/mL (95% CI: 7.9–10.3)] when compared to the lower-IL-15 group [HOMA-IR: 3.1 (95% CI: 2.6–3.6) and insulin: 12.9 (95% CI: 11.1–14.9)] after 9 months of follow-up. Conclusion: Higher levels of circulating IL-15 are positively associated with improvements in IR in PW with MS.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-03-01T21:03:36Z
2023-03-01T21:03:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/09513590.2022.2105832
Gynecological Endocrinology.
1473-0766
0951-3590
http://hdl.handle.net/11449/241448
10.1080/09513590.2022.2105832
2-s2.0-85135260883
url http://dx.doi.org/10.1080/09513590.2022.2105832
http://hdl.handle.net/11449/241448
identifier_str_mv Gynecological Endocrinology.
1473-0766
0951-3590
10.1080/09513590.2022.2105832
2-s2.0-85135260883
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Gynecological Endocrinology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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