Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/09513590.2022.2105832 http://hdl.handle.net/11449/241448 |
Resumo: | Objective: To determine if higher levels of circulating interleukin (IL)-15 are positively associated with improvement in insulin resistance in postmenopausal women (PW) with metabolic syndrome (MS). Methods: According to the median value of IL-15 at baseline, PW older than or equal to 45 years were divided into two groups: higher (n = 43) and lower (n = 42) IL-15. There was a 9-month follow-up period with clinical assessments at baseline and at 9 months (criteria of metabolic syndrome, body fat, and insulin resistance). Insulin resistance (IR) was calculated according to the Homeostasis Model Assessment-estimated insulin resistance (HOMA-IR). For IL-1β, IL-6, IL-10, IL-13, IL-33, IL-15, and TNF-α was determined using immunoassay Magnetic Bead Panel. Results: There was an interaction between the time and group only for insulin (p =.008) and HOMA-IR (p =.024). After adjusting for confounding variables (clinical and ILs), the HOMA-IR (p =.006) and insulin (p =.003) were lower in the higher-IL-15 group [HOMA-IR: 2.2 (95% CI: 1.9–2.5) and insulin: 9.1 µIU/mL (95% CI: 7.9–10.3)] when compared to the lower-IL-15 group [HOMA-IR: 3.1 (95% CI: 2.6–3.6) and insulin: 12.9 (95% CI: 11.1–14.9)] after 9 months of follow-up. Conclusion: Higher levels of circulating IL-15 are positively associated with improvements in IR in PW with MS. |
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Repositório Institucional da UNESP |
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Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndromecytokineInsulin resistanceinterleukin-15metabolic syndromepostmenopausalObjective: To determine if higher levels of circulating interleukin (IL)-15 are positively associated with improvement in insulin resistance in postmenopausal women (PW) with metabolic syndrome (MS). Methods: According to the median value of IL-15 at baseline, PW older than or equal to 45 years were divided into two groups: higher (n = 43) and lower (n = 42) IL-15. There was a 9-month follow-up period with clinical assessments at baseline and at 9 months (criteria of metabolic syndrome, body fat, and insulin resistance). Insulin resistance (IR) was calculated according to the Homeostasis Model Assessment-estimated insulin resistance (HOMA-IR). For IL-1β, IL-6, IL-10, IL-13, IL-33, IL-15, and TNF-α was determined using immunoassay Magnetic Bead Panel. Results: There was an interaction between the time and group only for insulin (p =.008) and HOMA-IR (p =.024). After adjusting for confounding variables (clinical and ILs), the HOMA-IR (p =.006) and insulin (p =.003) were lower in the higher-IL-15 group [HOMA-IR: 2.2 (95% CI: 1.9–2.5) and insulin: 9.1 µIU/mL (95% CI: 7.9–10.3)] when compared to the lower-IL-15 group [HOMA-IR: 3.1 (95% CI: 2.6–3.6) and insulin: 12.9 (95% CI: 11.1–14.9)] after 9 months of follow-up. Conclusion: Higher levels of circulating IL-15 are positively associated with improvements in IR in PW with MS.Department Health Science Oeste Paulista University–UNOESTE, SPApplied Physiology Nutrition and Exercise Research Group–PhyNEr Institute of Health Sciences Federal University of Triangulo Mineiro–UFTM, Minas GeraisDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University-UNESP, São PauloDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University-UNESP, São PauloOeste Paulista University–UNOESTEFederal University of Triangulo Mineiro–UFTMUniversidade Estadual Paulista (UNESP)Orsatti, Claudio LeraOrsatti, Fabio LeraBezerra, Thaiz GeovanaQuevedo, AnaNahas, Eliana Aguiar Petri [UNESP]2023-03-01T21:03:36Z2023-03-01T21:03:36Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/09513590.2022.2105832Gynecological Endocrinology.1473-07660951-3590http://hdl.handle.net/11449/24144810.1080/09513590.2022.21058322-s2.0-85135260883Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGynecological Endocrinologyinfo:eu-repo/semantics/openAccess2024-08-16T14:06:30Zoai:repositorio.unesp.br:11449/241448Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:06:30Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome |
title |
Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome |
spellingShingle |
Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome Orsatti, Claudio Lera cytokine Insulin resistance interleukin-15 metabolic syndrome postmenopausal |
title_short |
Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome |
title_full |
Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome |
title_fullStr |
Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome |
title_full_unstemmed |
Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome |
title_sort |
Interleukin-15 are associated with insulin resistance in postmenopausal women with metabolic syndrome |
author |
Orsatti, Claudio Lera |
author_facet |
Orsatti, Claudio Lera Orsatti, Fabio Lera Bezerra, Thaiz Geovana Quevedo, Ana Nahas, Eliana Aguiar Petri [UNESP] |
author_role |
author |
author2 |
Orsatti, Fabio Lera Bezerra, Thaiz Geovana Quevedo, Ana Nahas, Eliana Aguiar Petri [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Oeste Paulista University–UNOESTE Federal University of Triangulo Mineiro–UFTM Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Orsatti, Claudio Lera Orsatti, Fabio Lera Bezerra, Thaiz Geovana Quevedo, Ana Nahas, Eliana Aguiar Petri [UNESP] |
dc.subject.por.fl_str_mv |
cytokine Insulin resistance interleukin-15 metabolic syndrome postmenopausal |
topic |
cytokine Insulin resistance interleukin-15 metabolic syndrome postmenopausal |
description |
Objective: To determine if higher levels of circulating interleukin (IL)-15 are positively associated with improvement in insulin resistance in postmenopausal women (PW) with metabolic syndrome (MS). Methods: According to the median value of IL-15 at baseline, PW older than or equal to 45 years were divided into two groups: higher (n = 43) and lower (n = 42) IL-15. There was a 9-month follow-up period with clinical assessments at baseline and at 9 months (criteria of metabolic syndrome, body fat, and insulin resistance). Insulin resistance (IR) was calculated according to the Homeostasis Model Assessment-estimated insulin resistance (HOMA-IR). For IL-1β, IL-6, IL-10, IL-13, IL-33, IL-15, and TNF-α was determined using immunoassay Magnetic Bead Panel. Results: There was an interaction between the time and group only for insulin (p =.008) and HOMA-IR (p =.024). After adjusting for confounding variables (clinical and ILs), the HOMA-IR (p =.006) and insulin (p =.003) were lower in the higher-IL-15 group [HOMA-IR: 2.2 (95% CI: 1.9–2.5) and insulin: 9.1 µIU/mL (95% CI: 7.9–10.3)] when compared to the lower-IL-15 group [HOMA-IR: 3.1 (95% CI: 2.6–3.6) and insulin: 12.9 (95% CI: 11.1–14.9)] after 9 months of follow-up. Conclusion: Higher levels of circulating IL-15 are positively associated with improvements in IR in PW with MS. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-03-01T21:03:36Z 2023-03-01T21:03:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/09513590.2022.2105832 Gynecological Endocrinology. 1473-0766 0951-3590 http://hdl.handle.net/11449/241448 10.1080/09513590.2022.2105832 2-s2.0-85135260883 |
url |
http://dx.doi.org/10.1080/09513590.2022.2105832 http://hdl.handle.net/11449/241448 |
identifier_str_mv |
Gynecological Endocrinology. 1473-0766 0951-3590 10.1080/09513590.2022.2105832 2-s2.0-85135260883 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Gynecological Endocrinology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128114481430528 |