Administração experimental de esteróide anabólico androgênico e álcool causa alterações histológicas e morfométricas nos ovários e útero de ratas adultas
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/226511 |
Resumo: | Abusive and indiscriminate use of androgenic anabolic steroid is an usual practice among youth and adults of both sex. Usually these substances were utilized simultaneously with others drugs, licit or not, that causes damage to health. The purpose of study was to evaluate the influence of experimental administration of nandrolone decanoate steroid (ND), associated or not to alcohol, in the ovaries and uterus of adult rats. Females with regular estrous cycle (n = 20), were distributed in the groups: a) control (physiological solution); b) ND (7.5 mg/kg BW; intraperitoneal); c) alcohol (0.2 mL/100g BW; oral); d) ND + AL. The teatments were realized by single dose per week, during twelve consecutive weeks. The ovaries of rats in the groups ND, AL and ND + AL presented intense follicular atresia and decrease in the number of antral follicles and corpora lutea. None treatment did affect ovarian weight, but uterine weight was increase (p<0.05) in the ND + AL group. There were alterations in the uterine histology and morphometry at function of each treatment. Isolated or simultaneous use of anabolic steroid and alcohol promotes ovarian and uterine toxicity in adult female rats. |
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Repositório Institucional da UNESP |
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Administração experimental de esteróide anabólico androgênico e álcool causa alterações histológicas e morfométricas nos ovários e útero de ratas adultasExperimental administration of anabolic androgenic steroid and alcohol causes histological and morphometrical alterations in the ovaries and uterus of adult ratsAlcoholAnabolic steroidHistomorphometryOvariesRatsUterusAbusive and indiscriminate use of androgenic anabolic steroid is an usual practice among youth and adults of both sex. Usually these substances were utilized simultaneously with others drugs, licit or not, that causes damage to health. The purpose of study was to evaluate the influence of experimental administration of nandrolone decanoate steroid (ND), associated or not to alcohol, in the ovaries and uterus of adult rats. Females with regular estrous cycle (n = 20), were distributed in the groups: a) control (physiological solution); b) ND (7.5 mg/kg BW; intraperitoneal); c) alcohol (0.2 mL/100g BW; oral); d) ND + AL. The teatments were realized by single dose per week, during twelve consecutive weeks. The ovaries of rats in the groups ND, AL and ND + AL presented intense follicular atresia and decrease in the number of antral follicles and corpora lutea. None treatment did affect ovarian weight, but uterine weight was increase (p<0.05) in the ND + AL group. There were alterations in the uterine histology and morphometry at function of each treatment. Isolated or simultaneous use of anabolic steroid and alcohol promotes ovarian and uterine toxicity in adult female rats.Departamento de Ciências Biológicas Universidade Estadual Paulista - UNESP, Assis, SPDepartamento de Ciências Biológicas - UNESP, Assis, SPDepartamento de Biologia Geral Universidade Estadual de Londrina - UEL, LondrinaDepartamento de Ciências Biológicas Universidade Estadual Paulista - UNESP, Assis, SPDepartamento de Ciências Biológicas - UNESP, Assis, SPUniversidade Estadual Paulista (UNESP)Universidade Estadual de Londrina (UEL)Camargo, Isabel Cristina Cherici [UNESP]de Gênova, Tatiana Cristina [UNESP]Machado, Marcela Cristina de Pontes [UNESP]Frei, Fernando [UNESP]Mesquita, Suzana de Fátima Paccola2022-04-29T00:49:44Z2022-04-29T00:49:44Z2011-09-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article656-665Bioscience Journal, v. 27, n. 4, p. 656-665, 2011.1516-37251981-3163http://hdl.handle.net/11449/2265112-s2.0-80052564698Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporBioscience Journalinfo:eu-repo/semantics/openAccess2024-06-13T17:38:32Zoai:repositorio.unesp.br:11449/226511Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:25:48.505511Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Administração experimental de esteróide anabólico androgênico e álcool causa alterações histológicas e morfométricas nos ovários e útero de ratas adultas Experimental administration of anabolic androgenic steroid and alcohol causes histological and morphometrical alterations in the ovaries and uterus of adult rats |
title |
Administração experimental de esteróide anabólico androgênico e álcool causa alterações histológicas e morfométricas nos ovários e útero de ratas adultas |
spellingShingle |
Administração experimental de esteróide anabólico androgênico e álcool causa alterações histológicas e morfométricas nos ovários e útero de ratas adultas Camargo, Isabel Cristina Cherici [UNESP] Alcohol Anabolic steroid Histomorphometry Ovaries Rats Uterus |
title_short |
Administração experimental de esteróide anabólico androgênico e álcool causa alterações histológicas e morfométricas nos ovários e útero de ratas adultas |
title_full |
Administração experimental de esteróide anabólico androgênico e álcool causa alterações histológicas e morfométricas nos ovários e útero de ratas adultas |
title_fullStr |
Administração experimental de esteróide anabólico androgênico e álcool causa alterações histológicas e morfométricas nos ovários e útero de ratas adultas |
title_full_unstemmed |
Administração experimental de esteróide anabólico androgênico e álcool causa alterações histológicas e morfométricas nos ovários e útero de ratas adultas |
title_sort |
Administração experimental de esteróide anabólico androgênico e álcool causa alterações histológicas e morfométricas nos ovários e útero de ratas adultas |
author |
Camargo, Isabel Cristina Cherici [UNESP] |
author_facet |
Camargo, Isabel Cristina Cherici [UNESP] de Gênova, Tatiana Cristina [UNESP] Machado, Marcela Cristina de Pontes [UNESP] Frei, Fernando [UNESP] Mesquita, Suzana de Fátima Paccola |
author_role |
author |
author2 |
de Gênova, Tatiana Cristina [UNESP] Machado, Marcela Cristina de Pontes [UNESP] Frei, Fernando [UNESP] Mesquita, Suzana de Fátima Paccola |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Estadual de Londrina (UEL) |
dc.contributor.author.fl_str_mv |
Camargo, Isabel Cristina Cherici [UNESP] de Gênova, Tatiana Cristina [UNESP] Machado, Marcela Cristina de Pontes [UNESP] Frei, Fernando [UNESP] Mesquita, Suzana de Fátima Paccola |
dc.subject.por.fl_str_mv |
Alcohol Anabolic steroid Histomorphometry Ovaries Rats Uterus |
topic |
Alcohol Anabolic steroid Histomorphometry Ovaries Rats Uterus |
description |
Abusive and indiscriminate use of androgenic anabolic steroid is an usual practice among youth and adults of both sex. Usually these substances were utilized simultaneously with others drugs, licit or not, that causes damage to health. The purpose of study was to evaluate the influence of experimental administration of nandrolone decanoate steroid (ND), associated or not to alcohol, in the ovaries and uterus of adult rats. Females with regular estrous cycle (n = 20), were distributed in the groups: a) control (physiological solution); b) ND (7.5 mg/kg BW; intraperitoneal); c) alcohol (0.2 mL/100g BW; oral); d) ND + AL. The teatments were realized by single dose per week, during twelve consecutive weeks. The ovaries of rats in the groups ND, AL and ND + AL presented intense follicular atresia and decrease in the number of antral follicles and corpora lutea. None treatment did affect ovarian weight, but uterine weight was increase (p<0.05) in the ND + AL group. There were alterations in the uterine histology and morphometry at function of each treatment. Isolated or simultaneous use of anabolic steroid and alcohol promotes ovarian and uterine toxicity in adult female rats. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-09-14 2022-04-29T00:49:44Z 2022-04-29T00:49:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Bioscience Journal, v. 27, n. 4, p. 656-665, 2011. 1516-3725 1981-3163 http://hdl.handle.net/11449/226511 2-s2.0-80052564698 |
identifier_str_mv |
Bioscience Journal, v. 27, n. 4, p. 656-665, 2011. 1516-3725 1981-3163 2-s2.0-80052564698 |
url |
http://hdl.handle.net/11449/226511 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
Bioscience Journal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
656-665 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129066080927744 |